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Can recent innovations in harmonic analysis 'explain' key findings in natural image statistics?

Recently, applied mathematicians have been pursuing the goal of sparse coding of certain mathematical models of images with edges. They have found by mathematical analysis that, instead of wavelets and Fourier methods, sparse coding leads towards new systems: ridgelets and curvelets. These new systems have elements distributed across a range of scales and locations, but also orientations. In fact they have highly direction-specific elements and exhibit increasing numbers of distinct directions as we go to successively finer scales. Meanwhile, researchers in natural scene statistics (NSS) have been attempting to find sparse codes for natural images. The new systems they have found by computational optimization have elements distributed across a range of scales and locations, but also orientations. The new systems are certainly unlike wavelet and Gabor systems, on the one hand because of the multi-orientation and on the other hand because of the multi-scale nature. There is a certain degree of visual resemblance between the findings in the two fields, which suggests the hypothesis that certain important findings in the NSS literature might possibly be explained by the slogan: edges are the dominant features in images, and curvelets are the right tool for representing edges. We consider here certain empirical consequences of this hypothesis, looking at key findings of the NSS literature and conducting studies of curvelet and ridgelet transforms on synthetic and real images, to see if the results are consistent with predictions from this slogan. Our first experiment measures the nonGaussianity of Fourier, wavelet, ridgelet and curvelet coefficients over a database of synthetic and photographic images. Empirically the curvelet coefficients exhibit noticeably higher kurtosis than wavelet, ridgelet, or Fourier coefficients. This is consistent with the hypothesis. Our second experiment studies the inter-scale correlation of wavelet coefficient energies at the same location. We describe a simple experiment showing that presence of edges explains these correlations. We also develop a crude nonlinear 'partial correlation' by considering the correlation between wavelet parents and children after a few curvelet coefficients are removed. When we kill the few biggest coefficients of the curvelet transform, much of the correlation between wavelet subbands disappears--consistent with the hypothesis. We suggest implications for future discussions about NSS.

Algorithms↗

Quantifying the amount of variation in survival explained by prostate-specific antigen.

PURPOSE: Post-therapy changes in prostate-specific antigen(PSA) have been proposed as surrogates for survival in clinical trials due to observed statistical associations. However, association alone does not satisfy the conditions of surrogacy. A measure that quantifies the amount of association is important. Using a population-based approach, we explore the relationship between PSA and survival and generate a measure to demonstrate the amount of the variation in survival explained by PSA. EXPERIMENTAL DESIGN: With serial PSA measurements from 254 patients with androgen-independent prostate cancer, we use a time-dependent Cox model with a nonlinear log relative risk function to quantify the strength of the association between time-dependent PSA and survival. The nonlinear log relative risk function provides a flexible Cox model and a more accurate measure of the strength of association between PSA and survival. RESULTS: Among these 254 patients, there were 247 deaths (median survival time = 13.0 months). Median follow-up time for those alive or censored was 59.3 months (range, 36.8-71.3 months). An association was observed between PSA and survival (P < 0.01, two-sided test). However, time-dependent PSA explains only 17% of the variation in survival. CONCLUSIONS: Use of this methodology demonstrates that there remains sufficient variation in survival unaccounted for by PSA measurements in this patient cohort. Other factors, perhaps unknown, exist that determine survival outcome. Consideration of PSA alone as a surrogate can produce misleading information regarding the risk of death; its use as a surrogate for survival is not warranted when designing a clinical trial in this patient population.

Disease-Free Survival↗

Serum antibodies to Helicobacter pylori and the CagA antigen do not explain differences in the prevalence of precancerous gastric lesions in two Chinese populations with contrasting gastric cancer rates.

Incidence and mortality rates for gastric cancer in rural People's Republic of China differ greatly over short distances. In Shandong Province, we studied asymptomatic adult subjects from Bei Duan village (n = 196) in Linqu County (a high-risk area for gastric cancer) and from Shi Huang village (n = 192) in Cangshan County (a low-risk area for gastric cancer). The prevalence of advanced precancerous gastric lesions (APGL) was assessed by microscopic examination of endoscopic stomach biopsies. ELISAs were used to detect serum IgG to Helicobacter pylori whole-cell antigen and to the CagA protein. A logistic regression model was used to quantify the role of the two H. pylori seromarkers in explaining the differences in prevalence of APGL between the two villages after adjusting for age and sex. The prevalence of APGL was much greater in Bei Duan than in Shi Huang. Although H. pylori seroprevalence by the whole-cell ELISA was similar in the two populations, seroprevalence of CagA was significantly greater in Bei Duan. Although age, sex, and both H. pylori seromarkers were associated with APGL in the logistic regression model, the effect of village of residence remained strong after adjustment for all four covariates. Only a relatively small proportion of the difference in prevalence of APGL between these two rural Chinese populations can be explained by differences in H. pylori or CagA seroprevalence.

