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PubMed1991

Evaluation of changing patterns in children poisonings and prevention.

Poisoning prevention strategies have to be modified according to the risk variations with age and time. Epidemiologic surveillance usefulness was confirmed by studying the 0-15 y-old children in the Trieste area from 1976-1987. Significant differences were observed in children under 5 due to an increase in caustic substance and home detergents poisoning and a decrease in analgesic-antipyretics ingestion. This was probably due to the introduction by law in our country of child-resistant containers and to a better awareness by parents. At 10 y-of-age and older, alcohol is the cause of most intoxications and more recently benzodiazepine poisonings have significantly increased. At this age poisoning results from deliberate ingestion in most cases; therefore education should be the main preventive strategy.

Adolescent↗
PubMed1991

Non-steroidal anti-inflammatory drugs in domestic animals: I. Their classification, mechanism of action and pharmacological effects.

A large number of non-steroidal anti-inflammatory drugs, of different chemical groups are available for veterinary use. These drugs act mainly by inhibiting the formation of endoperoxides (prostaglandins and thromboxanes) through the inhibition of cyclo-oxygenase in the eicosanoid pathway. A wide range of pharmacological effects, including analgesic, antipyretic and anti-inflammatory effects occur as a result of this inhibition. The classification, mechanism of action and pharmacological effects of these drugs are reviewed.

Animal Diseases↗
PubMed1990

Patients, doctors and their drugs. A study at four levels of health care in an area of Sri Lanka.

Few drug utilization studies have been conducted in Sri Lanka and they were register based. We wished to combine records with interviews to study drug use before hospital admission and drug prescribing in wards among 850 randomly chosen inpatients. Four institutions representing different levels of health care were studied. At the end of the study, all 25 practitioners involved were interviewed about how they perceived their prescribing practices. During the 48 h before admission drugs were used by 84% of the patients, of whom 73% took Western and 29% Ayurvedic drugs: combinations were common. The drugs most commonly named were aspirin and paracetamol. The medical records were an unreliable source of information in this respect. Infectious and parasitic disorders, together with respiratory diseases, constituted 40% of the diagnoses. The total number of prescriptions was 3,226. The number of drugs prescribed per patient varied between the institutions, the two extremes being the University (2.7) and the peripheral unit (5.1). Analgesics--antipyretics was the most commonly prescribed class at all institutions, 45.7% and 86%, respectively, of the patients being exposed to these drugs at the two institutions. The prescribing of antibiotics (53%) and antihistamines (65%) was considerably more common in the peripheral unit. The most commonly prescribed single drug products were paracetamol (31.3%), aspirin (20.9%), diazepam (21.8%), chloroquine (14.5%), ampicillin and multivitamins (both 12.6%). Most practitioners indicated deliberate use of active drugs as placebos, one drug chosen being vitamin. They were aware of the need for drug information from sources other than the industry.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1990

[The epidemiological aspect of chronic kidney lesions of drug origin].

In order to establish the prevalence of the intake of the most widely used nephrotropic drugs (non-steroidal anti-inflammatory agents and analgesic-antipyretic drugs), the authors have carried out epidemiological studies among the urban population. 5996 persons living in Riga were examined according to the designed by the authors 4-staged system using computer at the final stage. All the examined underwent analysis of the morning portion of urine. The drugs indicated were discovered to be taken for a long time in 14% of cases (in 15.4 among women and in 11.8% among men). The use of the drugs was motivated by degenerative dystrophic alterations in the bones and joints (56.27%), complicated virus infections (9.68%), headache (2.99%), and by combination of the three enumerated causes (30.34%). In 0.72% of cases, the causes of drug intake could not be established. Depending on the presence of a concrete urinary symptom, a high relative and a high absolute risk of the development of chronic tubulointerstitial renal lesions provoked by drugs have been defined in cases of the prolonged use of the drugs under study.

Age Factors↗
PubMed1990

[Anti-inflammatory drugs in ORL].

