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[Tardive dystonia].

Two patients with tardive dystonia are presented. Tardive dystonia is a late-onset side effect of dopamine antagonist, which occurs in approximately 2% of the patients in the course of treatment with neuroleptic medication. The dystonia usually starts by affecting the musculature of face and (or) neck and is often progressive to a segmental localization. Of differential diagnostic importance are: conversion disorder, acute dystonia, Wilson's disease, idiopathic dystonia and dystonia triggered by other agents. Treatment starts with reevaluation of the need for ongoing neuroleptic treatment. Investigation of the pharmacotherapy of the dystonia concerns mostly treatment with dopamine depletors or with high doses of anticholinergic agents. Improvement of 50% of the patients is reported, although total recovery is rare. Many other substances and also some physical methods (ECT and surgery) have been used with varying results.

Adult↗

PSYCHOLOGICAL FACTORS IN 155 PATIENTS WITH FUNCTIONAL UTERINE BLEEDING.

One hundred and fifty-five women with functional uterine bleeding were studied to evaluate the importance of concomitant psychological disorders. Psychological illnesses were diagnosed in 128 patients (82.6%), most of which arose from problems directly related to sexual or reproductive functions. The remaining 27 patients (17.4%) were different in that they were psychologically stable and all but two were at puberty or approaching the menopause.Histological studies of endometrial samples from 135 of these patients indicated little evidence of abnormal sex hormone activity; 77 (57%) showed normal secretory phase endometrium and 32 (23.7%), proliferative phase endometrium. The remaining 26 (19.2%) showed evidence of some endocrine dysfunction, 15 such specimens being obtained from psychologically stable patients.It is probable that psychological disturbances are the principal cause of functional uterine bleeding during the prime reproductive years. The psychological component of the illness is the most important and determines the ultimate prognosis.

Adolescent↗

WITCHCRAFT TODAY.

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Adolescent↗

Psychogenic dystonia.

Psychogenic dystonia has been a controversial diagnosis over the past century. While this entity does exist, it makes up the minority of cases of dystonia seen at specialized centres. The diagnosis of psychogenic dystonia must only be undertaken by a neurologist with considerable experience in the assessment and treatment of organic dystonia. Features in the history and physical examination will reveal both clinical inconsistencies and incongruities with organic dystonia that support a psychogenic cause for the patient's symptoms. Patients with psychogenic dystonia suffer from motor conversion disorder, and co-morbid depression, anxiety and disorders of personality are frequent. While there have been no neuroimaging studies to date in patients with psychogenic dystonia, imaging studies in patients with organic dystonia offer insights on how one might assess this problem using functional neuroimaging. Neurophysiologic studies in patients with organic forms of dystonia may also be employed to further distinguish psychogenic from organic dystonia when doubt exists. The prognosis of psychogenic dystonia is disappointing, with the majority of patients suffering significant long-term disability. Recommendations are given regarding disclosure of the diagnosis of psychogenic dystonia to the patient as well as appropriate treatment.

Dystonia↗

[Refractory partial epilepsy: what are the neuropediatrician's criteria for drug resistance?].

Despite the emergence of new antiepileptic drugs, 10 to 20% of children with epilepsy, half of whom have localization-related epilepsy, remain refractory to drug treatment. Careful syndromic identification is essential before retaining the diagnosis of intractable childhood epilepsy in order to optimize treatment and avoid iatrogenic worsening. The use of appropriate associations of new antiepileptic drugs should lead to better control in some situations, but further studies are still necessary. A significant number of children with medically intractable localization-related epilepsy may benefit from surgical treatment. Because of the cognitive consequences of epilepsy in children, the question of the appropriate time for surgery is still debated; the current trend is for early surgery in children. For many authors, intractability can be assessed after 18 months of evolution, and retained when seizures persist at a frequency of one or more a month despite more than two correctly administered antiepileptic drugs. In case of epileptogenic encephalopathy, time to surgery may be shorter. Early predictive criteria of intractability have been identified by several cohort studies and include the presence of frequent seizures at disease onset, status epilepticus, with the prevalence of certain etiologies such as encephalitis or neuronal migration disorders. Conversely, some children may develop late intractability after an early benign course; the identification or early predictive criteria is still unclear in this situation.

Adolescent↗

Electrodermal biofeedback in treating psychogenic nonepileptic seizures.

Psychogenic nonepileptic seizures are operationally defined as episodes of altered movement very like epileptic seizures, but associated with psychological problems and not with ictal discharges. Children with psychogenic nonepileptic seizure (PNS) could be categorized either under somatoform in the ICD-10 or conversion disorders in DMS-IV. The history, psychometric evaluation and therapeutic approach concerning nonepileptic psychogenic seizures in a 13-year-old girl are presented and discussed. The novelty of the treatment is the electrodermal (EDR) biofeedback procedure combined with cognitive-behavioral therapy. We infered that biofeedback for PNE in pediatric patients is highly cost-effective, discriminative for the actual level of stress and gives good therapeutic results through enhancing self awareness and relaxation, when used in combination with standard psychometric and psychotherapeutic methods. The stabilization of the hypersensitivity, lower neurotic tendencies and emotional maturation were obtained after 10 sessions of EDR biofeedback, each with the duration of 45 minutes/day. Mean value of EDR before treatment was 4919 (+/- 145.5) and the last value obtained with training showed a mean value of 5400.8 (+/- 147.9) microOmega. The following controls showed no more attacks, stabilization of the neurotic tendencies, progression of the maturational process and good academic results.

Adolescent↗