Antibodies, Bacterial↗

Failure of the biotic ligand and free-ion activity models to explain zinc bioaccumulation by Chlorella kesslerii.

Zinc accumulation by Chlorella kesslerii (Chlorophycee) was studied for [Zn2+] ranging from 4 pM to 1 mM. A first-order uptake flux as predicted by the free ion activity model (FIAM) and the biotic ligand model (BLM) was not observed. Furthermore, when algae were preconditioned in slightly limiting (10 pM) versus optimal (1 nM) free zinc concentrations, the internalization flux increased and was nearly constant over the range of [Zn2+] examined. This observation was attributed to the synthesis of membrane-bound zinc transporters. Neither solution Zn chemistry nor surface-bound Zn was a good predictor of Zn uptake fluxes. Several hypotheses were examined to explain the failure of the steady-state uptake models. Although zinc excretion and a Zn diffusion limitation were observed, neither result could explain the majority of observed deviation from the models. Bioaccumulation experiments performed with inhibitors (vanadate and carbonyl cyanide m-chlorophenylhydrazone [CCCP]) demonstrated clearly that zinc transport is an energy-dependent process in Chlorella kesslerii. The presence of an active transport signifies that Zn uptake may function independently of the electrochemical Zn gradient and that, in some cases, both uptake fluxes and receptor-bound Zn may be independent of solution chemistry.

Adsorption↗

Can known risk factors explain racial differences in the occurrence of bacterial vaginosis?

BACKGROUND: Black women are more likely to have bacterial vaginosis (BV) than are non-Hispanic white women. We examined whether this disparity can be explained by racial differences in known BV risk factors. METHODS: Nine hundred black and 235 white women were enrolled from five US sites. At baseline, structured interviews were conducted and vaginal swabs self-collected for Gram-stain and culture. RESULTS: Black women were more likely than white women to have BV/intermediate vaginal flora. They also were more likely to be older, have lower educational attainment and family incomes, have a history of a sexually transmitted disease, and douche. After adjustment for demographic and lifestyle factors, blacks remained at elevated risk for BV/intermediate flora (OR 2.2, 95% CI 1.5-3.1). Blacks also were more likely to have specific BV-related vaginal microflora, as well as gonococcal or chlamydial cervicitis (OR 2.2, 95% CI 1.2-3.8) after adjustment for known BV risk factors. CONCLUSION: Risk factor differences did not explain the observed racial disparity in the occurrence of BV, BV-related microflora, or gonococcal or chlamydial cervicitis. These findings highlight our limited understanding of the factors accounting for the occurrence of bacterial vaginosis and cervicitis among black and white women.

Adolescent↗

[Sensory sensitization, part II: Pathophysiology in dysfunctional disorders. Understanding the inner life of the nerve pathways may explain hitherto unexplainable symptoms].

This article is based on a vast clinical experience from patients presenting with widespread pain syndromes as well as dysfunctional symptoms from inner organs. A literature survey has been performed. Allodynia and hyperalgesia that partly explain the fibromyalgia and local myalgia syndromes seem to arise from a pathophysiological process of nociceptive sensitisation. It is proposed that the concept of "sensory sensitisation dysfunctional disorders" be applied to conditions like bronchial hyperreactivity, Da Costas syndrome, Dercum's disease (Adipositas dolorosa), dry eyes and mouth syndrome, fibromyalgia, gastralgia, globus hystericus, interstitial cystitis, chronic prostatitis, irritable bowel syndrome, photo- and phonosensitivity, rhinitis, tension headache, tinnitus, vestibulitis syndrome. These dysfunctional disorders cannot be satisfactorily explained by presently known pathophysiological models like ongoing inflammatory process, tissue degeneration, fibrosis, blood vessel diseases, tumours, immune reactions, toxic or deficiency conditions, metabolic disturbances. Neurogenic mechanisms also seem to play an important role in the pathophysiology of arthritic conditions, and might be worthwhile to include in forthcoming discussions concerning the aetiology of chronic inflammatory disease.

