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At least 487 records · Page 27Linked to original sources
PubMed2005

The role of gastric distention in differentiating recurrent tumor from physiologic uptake in the remnant stomach on 18F-FDG PET.

UNLABELLED: Physiologic (18)F-FDG uptake in the stomach can often cause false-positive results and lowers the usefulness of (18)F-FDG PET in evaluating the remnant stomach. We assessed the role of gastric distension to see whether it is beneficial for the differentiation of recurrent tumors from physiologic (18)F-FDG uptake in the remnant stomach. METHODS: Thirty patients (22 men and 8 women; age range, 27-80 y; mean age, 58.3 y) with a history of subtotal gastrectomy for gastric cancer underwent (18)F-FDG PET for various clinical indications. After whole-body imaging, the patients were asked to drink water, and then spot imaging of the stomach was performed. (18)F-FDG uptake in the remnant stomach was considered positive for malignancy if it was persistently increased, whether focal or diffuse, after water ingestion. We used 2 standardized uptake value (SUV) criteria to differentiate benign from malignant uptake. First, a lesion was considered benign if its SUV was less than 2 on whole-body imaging. Second, for a lesion with an SUV of 2 or above, it was classified as benign if SUV decreased by more than 10% after water ingestion. RESULTS: Visual analysis of whole-body images produced 9 true-negative, 4 false-positive, 16 true-positive, and 1 false-negative results. Use of additional spot images produced 12 true-negative, 1 false-positive, 15 true-positive, and 2 false-negative results. When an SUV cutoff of 2 was applied for malignancy before water ingestion, all 17 patients with local recurrence were correctly identified, but 11 of the 13 patients without local recurrence were falsely considered to have a recurrent tumor in the remnant stomach. To reduce the false-positive results, we used the second SUV criterion after water ingestion. Use of that criterion produced 4 false-negative results although it correctly identified the 11 false-positive results as true negative. CONCLUSION: Gastric distension by having patients drink a glass of water seems to be a simple, cost-effective way of improving the diagnostic accuracy of (18)F-FDG PET in patients with suspected recurrence in the remnant stomach. Visual analysis with special attention to the configuration of (18)F-FDG activity after water ingestion seems to be more useful than the change in SUV in evaluating the remnant stomach.

Adenocarcinoma↗
PubMed1990

Comparison of automated quantitative coronary angiography with caliper measurements of percent diameter stenosis.

Measurement of coronary artery stenosis is an invaluable tool in the study of coronary artery disease. Clinical trials and even day-to-day decision making should ideally be based on accurate and reproducible quantitative methods. Quantitative coronary angiography (QCA) using digital angiographic techniques has been shown to fulfill these requirements. Yet many laboratories have abandoned visual analysis in favor of the intermediate quantitative approach involving hand-held calipers. Thus, the purpose of this study was to determine the relation between QCA and the commonly used caliper measurements. Percent stenosis was assessed in 155 lesions using 3 techniques: QCA, caliper measures from a 35-mm cine viewer (cine) and caliper measures from a video display (CRT). Good overall correlation was noted among the 3 different techniques (r greater than or equal to 0.72). Both of the caliper methods underestimated QCA for stenosis greater than or equal to 75% (p less than or equal to 0.001) and overestimated stenosis less than 75% (p less than 0.05). Reproducibility assessed in 52 lesions by independent observers showed QCA to be superior (r = 0.95) to either of the caliper measurements (cine: r = 0.63; CRT: r = 0.73). Therefore, the commonly used caliper method is not an adequate substitute for QCA because overestimation of noncritical stenoses and underestimation of severe stenoses may occur and the measurements have poor reproducibility. These factors definitely preclude its use in rigorous clinical trials. Moreover, since they do not appear to overcome known deficiencies of visual analysis, caliper measurements for day-to-day clinical use must also be seriously questioned.

Cineangiography↗
PubMed2002

An oscillatory correlation model of visual motion analysis.

We describe and evaluate a model of motion perception based on the integration of information from two parallel pathways: a motion pathway and a luminance pathway. The motion pathway has two stages. The first stage measures and pools local motion across the input animation sequence and assigns reliability indices to these pooled measurements. The second stage groups locations on the basis of these measurements. In the luminance pathway, the input scene is segmented into regions on the basis of similarities in luminance. In a subsequent integration stage, motion and luminance segments are combined to obtain the final estimates of object motion. The neural network architecture we employ is based on LEGION (locally excitatory globally inhibitory oscillator networks), a scheme for feature binding and region labeling based on oscillatory correlation. Many aspects of the model are implemented at the neural network level, whereas others are implemented at a more abstract level. We apply this model to the computation of moving, uniformly illuminated, two-dimensional surfaces that are either opaque or transparent. Model performance replicates a number of distinctive features of human motion perception.

