PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “IOPANOIC ACID”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 487 records · Page 27Linked to original sources
PubMed1999

Incorporation of an (125)I-labeled hexa-iodinated diglyceride analog into low-density lipoprotein and high specific uptake by cells of cervical carcinoma cell lines.

The feasibility of using low-density lipoprotein (LDL) to deliver cytotoxic drugs to tumor cells has been explored since the 1980s, when cells of a number of cancer cell lines were found to have higher LDL receptor activity than normal cells. Such differential uptake between tumor and normal cells may provide a unique opportunity to use LDL as a tumor-specific carrier of radiopharmaceuticals for the clinical management of cancer. In this study, an (125)I-labeled hexa-iodinated diglyceride analog, 1, 3-dihydroxypropan-2-one 1,3-diiopanoate (DPIP), was synthesized and incorporated into LDL using a fusion technique. It was found that approximately 500 [(125)I] DPIP molecules were incorporated into each LDL particle. Cells of three human cervical tumor cell lines, HeLa, SiHa and C-33A, were used to examine the cellular uptake of the [(125)I]DPIP-LDL conjugate. It was shown that the [(125)I]DPIP-LDL conjugate was specifically bound to and taken up by cervical tumor cells through an LDL receptor-mediated endocytosis pathway. The results suggest that LDL may be a selective carrier for delivering hydrophobic radiopharmaceuticals to cancer cells and particularly for the diagnosis of cervical tumors.

Binding Sites↗
PubMed1975

[Theoretical considerations for improving oral cholegraphy (author's transl)].

Oral cholegraphy is one of the most accurate procedures in diagnostic radiology. Nevertheless it is not without shortcomings. To achieve an enhancement of its reliability the biochemical and physiological processes involved in an ultimately sufficient biliary-tract opacification are analysed. From these theoretical considerations some conclusions are drawn which could be important for the improvement of oral cholegraphy and which appeared to be worth testing in practice.

Administration, Oral↗
PubMed1976

A diagnostic technique for acalculous cholecystitis.

Routine oral cholecystography with Telepaque frequently will show normal visualization of the gallbladder in the presence of acalculous cholecystitis and cholesterolosis. Roentgenograms of the abdomen that show persistent opacification of the gallbladder 36 hours after the administration of Telepaque are suggestive of cholecystic disease. Twenty-six patients with previously normal cholecystograms but with continuing symptoms of biliary tract disease were studied with 24 hour delayed films of the gallbladder. All had persistent visualization of the gallbladder, and all had diseased gallbladders verified at operation and by pathologic examination.

Cholecystitis↗
PubMed2003

Use of oral cholecystography agents in the treatment of hyperthyroidism of subacute thyroiditis.

AIM: In this study, we describe our experience in treating subacute thyroiditis patients with 2 OCAs (sodium ipodate and sodium iopanoate). METHODS: We studied 10 consecutive patients with subacute thyroiditis treated with 1 of the 2 oral cholecystography agents (OCAs). RESULTS: Hyperthyroidism was controlled and symptoms improved markedly in each case without any evidence of subsequent relapse of thyroiditis after withdrawal of OCAs. Three of the 10 patients had been treated previously with corticosteroids and had demonstrated relapse of thyroiditis and hyperthyroidism after tapering or withdrawal of steroids. We observed no side effects of treatment with OCAs. CONCLUSION: Our data suggest that OCAs are effective and safe agents for management of hyperthyroidism in patients with subacute thyroiditis, even when they have relapsed after treatment with corticosteroids.

Acute Disease↗