Chronic Disease↗

Private nurses and playboy bunnies: explaining permissible sex discrimination.

Discrimination on the basis of sex in employment is illegal--usually. In cases in which employers contend that sex-based hiring is necessary to protect the privacy interests of their customer, however, and in cases in which employers contend that sex-based hiring is necessary to provide a particular type of sexual titillation for their customers, courts sometimes do allow employers to discriminate. Courts say that they allow sex discrimination in employment when it is necessary to preserve the "essence of the business." This Article shows, however, that there is no plausible conception of business "essence" that can explain and make sense of the existing case law. The Article therefore looks beyond the courts' rhetoric to explain and defend why courts distinguish in the ways they do between permissible and impermissible sex discrimination in employment.

Journal Article↗

Rotation otolith tilt-translation reinterpretation (ROTTR) hypothesis: a new hypothesis to explain neurovestibular spaceflight adaptation.

Normally, the nervous system must process ambiguous graviceptor (e.g., otolith) cues to estimate tilt and translation. The neural processes that help perform these estimation processes must adapt upon exposure to weightlessness and readapt upon return to Earth. In this paper we present a review of evidence supporting a new hypothesis that explains some aspects of these adaptive processes. This hypothesis, which we label the rotation otolith tilt-translation reinterpretation (ROTTR) hypothesis, suggests that the neural processes resulting in spaceflight adaptation include deterioration in the ability of the nervous system to use rotational cues to help accurately estimate the relative orientation of gravity ("tilt"). Changes in the ability to estimate gravity then also influence the ability of the nervous system to estimate linear acceleration ("translation"). We explicitly hypothesize that such changes in the ability to estimate "tilt" and "translation" will be measurable upon return to Earth and will, at least partially, explain the disorientation experienced when astronauts return to Earth. In this paper, we present the details and implications of ROTTR, review data related to ROTTR, and discuss the relationship of ROTTR to the influential otolith tilt-translation reinterpretation (OTTR) hypothesis as well as discuss the distinct differences between ROTTR and OTTR.

Adaptation, Physiological↗

Can differences in labor induction rates be explained by case mix?

OBJECTIVE: To determine whether differences in case mix account for variations in labor induction rates between hospitals and whether case mix adjustment is helpful in evaluating hospital induction rates. STUDY DESIGN: Using a New York State birth certificate database, factors associated with induction of labor were entered into a logistic regression to calculate labor induction probabilities. The probabilities were used to calculate expected induction rates at each of 16 regional hospitals. Each hospital's observed and expected induction rates were compared to determine the degree of residual variation. RESULTS: Excluding women who delivered by cesarean section without labor, the regional labor induction rate was 20.8%, with a 3.9-fold difference between the highest and lowest hospital rates (P < .0001). Adjusting for risk factors explained only 12.6% of the variation in induction rates. Risk adjustment to compare labor induction rates had a minimal effect on rank ordering of rates but made clearer some hospitals' rates. CONCLUSION: Differences in case mix do not explain labor induction rate variation, but adjustment for case mix may aid in interpreting rates at individual hospitals.

Adult↗

[The nursing process according to Orem. A concrete very simple example explains how to follow this nursing process].

The author shows how Orem's theory, based on self care, can be applied to the nursing care of a patient with severe cardiac illness. To do so, she explains in detail what is looked for in the patient's history to delineate problems, and then uses a systematic care plan approach to solve them. In the patient's history, the nurse looks for information on each need, and on the specific factors in the patient's life and health history that will have an impact on the patient's capacity to meet Orem's goal of self care. Inabilities are labelled self care deficits. When the self-care deficit is well understood, it is important then to determine the source of the patient's difficulty. Orem states that there are two main phases to self-care: the decision and the action. The author illustrates this through a discussion of the patient's difficulty to stop smoking. She then explains a particular method to write a nursing diagnosis that directs the nurse to work, not on the deficit itself, i.e. in this case smoking, but rather on the patient's lack of knowledge. The "SMART" approach to writing nursing care objectives (specific to the patient and the current situation, measurable, attainable by the client in a reasonable period of time, realistic for the current situation, and truthful or having clear significance for the patient at the moment) is detailed along with interventions that respect Orem's concept of nurse-patient contracts. The nursing process based on Orem's conceptual framework is not difficult to manage.(ABSTRACT TRUNCATED AT 250 WORDS)

Female↗

Effects of socio-economic and behavioural characteristics in explaining central obesity--a study on adult Asian Indians in Calcutta, India.

