SEARCH · PubMed Health

Results for “Developability”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 487 records · Page 27Linked to original sources

PubMed1985

Sight saving strategies for developing nations: toward an appropriate philosophy of blindness treatment and prevention for ministries of health, international agencies and mission societies in developing nations.

Saving the sight of millions of blind people in Developing Nations requires the development of an appropriate philosophy of blindness treatment and prevention. Guidelines are presented in this paper, emphasizing the importance of training national workers, using appropriate ophthalmic technology and promoting international cooperation of governments, development agencies, and mission societies.

Blindness↗

PubMed1982

Seasonality and nutritional status. A review of findings from developed and developing countries.

Studies of seasonality and growth from developed nations demonstrate distinct effects on weight and height gains according to the season. When maximal group gains in height are recorded, minimal weight gains are detected. Only a quarter and a third of all children had their minimal and maximal height gains respectively, in the same period as minimal and maximal group gains occurred. Rain and pre-harvest months are usually associated separately with the disease incidence peaks and with lower energy and nutrient intake. In most areas of the developing world, however, rainy months with a higher incidence of diseases coincide with the lean or hungry pre-harvest months. Some communities have devised certain mechanisms which are likely to buffer negative seasonal effects (rainy or pre-harvest months) on health and nutritional status. Thus, either as a result of lower intakes of energy and nutrients and/or less efficient utilization of energy and nutrients, one is likely to find important seasonal effects in poor agricultural communities of developing countries. The importance of adequate knowledge about seasonal effects to support the better use of existing resources allocated to health and nutrition programs is discussed.

Body Weight↗

PubMed1981

Postnatal development of masticatory organs in rats. III. Effects of mastication on the postnatal development of the M. masseter superficialis.

When suckling of rats was continued on days 17--25 after birth, the development of the M. masseter superficialis was inhibited: increase in the diameter and SDH activity of its muscle fibers was retarded. Conversely, forced weaning of rats on 17 after birth stimulated the development of the muscle. These results suggest that mastication after weaning is involved in the further postnatal development of the M. masseter superficialis in rats.

Animals↗

PubMed1994

Poverty and child development: relevance of research in developing countries to the United States.

Data from low-income countries are helpful in understanding the effects of poverty on child development in the U.S. Illustrative are 3 public health issues: (1) In the U.S., among poor African-American and Hispanic babies anemia is as high as 20%-24%, while in low-income countries, iron deficiency anemia (IDA) causes poor performance on mental and motor tests among babies and children. These data suggest that IDA is a major public health problem among poor minority children that requires prompt attention. (2) In 1993 the U.S. government appropriated $2.86 billion for the Special Supplemental Food Program for Women, Infants, and Children (WIC). Evaluations of WIC, however, have failed to yield conclusive information on the benefits of the program. In low-income countries, nutritional supplements targeted to at-risk groups have resulted in developmental benefits. Thus, WIC is likely to buffer intellectual development against the adverse effects of malnutrition observed among poor children. (3) Evidence from developing countries suggests that concurrent illnesses and poor nutrition interfere with schooling. However, in the U.S., attention to such issues has declined, while common illnesses have increased among the poor. A reappraisal of this issue is warranted to meet the education and health goals proposed for the year 2000 in the U.S.

Adolescent↗

PubMedDate not supplied

How to develop a staff development indicator.

In this article, the author describes a step-by-step approach to generating staff development indicators, as well as examples of the evolving indicator during the development process. Quality improvement indicators are necessary, not only for patient care activities, but also for service activities related to patient care. Staff development is one such service.

Humans↗

PubMed1977

The effects of experimental unilateral anotia on skull development in the chick embryo. IV. Development of the bony skull in embryos of 9-20 days of incubation.

The study of the development of the bony skull in chick embryos with unilateral (right-sided) anotia revealed the following characteristics: 1. The perichondral bones initially follow exactly the cartilaginous structures to which they are related. Later, they may expand desmally to fill up the gaps and diminish the degree of pre-existing asymmetry. 2. The desmal bones which develop in close contact with cartilage, develop parallel to its margins and, hence, appear to be greatly dependent on the chondrocranium. 3. Among the desmal bones which arise independently from cartilage, only the bones of the cranial vault proved to be influenced by the unilaterally anotic condition.

Animals↗

PubMed1992

Population and women in development: gender issues in the context of population and development.

"The objective of this paper is to examine women's productive and reproductive roles and their intricate linkages and the interplay with the demographic variables of population and development. Although these interactions...are not yet fully understood, attempts will be made utilizing available data and literature to make an analysis of the linkages and interplays that exist between population variables with factors associated with the role, status and participation of women in the social and economic lives of African societies.... The paper will analyze the linkages and integrate the implications for population policies and programmes towards the enhancement of women's role and status and their participation in the development process."