Humans↗
PubMed1991

Visual hierarchical analysis of Block Design configural errors.

Patients have been frequently observed to violate the overall configuration on the WAIS-R Block Design subtest. The significance of these configural errors was investigated with hierarchical patterns consisting of large "global" shapes made from smaller "local" shapes. Subjects were administered two similarity judgment tasks in which they were asked to decide which of two hierarchically structured comparison figures most resembled a standard figure. Results indicated that subjects who made configural errors on Block Design were less likely than a matched sample who did not make configural errors to select the comparison figure that resembled the standard figure at the global level. Furthermore, the present findings were obtained from subjects without known right-hemisphere lesions, suggesting that the correlation between Block Design errors and global/local performance is applicable to a broad range of patient and non-patient populations. The data are consistent with the view that errors on Block Design may reflect differences in the perceptual encoding of global/local features.

Adult↗
PubMed2005

Sorting points into neighborhoods (SPIN): data analysis and visualization by ordering distance matrices.

SUMMARY: We introduce a novel unsupervised approach for the organization and visualization of multidimensional data. At the heart of the method is a presentation of the full pairwise distance matrix of the data points, viewed in pseudocolor. The ordering of points is iteratively permuted in search of a linear ordering, which can be used to study embedded shapes. Several examples indicate how the shapes of certain structures in the data (elongated, circular and compact) manifest themselves visually in our permuted distance matrix. It is important to identify the elongated objects since they are often associated with a set of hidden variables, underlying continuous variation in the data. The problem of determining an optimal linear ordering is shown to be NP-Complete, and therefore an iterative search algorithm with O(n3) step-complexity is suggested. By using sorting points into neighborhoods, i.e. SPIN to analyze colon cancer expression data we were able to address the serious problem of sample heterogeneity, which hinders identification of metastasis related genes in our data. Our methodology brings to light the continuous variation of heterogeneity--starting with homogeneous tumor samples and gradually increasing the amount of another tissue. Ordering the samples according to their degree of contamination by unrelated tissue allows the separation of genes associated with irrelevant contamination from those related to cancer progression. AVAILABILITY: Software package will be available for academic users upon request.

Algorithms↗
PubMed1999

Parametric fMRI analysis of visual encoding in the human medial temporal lobe.

A number of functional brain imaging studies indicate that the medial temporal lobe system is crucially involved in encoding new information into memory. However, most studies were based on differences in brain activity between encoding of familiar vs. novel stimuli. To further study the underlying cognitive processes, we applied a parametric design of encoding. Seven healthy subjects were instructed to encode complex color pictures into memory. Stimuli were presented in a parametric fashion at different rates, thus representing different loads of encoding. Functional magnetic resonance imaging (fMRI) was used to assess changes in brain activation. To determine the number of pictures successfully stored into memory, recognition scores were determined afterwards. During encoding, brain activation occurred in the medial temporal lobe, comparable to the results obtained by others. Increasing the encoding load resulted in an increase in the number of successfully stored items. This was reflected in a significant increase in brain activation in the left lingual gyrus, in the left and right parahippocampal gyrus, and in the right inferior frontal gyrus. This study shows that fMRI can detect changes in brain activation during variation of one aspect of higher cognitive tasks. Further, it strongly supports the notion that the human medial temporal lobe is involved in encoding novel visual information into memory.

Adult↗
PubMed2006

Synthesis, structural analysis, and visualization of a library of dendronized polyphenylacetylenes.

A library of eleven high cis-content cis-transoidal polyphenylacetylenes (PPAs) dendronized with self-assembling dendrons was prepared from a library of fifteen convergently synthesized macromonomers. Using [Rh(C triple bond CPh)(nbd)(PPh(3))(2)] (nbd=2,5-norbornadiene) in the presence of 10 equiv of N,N-dimethylaminopyridine, predictive control over molecular weight and narrow molecular weight distribution are obtained. The PPA backbone serves as a helical scaffold for the self-assembling dendrons. The dendron primary structure dictates the diameter of the cylindrical PPAs in bulk, both in the self-organized hexagonal columnar (Phi(h)) lattice determined by X-ray diffraction (XRD) and in monolayers on highly ordered pyrolytic graphite (HOPG) and mica visualized by atomic force microscopy (AFM). Thermal and bulk phase characteristics of the cylindrical PPAs reinforces the generality that flexible polymer backbones adopt a helical conformation within the cylindrical macromolecules generated by polymers jacketed with self-assembling dendrons.

