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At least 505 records · Page 28Linked to original sources
PubMed1984

Splenic lymphosarcoma in a horse.

A 10-year-old Tennessee Walker gelding, with a history of progressive weight loss, intermittent colic and lethargy, had a slight fever, tachycardia, tachypnea, pallor, ascites and marked ventral edema. Blood analyses revealed anemia, leukocytosis, neutrophilia with a left shift, lymphopenia, monocytosis, hypoproteinemia and a slightly increased SDH level. Abdominocentesis produced red-orange fluid with many RBC and an increased fibrinogen content. Rectal palpation revealed a large mass in the left caudal abdominal quadrant. The animal died shortly after resection of the mass. The histopathologic diagnosis was lymphosarcoma, involving the spleen, liver and lung.

Animals↗
PubMed1984

The growth and dissemination of continuously irradiated LS/B1 lymphosarcoma cells.

Transplantable strain of murine lymphosarcoma growing as a free suspension in the peritoneal cavity of isologous hosts was continuously irradiated by 60Co unit at a low exposure rate of 1.2 Gy/day for 350 weeks. Long-term irradiation did not alter substantially the viability and invasiveness of tumor cells. In the host of irradiated cells the spleen mass was six times higher around the day 8. Histological sections of the spleen revealed areas of edema and hemorrhage and infiltration and proliferation of tumor cells mostly in subcapsular area. Most of the splenomegaly is considered to be due to hyperemia caused by mass of erythrocytes in dilated spleen sinuses. Continuous irradiation is supposed to lead to more pronounced sarcomatous character of LS/B1 tumor.

Animals↗
PubMed1984

[Regression of the Pliss lymphosarcoma in rats and biochemical indices in hypovitaminosis A].

It has been shown that in rats with alimentary hypovitaminosis A, with a sufficiently pronounced decrease in the content of free retinol in blood serum (below 140 ng/ml) and in the liver tissue (below 360 ng/g), there is a complete regression of Pliss's lymphosarcoma. Under the conditions indicated, retinoic acid, in contradistinction to retinol, does not promote the tumor growth. A relative and absolute reduction in blood plasma of the essential amino acids, arginine, methionine and lysine, might be one of the reasons for tumor regression under hypovitaminosis A.

Animals↗
PubMed1984

[N-acetyltransferase activity during growth of the transplantable Pliss lymphosarcoma and during pregnancy in rats].

Study of the distribution of female noninbred rats according to N-acetyltransferase activity has permitted the conclusion to be derived that the animals may have a "slow", "intermediate" and "fast" phenotype of acetylation. It was discovered that the rate of N-acetyltransferase activity increased 1.5-2-fold on days 12 and 15 after transplantation of Pliss's lymphosarcoma. The time course of changes in N-acetyltransferase activity was characterized by individual features. The pattern of changes in N-acetyltransferase activity in pregnancy was dependent on the initial acetylation phenotype: in animals with a "slow" and "intermediate" phenotype of acetylation, the activity ascended by the 21st day of pregnancy, whereas in animals with a "fast" phenotype of acetylation, it declined.

Acetyltransferases↗
PubMed1984

Cryotherapy of cutaneous lymphosarcoma in a German shepherd.

Multiple cutaneous lymphosarcoma lesions in a 10-year-old German Shepherd regressed and totally healed by 5 weeks after cryotherapy of the larger lesions. The dog remains clinically normal 1 year after surgery, without use of corticosteroids or chemotherapy.

Animals↗
PubMed1984

Response of lymphosarcoma LS/BL cells to continuous irradiation.

Mouse lymphosarcoma LS/BL cells growing as an ascites tumor in the peritoneal cavity of C57BL mice were continuously irradiated in vivo at a low exposure rate of 1.2 Gy per day (5 rad/hr). The growth of the ascites tumor evaluated by direct counting of the cells in the peritoneal cavity and their capacity to form colonies in livers declined with increasing time of continuous irradiation. The radiosensitivity and repair ability of LS/BL cells were studied by a serial dilution method using host survival time as the end point and by the liver colony assay. The radiosensitivity of continuously irradiated LS/BL-CI cells showed no remarkable change as measured by the Do values, but from the 150th week of irradiation the initial shoulder on the survival curves appeared and its width increased with time of exposure. The extrapolation number (n) increased from 1.0 to 8.4 after 350 weeks of irradiation. The reappearance of the initial shoulder was proved with the split-dose technique.

