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Cluster analysis of depressed college students' social behaviors.

Measures of interpersonal behaviors exhibited by depressed college students toward their dormitory roommates were cluster analyzed, and this procedure produced 2 relatively distinct subgroups: a dependent, friendly, overgenerous type and an autocratic, competitive, aggressive, mistrustful type. These 2 groups were studied over a 9-month period; findings revealed that behaviors associated with each cluster were relatively stable and unrelated to gender or initial symptom severity. In longitudinal analyses, depressives in one group showed symptom abatement across time, whereas symptoms of the other group remained elevated. The roommates of depressives exhibited relatively high levels of hostility and a progressive decline in social contact and satisfaction with their depressed cohabitant. The results are discussed in relation to other typological approaches to unipolar depression.

Cluster Analysis↗

Altered sexual and social behaviors in trp2 mutant mice.

We have used gene targeting to generate mice with a homozygous deficiency in trp2, a cation channel expressed in the vomeronasal organ (VNO). Trp2 mutant animals reveal a striking reduction in the electrophysiological response to pheromones in the VNO, suggesting that trp2 plays a central role in mediating the pheromone response. These mutants therefore afford the opportunity to examine the role of the VNO in the generation of innate sexual and social behaviors in mice. Trp2 mutant males and nursing females are docile and fail to initiate aggressive attacks on intruder males. Male-female sexual behavior appears normal, but trp2 mutant males also vigorously mount other males. These results suggest that the cation channel trp2 is required in the VNO to detect male-specific pheromones that elicit aggressive behaviors and dictate the choice of sexual partners.

Aggression↗

An analysis of the effects of multiple setting events on the social behavior of preschool children with special needs.

We examined the effects of four combinations of setting events on the social interactions of 7 preschool children with social delays. In Study 1, the status of the teacher, activity materials, and peer varied across conditions. In Study 2, the status of the teacher and materials varied across conditions. Within the combinations of setting events, we also examined teacher behavior. Teacher presence and absence was varied in both studies. The type and rate of teacher prompting were varied in Study 2. The four combinations of setting events produced different rates of social behavior by the children with social delays. The optimal combination of setting events for promoting peer interaction and reducing teacher-child interaction included teacher absence from the activity, a limited number and form of materials, and children paired with a socially skilled partner.

Aggression↗

Social behavior and meningococcal carriage in British teenagers.

Understanding predisposing factors for meningococcal carriage may identify targets for public health interventions. Before mass vaccination with meningococcal group C conjugate vaccine began in autumn 1999, we took pharyngeal swabs from approximately 14,000 UK teenagers and collected information on potential risk factors. Neisseria meningitidis was cultured from 2,319 (16.7%) of 13,919 swabs. In multivariable analysis, attendance at pubs/clubs, intimate kissing, and cigarette smoking were each independently and strongly associated with increased risk for meningococcal carriage (p<0.001). Carriage in those with none of these risk factors was 7.8%, compared to 32.8% in those with all 3. Passive smoking was also linked to higher risk for carriage, but age, sex, social deprivation, home crowding, or school characteristics had little or no effect. Social behavior, rather than age or sex, can explain the higher frequency of meningococcal carriage among teenagers. A ban on smoking in public places may reduce risk for transmission.

Adolescent↗

Secretin receptor-deficient mice exhibit impaired synaptic plasticity and social behavior.

Secretin is a peptide hormone released from the duodenum to stimulate the secretion of digestive juice by the pancreas. Secretin also functions as a neuropeptide hormone in the brain, and exogenous administration has been reported to alleviate symptoms in some patients with autism. We have generated secretin receptor-deficient mice to explore the relationship between secretin signaling in the brain and behavioral phenotypes. Secretin receptor-deficient mice are overtly normal and fertile; however, synaptic plasticity in the hippocampus is impaired and there are slightly fewer dendritic spines in the CA1 hippocampal pyramidal cells. Furthermore, secretin receptor-deficient mice show abnormal social and cognitive behaviors. These findings suggest that the secretin receptor system has an important role in the central nervous system relating to social behavior.

Animals↗

Drug-produced changes in human social behavior: facilitation by d-amphetamine.

The effects of oral d-amphetamine 5-30 mg on human social and verbal behavior were studied using repeated observations within subjects under a time-sampling observation procedure in a residential research ward. d-Amphetamine increased socializing in all three subjects studied, but only increased standing in one of the subjects. In the second experiment throat microphones and voice-operated relays were used to measure automatically quantitative aspects of dyadic verbal interactions during 1-hr daily sessions. Total speaking time showed dose-related increases in 5 of the 7 subjects receiving d-amphetamine. Adjective checklist self-report scores indicating stimulant drug effects were as sensitive and reliable as the speaking measure to the effects of d-amphetamine in these subjects. Speaking time also increased in 2 of the 8 partners who received placebo when the subjects with whom they were paired received d-amphetamine. This represents a socially mediated indirect drug effect. Adjective checklist scores of the partners receiving placebo were not changed when the paired subjects received d-amphetamine. Under controlled experimental conditions the naturalistic human behaviors of socializing and speaking are sensitive dependent variables for behavioral pharmacology research.

Adult↗

Fimbria-fornix lesions and sexual-social behavior of the guinea pig.