The present cross-sectional study on adult Asian Indians in Calcutta, India was undertaken to look into the effects of socio-economic and behavioural characteristics in explaining waist-hip ratio (WHR). A total of 500 apparently healthy individuals (300 men and 200 women) were subjects in the study. A random sampling procedure using local voter's registration list was followed to select the subjects. Only one adult (> or = 30 years) from each household was considered as participant. A total of 24 items, 14 socio-economic and 10 behavioural characters were considered. For socio-economic characters, a number of items namely employment status, types of occupation, education status, nature of housing and marital status were taken into consideration. Smoking status, physical exercise by means of outdoor activity, drinking habits and diets on the other hand were considered as behavioural characters. Information on socio-economic and behavioural characteristics was collected using an open-ended schedule specifically designed in this regard. Anthropometric measures namely height, weight and circumference of waist and hip were obtained from participants using standard techniques. The median WHR for men and women was 0.94 and 0.90 respectively. Analysis of variance revealed significant sex difference for all anthropometric measures. It was observed that more women were leading sedentary (outdoor activity not housework was considered) life than men (85.4% vs. 75.4%). Furthermore, women were predominantly nonsmokers (98.8%) whereas 40.2% men were smokers as against 51.4% ex-smokers (those who have quitted smoking during past two years). Multiple regression analysis (adjusted for age and sex) of WHR by socio-economic and behavioural characters revealed that occupation, housing, marital status, smoking condition, physical exercise, drinking habits and diets pattern cumulatively explains 75% (R2=0.75) of total variation of WHR in the study population.

Adult↗

[New explaination of mechanisms of indications of Suliao (GV 25) and Shuigou (GV 26)].

OBJECTIVE: To newly explain mechanisms of indications of Suliao (GV 25) and Shuigou (GV 26). METHODS: Analyze mechanisms of indications of Suliao (GV 25) and Shuigou (GV 26) in TCM "viscera-state doctrine" as the center and in combination with anatomy of western medicine. RESULTS: Not only put forward the corresponding relation ("re-preparation" of external forms) of the five sense organs with five solid organs, and also use this theory to explain the reasons why Suliao (GV 25), Shuigou (GV 26) and round some extra-ordinary points (Bijian, Bizhonggou) have same indications. CONCLUSION: This thinking has guiding significance for developing new acup-moxibustion treatment points and determining the angle and direction of needling.

Acupuncture Points↗

Perception of racism explains the difference between Blacks' and Whites' level of healthcare trust.

OBJECTIVE: To test the hypothesis that the level of healthcare trust does not differ between Blacks and Whites. DESIGN: Cross-sectional telephone-based survey. METHODS: This study recruited low-income residents of Miami-Dade and Duval counties in Florida by using random-digit dialing (RDD). One thousand and five residents participated; however, analyses were limited to Black (n=550) or White (n=374) respondents. Trained interviewers used a structured questionnaire to obtain information about respondent demographics, trust in health care, perception of racism, and access to care. RESULTS: Black respondents included fewer males (P=.0146) and younger subjects (P < or = .05); otherwise, they were similar to White respondents. Compared to Duval County respondents, Miami-Dade respondents were younger (< or = .05), richer (< or = .05), and mostly males (P=.0355). Blacks perceived more racism than did Whites (P<.0001). Healthcare trust differed by race and respondents' county (P<.0001). The proportion of variance in healthcare trust explained (R2) by race was 2%. Introducing perception of racism into the model eliminated differences in trust between White and Black respondents. Overall, the model explaining healthcare trust accounted for 21.2% of the variance in trust; the model adjusted for respondents' county, demographics, access to care, and liking treatment during routine appointment. CONCLUSION: This study observed that perception of racism accounted for the residual differences in healthcare trust between Whites and Blacks; therefore, healthcare distrust may not be an attribute of Blacks. Respondents' experience with the healthcare system accounted for most of the difference in trust.

Adult↗

Measuring severity of illness: six severity systems and their ability to explain cost variations.