Animals↗
PubMed1984

[Growth activity and radiosensitivity of Pliss lymphosarcoma cells fractionated by sedimentation].

The sedimentation fractionation of ascitic form of Plyss lymphosarcoma was performed in the linear 1-3% sucrose gradient with 1 g. Fractions were different in cell sizes, protein content and also in intensity of the 3H-thymidine incorporation. Fractions which contained cells in the G1, G1 + S and S + G2 phases were transplanted in vivo in a solid form. Cells with the low sedimentation rate had the maximum growth capacity. The growth rate of G1 + S cells was similar to that of the initial tumour. Cells of high-rate sedimentation were characterized by the low growth activity. The values of D0 for these 3 fractions were 1.64, 2.05 and 2.11 Gy, and those of n 1.9, 2.9 and 1.6, respectively. These differences were not a result of selective injury of cells in fractions or their contamination by nontumour cells.

Animals↗
PubMed1984

[Lymphosarcoma of the large intestine].

The work is devoted to the clinical course, diagnosis and treatment of 25 patients with lymphosarcoma of the colon. Three forms of the disease (carcinoid, pseudoinflammatory and latent) were established according to clinical manifestations of the disease. The rational method of treatment is thought to be a timely radical operation in combination with the adjuvant chemo- and radiotherapy.

Adolescent↗
PubMed1984

Effect of vaccine prepared from Corynebacterium parvum on the growth of Gardner lymphosarcoma in C3H strain mice.

The present paper discusses the effect of a vaccine prepared with formol-killed Corynebacterium parvum (alias Propionibacterium acnes) on the growth of solid Gardner lymphosarcoma transplanted on C3H (H-2k) mice. The vaccine was injected at various time intervals prior to, simultaneously with, or following transplantation of the tumor to intact mice or mice immunized with 60Co-irradiated Gardner tumor cells. The effectivity was evaluated in terms of numbers of mice surviving without tumor 60-day observation period or prolongation of survival time. Reliable effectivity showed vaccine (0.8 mg dry weight of C.p.) in the mixture with tumor transplant or when introduced 6 days earlier into the site of tumor transplantation. The preventive action of the vaccine was more pronounced in the mice immunized with inactivated tumor. The vaccine applied to mice with a transplanted tumor was ineffective and failed to significantly prolong the survival time even in mice which had previously been immunized with an inactivated tumor.

Animals↗
PubMed1984

Treatment of C3H mice bearing solid Gardner lymphosarcoma with vaccine prepared from Corynebacterium parvum combined with methotrexate and Alexan.

C3H mice after transplantation of solid Gardner lymphosarcoma were injected with Methotrexate (MTX) or Alexan. The prolonged survival time of mice treated with antimetabolites was in some cases evidently reduced after an additional injection of Corynebacterium parvum (C.p.). This reduction did not depend on the sequence of corynebacterial vaccine or MTX injections. Significantly better effect of combined treatment with MTX injection and C.p. was found only once in mice preimmunized with the tumor irradiated from 60Co gamma source.

Animals↗
PubMed1983

Anterior uveitis as a first sign of primary orbital lymphosarcoma.

A 47-year-old woman had a painless anterior uveitis in her right eye. Later, it appeared to be secondary to a developing extraocular orbital tumor, which also caused marked proptosis. Histopathologic examination of the tumor revealed lymphocytic lymphosarcoma. The tumor regressed rapidly after irradiation and cytological treatment.

Anterior Chamber↗
PubMed1984

Changes in the repair ability of continuously irradiated lymphosarcoma LS/BL cells.

