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Specific immunotherapy 3 years follow-up in asthmatic children.

Seventy seven children, aged 4-10 years with bronchial asthma and sensibilization to D.pt were included in this study, divided in two groups: group A included 42 children submitted during 3 years to Sl; group B included 35 children followed during the same time period but not submitted to Sl. This group was regarded as the control group. The clinical evolution was evaluated every three months by clinical assessment, medication scores and DEMI. Total IgE, RAST, D.pt and IgG4 have been determined every year. The obtained results showed a clear improvement of the clinical score and reduction of medication use in the group submitted to Sl. In this group there was a total absence of medication during the last 6 months of Sl in 45.2% of the patients, while in the control group only 5.7% of the patients went completely without symptomatic and prophilactic therapy during the same time period. None of the children presented acute systemic reactions that could constitute a risk for their lives. 4 children presented systemic reactions, 3 of them with a bronchial asthma crisis, reversible with bronchodilating therapy and a child presented a rash reaction; two of them abandoned Sl. 13 children presented grade IV local reactions and one of them abandoned Sl; the others continued Sl with a reduction of the maintenance dose. Sl proved to be a safe and efficient ethiopathogenic therapy for child bronchial asthma treatment, when based on a clear selection of the cases and fulfillment of the safety rules established by the Allergology and Clinical Immunology European Academy.

Adolescent↗
PubMed1998

[A clinical evaluation of clustered immunotherapy in house-dust-mite-sensitive adult bronchial asthma].

Clustered immunotherapy (C-IT) using house-dust (HD) antigen was performed in eight HD-mite-sensitive adult bronchial asthmatics. Six mg of mequitazine was given 2 hours before each visit. For each visit, injections of antigen were performed four times with an hour interval. Either 0.1 ml of 10-fold concentration of the HD or a final dose at the end of the fifth week was determined as a maintenance dose. All cases have reached to ten-fold concentration of the HD antigen within 5 weeks and been able to introduce maintenance therapy without any systemic reaction. Following C-IT, a rapid increase in morning peak expiratory flow rate was observed which is followed by decrease in clinical scores. Furthermore, an increase in mite-specific IgG4 antibody and a decrease in peripheral blood eosinophils were observed 16 weeks following C-IT. These results suggest that C-IT using HD antigen can be performed safely and securely and provides rapid immunological responses as well as clinical benefit in HD-mite-sensitive adult asthmatics.

Adolescent↗
PubMed1964

[ATOPIC DERMATITIS].

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Adrenal Cortex Hormones↗
PubMed1964

ALLERGY TO INSULIN.

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Adrenocorticotropic Hormone↗