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At least 487 records · Page 27Linked to original sources
PubMed2005

Effect of a preparation containing a fucose-rich polysaccharide on periorbital wrinkles of human voluntaries.

BACKGROUND: Skin aging is accompanied by wrinkle formation. At some sites, as the periorbital skin, this is a relatively early phenomenon, variable from one woman to the other and even between the right and left eye. PURPOSE: We tested the effect of a preparation with fucose-rich oligo- and polysaccharide (FROP-3) on periorbital wrinkles (crow's feet) on a team of voluntaries. METHOD: The efficiency of a preparation containing as active principle a fucose-rich polysaccharide in a base-cream for the treatment of temporal periorbital wrinkles on 20 voluntary women was tested as follows: the women applied the cream twice a day for 4 weeks. Negative replicas were taken on the periorbital skin before and after 4 weeks of application of the cream. The results were evaluated by semi-automated morphometry on the plastic replicas and expressed as the 'wrinkle-factor' obtained by multiplying total wrinkle length in millimeters by the average wrinkle width. RESULTS: After 4 weeks of treatment, there was a significant improvement of the periorbital wrinkles for the majority of the voluntary team who tested the cream. On the 29 periocular wrinkles examined 65% showed an improvement at the end of the treatment. In two cases, the improvement was 100% on one eye (disappearance of the crow's feet) and of 75% and 79% on the other eye. On six eyes, there was no significant change after the end of the treatment, and on four eyes a worsening was observed. The age-dependent modifications showed that improvement was independent of age and was the result of individual skin reactions to the cream. The occurrence and the severity of crow's feet is highly individual, and differs from one side of the face to the other for the same person. These strong individual variations explain the highly variable results, not only from one woman to the other but also comparing one side of the face to the other for the same person. CONCLUSION: Under the effect of 4 weeks of treatment with the FROP-3-containing cream, most of the voluntaries had their periorbital wrinkles attenuated and some women showed a total regression of crow's feet on one of their eyes.

Adult↗
PubMed2006

[Atypical clinical presentation of pigmented purpuric dermatosis].

The term pigmented purpuric dermatosis (PPD) is used for a group of mainly asymptomatic, sometimes pruritic dermatoses that are clinically characterized by an eruption of pinpoint purpuric lesions along with yellow, orange, red and/or brown, often patchy pigmented areas. Traditionally five subtypes have been distinguished, but atypical clinical patterns may also occur. Because of the variable clinical spectrum and the similar histopathologic findings, a strict nosological classification is sometimes difficult or even impossible to achieve. We report a case of PPD with atypical clinical features in a young woman, underlining the difficulties in the clinical classification of this spectrum of diseases.

Adult↗
PubMed2006

[Eruptive melanocytic nevi of the palms and soles in a patient with Crohn disease].

Eruptive melanocytic nevi of the palms and soles are a rare phenomenon which has been associated with a number of different diseases. A variety of pathogenetic mechanisms have been proposed. A 22-year-old woman with Crohn disease since 1998 presented with multiple eruptive melanocytic nevi of the palms and soles. She is the second case in the literature describing the association between Crohn disease and eruptive melanocytic nevi. In contrast to the first report by Belloni-Fortina et al., in our case the melanocytic nevi appeared only on the palms and soles.

Adult↗
PubMed2006

[Angioma serpiginosum following the lines of Blaschko--an effective treatment with the IPL technology].

Angioma serpiginosum, first described by Hutchinson in 1889, is a rare benign vascular nevus with dilatation and proliferation of the capillaries in the upper dermis. A 15-year-old boy presented with an angioma serpiginosum on the right side of the body following the lines of Blaschko. Both the clinical pattern and the appearance in a male are unusual. Treatment with IPL technology (intense pulsed light), which emits polychromatic light from a high-intensity flashlamp, proved to be an effective approach.

Adolescent↗
PubMed2006

Three-dimensional documentation of wound healing: first results of a new objective method for measurement.