The radiosensitivity and repair ability of LS/BL lymphosarcoma cells were studied by means of a serial dilution method using host survival-time as the end point and by means of liver colony assay. The survival curves of LS/BL cells originally showed an exponential dose-response relationship without any shoulder. During the years of cultivation in vivo and progressive adaptation to ascites growth the survival curves of LS/BL cells became less steep and the D0 values increased from 1.0 to 1.5 Gy. The continuous irradiation in vivo of LS/BL cells at the exposure rate of 4.7 cGy h-1 did not lead to any remarkable change of the D0 values, but from the 150th week of irradiation the initial shoulder appeared on the survival curve and its width enlarged with the time of irradiation. The extrapolation number (n) equalled 1.0 at the onset of continuous irradiation and increased to 8.4 after 350 weeks of exposure. The results of experiments in which the split-dose technique was used proved the reappearance of the initial shoulder.

Animals↗
PubMedDate not supplied

[Changes in the chromosome map of mouse lymphosarcoma cells with prolonged irradiation].

In experiments on lymphosarcoma cells LS/BL, a study was made of changes in the chromosome pattern after long-term continuous irradiation at a low dose rate (35.8 X 10(-5) mC X kg-1 X s-1). To ensure reliable detection of changes in the chromosome length the method of automated computer analysis of the chromosome pattern with subsequent statistical evaluation was used. The radiation effect was manifested by a higher frequency of shape abnormalities in continuously exposed cells.

Animals↗
PubMed1983

Hormonal regulation of transcription of rDNA. Inhibition of transcription during glucocorticoid-mediated inhibition of proliferation of lymphosarcoma P1798 cells in culture.

A lymphosarcoma cell line designated P1798.S6M has been characterized with respect to glucocorticoid responsiveness in culture. Cells ceased to proliferate in the presence of 10(-7) M dexamethasone. Cell viability remained high and glucocorticoid-sensitive cells could be rescued from cultures treated with dexamethasone for 24 or 48 h. These data indicate that P1798.S6M undergoes reversible arrest in the presence of dexamethasone. The system was used to study the effects of mitotic arrest upon transcription of rDNA. Incorporation of [methyl-3H]methionine into rRNA was rapidly inhibited and pulse-chase experiments indicated that 28 S RNA was not synthesized after 24 h of exposure to dexamethasone. Hybridization studies indicated that the amount of pre-rRNA was reduced by 90 to 95% in cells treated for 24 h. Transcription studies were carried out in isolated nuclei. Twenty-four hours after addition of dexamethasone, template-bound RNA polymerase I activity decreased by 89 to 96%. Total RNA polymerase I activity did not decrease, whereas disengaged nuclear polymerase I activity increased dramatically. Filter hybridization studies indicated that labeling of nascent pre-rRNA chains in vitro was inhibited 93%. These data are interpreted as follows: Dexamethasone reversibly inhibits proliferation of P1798.S6M cells and transcription of rDNA. Total RNA polymerase I activity does not decrease, but the amount of template-bound enzyme is reduced with a concomitant increase in the amount of disengaged polymerase I. This indicates that initiation of transcription is inhibited in cells undergoing mitotic arrest in the presence of dexamethasone.

Animals↗
PubMed1983

Lymphosarcoma in a cat.

Feline leukaemia virus (FeLV) antigen was detected in a cat from Cape Town which was subjected to euthanasia after a long history of upper respiratory infection and progressive emaciation. Based on the necropsy findings and subsequent histopathological examinations, a diagnosis of lymphosarcoma was made. It is regarded as likely that this tumour was caused by infection with FeLV.

Animals↗
PubMed1983

[Primary lymphosarcoma of the prostate gland].

Two large tumor nodes of a total weight of about 100 g were removed from the prostate gland of a patient of 28 with the duration of the disease symptoms of approximately 3 1/2 months. Histological diagnosis of polymorphocellular sarcoma was made. On the 19th day postoperation the patient died with phlegmon of the small pelvis tissues in the presence of cachexia. The autopsy revealed a tumor of the prostate gland outgrowing into the soft tissues of the small pelvis without metastases. Histologically it was a diffuse prolymphocytic lymphosarcoma of the prostate gland with small-loop argirophilic reticulum. This neoplasia was combined with multiple glandular gastric polyps.

Adult↗