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At least 487 records · Page 27Linked to original sources
PubMed1976

Automation in the hematology laboratory.

In the routine laboratory for hematology conflicting results may be obtained for the red blood cell parameters with the Coulter Counter Model S. These parameters2) are: mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC). When the values of the MCHC are above 36 g/dl something must be wrong with the blood sample of the patient. One of the reasons can be agglutination e.g. by cold agglutinins. The blood sample should be reanalysed before and after heating for 1 hour at 37 degrees C. If the values change: cold agglutinins are present; if no change occurs paraproteins, or other disturbing factors, such as bilirubin or high leucocyte levels, will be found. MCH values may also be high in some cases e.g. if the red blood cells are coated with antibodies (Coombs test positive) or after ingestion of medicines like Azathioprine. These examples show that it is possible in some cases to correlate immunological findings with the red blood cell parameters. In addition to the results with the Coulter Counter Model S, some observations on the Hemalog (Technicon) are also presented.

Blood Cell Count↗
PubMed1999

Instrumentation for the genome project.

Much of the recent rapid progress in large-scale genomic sequencing has been driven by the dramatic improvements both in the area of biological protocols and in the availability of improved laboratory instrumentation and automation platforms. We discuss recent developments in the area of bioinstrumentation that are contributing to the current revolution in genetic analysis. Examples of systems for laboratory automation are described together with specific single-purpose instruments. Emphasis is placed on those tools that are contributing significantly to the scale-up of genomic mapping and sequencing efforts. In addition, we present a selection of more advanced measurement techniques and instrumentation developments that are likely to contribute significantly to future advances in sequencing and genome analysis.

Automation↗
PubMedDate not supplied

[Evaluation of the automated coagulation analyser ACL TOP (instrumentation laboratory)].

The ACL TOP is a fully automated random access analyser for coagulometric, chromogenic ou immunologic measurements. The aim of the present study was to evaluate its performances. The tests performed were: prothrombin time (PT), activated partial thromboplastin time (aPTT), prothrombin time derived fibrinogen (FibD), factor VIII (FVIII), antithrombin (AT) and free protein S antigen (PS). The comparison study was performed by analyzing patients samples in duplicate with ACL TOP and the analyser MDA II (BioMérieux) or CA 6000 (Dade-Behring). Imprecision (CV%) was < 4% for routine tests and < 5% for FVIII, AT and PS, except a between-run imprecision < 7,5% for low AT levels. The measured lower limits of linearity for FVIIII, AT and PS were satisfactory. The correlation observed between the ACL TOP and the other analysers was strict for PT and AT and good for TCA and FibD. Triglyceride levels > or = 6 mmol/L interfered with PT and FibD measurements. No sample or reagent carryover was observed in the conditions of the study. Overall, the ACL TO is an analyser with very satisfactory analytical and technical performances and is well suited for routine and specialized coagulation laboratories.

Blood Coagulation Tests↗
PubMed2001

Automation and high through-put for a DNA database laboratory: development of a laboratory information management system.

Automation and high through-put production of DNA profiles has become a necessity in every DNA database unit. In our laboratory we developed a Laboratory Information Management System (LIMS) controlled workflow architecture, which comprises a robotic DNA extraction- and pipetting-system and a capillary electrophoresis unit. This allows a through-put of 4,000 samples per person per year. Improved sample handling and data management, full sample- and batch-histories, and software-aided supervision of result data, with a consequent average turn-around time of 8 days, are the main features of our new system.

Austria↗
PubMed1978

[Organization, possibility and limits of the automation in an hospital testing laboratory (author's transl].

The AA. analize the most important items and they make some considerations to put in evidence which should be the general lines for a right application of an automation of an Hospital testing laboratory. After having studied carefully the essential items to face the automation, the AA. analize the advantage and the disadvantage of the matter. They sustain the essentiality to give to an outline of a rapid and exact entry on the most complete way to give to doctors the possibility to improve the clinical-diagnostics valutation and reduce the periods in bed. Having considered the different systems of automation, the AA. examine the problems relative to the cost of equipment, to the rooms, to the personnel, studying in particular the costs relative to the repeated tests, to the specific tests and to the urgencies. They conclude stating again that a good equipment can resolve the actual difficulties existing in the labs and that can improve the functionality of the Hospitals.

Autoanalysis↗
PubMed2000

[Developmental frontier of a modular automated system].