BACKGROUND: The objective assessment of wound healing is one essential parameter of quality assurance in a modern chronic wound management program. In the past assessment has been based exclusively on a two-dimensional measurement of the wound surface with planimetry or digital photo documentation in combination with such measurements. An objective method for measuring the volume of chronic wounds has not yet been available. PATIENTS AND METHODS: In cooperation with the company RSI, we linked digital photography, optical raster by means of digital scanner, and picture processing software (DigiSkin) for an exact three-dimensional image of chronic wounds. The generated point clouds allow the visual, computer-assisted three-dimensional quantification and can document the course of healing of chronic wounds. RESULTS: In comparison to currently available systems, our new method makes possible the objective measurement of volume changes and wound healing course in chronic wounds.We demonstrate the utility of the system in reference to three patients with chronic venous leg ulcers. CONCLUSIONS: Using this new, objective three-dimensional wound measurement system,it is possible to reliably quantify changes in wound healing for the first time. Future clinical studies have a new option for the gathering of data which will facilitate evidenced-based conclusions.

Aged↗
PubMed2006

Clear differences in hand-held dermoscopes.

In order to correctly evaluate melanocytic and non-melanocytic skin tumors using a hand-held dermoscope, it is essential to have adequate magnification and illumination to allow the differential structures to be clearly seen. One example of a dysplastic compound melanocytic nevus and a thin malignant melanoma were examined with five different handheld dermoscopes (Heine Delta 10, Heine Delta 20, Dermogenius and Dermlite Foto 37 with and without glass plate) in order to assess the image quality. The magnification was identical in all dermoscopes. In the newer dermoscopes (Heine Delta 20, Dermogenius and Dermlite Foto 37 with and without glass plate) the light sources were clearly improved, as now 6 or 24 LEDs, respectively, are employed. This distinctly improved the image quality with regard to color and visible differential structures compared to the dermoscope (Heine Delta 10) with only one light source. Clear differences is assessing differential structures were seen in one dermoscope (Dermlite Foto 37 without glass plate). Using this dermoscope without any glass plate or liquid between the dermoscope and the skin, exophytic tumors were better visualized in a three-dimensional fashion but fewer differential structures were seen.

Adult↗
PubMedDate not supplied

Three-dimensional line-field Fourier domain optical coherence tomography for in vivo dermatological investigation.

We demonstrate 3-D optical coherence tomography using only 1-D mechanical scanning. This system uses the principle of Fourier domain optical coherence tomography for depth resolution, 1-D imaging for lateral vertical resolution, and mechanical scanning by a galvanometer for lateral horizontal resolution. An in vivo human fingerpad is investigated in three dimensions with an image size of 480 points (vertical) x 300 points (horizontal) x 1024 points (depth), which corresponds to 2.1 x 1.4 x 1.3 mm. The acquisition time for a single cross section is 1 ms and that for a single volume is 10 s. The system sensitivity is 75.6 dB at a probe beam power of 1.1 mW.

Dermoscopy↗
PubMedDate not supplied

Investigation of the homogeneity of the distribution of sunscreen formulations on the human skin: characterization and comparison of two different methods.

The efficacy of sun protection, mostly realized by the application of sunscreen formulations, is commonly described by the sun protection factor (SPF). Previous investigations have shown that the efficacy of the sun protection inter alia depends on the homogeneity of the distribution of the topically applied sunscreen formulation on the human skin. Therefore, suitable methods are required to determine the homogeneity of topically applied substances on the skin surface. This study provides and compares two different methods, which enable this determination. Laser scanning microscopy allows the analysis of tape strips removed from skin treated with a sunscreen. These reflect the inhomogeneous distribution on the skin that can complementary be determined directly, utilizing a dermatological laser scanning microscope. For the second method, a chromatic confocal setup was utilized, which enables the study of the microtopography of skin replicas before and after the application of a sunscreen product. The two methods were applied for the evaluation of three different sunscreen formulations for each method. A correlation of the homogeneity of distribution with the in vivo SPF could be confirmed. Both methods are suitable to investigate the homogeneity of the tested sunscreen formulations, although they provide different advantages and disadvantages.