Africa↗

PubMed1988

The human factor in national development: some reflections on population and development in Nigeria.

The relationship between the effective utilization of human resources and successful socioeconomic development in Nigeria is examined. The author argues that Nigeria's current socioeconomic difficulties cannot be blamed on population growth alone, and maintains that "underutilization of human resources; lopsided production and distribution mechanisms; economic depression; and under-developed science and technology system; erratic climatic and agronomic conditions; the illegal exportation of food; [and] corruption and mismanagement of revenue, all constitute forces that simultaneously limit the national capacity to produce more resources for the growing population."

Africa↗

PubMed1994

Sustainable development is healthy development.

Economic growth has brought with it substantial environmental damage. Nature has been abused and little consideration has been given to the consequences, among them the adverse effects on health. Healthy people are vital for local development that is both economically and ecologically sound. The health sector should be actively involved in the movement for sustainable development. What this would require in practice is considered below, with particular reference to the quality of life in regions of tropical forest.

Conservation of Natural Resources↗

PubMed1997

Development of cholinergic and GABAergic neurons in the rat medial septum: effect of target removal in early postnatal development.

During normal development of the nervous system, the target fields influence the survival and differentiation of projection neurons, but the factors regulating this interaction remain obscure. In the present study, we have raised the question whether the target region is essential for the postnatal development and maintenance of two different types of central projection neurons, cholinergic and GABAergic septohippocampal cells. In early postnatal rats (P5, P10), the hippocampus was eliminated by unilateral intrahippocampal injections of the excitotoxin N-methyl-D-aspartate. After a long survival time (at P70), we have immunostained serial sections of the septal region with antibodies against choline acetyltransferase (ChAT), the acetylcholine-synthesizing enzyme, or the calcium-binding protein parvalbumin (PARV) which is known to be contained in GABAergic septohippocampal neurons. In the medial septum ipsilateral to the lesioned side, about 60% of ChAT-immunoreactive neurons and 62% of PARV-immunoreactive neurons were found in adulthood even after complete elimination of the hippocampus. Some immunoreactive cells appeared heavily shrunken, but electron microscopic analysis revealed ultrastructural characteristics typical for medial septal neurons obtained from controls. Our results indicate that target elimination during development affected both types of projection cells, although only the cholinergic cells are known to be responsive to target-derived factors.

Animals↗

PubMed1998

Electron microscope characterization of AgBr heterojunctions with silver carboxylates and their influence on the morphology of developed silver particles in thermally developed photomaterials.

Silver halide crystals formed during in situ treatment of silver stearate crystals with various halidizing agents are observed by scanning and transmission electron microscopy to form on the lateral edges of the silver carboxylate crystals. The location of the silver halide phase on the crystal edge is dictated by the anisotropic structure of the silver stearate crystal lattice, specifically, the layered structure in which silver ion layers are separated by long-chain hydrocarbon groups. The formation of AgBr on the lateral faces of these crystals is proposed to be typical not only of the formation of silver halide on silver stearate but also for all silver carboxylates of the general formula [AgCnH2(n-1)O2]2 when the crystals of these silver carboxylates have anisotropic, layered structures. The silver bromide/silver carboxylate heterojunction in an in situ system has been clearly observed by transmission electron microscopy. The heterojunction is comprised of a distorted silver carboxylate lattice, which accommodates the misalignment between the AgBr and [Ag(O2CR)]2 crystal lattices. The nature of heterojunction between the AgBr and the silver carboxylate when the AgBr is prepared separately from the preparation of the silver carboxylate differs from the in situ heterojunction. In this case, a layered compound, proposed to have a Ag1-xNaxSt composition, forms between the AgBr and the silver stearate which is a unique feature of this interface. The differences in the structure of interfaces formed between the silver halide and the silver fatty acid complex result in different silver particle morphologies during thermal development of exposed photothermographic films. The developed silver is generally filamentary when the photothermographic material contains silver halide prepared by the in situ exchange reaction between silver carboxylate and a brominating agent. If the photothermographic material is prepared from previously synthesized silver halide crystals, the preformed AgBr route, the developed silver generally crystallizes as dendritic crystals.

Bromides↗

PubMed1996

Evidence for neuronal regulation of oligodendrocyte development: cellular localization of platelet-derived growth factor alpha receptor and A-chain mRNA during cerebral cortex development in the rat.

