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503 records · Page 28Linked to original sources
PubMed2004

Factors inducing in-stent restenosis: an in-vitro model.

In-stent restenosis is caused by the proliferation of the smooth muscle cells (SMCs) following a host response towards the implanted device. However, the precise biochemical and cellular mechanisms are still not completely understood. In this paper, the behaviour of SMCs has been investigated by an in vitro model where the cells were stimulated by platelet derived growth factor (PDGF) on tissue-like substrates as well as on biomaterials such as stainless steel (St) and diamond-like carbon (DLC)-coated St. The results demonstrated that SMCs have a completely different adhesion mode on St and become particularly prone to proliferation and pro-inflammatory cytokine secretion under PDGF stimulus. This would suggest that restenosis may caused by the accidental contact of the SMC with the St substrate under an inflammatory insult.

Carbon↗
PubMed2005

Videodermatoscopy: a useful tool for diagnosing cutaneous dystrophic calcifications.

A suspected diagnosis of cutaneous calcification is based on the presence of slightly elevated or ulcerated firm, white papules and plaques; these lesions often extrude white, chalky material. In clinical practice, however, a biopsy is required to confirm clinical suspicions. We attempted to demonstrate cutaneous calcinosis in vivo by using Raman spectroscopy, a nondestructive analytical method based on the analysis of light scattered from the investigated material. We used digital videodermatoscopy to improve the detection of cutaneous calcifications in vivo in two patients with CREST syndrome. A characteristic flower-like arrangement was observed at x-50 magnification. We believe this pattern may be highly indicative of cutaneous dystrophic calcinosis.

Adult↗
PubMed2005

[State of the art in melanoma diagnosis].

The incidence of melanoma has been rising over the ten last years and is increasing faster than for other cancers. According to informations of the national cancer registry, there are approximately 1500 new cases of melanoma per year in Switzerland. The incidence for melanoma is 7.5 new cases per 100000 inhabitants per year for Europe, 17.9 for Switzerland and 24.7 in the Canton of Geneva. Often the diagnosis is made in advanced stages which is the reason why melanoma is responsible for more than 90% of all skin cancer related deaths. In this context screening and early diagnosis are particularly important. In this article we are going to review the different established techniques for non invasive melanoma diagnosis as well as some very promising approaches which are still at an experimental stage.

Dermoscopy↗
PubMed2005

Subtelomeric chromosomal rearrangements detected in patients with idiopathic mental retardation and dysmorphic features.

Subtelomeric chromosomal rearrangements detected in patients with idiopathic mental retardation and dysmorphic features: Cryptic aberrations involving the subtelomeric regions of chromosomes are thought to be responsible for idiopathic mental retardation (MR) and multiple congenital anomalies, although the exact incidence of these aberrations is still unclear. With the advent of chromosome-specific telomeric Fluorescence In Situ Hybridization (FISH) probes, it is now possible to identify submicroscopic rearrangements of distal ends of the chromosomes that can not be detected by conventional cytogenetic methods. In this study, cryptic subtelomeric chromosomal aberrations were detected in two of ten patients with idiopathic MR and dysmorphic features by using FISH probes of subtelomeric regions of all chromosome arms. A cryptic unbalanced de novo translocation was detected between the subtelomeric regions of the chromosome 10p and 18p in a patient with severe mental retardation, sensorineuronal deafness and several dysmorphic features. In the other patient, with mild mental retardation and dysmorphic features, a de novo subtelomeric deletion of chromosome 2q was found. In conclusion, in both familial and sporadic cases with idiopathic MR and dysmorphic features, the detection of chromosomal aberrations including subtelomeric rearrangements is of great importance in offering genetic counseling and prenatal diagnosis.

Abnormalities, Multiple↗
PubMed2005

Managing skin cancer--23 golden rules.

From their collective experience in Australia and the USA, dermasurgeons Anthony Dixon and Scott Hall have compiled a list of "golden rules" for general practitioners to help reduce errors and problems with skin cancer management. It is anticipated that these tips will provide a brief yet informative reference when faced with skin cancer management concerns in general practice.

Bandages↗
PubMed2005

[Guideline 'Melanoma' (3rd revision)].

