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Pseudoneglect and reversed pseudoneglect among left-handers and right-handers.

Two experiments were carried out to examine specific hand contribution to pseudoneglect and reversed pseudoneglect phenomena in dextrals and sinistrals when bisection tasks were conducted exclusively in the midline spatial condition. Both dextrals and sinistrals showed the same overall pattern deviation: in the tactile scanning task, both right and left hands deviated to the left of the midpoint and in the kinesthetic scanning tasks, the right hand deviated to the left and the left hand to the right of the midpoint. However, when these deviations were tested against zero (i.e. the objective midpoint) clear differences appeared related to hand, task and handedness. These results were discussed with respect to "enhancement theory".

Adult↗

Parkinson's disease: reorganization of the reach to grasp movement in response to perturbation of the distal motor patterning.

This study assessed the kinematic changes to the reach to grasp movement in response to a perturbation of object size in 15 Parkinson's disease (PD) and 15 control subjects. For non-perturbed trials subjects reached 35 cm to grasp and lift either an illuminated small (0.7 cm) or large (8 cm) diameter cylinder. For perturbed trials (20%), illumination shifted unexpectedly from the small to the large or from the large to the small cylinder at the onset of the reach. For Condition One trials subjects were given no instructions as to which grasp to use. With perturbation, they thus naturally changed grasp from precision grip to whole hand prehension or vice versa. The results for the PD subjects indicated a slowness at the transition from one to another grasp. This contrasted to the smooth transitions when perturbation required only a change of grasp aperture (precision grip--Condition Two; whole hand prehension--Condition Three). PD subjects thus showed dysfunction in the suppression/activation of different grasp programs rather than deficits in the on-line modification of an operating program.

Aged↗

The efficacy of kinesthetic reading treatment for pure alexia.

This paper presents an effective treatment for pure alexia by a type of single-case design, which we termed a "material-control single-case design" [Sugishita et al., Neuropsychologia, Vol. 31, 559-569, 1993]. Two patients with pure alexia were treated using kinesthetic reading (reading by tracing or copying the outline of each letter with the patient's finger). The results clearly demonstrated that both patients significantly improved their reading and copying performances. Their recovery of reading performance arose from improvement in copying. The results of tachistoscopic reading tests suggested that the patient obtained the ability to read without kinesthetic movements.

Adult↗

Coordination of aimed movements in a case of unilateral cerebellar damage.

We have studied multi-joint arm movements in a patient with right cerebellar damage. Our patient's kinetic tremor was reduced in the absence of visual feedback, but increased when performing a concurrent cognitive task. We suggest that her kinetic tremor reflects use of a slow cortical feedback circuit for error-corrections during movement. Analysing the spatial relation between hand aperture and hand transport in prehensile movements, we found preserved strategic, trial-to-trial coordination, but impaired reactive, within-trial coordination. We conclude that the proprioceptive representations provided by the normal cerebellum play an important role in coordinating multi-joint movement.

Adult↗

Impairment of grasping movements following a bilateral posterior parietal lesion.

The observation of a patient (A.T.) with a bilateral posterior parietal lesion of vascular origin is reported. A.T. presented a bilateral (more marked on the right) deficit in grasping simple objects (neutral cylindrical dowels) without deficit in reaching toward the location of these objects. The major symptom was an exaggerated anticipatory opening of the fingers with poor correlation with object size, resulting in awkward grasps. It was present both when the hand was visible to the subject and when it was not. This deficit was much less marked if the neutral objects were replaced by usual objects of the same sizes. Finally, in tasks where she had to indicate with her fingers the size of visual objects presented as virtual images through a mirror, or the size of imagined usual objects, A.T. performed normally. These results are discussed within the framework of a dual representation of objects. Only the "pragmatic" representation for steering object-oriented actions would be impaired in this patient as a result of posterior parietal damage. By contrast the semantic representation for object identification would be intact.

Adult↗

Differences in the visual control of pantomimed and natural grasping movements.

In a series of experiments, we studied the differences between natural target-directed grasping movements and 'pantomimed' movements directed towards remembered objects. Although subjects continued to scale their hand opening for object size when pantomiming, grip formation and other kinematic variables differed significantly from those seen in normal target-directed actions. This was true whether the subjects had just seen the target object 2 sec before (Experiments 1 and 2) or whether the target object was still present and they were simply required to pantomime the grasping movement beside it (Experiment 3). We argued that these pantomimed reaches were being driven by stored perceptual information about the object, and were not utilizing the normal visuomotor control systems that direct actions in real time. This interpretation received strong support from observations of a patient with visual form agnosia who was also tested. In an earlier report, we had shown that this patient showed anticipatory scaling of her grasp despite her inability to discriminate between objects perceptually on the basis of size. The present study showed, however, that the requirement to remember an object even briefly, or to pantomime an action beside it, was enough to completely disrupt her visuomotor scaling (Experiments 2 and 3). That this reflected a failure of perception rather than imagery or understanding was supported by the fact that she could convincingly pantomime actions to imagined, familiar objects, the sizes of which were known to her (Experiment 4). All these results suggest that the mechanisms underlying the formation of perceptual representations of objects are quite independent of those mediating on-line visuomotor control.

Adult↗

Motor learning after recovery from hemiparesis.

Twenty patients who had almost completely recovered from hemiparesis following unilateral cerebrovascular accident and 16 control subjects had to perform motor learning tasks including a three-dimensional motor problem and two standard precision tests. The ability of hemiparetic patients to solve simple spatial-motor problems and to gain by training was preserved with limitations concerning high precision control. However, hemiparetic patients had a higher demand for time and corrections, as well as a reduced consistency of performance. Thus recovery from hemiparesis was accompanied by reduced skillfulness and automaticity of motor control.