Oligodendrocyte responses in vitro to platelet-derived growth factor (PDGF) include proliferation, survival, migration, and changes in cell morphology and molecular expression. Studies of mixed glial cultures established that astrocytes secrete PDGF; thus astrocytes are considered to be key regulators of oligodendrocyte development in vitro. We previously demonstrated PDGF alpha receptor mRNA expression by oligodendrocyte progenitors and preoligodendrocytes during postnatal development of rat cerebral cortex. In the present study, we have mapped the spatial and temporal expression of PDGF A-chain ligand mRNA and alpha receptor mRNA to determine if the cell-cell interactions that form the basis for PDGF regulation of oligodendrocyte development in vitro are also present in vivo. By in situ hybridization (ISH) we demonstrate that at embryonic day 17 (E17) cells expressing receptor mRNA (PDGFR alpha +) are initially in the subventricular zone, at a distance from cells expressing ligand mRNA (PDGF+) in the cortical plate. By E20 PDGFR alpha + cells are found throughout the corpus callosum and cortical gray matter. PDGF+ cells are restricted to the cortical plate prenatally and only appeared in the corpus callosum postnatally. Combined immunocytochemistry and ISH demonstrated the PDGF+ cells colocalized with neurofilament, but not with GFAP. These data establish that PDGF is expressed by neurons during PDGFR alpha + oligodendrocyte progenitor migration from the subventricular zone to the corpus callosum and gray matter. Furthermore, neurons continue to express PDGF during the generation and differentiation of appropriate numbers of oligodendrocytes needed to myelinate axons as the nervous system matures.

Animals↗

PubMed2005

Fasting serum sulfate levels before and after development of osteoarthritis in participants of the veterans administration normative aging longitudinal study do not differ from levels in participants in whom osteoarthritis did not develop.

OBJECTIVE: To determine whether the development of osteoarthritis (OA) in men over a 33-year period is related to lower sulfate levels in stored serum collected during that time interval. METHODS: Stored serum samples from participants in the Veterans Administration Normative Aging Study were assayed for sulfate by ion-exchange chromatography. Samples had been obtained every 3-5 years during part or all of a 33-year portion of the study. Sulfate levels were determined in serum from all participants who underwent knee replacement surgery and had evidence of radiographic hand OA, from some of the participants who had evidence of radiographic hand OA but had not undergone knee replacement surgery, from all participants who underwent knee replacement surgery but had no evidence of radiographic hand OA, and from age-matched participants who had no evidence of OA by history, physical examination, or hand radiography. RESULTS: Serum sulfate levels in participants, with or without radiographic hand OA and/or knee replacements, who were ages 34-72 years at the first examination, ranged from 0.21 mM to 0.51 mM over the course of a maximum of 33 years. Both the overall mean and median sulfate levels rose from 0.32 mM at age 40-50 years to 0.38 mM at age 70-80 years, and the overall mean and median for all ages was 0.36 mM. There were no significant differences in sulfate levels between subjects in any of the 4 groups. CONCLUSION: There was no evidence of a relationship between these serum sulfate levels and the development of OA. However, all samples were collected after overnight fasting, and no participant was younger than age 34 years at the initiation of the study. It remains to be determined whether differences in the time of ingestion of daily dietary protein providing sulfate are related to the development of OA, or whether sulfate levels measured at an earlier age could be a factor.

Adult↗

PubMed2004

Development and effects of client trust in criminal defense attorneys: preliminary examination of the congruence model of trust development.

The present study examines the relation between client participation in attorney-client relationships, the development of client trust in criminal defense attorneys, and client satisfaction with attorneys and case outcomes. The congruence model of trust development (CMTD) is proposed to explain the relation between desired participation by clients, allowed participation by attorneys, and the development of client trust in attorneys. The CMTD predicts that clients who trust their attorneys will subsequently be satisfied with their attorneys and case outcomes. A sample of 96 experienced criminal defendants currently in prison completed the Attorney-Client Trust Scale (ACTS: Boccaccini and Brodsky, 2002) and provided information about their experiences with their most recent criminal defense attorneys. Findings were generally consistent with the CMTD in suggesting that (i) allowed participation is associated with trust in attorneys, and (ii) trust is associated with satisfaction with attorneys and case outcomes.

Adult↗

PubMed2007

Developing a framework for development: a discussion.

A multitude of scientific disciplines study the development of behavior. Their use of different methodological and conceptual approaches makes integration of findings difficult. In a symposium at the 38th Annual Meeting of the International Society for Developmental Psychobiology in Washington DC, the question was discussed if a general theory of development could unify the field. The three participants explain their views and discuss the possibility of a theoretical framework for development.