The guidelines 'Melanoma' (3rd revision) are evidence-based in nature. A number of outcomes are summarised in this article. Dermatoscopy deserves a standard role in the clinical diagnosis of pigmented skin abnormalities. Pathological findings from a diagnostic excision should be recorded meticulously to include anatomical localisation, type of intervention used, excision margin, diagnosis, Breslow thickness, and the completeness of the removal. The sentinel node procedure should be reserved for patients who want to be as informed as possible about their prognosis. The procedure is not considered a part of standard diagnosis. Sentinel node assessment should include stains for specific markers and should be conducted in multiple sections. The following margins of non-affected skin are recommended for therapeutic re-excision of melanoma: in situ melanoma, 0.5 cm; Breslow thickness < or = 2 mm, 1 cm; Breslow thickness > 2 mm, 2 cm. Pathological assessment of a re-excised specimen depends on the completeness of the first excision. Systematic adjuvant treatment of patients with melanoma is not recommended outside the context of a clinical study. Patients with metastatic melanoma are preferably treated within a clinical study. Outside of a clinical study, these patients should be treated with dacarbazine. There is no evidence to suggest that survival is improved by frequent follow-up. However, follow-up can be a useful way to meet the information needs of patients and care requirements for physicians.

Dermatology↗
PubMed1996

[Malignant melanoma in dermatoscopical picture].

Dermatological investigation offers a more precise clinical diagnosis of malignant melanoma in 20-30% of cases. It gives a correct visualization of melanocytic structures up to dermatoepidermal junction in ten fold magnification. A less distinct picture can be obtained from medium corial structures. Lentigo maligna melanoma and superficially spreading melanoma can be well distinguished from other pigmented lesions. Dermatoscopy offers an inspirative view between a clinical and microscopical picture plane.

Dermoscopy↗
PubMedDate not supplied

Dermatoscopy of "dysplastic nevi": a beacon in diagnostic darkness.

The sequential progression model for melanocytic tumours from common nevus to malignant melanoma was proposed by Clark almost 30 years ago. The "dysplastic nevus" has frequently been considered a logical offspring of this concept and as a direct precursor of melanoma, analogous to the epithelial dysplasia-carcinoma sequence. Despite the use of modern molecular methods, there is no consensus as to if the dysplastic nevus represents a true precursor lesion of melanoma, a separate distinct type of nevus, or a diagnostic dilemma. Currently, the concept of melanocytic dysplasia remains subject to confusing definitions at all levels of the diagnostic process, i.e. clinical appearance, dermatohistopathology, and molecular biology. In this review, we collect evidence that nevi fulfilling Clark and Elder's classic histological criteria mostly represent "endpoints" of nevocytic evolution, whereas a minority of "dysplastic nevi" represent true melanoma precursors. The unsolved dilemma is that neither clinical, histopathological nor molecular criteria exist to make a distinction between dysplastic nevi and early melanomas. Our analysis of the current knowledge on dysplastic nevi shows that dermatoscopy remains the only quantifiable, easily applicable and reproducible diagnostic tool to approach the problem. Due to a "quantum leap" in optical resolution, objective scores can be established, e.g. the total dermatoscopy score (TDS) according to the ABCD rule, and documentation of changes over time are possible by digital image storage devices. Although dermatoscopy does not solve the dilemma of discriminating early, basically feature-less melanomas from dysplastic nevi, and it does not prove that dysplastic nevus is a distinct entity, it helps make melanocytic tumours with unclear malignant potential a manageable disease.

Dermatology↗
PubMedDate not supplied

Skin capacitance imaging, a new technique for investigating the skin surface.

Thanks to the recently introduced silicone image sensor technology, skin capacitance imaging has now been made possible. The dedicated device is called SkinChip. This method is easy to handle and provides information about the skin microrelief, the level of stratum corneum hydration and the sweat gland activity. The apparatus sees and measures these parameters with a 50 microm resolution. A series of conditions have been explored using skin capacitance imaging. This review summarizes relevant findings about regional variability on the body, changes occurring with ageing, effects of a hydrating formulation, reactivity kinetics of corneocytes to surfactants, acne and skin pores characteristics, as well as hyperkeratotic dermatoses and tumours.

Dermatology↗