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At least 469 records · Page 26Linked to original sources
PubMed1987

Interspecies differences in rhodanese (thiosulfate sulfurtransferase, EC 2.8.1.1) activity in liver, kidney and plasma.

Rhodanese levels have been measured in liver, kidney and plasma from a number of species. Liver activity was low in marmosets, pigeons and beagle bitches. Levels were high in rats and somewhat lower in hamsters and guinea pigs while levels in two strains of rabbits were intermediate between guinea pigs and marmosets. The relationship between hepatic and plasma rhodanese and cyanide sensitivity is discussed.

Animals↗
PubMed1980

Chlorambucil inhibition by dimethyl sulfoxide and thiosulfate: implications for chlorambucil chemotherapy.

Chlorambucil alkylation of pyridine, a model for nucleotides, appears to be first order in chlorambucil, but zero order in pyridine, and is strongly inhibited by dimethylsulfoxide. The same results are seen with chlorambucilyl [3H]prolyl proline; full alkylation activity was regained upon removal of dimethylsulfoxide. Chlorambycilyl [3H]prolyl proline alkylation of tRNA also appears to be first order in alkylator, but somewhat dependent on tRNA concentration, and is also strongly inhibited by dimethylsulfoxide. 10 mM Na2S2O3 completely inhibits alkylation by aqueous 1 mM chlorambucil. Up to 1 M chlorambucil in Me2SO retains full alkylation activity for at least a year. We suggest that the risk of carcinogenesis inherent in chlorambucil chemotherapy may be avoided by the topical application or injection of 1 M chlorambucil in Me2SO, in conjunction with oral administration of Na2S2O3.

Alkylation↗
PubMed2000

Rhodanese (thiosulfate:cyanide sulfurtransferase) from frog Rana temporaria.

The molecular mass of rhodanese from the mitochondrial fraction of frog Rana temporaria liver, equaling 8.7 kDa, was determined by high-performance size exclusion chromatography (HP-SEC). The considerable difference in molecular weight and the lack of common antigenic determinants between frog liver rhodanese and bovine rhodanese suggest the occurrence of different forms of this sulfurtransferase in the liver of these animals.

Animals↗