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PubMedDate not supplied

[Possibility of achieving the Pasteur effect by ascites carcinoma cells in vivo].

Possibility of Pasteur effect in cancer cells in vivo was studied on mice with Ehrlich ascites carcinoma and rats with carcinoma of ovaries++. The experiments were run in two series. In the first series, all animals were saturated with oxygen through inhalation. In this series, part of the animals were given glucose subcutaneously. In the second series, all animals were given oxygen intraperitoneally and some of the animals with carcinoma of ovaries++ were given glucose subcutaneously. Values of inhibition of glycolytic activity in cancer cells under various experimental conditions were estimated through a calculated coefficient. Results of the experiment evidenced that inhalational saturation of animals with oxygen did not inhibit glycolysis of ascites cells in vivo while after intraperitoneal administration of oxygen, coefficient of inhibition of glycolytic activity in mice with Ehrlich ascites++ carcinoma after 45-65 min was 50-615, respectively. Experiments on rats showed that inhibition of glycolytic activity in rats can be revealed during simultaneous administration of oxygen intraperitoneally and of glucose subcutaneously. The authors reached the conclusion that under adequate supply of cancer cells with oxygen respiration can suppress glycolysis at the level of organism as well.

Animals↗
PubMedDate not supplied

Immuno BCG Pasteur F vaccine.

Immuno BCG Pasteur-F (fresh) vaccine is prepared from young cultures, 7-8 days old. Suspended in Dubos' modified medium it may be preserved for 3 months at 4 degrees C or for many years at--70 degrees C. Tests with the vaccine for colony-forming units during storage, biological controls in animals and allergy in children have demonstrated its good stability.

Animals↗
PubMed1984

[Controlled results of the oral anticholera vaccine from the Institut Pasteur during the Shaba-Zaire epidemic in 1983].

Pasteur Institute oral cholera vaccine has been evaluated in the district of Malemba NKulu (Zaire). A cholera epidemic began 7 months after the vaccination. 216 cholera cases occurred among 18,377 control non-vaccinated subjects and 57 cases occurred among 6,249 subjects vaccinated by the conventional parenterally administered vaccine. In contrast, only 6 cholera cases occurred among 12,014 subjects vaccinated by the oral cholera vaccine.

Administration, Oral↗
PubMed1980

The effect of freezing and pasteurizing bovine milk on its ability to protect neonatal guinea-pigs against colonization of the small intestine by Escherichia coli.

The ability of frequent feeding of bovine milk diets to prevent the colonization of the small intestines of newborn guinea-pigs with orally inoculated Escherichia coli was tested. At 3--4 days small intestinal samples from suckled controls were frequently sterile or were colonized with only very low numbers of Esch. coli. No bovine milk diet exhibited a significant "protective" effect but the diets could, however, be ranged in order of effectiveness in decreasing colonization by Esch. coli. Raw, fresh bovine milk was best, followed by milk pasteurized at 56 degrees or 63 degrees, then boiled milk; frozen milk was the worst. Because of this last finding, neither the bacteriostatic lactoferrin-dependent activity nor the lactoperoxidase could be correlated with the ability to decrease the colonization of the small intestines by Esch. coli.

Animals↗
PubMedDate not supplied

[Endotoxin content of samples of pasteurized milk: preliminary findings].

By Limulus lysate assay, endotoxin was found in pasteurized milk samples from commercial source. The range was 32 to 128 microgram per ml, without any change when the samples were refrigerated. By contrast, the endotoxin content rose 512 to 2048 microgram per ml when milk was maintained at room temperature for 24 hours and 1024 to 6400 microgram per ml when samples were examined after 72 hours. These findings suggest a possible clinical implication, and support the concept that Limulus assay appears to be a rapid, reliable, and sensitive test for a quality control in commercial milk samples.

Animals↗
PubMed1995

[Introduction to the commemorative session of the centennial of the death of Louis Pasteur].

When elected a member of Académie de médecine in 1873, Pasteur was well known for his achievements in chemistry, fermentation and silk worm diseases. He denied spontaneity of diseases, their cause are living germs. Passionate disputations took place in Academy on subjects of septicaemia, childbirth fever, or fowl cholera. In 1881, his success was obtained by vaccination of sheep against epidemic anthrax: his method of virus action softening was available for many human infections diseases, in spite of many disputations. The same method applied to rabies gave him universal glory. When he died in 1895, his views on infections diseases were accepted by Academie de medecine and all over the world.

France↗
PubMed1995

[Evolution of human anti-rabies vaccines from Pasteur to the present].