The idea of anti-inflammatory therapy in medicine arose in the 1950's with the development of corticosteroids. Prior to this time the treatment of phlogistic pathologies was aimed at achieving analgesic, antipyretic and diaphoretic effects. Cortisone and its derivatives have spurred the setting up of a series of pharmacological tests to study their anti-inflammatory activity and to verify their clinical efficacy in rheumatology. The side effects of corticosteroids have promoted research into non steroid anti-inflammatory drugs (NADs). A new pharmacological class has been created which includes substances-some previously known and some newly synthesized-which can also be used in disease other than rheumatic pathologies. In the E.N.T. field, both cortisone (and its derivatives) and NADs have been applied in many different types of inflammatory pathologies: infective and non infective, acute, subacute, recurrent, chronic and chronic with exacerbations. Modern antiphlogistic therapy avails itself of other therapeutic means of defense as well; means such as proteolytic and secretolytic enzymes, antiedematous substances and the old sulphuric crenotherapy whose action mechanism can, today, be newly interpreted and reassessed in light of modern pharmacological knowledge.

Adrenal Cortex Hormones↗
PubMed1990

[Pharmacological and clinical profile of tiaprofenic acid].

Tiaprofenic acid is a new generation anti-inflammatory drug synthesized to be a valid alternative to both cortisone preparations and other NSADs since it is less toxic yet equally effective. Its anti-inflammatory, analgesic, antipyretic activity is due to a particular interference mechanism active in the early phases of the inflammatory process (PG synthesis inhibition, stabilization of lysosomal membranes). Thanks to its good trophism toward tissues in the otolaryngological area and its tolerability this drug would appear particularly suited for the treatment of inflammatory E.N.T. pathologies.

Animals↗
PubMed1990

Drug use in a trauma intensive-care unit.

Medication prescribing patterns and costs of specific drug therapies in a trauma intensive-care unit (TICU) were studied. Demographic data and total drug use (scheduled, p.r.n., and single-dose medications) were recorded for all patients admitted to a TICU whose length of stay exceeded 24 hours. Scheduled and p.r.n. medications were categorized into major drug classes for purposes of analysis. Cost estimates were calculated for all scheduled medications. Correlations were made between demographic variables, injury severity indices, drug use, and length of stay by using simple linear regression. A one-way ANOVA was used to compare drug use between the trauma types. For the 278 patients who met the inclusion criteria, the mean +/- S.D. number of drugs prescribed was 9.1 +/- 6.5. Scheduled medications accounted for 58% of total drug use. Mean +/- S.D. duration of scheduled drug therapy was 5.0 +/- 4.8 days. Age (by decade), injury severity score, trauma score, and length of stay correlated with total and scheduled drug use per patient. Drug use (total, scheduled, and p.r.n.) did not differ significantly by trauma type. Antimicrobial therapy, stress ulcer prophylaxis, and bronchodilator therapy accounted for more than 66% of all scheduled drugs used; total cost estimates for these three drug categories exceeded $47,000 over the six-month study period. Analgesics, antipyretics, sedatives, and muscle relaxants constituted nearly 75% of all p.r.n. drug orders. Drug use in the TICU was extensive. The drug categories identified in this study may be useful in future cost containment efforts and initiation of drug use evaluations.

Adolescent↗
PubMedDate not supplied

[Drugs and health. 2. Study on the presence, use, storage and disposal of drugs in a sample of families in Adria (Rovigo) Local Health Unit 31, Venetian region].

As part of a health education scheme for the schools on "Drugs and Health", a questionnaire was distributed to a number of pupils in order to ascertain the domestic presence, use, conservation, and disposal of drugs. The questionnaire proved a very effective system for the extension of the educational project to the families of the pupils, but the information thus gathered was only of limited value. On the average, in the family 12.8 different type of drugs were present, mainly ethical drugs (76.6%). Most drugs were Articulars, Analgesics-antipyretics and Bronchopulmonary drugs. Only 30.2% of the drugs kept at home were currently used. Self-treatment (14.9%) and self-prescription (8.1%) were noted, as well as improper use of the drugs (5.9%). No answer to the questionnaire mentioned the presence of expired drugs: probably they were disposed of during the survey at home. Although these facts showed the positive effects of the educational project, nonetheless it was not possible to establish the real number of drugs kept at home. The way the answers to the questionnaire were biased and the fact that it was meant to be part of the project, have reduced the objectivity of the information thus obtained, underlining, however, its educational value.

Adult↗
PubMedDate not supplied

[Mucosynechial conjunctivitis and bilateral corneal ulcers in Lyell's syndrome].