Animals↗

PubMed2006

Plasticity in the development of handedness: evidence from normal development and early asymmetric brain injury.

Previous research revealed that shifting patterns of hand preference in the first year of life are linked to infants' sensory-motor experiences as they learn to sit, creep, and walk. In this report, we examine whether new and different forms of locomotion and sensory-motor experiences similarly contribute to alter patterns of hand preference in early development. We examined the cases of three infants with unique developmental histories. Two infants adopted distinctive forms of locomotion in lieu of typical hands-and-knees crawling. One infant scooted using both hands and legs in a coupled fashion, while the other infant performed an asymmetrical, left-biased belly-crawl using only one arm to drag his body. The third infant suffered damage to his left-brain hemisphere shortly after birth and received intense physical therapy to his right arm as a result of it. We followed all three infants on a weekly basis and tracked changes in their reaching behavior, mode of locomotion, and postural achievements. The two infants with unique locomotor patterns displayed changes in hand preference that reciprocated the arm patterns that they used during locomotion. The infant who coupled his body for scooting began to reach bimanually, while the infant who adopted the left-biased belly-crawl developed a strong unimanual, right-hand, preference. The infant with left-hemisphere damage initially displayed a right-hand preference, then a temporary decline in preferred hand use as he began to cruise and walk, and ultimately resumed a right-hand preference in the 2nd year of life. This data is consistent with previous work showing that the development of hand preference in the 1st year of life is highly malleable and sensitive to a variety of new sensory-motor experiences.

Age Factors↗

PubMed2004

Development-related changes in the expression of shear stress responsive genes KLF-2, ET-1, and NOS-3 in the developing cardiovascular system of chicken embryos.

Blood flow patterns play an important role in cardiovascular development, as changes can cause congenital heart malformations. Shear stress is positively correlated to blood flow. Therefore, it is likely that shear stress is also involved in cardiac development. In this study, we investigated the expression patterns of ET-1, NOS-3, and KLF-2 mRNA in a series of developmental stages of the chicken embryo. These genes are reported to be shear responsive. It has been demonstrated that KLF-2 is confined to areas of high shear stress in the adult human aorta. From in vitro studies, it is known that ET-1 is down-regulated by shear stress, whereas NOS-3 is up-regulated. Therefore, we expect ET-1 to be low or absent and NOS-3 to be high at sites where KLF-2 expression is high. Our study shows that, in the early stages, expression patterns are mostly not shear stress-related, whereas during development, this correlation becomes stronger. We demonstrate overlapping expression patterns of KLF-2 and NOS-3 in the narrow parts of the cardiovascular system, like the cardiac inflow tract, the atrioventricular canal, outflow tract, and in the early stages in the aortic sac and the pharyngeal arch arteries. In these regions, the expression patterns of KLF-2 and NOS-3 exclude that of ET-1. Our results suggest that, in the embryonic cardiovascular system, KLF-2 is expressed in regions of highest shear stress, and that ET-1 and NOS-3 expression, at least in the later stages, is related to shear stress.

Animals↗

PubMed1995

T lymphocyte development in p56lck deficient mice: allelic exclusion of the TcR beta locus is incomplete but thymocyte development is not restored by TcR beta or TcR alpha beta transgenes.

The protein tyrosine kinase, p56lck, is involved in signal transduction in mature T cells and in the molecular events controlling early thymocyte differentiation. Thymuses of mice deficient for p56lck expression (p56lck-/-) consist of immature CD4-CD8- double-negative (DN) and CD4+CD8+ double-positive (DP) thymocytes and are severely reduced in total cell number. In this report we have studied DN thymocytes from p56lck-/- mice and found an increase in the proportion of the CD44-CD25+ subset, suggesting that transit through this stage, which is known to require T cell receptor (TcR) beta expression, may be delayed in the absence of p56lck expression. In addition, the expression of a transgenic TcR beta chain or TcR alpha beta pair did not restore thymic development in p56lck-/- mice. However, in contrast to mice expressing a dominant negative isoform of p56lck in which DP thymocytes do not develop, DP thymocytes still develop in nontransgenic and TcR transgenic p56lck-/- mice. These results demonstrate that expansion of the DP subset is impaired in p56lck-/- mice. In contrast, allelic exclusion is not severely compromised. Although there was an increase in the number of peripheral T cells expressing more than one V beta chain in TcR transgenic p56lck-/- mice, we found that inhibition of endogenous TcR beta gene rearrangement was almost complete in thymocytes of V beta transgenic p56lck-/- mice and we could not detect any peripheral T cells that expressed more than one V beta chain in non-transgenic p56lck-/- mice.

Alleles↗