Since the first immunization of man against rabies in 1885 by Louis Pasteur, antirabies vaccine has been continuously improved. Treatment failures, clinical infections by the fixed virus, neuroparalytic accidents in connection with myelin were progressively eliminated. Vaccines can be standardized and accurately controlled. After the original spinal cord, adult or newborn animals brains, embryonated eggs, primary tissue cultures, diploid and permanent cell lines have been used for the vaccine production. Today, safe and potent vaccines are available. New products might be developed from the technology of genetic recombinants.

History, 19th Century↗
PubMed1994

[Occurrence of Listeria monocytogenes in raw milk, pasteurized type C milk and minas frescal cheese commercialized in Piracicaba-São Paulo].

Samples of raw milk, pasteurized C type milk and minas frescal cheese were analyzed for the presence of Listeria monocytogenes by a method developed for dairy products by Lovett (1) and by Lovett & Hitchins (2). A total of 20 samples of each product and from different commercial brands were analyzed, obtained from various retail stores in Piracicaba, SP. According to the pattern of sampling and methodology adopted, none of the samples of the aforesaid products was positive for the presence of L. monocytogenes or another species of the genus. It was possible to observe differences in the degree of selectivity of the selective media utilized, notwithstanding the LPM agar showing to be superior to MMA. Based on the literature and on the result obtained, becomes evident the need of a more suitable method for the detection and isolation of L. monocytogenes from foods, even when the patogen appears in low numbers, with purpose to obtain rapid, reliable and reproducible results.

Animals↗
PubMedDate not supplied

Enumeration of total bacteria in raw and pasteurized milk by reflectance colorimetry: collaborative study.

Seven out of 9 laboratories completed a collaborative study comparing a reflectance colorimetric (RC) bioactivity monitor (Omnispec 4000) method to the standard plate count (SPC) method for estimation of total bacteria in raw and homogenized pasteurized milk. Each laboratory analyzed 12 different samples by the SPC method and 24 samples (12 blind duplicates) by the RC method. For the RC method RSDr was 1.7%, and RSDR was 4.5%. RSDR for the SPC method was 20.8%. The method was adopted first action by AOAC INTERNATIONAL.

Animals↗
PubMedDate not supplied

Pesticide residues in composited milk collected through the U.S. Pasteurized Milk Network.

The U.S. Food and Drug Administration (FDA) has implemented a comprehensive monitoring program to determine the incidence and levels of organohalogen pesticide residues in milk representing most of the U.S. supply consumed in metropolitan areas. Residue findings for 806 composite milks collected through the Pasteurized Milk Program by the U.S. Environmental Protection Agency (EPA) in 1990-1991 are reported. Milk was collected on a monthly basis from 63 stations selected by EPA for radionuclide monitoring. These stations provide an estimated 80% of the milk delivered to U.S. population centers. At each station, milk from selected sources had been composited to represent the milk routinely consumed in its metropolitan area. Portions of these composites were forwarded to an FDA contract laboratory for pesticide residue analysis. Pesticide residues were found in 398 (49.4%) of 806 test samples, on the basis of a 0.0005 ppm limit of detection for each residue on a whole-product basis. A total of 455 occurrences of pesticide residues were found; p,p'-DDE and dieldrin accounted for 384 (84.4%) of these occurrences. The highest level was 0.019 ppm p,p'-DDE.

Animals↗
PubMed1993

Pasteur oral cholera vaccine: studies of reactogenicity, clinical acceptability and immunogenicity in human volunteers.

Pasteur cholera vaccine consists of isolated antigenic fractions from V. cholerae El Tor Ogawa and Inaba. Enteric coated microgranules were prepared from antigen lyophilisate. Three doses of this vaccine were administered orally to 19 healthy young Thai adults at one week intervals. None of the volunteers experienced untowards reactions. The vibriocidal antibody responses manifested a significant antibody rise (> or = 4 fold) to serovar Inaba in 8 vaccinees (42.1%) and Ogawa in 4 (21.1%). Five and 6 vaccinees (26.3% and 31.6%) showed a > or = 4 fold rise of IgG and IgA anti-LPS, respectively.

Administration, Oral↗
PubMed1993

Survival of Salmonella enteritidis during the manufacture of feta cheese made of pasteurized ewe's milk.

The behaviour of Salmonella enteritidis during the Feta cheese making process was investigated. Two lots of pasteurized whole ewe's milk were inoculated to contain 10(6) cfu/ml of S. enteritidis (strain AS1 and AS2) and were processed into Feta cheese following standard procedures. All samples were examined for S. enteritidis both quantitatively and qualitatively, while moisture, fat, water activity and pH were also measured. S. enteritidis was enumerated in duplicate samples by surface plating on SS agar. Selected salmonella-like colonies were identified biochemically and serologically. The enumerations have shown that S. enteritidis was initially entrapped in the curd. Then the growth of S. enteritidis gradually decreased and no Salmonellae were quantitatively enumerated after the 23rd day. However S. enteritidis was detected qualitatively in samples taken until the 38th day.