The patient, aged 44, presented fever and chills with altered general condition and received an analgesic-antipyretic treatment with salicylic acid and pyrazolon derivatives. A bullous eruption that followed was labelled incipient Lyell syndrome. Both cornea presented ulcers with a tendency to perforation and mucosynechial conjunctivitis. Pathogenic Staphylococcus albus was isolated from the conjunctival secretion. The ocular phenomena improved under mydriatic treatment and trophic medication. Lyell's syndrome is the result of a severe medicamentous toxemia. Stress is laid on the role of Staphylococcus aureus, phage type 71, in the process of epidermal necrosis with detachment of the epithelium and ulceration of the mucosa.

Adult↗
PubMed1989

Placental transfer of paracetamol.

Paracetamol (1 g orally) was given to each of 10 healthy pregnant women undergoing normal vaginal delivery at the onset of second stage of labour. Following delivery, there was no significant difference in the serum concentration of paracetamol in the mother and the foetus (p less than 0.1), the mean value being 5.925 +/- 2.15 mg/ml and 7.875 +/- 2.22 mg/ml respectively. Paracetamol may be recommended as a safe analgesic-antipyretic during pregnancy and labour.

Acetaminophen↗
PubMed1989

[The relief of postspinal headache using the Whitacre cannula. A clinical study].

In a prospective study spinal anesthesia was performed in 500 patients (338 male and 162 female patients between 16 and 91 years of age: mean 46 years), with a total number of 603 spinal anesthetics. In all cases a 22G Whitacre needle was used. All patients were mobilized from the day of the operation onward and visited 4 days later by the interviewer and asked about any symptoms, especially headache. Mild postspinal headache occurred in 11 cases (1.8% of total), all in patients younger than 50 years of age and more in women. There were 6 patients among the 11 who did not need specific therapy their headache; for the others antipyretic analgesics, adequate hydration and/or bedrest were satisfactory. The study shows that the incidence of postspinal headache was significantly reduced by the use of Whitacre's pencil-point needle in comparison with findings reported in the literature.

Adolescent↗
PubMed1978

Aspirin and gastrointestinal bleeding.

There is no other over-the-counter (OTC) drug having the widespread use of aspirin. Evoking the well-established analgesic, antipyretic, and anti-inflammatory activities with an amazingly low degree of toxicity, its use has increased in this country to the astounding figure of more than 20 tons daily. The observation that comparatively small daily doses of aspirin may serve as a means of preventing certain types of cardiovascular disasters may lead to even more widespread use of the drug. The most frequent untoward side effect of aspirin is gastric discomfort with or without microbleeding. The amount of bleeding is usually quite small but owing to the long interest of the author in buffered aspirin, it is prudent to determine whether or not this action of aspirin is serious.

Aspirin↗
PubMed1987

Carcinogenicity of bucetin in (C57BL/6 X C3H)F1 mice.

The carcinogenicity of bucetin [(3-hydroxy-p-butyrophenetidide) CAS: 1083-57-4], an antipyretic analgesic drug, was examined in 300 (C57BL/6 X C3H)F1 mice. Groups of 50 mice of each sex were treated with 1.5 or 0.75% bucetin in their basal diet for 76 weeks and then fed a basal diet for 8 weeks. Control groups were given a basal diet for 84 weeks. In 10 of 46 (22%) male mice given the high dose of bucetin and in 6 of 45 (13%) given the low dose, renal cell tumors were induced. Dysplastic lesions of the proximal tubules were frequently seen in the males given bucetin in a dose-related fashion. Neither tumorous nor preneoplastic lesions developed in the kidneys of bucetin-treated female mice and control animals. Papilloma of the urinary bladder in 1 male mouse and papillary or nodular hyperplasia in 9 mice of both sexes were observed in groups given the high dose of bucetin.

Aminophenols↗
PubMed1986

Research on heterocyclic compounds. XIX--2-Methylimidazo[1,2-a]pyridine-3-acetic acids.

A group of methyl substituted imidazo[1,2-a]pyridine-3-acetic acids was synthesized by reaction of some methyl derivatives of 2-aminopyridine with ethyl 3-bromolevulinate and subsequent hydrolysis. These new acidic compounds were tested for their antiinflammatory, analgesic, antipyretic and ulcerogenic activities in order to compare the results with those previously obtained with similar compounds.

