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Artificial insemination with donor sperm: a review of 108 patients.

Artificial insemination with donor sperm (AID) has been a major form of treatment among infertile couples with defects in sperm production. In this report, we review our experience from 1980-1985. A total of 108 patients underwent AID, with 75 resultant pregnancies. Of patients achieving pregnancy, 47% became pregnant after the third cycle and 92% by the twelfth cycle. A higher success rate and/or smaller number of AID cycles were positively associated with patient age of 35 or less and negatively associated with endometriosis. This information is useful in counseling couples interested in pursuing AID.

Adult↗

Factors in the infertile couple influencing the success of artificial insemination with donor semen.

Factors influencing the success of artificial insemination with donor semen (AID) were investigated in a series of 928 infertile couples. A simple approach with one insemination/cycle, timed only by cycle length and basal body temperature, was used. The overall life-table cumulative conception rate was 82% and the average fecundability was 10%. The following factors were associated with a higher success rate: women less than 36 years, azoospermic compared with oligozoospermic husband and women with no history of abdominal surgery. The success rate decreased with increasing duration of infertility and in women with an abnormal hysterosalpingography or laparoscopy, and was unrelated to menarcheal age, the distance between the couples place of residence and the clinic, or if the woman had been pregnant before starting AID treatment.

Female↗

Artificial insemination with frozen stored donor semen.

The results of artificial insemination with donor semen (AID) are reported. The semen samples were stored in liquid nitrogen until needed. Eighty-two pregnancies occurred in 214 patients treated for 1610 cycles. Life table conception rates were 24.3 +/- 2.9 after six months and 32.7 +/- 3.3 after 12 months of treatment. Thirty of the 82 patients conceived within three treatment cycles and 53 by the sixth treatment cycle. Of the 82 pregnancies, there were 12 miscarriages, no stillbirths or neonatal deaths and one baby was born with a congenital abnormality.

Counseling↗

Timing of ovulation for artificial insemination.

Two studies involving eighty women having treatment with artificial insemination by donor (AID) have demonstrated that the use of a urinary semi-quantitative assay for luteinising hormone (LH) gives pregnancy rates comparable to those obtained using plasma LH for the timing of insemination. The advantage of self test assay is evident in a scattered region such as Grampian.

Adult↗

Changes of evaluation for natural-service sampled bulls brought into artificial insemination.

United States Department of Agriculture Sire Summary files were used to select bulls with a published Modified Contemporary Comparison sire evaluation prior to entry into artificial insemination. Canadian bulls were not included. Of the Brown Swiss, Guernsey, Holstein, and Jersey bulls that entered artificial insemination since 1974, 28 Brown Swiss, 19 Guernseys, 298 Holsteins, and 45 Jerseys (4 to 12%) had natural service evaluations. Of these bulls, 10 Guernseys, 154 Holsteins, and 28 Jerseys had an increase of Repeatability of 30% or more after entering artificial insemination. Evaluations for bulls just prior to their entering artificial insemination were compared with their most recent evaluations through July 1983. Average Repeatabilities for evaluations of bulls just prior to their entering artificial insemination were 32% for Guernseys, 32% for Holsteins, and 31% for Jerseys and 88, 90, and 87% for their most recent evaluations. Average Predicted Differences prior to entering artificial insemination were 305 kg for Guernseys, 394 kg for Holsteins, and 452 kg for Jerseys for milk and 11, 10, and 16 kg for fat. Most recent average Predicted Differences were 268, 380, and 532 kg for milk and 7, 10, and 18 kg for fat. Predicted Differences of natural service bulls were not overevaluated regardless of number of herds for sampling or year of entry into artificial insemination. Artificial insemination organizations can continue to acquire bulls with natural service evaluations calculated with the Modified Contemporary Comparison and be confident that these Predicted Differences are not overestimated.

Animals↗

Artificial insemination homologous and its role in the management of infertility.

Fifty-seven cases of homologous artificial insemination (AIH) were reviewed as well as the reason for performing the insemination. Three patients had AIH because of impotence, and two conceived. Twenty-nine patients whose husbands had sperm counts of less than 40 million/ml had AIH combined with split ejaculates, and seven (24.1%) became pregnant. Twenty-five patients had AIH because of persistent, unexplained, poor postcoital tests despite a normal semen picture, and eight (32%) became pregnant.

Erectile Dysfunction↗