Animals↗
PubMed1993

A higher than expected incidence of factor VIII inhibitors in multitransfused haemophilia A patients treated with an intermediate purity pasteurized factor VIII concentrate.

In May 1990, 218 patients with haemophilia A regularly attending the Leuven Haemophilia Center were randomly assigned to a group receiving either of two newly introduced factor VIII concentrates: factor VIII-P, an intermediate purity pasteurized concentrate, or factor VIII-SD, a high purity concentrate treated with solvent-detergent for viral inactivation. Patients were followed from May 1990 until October 1991. Between August 1991 and October 1991 a clinically important factor VIII inhibitor was detected in five out of the 109 patients receiving factor VIII-P while none of the 109 patients receiving factor VIII-SD developed such antibodies. All patients acquiring an inhibitor had previously been clinically tolerant to transfused factor VIII with 200 to more than 1,000 days of exposure to factor VIII prior to May 1990. Patients with inhibitors were transfused daily with 30 U factor VIII-SD per kg body weight, which was associated with a gradual decline of the inhibitor level. In all patients the antibodies were relatively slow-acting and predominantly directed towards the light chain of factor VIII. This study demonstrates a higher than expected incidence of factor VIII inhibitors associated with the use of a specific factor VIII concentrate in multitransfused haemophilia A patients. It indicates the usefulness of evaluating newly introduced concentrates in prospective, randomized trials.

Adolescent↗
PubMed1996

[Prevalence of toxoplasmosis in Tananarive. Study conducted at the Pasteur Institute of Madagascar (PIM) on a sample of 2354 subjects].

The prevalence of Toxoplasma antibodies was studied in 2,354 individuals in Tananarive, at the Institut Pasteur of Madagascar. The seroprevalence among the malagasy population amounts to 52.1%. At the age of 10 years old, 36.3% of our sample have already acquired toxoplasma antibodies, proving an early infection. No differences have been observed between sexes. The toxoplasmosis prevalence among the female population coming from France, India and Pakistan and living in Tananarive seemed the same than in their home countries, whereas female population coming from China had shown a different seroprevalence compared to their home country.

Adolescent↗
PubMed1977

[Hygienic studies of the manufacture of pasteurized and sterilized canned meat products].

Studied was microbiologically the hygiene condition of premises, equipment, glassware and containers, instruments and tools, raw meat, the hands of workers and work clothing, canned products prior to sterilization, and air along all technologic lines for the production of pasteurized and sterilized canned meat: In case of underestimating the measures of industrial hygiene. In case of permanent and severe control on the measures of industrial hygiene. Determined were the total counts of bacteria--of coliforms, Salmonellae, anaerobes and staphylococci. Results made it clear that the observation of hygiene along all technologic lines of production is an immediate task. Strictly observed hygiene in meat production has given very good results up to 90-100 per cent of the washings prove sterile. Experiments have pointed to the necessity of observing the measures of industrial hygiene that guarantee the high quality of canned meat.

Air Microbiology↗
PubMed1998

[Cancer in Madagascar. Experience of the Institut Pasteur de Madagascar from September 1992 to June 1996].

The Unit of the anatomo-pathology in the "Institut Pasteur de Madagascar" (IPM) examined in the period from September 1992 to June 1996 tissue specimens from 10,275 patients. Tumorous pathology presented 40% of the tissues and half of which were of malign etiology. 64% of the cancer diagnosed were in females. Cervical cancer was most frequently observed (17%), followed by breast cancer (16%). Cancer in the gastro-intestinal tract (15%) was most often located in the colon without sex difference. Stomach cancer occurring predominantly in males presented 25% of the total cases of cancer in the gastro-intestinal tract. Cancer of liver is rarely diagnosed despite the high prevalence of infection with hepatitis B virus. Skin cancer constituted 9% of the malign diagnosis and was mainly found in males. Children under 15 years old presented 7.4% of the total cases of malignancy with the haematopoietic tissues (30%) and the eyes (17%) as the most frequent topic locations. Due to a very low seroprevalence of the HIV in Madagascar, malign tumours associated to AIDS were only seen in a few rare cases. The review of cancer cases in the IPM may not be representative for the cancer epidemiology of Madagascar because of a general very low level of health care coverage, especially in the rural areas. Furthermore, a major part of the specimens originates from easily accessible organsystems, whereas other organs seem less investigated due to lack of appropriate available technique. Therefore, it is not feasible for the moment to establish a cancer register in Madagascar, although the Unit of Pathology in the IPM can offer a valid cancer diagnostical service.

Adolescent↗