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PubMed1989

[Recent concepts on amelogenesis: towards a molecular understanding of the pathology of human enamel].

Recent studies concerning amelogenesis demonstrate the key role of ameloblasts in the elaboration of mature enamel; this highly differentiated epithelial cell elaborates a specific extra-cellular proteic matrix, secondarily mineralized and participating in the elaboration of mature enamel. While the matrix of immature enamel is essentially made of two main classes of proteins--amelogenins and enamelins--specific proteins are found in mature enamel, the tuft proteins as well as enamelin-type proteins. In light of recent results concerning enamel proteins, we will review the different pathological processes of human enamel. In fact, the clinical observation of various forms of imperfect amelogenesis enables to recognize several aetiological mechanisms. This could either be a pathological process of genetic nature originating in the ameloblast--imperfect, mendelian-type amelogenesis--or secondary abnormalities of the calcification process, without anomalies of the genes responsible for the protein framework, which could be called post-ameloblastic pathological process.

Ameloblasts↗
PubMed1978

Enamel defects.

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Amelogenesis Imperfecta↗
PubMed1977

[Arrest of dental development in the osteopetrotic rat and the healing effect of normal bone marrow].

The development of the osteopetrotic "op" rat's mandible was examined from birth to 4 months of age. Before birth the growth of incisors is disturbed and after birth the molar growth stops. Bone resorption is severely reduced and enamel formation ceases soon on the inferior aspect of the incisor, due to degeneration of ameloblasts and lack of vascularisation. A single injection or normal bone marrow cured the disorder at the long bone level within 2-3 months and had a beneficial effect in re-establishing the growth of dental tissue, yet without leading to tooth eruption.

Amelogenesis Imperfecta↗