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Results for “Immunologic Deficiency Syndromes”

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At least 469 records · Page 26Linked to original sources
PubMed1982

A case of Di George syndrome treated with thymopoietin pentapeptide (TP-5) demonstrating an adherent suppressor cell of lymphocyte function.

A child with the classical features of Di George syndrome is described. The patient was treated with TP-5 and the number of peripheral blood E-rosette forming cells rose from 11% to 69% but then fell to 33% prior to death. There was poor correlation between the number of T-cells estimated by rosetting with sheep red blood cells and that measured by cytotoxicity to the OKT3 antiserum and complement. Although the total T-cell numbers were reduced, the ratio of inducer/helper cells: suppressor/cytotoxic cells remained normal as assessed by the use of the specific monoclonal antisera OKT4 and OKT8. Lymphocyte proliferation after mitogenic activation and the production of lymphocyte mitogenic factor by PWM stimulated lymphocytes was significantly depressed but was considerably improved by the removal of adherent cells. It appears as though an adherent suppressor cell was partially responsible for the depressed lymphocyte function observed in this patient.

B-Lymphocytes↗
PubMed1980

Immunodeficiency in Down's syndrome: low levels of serum thymic factor in trisomic children.

The activity of thymus-dependent serum factor SF was significantly lower in 18 children wit Down's syndrome (DS) than in 14 matched controls. The percentage of circulating T lymphocytes forming E-rosettes was also low in DS. Together with the previous finding of immature of T lymphocytes in peripheral blood, the present data suggest that the basic immune defect of DS is failure in differentiation of peripheral post-thymic precursors to fully immunocompetent T lymphocytes resulting from lack of thymic hormonal factors.

Child, Preschool↗
PubMed1983

Opportunistic diseases.

Explore the source record for details and available documents.

Acquired Immunodeficiency Syndrome↗
PubMed1986

Cushing's syndrome--transitory immune deficiency state?

A 28 year old female patient with Cushing's syndrome due to an adrenal adenoma also suffered from recurrent urinary infections (proteus), tonsillitis (streptococcus), permanent candidiasis and perimandibular abscess (Staphylococcus pyogenes). Suppression of cellular and humoral immunity was confirmed by in vitro tests. After successful right adrenalectomy the clinical signs of Cushing's syndrome disappeared and no evidence of either bacterial or fungal infection were noted one year postoperatively. Immunological tests showed the restitution of both cellular and humoral immunity. The course of the disease in the patient supports the idea that Cushing's syndrome might be considered as a transitory immune deficiency state.

Adenoma↗
PubMed1975

Attempted immunologic reconstitution of patients with combined immune deficiency syndrome with bone marrow transplantation from histoincompatible donors.

The immunologic reconstitution from patients with combined immune deficiency syndrome was attempted with bone marrow transplantation from histoincompatible donors. None of the patients achieved long-term immunologic reconstitution. In all cases, the incompatible bone marrow was treated before transplantation. Physical separation of the stem and immunocompetent cells was attempted in 2 cases with the use of enhancing antibody in one of the attempts. The selective destruction of the immunocompetent bone marrow cells after specific stimulation was attempted in the last 2 cases.

Antibody-Producing Cells↗