Journal Article↗
PubMed1995

Three-dimensional analysis and visualization of myofibrillogenesis in adult cardiomyocytes by confocal microscopy.

Confocal light microscopy has found its place among the standard analytical tools in cell and molecular biology. When combined with techniques such as immunofluorescence or fluorescent in situ hybridization, the spatial distribution of individual biological components can be traced within cells and tissues and, under certain circumstances, even with living samples. In this article, advanced 3D visualization techniques have been applied to analyze the distribution of myofibrillar proteins in cultured adult rat cardiomyocytes. By combining confocal immunofluorescence microscopy with specially designed three-dimensional visualization, we have obtained images which are similar to those obtained with the scanning electron microscope. The subcellular distribution of proteins expressed after transfection of cDNA is monitored in the cultured heart cells. The expressed proteins are distinguished from their endogenous counterparts by the use of an epitope tagging technique. The described methods are suitable to specifically monitor the behavior of several closely related isoprotein mutants in cell or tissue preparations.

Animals↗
PubMed2000

An event-related brain potential analysis of visual word priming effects.

Two experiments are reported that provide evidence on task-induced effects during visual lexical processing in a prime-target semantic priming paradigm. The research focuses on target expectancy effects by manipulating the proportion of semantically related and unrelated word pairs. In Experiment 1, a lexical decision task was used and reaction times (RTs) and event-related brain potentials (ERPs) were obtained. In Experiment 2, subjects silently read the stimuli, without any additional task demands, and ERPs were recorded. The RT and ERP results of Experiment 1 demonstrate that an expectancy mechanism contributed to the priming effect when a high proportion of related word pairs was presented. The ERP results of Experiment 2 show that in the absence of extraneous task requirements, an expectancy mechanism is not active. However, a standard ERP semantic priming effect was obtained in Experiment 2. The combined results show that priming effects due to relatedness proportion are induced by task demands and are not a standard aspect of online lexical processing.

Adult↗
PubMed1985

Critical analysis of visual function evaluating techniques in newborn babies.

The most widely-used techniques for testing visual function in babies are reviewed. Advantages and limitations of optokinetic nystagmus testing, visual evoked responses and preferential looking techniques are considered. The theoretical basis and the clinical applicability of those techniques are outlined. Other simple methods are considered as well, which allow practicing ophthalmologists to assess the presence or absence of vision in babies. The importance of early diagnosis for prevention and treatment of visual deficits in babies is stressed.

Evoked Potentials, Visual↗
PubMed1988

Cluster analysis in visual field quantification.

The central visual fields of 2165 normal and 106 glaucoma eyes were measured using a threshold related suprathreshold strategy. The effects of altering the cluster radius in normals and glaucoma eyes sheds light on the nature of defects in these two groups. It is estimated that approximately 13% of normals have clusters; the great majority of these individuals have one cluster of two defects. Most clusters in normals are formed artefactually due to angioscotoma and/or physiological variations in the blind spot position. Clusters due to other factors occur rarely. Clusters are found with equal frequencies in the superior and inferior fields in normal eyes, but with a greater frequency in the superior field in glaucoma eyes. The use of clusters in quantification is both sensitive and specific. Using results from this large sample and looking at other visual field properties, it is possible to devise weighted probability indices to score visual fields.

Adult↗
PubMed1986

Cortical mechanisms for local and global analysis of visual space in the cat.

The effects of lesions in the striate or extra-striate visual cortex of cats were evaluated using visual discrimination problems which required either local or global pattern processing. The results indicate that damage to areas 17 and 18 preferentially impairs local processes, while in addition they suggest that damage to the extra-striate cortex preferentially affects global processing. These findings may be related to the observations that cats with large lesions in the extra-striate cortex demonstrate deficits in form perception without reductions in visual acuity and those with lesions in areas 17-18 show elevations of acuity thresholds while maintaining excellent pattern and form vision.

Animals↗
PubMed1990

Jordan Left-Right Reversal Test: an analysis of visual reversals in children and significance for reading problems.

The Jordan Left-Right Reversal Test (JLRRT) was first published in 1974 (1) as a convenient measure of symbol reversals in children. A current revision of the test, based on 3,000 children, showed error scores to be inversely related to age and sex. Learning disabled children and a group of below average readers made significantly more errors, indicating that visual reversals are dysfunctional for reading skills.

Attention↗