Adult↗

Right-hippocampal contralateral-hand effect in the recall of spatial location in the tactual modality.

The recall of spatial location in the tactual modality was investigated in 53 patients with unilateral temporal lobectomy, one patient with bilateral hippocampal damage and 23 normal control subjects. Using only active touch, blindfolded subjects had to locate the position of a map pin within a circular space and then recall its position after a 12- or 24-sec delay. Left temporal-lobe patients (N = 23) were found to perform normally as were right temporal-lobe patients with removals that did not exceed the pes of the hippocampus (N = 22). In contrast, right temporal-lobe patients with large hippocampal excision (N = 8) were impaired on the 24-sec (but not at the 12-sec) delay condition. When performance of the two hands was compared, no difference was found for the left-temporal, right-temporal-small-hippocampal-removal and normal control groups. In contrast, for the right temporal-large-hippocampal-removal group performance on the hand contralateral to the side of temporal lobectomy (left hand) was impaired, whereas right-hand performance in this group was normal. The patient with bilateral hippocampal damage was inferior to the most impaired patient with unilateral temporal lobectomy. These findings suggest that the right and left medial-temporal regions differ in their functional relationships to cerebral areas mediating tactual processing, intact right medial-temporal structures being involved in tactuo-spatial retention bimanually while left medial-temporal structures serve a more specific role confined to the contralateral (right) hand.

Adolescent↗

Formation and lateralization of internal representations underlying motor commands during precision grip.

The capability to store and retrieve weight-related information from a lift to scale the force output during a subsequent lift was examined in 10 healthy adults and 50 children (age 2-10 years), as well as a 22-year-old patient with corpus callosum agenesis. Subjects lifted a test object between the thumb and index finger while the isometric fingertip forces were measured. The results suggest that both healthy children and adults can transfer weight-related information between the right and left hand, although a lateralization was found. Also, the storage and retrieval of weight-related information appears to be a dynamic process dependent on both previous sensory information and knowledge of future movements. Late maturation of interhemispheric connections and asymmetric loss of some information during the transfer between hemispheres suggest a lateralization of the internal representation. The patient with a corpus callosum agenesis supported this hypothesis.

Adolescent↗

Impairments of movement execution in unilateral neglect: a kinematic analysis of directional bradykinesia.

A kinematic analysis was performed on goal-directed movements made by 14 patients with right hemisphere damage and left unilateral neglect (seven mild, seven severe), and 14 healthy controls. Leftward and rightward pen strokes of varying extents were made to targets of varying size on a centrally located digitising tablet. While mild unilateral neglect patients performed like controls, patients with severe unilateral neglect were slower to initiate leftward than rightward strokes and were slow and inefficient in movement execution. Leftward strokes made by severe unilateral neglect patients were characterised by prolonged movement time, lower peak velocity and departed from optimal bell-shaped velocity profiles. Their leftward strokes also showed prolonged accelerative phases, implying difficulties in force production, while the high proportion of their total movement time spent in decelerating with rightward strokes suggested an abnormal emphasis on terminal visual guidance. Leftward strokes made by these patients also contained more submovements than rightward strokes, suggesting poor force control. An impaired internal representation of the location of left-sided targets and desired movement trajectories in severe unilateral neglect causes breakdown in the temporal control of goal-directed movements.

Aged↗

A simple, computer-assisted system for measuring latencies of contact placing.

A system for measuring the latencies of two components of contact placing, limb withdrawal and landing, is described. Timing functions are performed by a microcomputer, which also records and displays the latencies, and summarizes the data. Procedures for testing contact placing are also described, and data collected from morphine-treated, Long-Evans hooded rats are presented.

Animals↗

Bandage backfall: labyrinthine and non-labyrinthine components.

A cataleptic animal clings in a vertical position, unmoving, for abnormally long periods by supporting some of its weight on its hindlegs, grasping with the forepaws, flexing its forelimbs, and holding the head horizontal. When the head is snugly wrapped with a bandage, the head slowly falls backward, the neck hyperextends, the forelimbs extend and the grasp is released, resulting in the animal falling backward to the ground. It was earlier suggested that in cataleptic animals, the bandage inhibits vestibular and kinesthetic mechanisms of head support, yielding the backfall sequence [35]. However, preliminary experiments showed that labyrinthectomized rats made cataleptic by haloperidol fall backwards when placed in a vertical clinging position, even without a bandage, suggesting that in the rat the bandage-backfall reaction depends only on the vestibular system. In the present paper, this result is verified but, by additional experiments, the latter conclusion is shown to be incorrect. In labyrinthectomized rats made cataleptic by other means (lateral hypothalamic damage, or bulbocapnine), backfall from clinging did not occur unless a bandage was applied. Therefore, the bandage does indeed appear to inhibit the kinesthetic mechanisms that maintain head support in labyrinthectomized cataleptic rats. Haloperidol, particularly in high doses, greatly weakens postural support in labyrinthectomized rats (causing the animal to sag down and fall back when clinging), although the effect is not detectable in rats with labyrinths intact. However, labyrinthectomy reveals that the bandage can trigger an active dorsiflexion of the neck which in itself appears to inhibit clinging and righting. Bandage-induced dorsiflexion is present to a much lesser degree in intact animals, indicating that labyrinthine mechanisms inhibit the dorsiflexion reflex. Therefore, in the intact, cataleptic rat the bandage backfall reaction appears to be produced by the combined effects of a passive component (inhibition of kinesthetic support mechanisms), and an active component (elicitation of dorsiflexion of the neck).

Animals↗