Administration, Topical↗
PubMed2006

Dermatoscope as vector for transmissible diseases - no apparent risk of nosocomial infections in outpatients.

PURPOSE: To determine nonpathogenic and potentially pathogenic bacterial growth isolated from dermatoscopes of dermatologists using oil as contact medium in the daily routine at two outpatient sections in Switzerland. METHODS: We investigated the microbiologic colonization of dermatoscopes (Dermatoskop Delta 10, Heine Optotechnik, or Dermogeniusbasic, Rodenstock) during routine use in the outpatient sections of the Departments of Dermatology at the University of Basel and Kantonsspital Aarau. 112 swabs (4 from Aarau, 108 from Basel) taken under standardized conditions were microbiologically worked up in the same laboratory. Oil (101) and 63% isopropyl alcohol (11) were used as contact medium. RESULTS: 39 of 112 swabs showed no bacterial growth. 73 of 112 showed growth of nonpathogenic bacteria (skin flora). Additionally to the cultivation of nonpathogenic bacteria, 3 swabs showed growth of oxacillin-sensitive potentially pathogenic Staphylococcus aureus. Of 11 swabs taken after using 63% isopropyl alcohol as a contact medium, 6 revealed no bacterial growth and 5 showed the growth of skin flora. CONCLUSIONS: The potential risk of nosocomial infection related to the routine use of dermatoscopes in outpatients is small, and the use of oil as a contact medium for dermatoscopy to enhance the optical quality seems to be unproblematic.

Anti-Bacterial Agents↗
PubMed2006

Acquired melanocytic naevus in childhood vulval pemphigoid.

BACKGROUND: Eruptive epidermolysis bullosa (EB) naevi comprise a subset of melanocytic naevi with atypical features that characteristically occur in areas of former blistering in patients suffering from hereditary EB. OBSERVATION: The case is reported of a girl who presented with pruritus, blistering and erosions of the vulval region. Clinical and immunopathological features were consistent with the diagnosis of childhood vulval pemphigoid. In the course of the disease, she developed an atypical melanocytic naevus on the left labium at a site of former blistering. Although its clinical and dermoscopic features resembled malignant melanoma, the lesion completely regressed clinically during the 24-month follow-up. CONCLUSION: This is the first report describing the development of a melanocytic naevus at sites of blistering in an auto-immune subepidermal blistering disease in childhood. Our observation extends the spectrum of disorders, in addition to the group of congenital EB, in which 'eruptive' atypical melanocytic naevi may occur. Knowledge of this complication is important for appropriate management and follow-up and to avoid radical surgery.

Child↗
PubMed2007

Hemosiderotic dermatofibroma: report of one case.

Dermatofibroma (DF) is a common benign fibrohistiocytic lesion which presents with a wide variety of clinicopathological features. Generally, the clinical diagnosis is easy, but differentiating it from other cutaneous tumors could be difficult in atypical cases and rare variants. We may find at least four different histopathological variants of DF; more than one of which may be present in a single tumor. Hemosiderotic DF is a variant composed of numerous small vessels, extravasated erythrocytes, and intra- and extracellular hemosiderotic deposits. The differential diagnosis may comprise melanoma as well as other melanocytic and nonmelanocytic tumors. We report the case of a 38-year-old man who presented with a hemosiderotic DF on the abdomen.

Adult↗
PubMed2006

Confocal reflectance theta line scanning microscope for imaging human skin in vivo.

