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PubMed1975

Facilitation of avoidance learning by chlordiazepoxide-amphetamine combinations in mice.

Chlordiazepoxide and amphetamine, given separately or in combination, were tested in mice subjected to 5 100-trial avoidance sessions in the shuttle-box. Facilitation of avoidance responding was much more evident and statistically significant when the two drugs were combined. Drug mixtures produced effects which could not be obtained when the drugs were given separately.

Amphetamine↗
PubMed1994

The 5-HT1A agonist tandospirone disrupts retention but not acquisition of active avoidance learning.

To determine the effects of the 5-HT1A partial agonist tandospirone on acquisition and retention, mice were trained on a one-way active avoidance task and tested for retention 24 h later. Groups of mice were injected with either saline or 1, 5, or 10 mg/kg tandospirone 30 min before acquisition. Training was complete when animals achieved a criterion of five avoidances in a block of six trials. Results showed that tandospirone did not alter the rate of acquisition of the avoidance response, but retention was significantly disrupted by the 1- and 5-mg/kg doses. These findings confirm previous suggestions that 5-HT1A agonists can cause anterograde amnesia.

Animals↗