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Occupational contact dermatitis in the workers employed in production of Texas textiles.

Pathological changes in the skin, of allergic type, have been detected in 35 of 131 weavers, employed in the production of primarily texas textiles. Patch tests yielded in 21 patients positive results with cotton and texas textiles. Approximately 50% of positive results of dermal tests have been found to be induced by naphthol compounds added to dyes in the process of preliminary dying. Moreover, 2 cases of extensive hyperchromatism in persons concerned with the above mentioned textiles have been observed which, due to the treatment procedures and removed from work in exposure have partly subsided.

Adult↗

The prognosis of occupational contact dermatitis.

Despite the development of new drugs and improvements in working conditions, the prognosis for recovery from contact dermatitis has not changed significantly over the past 50 years. This chapter reviews the prognosis for both irritant and allergic contact dermatitis and discusses the main reasons that contact dermatitis persists, including misdiagnosis and continued exposure to irritants and allergens.

Dermatitis, Occupational↗

Occupational contact dermatitis to nickel: experience of the British dermatologists (EPIDERM) and occupational physicians (OPRA) surveillance schemes.

AIMS: To examine, from occupational surveillance reporting data, whether scheme reporters considered nickel exposure to play a role in occupational contact dermatitis (OCD) in the UK. METHODS: Data on occupational skin disease in the UK are collected by two occupational disease surveillance schemes, EPIDERM and OPRA. Cases of OCD believed to have relevant nickel exposure reported to EPIDERM or OPRA from February 1993 to January 1999 were studied. RESULTS: An estimate of 1190 cases of occupational contact dermatitis thought to have relevant nickel exposure (12% of total estimated OCD) was derived from reports by dermatologists, an average of 198 per year. The highest incidence rates were seen in hairdressers (23.9/100 000 workers/year), bar staff (4.7), chefs and cooks (4.4), retail cash and checkout operators (2.8), and catering assistants (2.5). From May 1994 to January 1999, 158 cases of nickel associated dermatitis (1.9% of total OCD cases) were estimated; the most frequently reported occupations were electronic assemblers, nurses, sales assistants, and general assemblers. From July 1997 to January 1999, 547 positive patch tests to nickel were reported; in 195 cases (36%), nickel was felt to be a relevant occupational allergen (for example, coin handling). In hairdressers, nurses, cooks, and beauticians, nickel was usually considered, if relevant at all, to be only one of several causes of dermatitis. CONCLUSIONS: Up to 12% of total estimated cases of OCD were thought to be due in part to nickel. Results suggest that nickel hypersensitivity is one of several contributors to OCD in subjects with multiple occupational exposures. Coin handling may be a source of OCD to nickel.

Adolescent↗

Occupational contact dermatitis to gold.

A case of occupational contact dermatitis to gold is presented. This is uncommon as gold is relatively insoluble. Allergic contact dermatitis to gold is confirmed by patch testing with gold sodium thiosulfate 0.5% in petrolatum. Occupational contact dermatitis in the gold industry can be reduced by providing workers with more protective gear and better ventilation.

Dermatitis, Allergic Contact↗

Epidemiology of occupational contact dermatitis in a North Italian population.

Occupational contact dermatitis (OCD) is a very important skin disease both for its high frequency and for its social and economic implications. The aim of our work is to evaluate the epidemiology of occupational contact dermatitis in a north-Italian population and the possibility of a correct etiological diagnosis using the patch test standard series of GIRDCA (Italian Group of Resarch on Contact Dermatitis). We patch tested 1,565 out-patients affected by dermatitis with standard series GIRDCA and with other specific professional haptens. The manifestations were suspected of being of occupational origin by a dermatologist on the basis of clinical and anamnestic data. Of all the recorded professions we have considered only the more numerically significant: food industry, building industry, textile industry, employees, cleaners, hospital personnel, hairdressers, housewives, mechanics and metallurgists. Sixty-nine percent of contact dermatitis was found in women, the hairdressers had the greatest number of patients in the younger group (68.7% in the 11-20 years age group) and the textile industry workers in older group (100% in the 41-50 years age group). A positive allergological anamnesis emerged in 32.3% of allergic contact dermatitis. Irritant contact dermatitis (10.6%) was more frequent than allergic contact dermatitis (8.4%). The hands are the most common localization (94. 4%). The allergen with the highest frequency of positive reactions is p-phenylenediamine (25.3%). We discuss the frequency of positives to various groups of allergens in each profession and the principal means of contact. Because of the frequency of this type of occupational skin disease, we stress the importance of prevention. The standard series GIRDCA was found to be adequate for recognizing occupational contact dermatitis in most of our patients (74%).

Adolescent↗

Occupational contact dermatitis in 100 consecutive patients.

One hundred consecutive cases of occupational contact dermatitis diagnosed in Warsaw are discussed. In 79 subjects allergic and in 21 patients irritant occupational dermatitis was found. The most numerous group were workers employed with epoxy resins (20 persons), next came masons (14 subjects), and third medical staff members (12 persons). In 46 patients the standard series was sufficient for diagnosis of allergic occupational contact dermatitis, but in thirty three cases it was indispensable to test them with additional subsances.