Animals↗
PubMed1987

Research on heterocyclic compounds. XXII. Imidazo[1,2-a]pyrimidines.

We have taken into consideration a group of 21 imidazo [1,2-a]pyrimidine derivatives, some of which were already known, whereas the others were synthesized and characterized by us to complete the series. Antiinflammatory, analgesic, antipyretic and ulcerogenic activities of such compounds were evaluated in comparison with indomethacin, in order to get useful information about structure-activity relationships.

Animals↗
PubMed1986

Diphenpyramide: a review of its pharmacology and anti-inflammatory effects.

Diphenpyramide is a non-steroidal anti-inflammatory compound which has no free ionizable or particularly reactive groups, in contrast to conventional non-steroidal anti-inflammatory agents. In animal tests, diphenpyramide showed anti-inflammatory action as powerful as that of indomethacin or phenylbutazone, with major peripheral analgesic, antipyretic and uricosuric properties. The therapeutic index was more favourable than that of the reference compounds. Diphenpyramide inhibits the synthesis of inflammatory prostaglandins and antagonizes the mediators of inflammation, but does not affect platelet aggregation or blood clotting. The major biotransformation products are biphenylacetate (BPA), which is pharmacologically active, p-hydroxy-biphenylacetate (p-HBPA) and alpha-aminopyridine (AP). The first is metabolized to p-HBPA which is excreted in the urine. The serum levels of the parent drug and BPA do not result in particularly elevated peaks. Elimination occurs mostly through the faeces. The anti-inflammatory action of diphenpyramide has been extensively proven in clinical trials in which patients with various inflammatory conditions, mainly of a musculoskeletal nature, were treated. The overall therapeutic efficacy was over 80% with a high proportion in osteoarthritis. In double-blind studies, the efficacy of diphenpyramide was significantly better than that of acetylsalicylic acid or indomethacin in osteoarthritis, and comparable with that of naproxen. The preferred dose of diphenpyramide in adults was 1000 mg/day in 2 divided doses for a period of about 30 days. The effective and safe dose in children was 13 to 33 mg/day. Side-effects were seldom reported (2.5%), were mild and transient and mainly of a gastro-intestinal nature. Specific tests on possible drug influence on the gastric mucosa showed diphenpyramide to be 'gastrosafe' both on short-term, high-dose as well as on long-term standard treatments. Biopsy and endoscopy of the mucosa failed to indicate any impairment; occult blood in stools could not be detected. Diphenpyramide seems, therefore, to be an anti-inflammatory drug that combines efficacy and tolerance in the treatment of a wide variety of inflammatory musculoskeletal disorders of primary of secondary nature, as well as the associated pain. Clinical observations also suggest that diphenpyramide could safely be administered to susceptible patients, such as children and infants or elderly, in need of effective anti-inflammatory treatment.

Absorption↗
PubMed1986

Efficacy of flunixin meglumine for the treatment of endotoxin-induced bovine mastitis.

The clinical effect of flunixin meglumine administration was determined in cows with acute mastitis induced by intramammary administration of endotoxin. In 12 lactating cows, 10 micrograms of Escherichia coli 026:B6 endotoxin were administered via a teat cannula into the teat cistern of single randomly selected rear quarters. Cows were challenge exposed as pairs. One cow in each pair was administered parenteral flunixin meglumine (6 cows) and 1 cow per pair was administered saline solution (6 cows). Multiple doses (7) of 1.1 mg of flunixin meglumine/kg of body weight or saline solution were administered at 8-hour intervals beginning 2 hours after endotoxin. Cow and quarter clinical signs as well as milk somatic cell concentrations, bovine serum albumin, electrical conductivity, and milk production were determined before and for 14 days after endotoxin inoculation. Intramammary endotoxin produced signs characteristic of acute coliform mastitis. Quarter and systemic abnormalities occurred and milk production was reduced by approximately 50% at 12 hours after endotoxin. Flunixin meglumine therapy significantly (P less than or equal to 0.05) reduced rectal temperatures and quarter signs of inflammation and improved clinically graded depression when compared with these signs in saline solution-treated controls. Milk production and laboratory indicators of inflammation in milk were not significantly (P greater than 0.05) different for flunixin meglumine vs saline solution controls. The clinical response observed was consistent with the antipyretic, analgesic, and anti-inflammatory properties of flunixin meglumine.

Animals↗