Male and female guinea pigs were given fimbria-fornix lesions and their sexual-social activity was compared to lesioned control animals. The lesions reduced the sexual and aggressive behavior of the male guinea pig. In the female, on the other hand, aggression towards the male increased during attempted copulation. Both experimental and control animals were given an open-field activity test. It was found that fimbria-fornix lesioned animals displayed less activity than did their control counterparts. These results were consistent with earlier findings and were related to previous observations of decorticate rats. It was suggested that the hippocampal output via the fimbria-fornix during sexual-social behavior plays a role in selecting motor patterns appropriate for the motivational state of the animal.

Aggression↗

Effects of corticotropin releasing factor and sauvagine on social behavior of isolated mice.

Corticotropin releasing factor (CRF) and sauvagine (SVG) when injected ICV both reduced aggressive behavior and sociability while increasing defensive behavior in isolated DBA/2 mice interacting with a group-housed intruder. SVG was more effective than CRF in producing such behavioral effects. These results add further evidence to the similarity between CRF and SVG, and are discussed in terms of the involvement of these peptides in emotional reactivity in the laboratory mouse.

Aggression↗

Social behavior and aggressive problems of cats.

Cats form social groups in which individuals recognize each other, and the cohesiveness of the group is maintained by a variety of amicable behaviors. Agonistic behavior may occur between group members and between group members and nongroup members. Within the domestic environment, agonistic behavior may become a problem when it is directed at housemates or humans. Differential diagnosis and treatment of various problems of aggressive behavior are discussed.

Aggression↗

Avoidance of Ontological Confrontation of Loneliness and some epidemilogical indices of social behavior and health.

A scale, Avoidance of the Ontological Confrontation of Loneliness, was developed to assist the psychometric recorded documentation of choice of avoidance versus confrontation strategy to the issue of loneliness. Analysis showed low scores (confronters) reported increased use of soft drugs and were absent from employment more often than medium or high scorers. Borderline statistically significant findings hint that high scorers (avoiders) lean toward less alcoholic beverage consumption while low scorers lean toward fewer automobile accidents and less use of medication than medium groupings. These results both advantages and disadvantages to strategies of awareness.

Adolescent↗

Characterization of factor(s) in culture supernatants affecting cell social behavior.

Treatment of embryonic chick heart fibroblast cultures with 0.2 M urea reversibly increases cellular overlap. The increase in cellular overlapping over that in control cultures may be quantitated by the overlap ratio (R), the ratio of the number of superimposed nuclei observed, to the number expected to occur when cells are assumed to be distributed randomly over the culture substratum (R = observed/expected overlaps). Reversal of the urea-induced increase in R is blocked by 0.2 micrograms/ml cycloheximide. In the presence of cycloheximide, normal (low) overlap ratios are restored to urea-treated cultures by adding non-dialyzable material recovered by washing fibroblast monolayers with serum-free medium. The overlap ratio assay revealed no effect of supernatant material added either to urea-treated cultures in the continued presence of urea, or to untreated cultures. Although unfiltered supernatants were shown by SDS-polyacrylamide gel electrophoresis to contain fibronectin (CSP; LETS; MWappar. = 220,000 d) and smaller proteins, the ability to reverse the urea-induced increase in overlap ratio was present in Diaflo and Millipore filtrates of culture supernatants in which fibronectin was greatly depleted or absent. In contrast, purified fibronectin preparations failed to lower urea-induced increases in overlap-ratio. Partially purified, biologically active supernatants, prepared from 14C-leucine or 125I-labeled cultures, contained several macromolecules smaller than fibronectin that were labeled by both radioisotopes. In particular, one band (MWappar. = 58--60,000 d) was present in polyacrylamide gels of active supernatant and also depleted in gels of homogenates from urea-treated cultures. These results indicate that external macromolecules other than fibronectin are synthesized by cultured fibroblasts and can affect cell social behavior or culture morphology.

Animals↗

Cultural, behavioral, social, and psychological perceptions of saliva: relevance to clinical diagnostics.

The search for a resource that can be used to detect a broad range of diseases easily and reliably is akin to a search for the diagnostic Holy Grail. Yet, each of us may have inside our mouths, a key to the pathological and disease biomarker library hidden inside our bodies. Saliva--the source of all this information--is the secretory product of glands located in or around the oral cavity. If one could read the stories of diagnostic information present within saliva, then the abundance of information waiting to be found could be comparable to a vast vault of information, such as the Internet. Upon dissection of this data, it would be seen that the source of this information is from saliva's origin as a filtrate of blood, and that the validity of both mediums should be equal. Although one day this may be the view, most people's hold of saliva, current and past cultures, have fared much more diverse meanings to the secretion. Ivan Pavlov's experiments has shown how closely tied salivation is with the thought of food, one of life's primary indulgences. The relationship between salivation and behaviors within our daily lives is undeniable. Yet most people never appreciate the uniqueness of saliva. Throughout the world, saliva carries definite positive and negative connotations, based upon its social, psychological, behavioral, and cultural settings. The thought of saliva may be viewed as grotesque in one population, yet may be the vehicle of blessing in other cultures. Saliva's double nature brings up some interesting cultural, social, behavioral, and psychological points about how saliva is perceived in the world, some of which are subsequently stated in order to present saliva as the spirited fluid it is.

Ceremonial Behavior↗