The clinical laboratory is faced with increasing problems such as healthcare reform, cost pressure and increased laboratory regulations. Despite these problems, the users have even higher expectations for laboratory services. To resolve these issues, the clinical laboratory must become more efficient by incorporating creative solutions and adapting to changes. One key word is increased automation of laboratory procedures and integration of automated systems. First, automation will reduce the dependence on manual labor. Second, laboratories could perform a larger menu of tests in-house. This not only reduces expense but also reduces the turn around time for testing. To realize cost reduction and reduce turn around time, we propose the Modular system.

Automation↗
PubMed1985

The medical and economic consequences of automation in bacteriology: a case study in a French university hospital.

In a bacteriology laboratory where automated and non-automated procedures co-existed during the study period (1 year), patients were randomly assigned to each type of procedure and we observed the physicians behaviour as well as patients well-being in a surgical service using the results from the laboratory. Contrary to our expectations, the reduction in the time delay necessary to obtain information did not alter either the prescribing behaviour of physicians nor the welfare of patients. Besides, the gain in time was significantly lower than expected. We also discuss in detail the meaning and relevance of the results.

Automation↗
PubMed2002

Automated transport and sorting system in a large reference laboratory: part 2. Implementation of the system and performance measures over three years.

BACKGROUND: Our laboratory implemented a major automation system in November 1998. A related report describes a 4-year process of evaluation and planning leading to system installation. This report describes the implementation and performance results over 3 years since the system was placed into use. METHODS: Project management software was used to track the project. Turnaround times of our top 500 tests before and after automation were measured. We compared the rate of hiring of employees and the billed unit per employee ratio before and after automation by use of linear regression analysis. Finally, we analyzed the financial contribution of the project through an analysis of return on investment. RESULTS: Since implementation, the volume of work transported and sorted has grown to >15,000 new tubes and >25,000 total tubes per day. Median turnaround time has decreased by an estimated 7 h, and turnaround time at the 95th percentile has decreased by 12 h. Lost specimens have decreased by 58%. A comparison of pre- and post-implementation hiring rates of employees estimated a savings of 33.6 employees, whereas a similar comparison of ratios of billed units per employee estimated a savings of 49.1 employees. Using the higher figure, we estimated that the $4.02 million cost of the project would be paid off approximately 4.9 years subsequent to placing the system into daily use. CONCLUSIONS: The overall automation project implemented in our laboratory has contributed considerably to improvement of key performance measures and has met our original project objectives.

Automation↗
PubMed1996

OpenLabs services for ordering laboratory investigations.

An automated system is described that screens requests for laboratory investigations from GPs and delivers feedback with respect to the adequacy of the requests. The system has to replace and extend the current system in which feedback is provided on a manual basis each half year, based on the tests requested during a period of one month, randomly selected from the previous half year. It has been reported elsewhere that the manual system reduced the number of tests requested considerably. The criteria used by the automated system and the manual system are based on guidelines and work agreements that GPs have agreed to follow when requesting investigations. It is concluded that the automated system is very user-friendly and that in the order of 4-17% of the requested tests could be identified as unnecessary, with a false negative rate in between 4% (for hyperthyroidism) and 23% (for hypothyroidism). The achieved reduction in the number of tests is in addition to the reduction obtained in the manual system.

Clinical Laboratory Information Systems↗
PubMed2004

The ADVIA Centaur immunoassay system--designed for infectious disease testing.

The ability to automate immunodiagnostics testing is critical for the efficiency of clinical laboratories. For automation of Infectious Disease testing, special design considerations must be made to ensure the integrity of the testing result while at the same time delivering productivity. The ADVIA Centaur was designed with the intent of performing a complete Infectious Disease panel including HBV, HCV, and HIV markers. Features such as disposable sample tips, sample and reagent delivery verification, and clog and clog detection have been incorporated in the design for assay robustness. Productivity features deliver best in class throughput performance for the Infectious Disease assays. Moreover, the underlying technology incorporating flexible assay protocols, universal solid phases and proprietary acridinium ester technology contribute to the assay design flexibility and analytical performance of the ADVIA Centaur immunoassay system.

AIDS Serodiagnosis↗
PubMed1990

Automated differentials in the hematology laboratory.

The white blood cell differential continues to be one of the most widely performed clinical laboratory procedures. However, its clinical usefulness is affected by sampling error and, to some extent, by classification criteria. It is also labor intensive and expensive to perform. Automated leukocyte differential instrumentation addresses many of the sources of error that occur with the manual differential. Current state-of-the-art instrumentation will give results that equal or exceed the routine manual differential. Because these instruments also examine red blood cell and platelet parameters, as well as providing white blood cell information, they can better screen for significant abnormalities as well as greatly reduce the expensive and time-consuming manual differential procedures.

Automation↗