This paper presents results from a study that used a common set of patient records to compared how well different severity measurement systems are able to explain the variations in estimated costs among hospital patients. The systems examined were: APACHE II, MedisGroups, Computerized Severity Index (CSI), Disease Staging, Patient Management Categories (PMCs), and Acuity Index Method. In regressions on costs, all of the measures were found to improve upon DRGs for some types of cases but to offer little or no improvement for others. Indicators of maximum severity, especially Max CSI, explained greater proportions of cost variation than measures of admission severity and measures based on discharge abstracts. In most of the analyses, PMCs and Disease Staging yielded somewhat higher R2 values than the measures of admission severity.

Abstracting and Indexing↗

Enamel remineralization: how to explain it to patients.

The term remineralization of initial enamel caries is frequently used, but mainly at research conferences and in lecture rooms. Clinicians avoid discussing remineralization and white-spot enamel lesion formation with patients because details of the processes are complex. Patients, therefore, incorrectly assume that cavitation occurs right at the onset of caries and that a restoration must be placed to halt further progression of the lesion. Although laboratory and clinical studies have shown that initial white-spot enamel lesions can remineralize, patients have little or no access to this information. The schematic diagrams in this paper explain the diffusion of organic acids from plaque between enamel crystals, the partial loss of mineral from enamel crystals, and subsequent demineralization and remineralization that produces the white-spot lesion. Further, these diagrams may help clinicians explain remineralization as simply as possible to patients who present with white-spot enamel lesions.

Dental Caries↗

Use of regression analysis to explain the variation in prescribing rates and costs between family practitioner committees.

There are proposals to set up prescribing budgets for family practitioner committees (now family health services authorities) and indicative prescribing amounts for practices. An intelligible model is therefore required for specifying budgetary allocations. Regression analyses were used to explain the variation in prescription rates and costs between the 98 family practitioner committees of England and Wales in 1987. Fifty one per cent of the variation in prescription rates and 44% of the variation in prescription costs per patient could be explained by variations in the age-sex structure of family practitioner committees. The standardized mortality ratio for all causes and patients in 1987, and the number of general practice principals per 1000 population in 1987, but not the Jarman under-privileged area score were found to improve the predictive power of the regression models significantly (P less than 0.01). The predictions of the model for the 10 family practitioner committees with the highest and lowest prescription rates or costs are reported and discussed. Potential improvements in models of prescribing behaviour may be thwarted by two problems. First, the paucity of readily available data on health care need at family practitioner committee and practice levels, and secondly, the increasing complexity in the statistical techniques required may render the procedure less intelligible, meaningful and negotiable in a contentious field.

Costs and Cost Analysis↗

Explaining variations in hospital death rates. Randomness, severity of illness, quality of care.

We used administrative (Part A Medicare) data to identify a representative sample of 1126 patients with congestive heart failure and 1150 with acute myocardial infarction in hospitals with significant unexpectedly high inpatient, age-sex-race-disease-specific death rates ("targeted") vs all other ("untargeted") hospitals in four states. Although death rates in targeted hospitals were 5.0 to 10.9 higher per 100 admissions than in untargeted hospitals, 56% to 82% of the excess could result from purely random variation. Differences in the quality of the process of care (based on a medical record review) could not explain the remaining statistically significant differences in mortality. Comparing targeted hospitals with subsets of untargeted ones, eg, those with lower than expected death rates, did not affect this conclusion. Severity of illness explained up to 2.8 excess deaths per 100 admissions for patients with myocardial infarction. Identifying hospitals that provide poor-quality care based on administrative data and single-year death rates is unlikely; targeting based on time periods greater than 1 year may be better.

Aged↗

Are racial differences in the prevalence of diabetes in adults explained by differences in obesity?

To determine whether the higher prevalence of diabetes found among blacks in the United States is explained by racial differences in obesity, we examined the prevalence of diabetes adjusted for adiposity, education, and income in a cohort of US Army veterans from the Vietnam era. Among 12,558 white men and 1677 black men, aged 30 to 47 years, blacks were more likely than whites to have diagnosed diabetes (adjusted prevalence ratio, 1.9; 95% confidence interval, 1.3 to 2.7). Within every age, adiposity, and socioeconomic stratum, blacks had a higher prevalence of diagnosed diabetes than whites. In a subgroup of veterans for whom fasting serum glucose values were measured, blacks were more likely than whites to have fasting hyperglycemia (fasting serum glucose value greater than or equal to 7.8 mmol/L) (adjusted prevalence ratio, 5.7; 95% confidence interval, 2.7 to 12.0). These data provide evidence that the higher prevalence of diabetes found among blacks is not explained by differences in obesity.

Adult↗