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[Problems of intravenous lidocaine treatment in status epilepticus or clustering seizures in childhood].

Lidocaine was administered intravenously as a substitute for diazepam, to 12 patients with status epilepticus or clustering seizures aged 26 days to 11 years. The medication was very effective in 3 cases with acute convulsions, which disappeared immediately after infusion of lidocaine without relapse. The medication was effective only temporarily in 4 patients; they experienced relapsing seizures during drip infusion of lidocaine intravenously for maintenance. All the relapsing seizures were secondarily generalized ones with diffuse ictal discharges. In 2 cases of localization-related epilepsy, complex partial seizures evolved to secondarily generalized seizures immediately after administration of lidocaine. It must be noticed that in a relatively large number of cases lidocaine is ineffective or even harmful.

Anticonvulsants↗

Seizure with prominent tonic initial signs followed by psychomotor features: a case report clinically manifesting an unusual ictal evolution.

A clinically tonic seizure phase, immediately followed by psychomotor features (right hand dystonic posture, left hand and oral automatisms), was recorded by video and EEG, in a patient who had gliosis of the left temporal lobe and left hippocampal atrophy. Interictal epileptiform discharges were frequently seen in the left temporal area, and at the time of the tonic seizure phase, ictal spike discharges were continuously observed at the left posterior temporal area, which was recognized only by applying a high frequency filter (HFF) of 15 Hz to the digitally recorded EEG because EMG artifacts totally obscured the EEG with a HFF of 60 Hz. It is most likely that tonic seizure can occur in an adult patient with temporal lobe epilepsy, and it is speculated that an epileptogenic focus might activate a certain brain area which is regarded as a symptomatogenic zone for tonic seizures. If the tonic seizure phase is immediately followed by psychomotor features as seen in the present patient, the former could be due to focal epilepsy.

Adult↗

[A role of peri-ictal SPECT for the identification of epileptogenic focus].

A 42-year-old man had complex partial epilepsy and secondary generalized seizure, without remarkable abnormalities in interictal EEG and head MRI. Three-dimensional SRT (3D SRT) analysis of peri-ictal SPECT data detected hyperperfusion in the right temporal lobe, the basal nucleus and the hippocampus, which showed hypoperfusion during interictal period. These findings suggested that the epileptogenic focus existed in the right temporal lobe. We concluded that 3D SRT analysis of peri-ictal SPECT would be helpful to identify the epileptogenic focus.

Adult↗

Vigabatrin--plasma enantiomer concentrations and clinical effects.

Plasma concentrations of the [R]- and [S]- enantiomers of the new anticonvulsant vigabatrin were measured by an enantiospecific gas-liquid chromatographic assay in a group of therapy-resistant epileptic patients in whom racemic vigabatrin was added to their existing antiepileptic drug regimens. The peak plasma concentrations of the biologically active [S]-enantiomer of vigabatrin were correlated with those of the [R]-enantiomer, with drug dose, seizure frequency and change in score on various tests of psychological function administered prior to and when the subjects were under steady-state conditions following vigabatrin therapy. Plasma [S]-vigabatrin concentrations correlated with drug dose, [R]-vigabatrin concentration and change in score of certain psychological tests reflecting verbal memory, recall and speed of information processing. No definite pharmacokinetic interactions were detected, though plasma phenobarbitone concentrations tended to fall during vigabatrin administration. There were too few data to assess the relation between [S]-vigabatrin concentrations and seizure frequency.

Adolescent↗

Psychiatric aspects of psychomotor epilepsy.

Psychomotor or temporal lobe epilepsy is a frequently missed diagnosis. It is often confused with grand mal and petit mal epilepsy. At times it is the first symptom of an organic neurological disease. It is often masked as a psychiatric disorder or is associated with a mental illness without clinically detectable seizures. These psychic manifestations simulate all of the neuroses and major psychiatric states. Excitement states with amnesia may lead to violent antisocial behavior. All these manifestations may be aggravated by alcohol. Thalamic epilepsy shows itself in similar psychiatric manifestations and accounts for behavior disorder in children more than temporal lobe epilepsy. Atypical seizures with vegetative or emotional aura and a characteristic electroencephalogram differentiate it from temporal lobe epilepsy. Proper understanding of the varied manifestations, with positive electroencephalographic findings, leads to the correct diagnosis in most cases. All patients with unusual or atypical personality or psychiatric-like states should have careful electroencephalographic examination. Anticonvulsant therapy and other psychiatric treatment procedures can relieve most cases. Surgical therapy sometimes is necessary.

Antisocial Personality Disorder↗

[The ecstatic epilepsy of Teresa of Jesus].

AIMS: Our aim is to define the ecstasies (raptures) of Teresa de Ahumada (Teresa of Jesus) and to link them with ecstasies recently identified as convulsive seizures (Dostoevsky s epilepsy, Saint Paul s disease, ecstatic epilepsy). DEVELOPMENT AND CONCLUSIONS: We review the Carmelite nun's pathography, with special attention given to the excellent detailed descriptions of her ecstasies. The stereotypic movements and comparison with similar cases leads us to consider them as being epileptic, possibly secondary to neurocysticercosis.

Catholicism↗

[Transcranial magnetic stimulation of patients with a single epileptic seizure].

Transcranial magnetic stimulation (TMS) was performed in 21 patients who had had loss of consciousness of unknown origin, in order to find out whether TMS could help in finding the cause of unconsciousness and to estimate the risk of provoking a seizure in patients who had single fits in the past. Furthermore, EEG recordings with hyperventilation, photostimulation, 24-hour EEG and sleep-deprivation EEG's were carried out as well as CCT or NMR investigation. In 15 patients the loss of consciousness was judged to be due to an epileptic seizure. None of the 21 patients had epileptic potentials in EEG recordings or showed an epileptic seizure during or after TMS, hyperventilation or photostimulation. One patient developed spike-wave activity in the sleep-deprivation EEG, another in the 24-hour EEG. On the basis of our results and previous reports, TMS does not seem to be helpful in the diagnosis of loss of consciousness of unknown origin. However, TMS can be used more liberally than hitherto in the study of motor pathways, in cases with a history of single epileptic seizures.

Adult↗