A confocal reflectance theta line scanning microscope demonstrates imaging of nuclear and cellular detail in human epidermis in vivo. Experimentally measured line-spread functions determine the instrumental optical section thickness to be 1.7 +/- 0.1 microm and the lateral resolution to be 1.0 +/- 0.1 microm. Within human dermis (through full-thickness epidermis), the measured section thickness is 9.2 +/- 1.7 microm and the lateral resolution is 1.7 +/- 0.1 microm. An illumination line is scanned directly in the pupil of the objective lens, and the backscattered descanned light is detected with a linear array, such that the theta line scanner consists of only seven optical components.

Dermoscopy↗
PubMed2006

In vivo assessment of human skin aging by multiphoton laser scanning tomography.

Changes of dermal collagen and elastin content are characteristic for skin aging as well as for pathological skin conditions. To evaluate these changes, we used in vivo multiphoton laser tomography to measure two-photon excited autofluorescence (AF) and second harmonic generation (SHG). We tested 18 patients of all ages and calculated the SHG-to-AF aging index of dermis (SAAID). We observed a negative relationship between the SAAID and age, which was accelerated for the female (n=7) subgroup. The current findings are the first in vivo demonstration of this relationship, and they show that specific characteristics of aged skin such as the ratio of extracellular matrix components collagen and elastin can be evaluated by in vivo AF and SHG measurements using near-IR femtosecond laser pulses.

Adult↗
PubMed2005

Lipid headgroup discrimination by antimicrobial peptide LL-37: insight into mechanism of action.

Interaction of the human antimicrobial peptide LL-37 with lipid monolayers has been investigated by a range of complementary techniques including pressure-area isotherms, insertion assay, epifluorescence microscopy, and synchrotron x-ray scattering, to analyze its mechanism of action. Lipid monolayers were formed at the air-liquid interface to mimic the surface of the bacterial cell wall and the outer leaflet of erythrocyte cell membrane by using phosphatidylglycerol (DPPG), phosphatidylcholine (DPPC), and phosphatidylethanolamine (DPPE) lipids. LL-37 is found to readily insert into DPPG monolayers, disrupting their structure and thus indicating bactericidal action. In contrast, DPPC and DPPE monolayers remained virtually unaffected by LL-37, demonstrating its nonhemolytic activity and lipid discrimination. Specular x-ray reflectivity data yielded considerable differences in layer thickness and electron-density profile after addition of the peptide to DPPG monolayers, but little change was seen after peptide injection when probing monolayers composed of DPPC and DPPE. Grazing incidence x-ray diffraction demonstrated significant peptide insertion and lateral packing order disruption of the DPPG monolayer by LL-37 insertion. Epifluorescence microscopy data support these findings.

Antimicrobial Cationic Peptides↗
PubMed2005

Dermoscopic evolution of a congenital combined nevus in childhood.

BACKGROUND: A combined nevus most commonly consists of a blue nevus in combination with a Clark or Spitz nevus. Dermoscopically, combined nevus can mimic melanoma owing to the presence of dermoscopic features common to both types of lesions. Benign clinical and dermoscopic changes can occur in nevi over time, especially in children and young adults. OBJECTIVE: To describe the dermoscopic evolution of a congenital combined nevus showing unusual dermoscopic features. METHODS: Digital dermoscopic analysis was performed at the initial visit and after 8 months. The lesion was surgically excised and histopathologically examined. RESULTS: An asymptomatic plaque with a central blue area and peripheral brown pigmentation located on the back of a 13-year-old boy was diagnosed dermoscopically as combined nevus. Dermoscopic analysis 8 months later showed color changes from steel blue to gray-blue and black in the central area of the lesion, an increased number of blue-black dots or globules, and peripheral irregular streaks. Histopathology revealed typical features of a congenital combined nevus (blue nevus + compound nevus). CONCLUSION: Over time, congenital combined nevus may show clinical and dermoscopic changes in size, color, and structure. Surgical excision is recommended when clinical and dermoscopic features are equivocal and the diagnosis of melanoma cannot be ruled out.

Adolescent↗
PubMedDate not supplied

Dermoscope.

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Dermoscopy↗