Construction Materials↗

[Occupational contact dermatitis induced by allergens present in rubber. II. allergy to antioxidants].

Out of 339 persons suffering from occupational dermatitis, the group of 51 patients (15%), allergic to rubber, were eligible for the study. The frequency of allergy to amine compounds and quinoline derivatives (8 chemical compounds), used in rubber mixtures to prevent rubber oxidation, was investigated. The group under study comprised of 20 workers of the metallurgic, 6 of the building and 3 of the rubber industries as well as 15 health service workers, 2 farmers and 5 drivers. Allergy to amine compounds was found in 30 persons (58.8%) and to quinoline derivatives in 5 persons (9.8%). N-isopropyl-N-phenyl-4-phenylenodiamine proved to be most allergenic (52.9% of allergic persons), then N-cyclohexyl-N-phenyl-4-phenylenodiamine (31.4%) and N,N-diphenyl-4-phenylenodiamine (23.5%). Allergy to amine antioxidants was two times higher among workers of the metallurgic and building industries as well as among farmers and drivers than in health service workers, and it was induced by contact with technical rubber.

Adult↗

Supplemental tests in the evaluation of occupational hand dermatitis in soldiers.

BACKGROUND: Hand dermatitis in soldiers is a considerable problem. The purpose of the study was to evaluate appropriate screening tests to improve the diagnosis of hand dermatitis in soldiers. MATERIALS AND METHODS: A group of 111 soldiers with occupational dermatitis from contact with fuels and oils underwent "tailored patch tests" with allergens relevant to their field of work and their environment. The control group consisted of 24 soldiers with various jobs similar to those of civilian life, who had not been exposed to oils and fuels. Seventy-three civilian patients, attending the clinic for patch testing, were also included. Twenty soldiers, who had a history of intensive contact with oil and fuels, but no contact dermatitis, and who were admitted because of various skin diseases (fungal infections, acne, etc.) also underwent the supplemental testing and served as an additional control group. RESULTS: Of the soldiers, 31 (29%) showed one or more positive skin tests of the oil series and 30 patients of this group one or more positive reactions to the standard patch tests trays. No patient of the control groups had a positive test to the oil series. CONCLUSIONS: Our results show the value of the supplementary tests as a first-step screening test for detection of oil allergy in soldiers and automobile-mechanics or in workers handling other gasoline- or diesel-powered engineering equipment. The test method appears to be practical, easy to perform, reliable and giving clear and accurate results, with a negligible rate of false positive reactions.

Allergens↗

Occupational contact dermatitis among rubber workers.

The occurrence of occupational contact dermatitis among workers in a rubber factory from 1976 to 1980 was studied. Insurance compensation was paid to 50 workers with dermatitis. 21 of the cases were allergic and 27 toxic contact dermatitis, giving a contact dermatitis frequency of 5.6/1000 workers. Paraphenylenediamine compounds were the main cause of allergic contact dermatitis and solvents the main cause of toxic contact dermatitis.

Dermatitis, Contact↗

Occupational contact dermatitis in nurses with hand eczema.

Occupationally related dermatitis is a common problem in nurses, who are exposed to a wide variety of allergenic and irritant substances. In a group of 44 nurses with hand dermatitis (40 female, 4 male), 18 were thought to have a predominantly allergic contact dermatitis, 15 an irritant dermatitis, 7 other form of eczema, 3 atopic dermatitis and one pompholyx. 10 of the 15 irritant cases were diagnosed as occupational. Of the 18 patients with allergic contact dermatitis, the allergens were thought to be occupationally relevant in 8 cases. In 6 of these 8 the dermatitis was due to natural rubber latex (3) or other rubber chemicals (3). 2 had additional evidence of immediate-type hypersensitivity to natural rubber latex (one was patch test allergic to latex, the other to thiuram mix). Natural rubber latex allergy, both delayed and immediate, is a significant problem, and nurses at risk should be tested for both types of hypersensitivity, as well as being patch tested to standard, rubber and medicaments series.

Adult↗

The sensitizing capacity of Compositae plants. I. Occupational contact dermatitis from Arnica longifolia Eaton.

Three patients with occupational contact dermatitis due to Arnica longifolia Eaton and Arnica montana L. are reported. During cultivation, harvesting of the flower heads, chemical investigation of the sesquiterpene lactone constituents and preparation of therapeutic tinctures, they had frequent contact with the plant materials. Patch tests with the two sesquiterpene lactones carabron and helenalin, isolated during investigation from A. longifolia Eaton, were positive in all three patients, though the second patient had never shown visible allergic reactions of the skin. Sensitization experiments with carabron in five guinea pigs were successful. The investigation results revealed that carabron, helenalin and the acetyl derivative of helenalin must be considered as the sensitizers of A. longifolia, and helenalin acetate and properly arnifolin as sensitizers of A. montana. Studies on cross reactivity in the sensitized animals with six related sesquiterpene lactones showed that only those compounds gave a positive test response which contain an alpha-methylene gamma-lactone group. Cross reactions were obtained with a crude extract of Chrysanthemum indicum L. The case reports supported by the patch test and investigation results demonstrate that persons handling a new drug from the Compositae family run a risk of developing an allergy after intensive contact with the plant and its constituents.

Adult↗