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At least 487 records · Page 27Linked to original sources
PubMed1998

Structural, ultrastructural studies and evolution of Trypanosoma cruzi-infected mice treated with thioridazine.

Thioridazine (THI) is a tricyclic drug that belongs to the phenothiazine series. THI had a lethal effect upon epimastigotes in culture medium in a concentration of 0.5 microM. Trypanocidal effect upon trypomastigotes of Trypanosoma cruzi was observed above 0.5 mM of THI. Ultrastructural studies showed intracellular vacuoles in both parasite forms and mitochondrion reorganization. To analyze the use of THI as a therapy, male mice were inoculated with 7.10(4) trypomastigotes of T. cruzi, Tulahuen strain, and treated with THI for 3 days, with 80 mg/kg/day. Survival and parasitemia of mice treated with lower doses were similar to those observed in the control group (14 days postinfection). THI treatment modified parasitemia levels. They were negative by day 20 p.i. Hearts from control untreated mice presented typical chagasic myocarditis. Hearts from THI-treated mice sacrificed by day 30 p.i. showed inflammatory infiltrates without amastigote nests. Three months postinfection a mild infiltrate located in the interventricular septum was observed. Survival of this group was 9 months. Present results show that THI had a direct effect upon parasitemia, improved survival of treated mice, and modified the evolution of experimental Chagas disease.

Animals↗
PubMed2000

Film Drainage between Colliding Drops at Constant Approach Velocity: Experiments and Modeling.

Experiments and modeling of the drainage of the thin liquid film between two deformable spherical drops approaching each other at constant velocity in another liquid are being presented. Two numerical models based on the lubrication theory have been developed considering the cases of immobile or mobile drop interfaces. The absolute film thickness and the thinning rate have been measured using laser interferometry for a wide range of capillary numbers. In all studied cases, the model with immobile interfaces was found to give the best predictions of the experimental time evolution of the film thickness and radial expansion. These results made it possible to derive a typical time scale of the drainage process. Copyright 2000 Academic Press.

Journal Article↗
PubMed1990

The evolution of a clinically relevant experimental model for the realistic evaluation of long-length (80-cm) arterial prostheses.

A new carotid-femoral experimental model has been developed which has significant clinical relevance to human limb salvage bypass grafting in the areas of graft length, hemodynamics and tissue environment. More significantly, the graft healing pattern observed with this model is similar to what is seen in humans. Therefore, this experimental model provides a challenging and critical site for dynamic healing studies and comparisons of different types of vascular prostheses.

Animals↗
PubMed1984

Histological evolution of caecal lesions in experimental amoebiasis.

Histopathological studies in guinea-pigs infected intracaecally with Entamoeba histolytica were carried out longitudinally on days 3, 7, 11, 15, 20 and 35 after infection. Three characteristic modes of development of caecal lesions were observed. These in order of their prevalence were the classical inflammatory cellular infiltration, lymphoid hypertrophy and necrotizing colitis. Occasional amoeboma formation was observed in progesterone-treated animals. This is the first time that histological lesions which mimic the human intestinal amoebiasis have been described in the experimental animal.

Animals↗