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At least 505 records · Page 28Linked to original sources
PubMed1986

[T mu and T gamma-lymphocyte counts and their ratio in patients with brucellosis].

The levels of circulating T mu- and T gamma-lymphocytes in brucellosis patients have been studied in relation to the clinical form of the disease, the severity of the process and the allergic transformation of the body. A decrease in the content of lymphocytes, affecting mainly T mu-cells and less commonly T gamma-cells, as well as a change in their ratio has been revealed. The level of this decrease depended on the clinical form of brucellosis, the severity of the course of acute and subacute brucellosis, the phase of chronic brucellosis and the allergic transformation of the body. The disproportion of immunoregulating cells in brucellosis, revealed in this study, is supposed to be of pathogenetic importance.

Adolescent↗
PubMed1976

Kinetics of thymus-derived lymphocyte count changes in rats affected by graft-versus-host reaction.

The effect of GVHR on thymus-dependent lymphocytes of various lymphoid organs has been followed autoradiographically and by scintillation technique in a temporal dependence on the induction of the reaction. GVHR was induced in (BD X Lw) F1 hybrid rats with parental spleen (BD) cells. As marker of the thymus-dependent lymphocytes the in vitro 3H-uridine incorporation was used. Compared to B cells, T lymphocytes of rats have a higher ability of incorporating labeled uridine. T lymphocytes in peripheral blood and the thoracic duct achieved their peak at 3 or 4 days following GVHR induction. On the fourth day, simultaneously with a GVH-altered thymus a rapid decline in the number of these cells was also observed. A mobilization of T lymphocytes from the spleen and lymph nodes into the circulation already in the very first days of the reaction might be responsible for the peak seen in PBL and TDL. The GVH-alteration lasting 21 days caused an evident reduction of thymus-dependent lymphocytes in all the organs studied here. The immunological attack of GVHR is considered to be primarily responsible for the exhaustion of T cells. The discussion bears on the possibility of a more progressive action of GVHR on the more mature T lymphocyte subpopulation.

Animals↗
PubMed1984

[Changes in the white blood picture and the T- and B-lymphocyte counts in the peripheral blood of pigs after treatment with E. coli endotoxin].

Studied were the changes in the total count of the white blood cells, the leukocyte formula, and the T- and B-lymphocytes of young pigs (2-3 months old) at various intervals following treatment with an E. coli enterotoxin. It was found that there set in an essential drop of the total count of the white blood cells during the first 24 hours after treatment, with a following rising trend. There were also characteristic changes in the ratio between the various types of white blood cells, with a rise of the lymphocytes and monocytes. The level of T-POK and B-POK rose after the endotoxin was injected--for the T cells it reached peak values between the 3d and 5th day, while for the B cells it was highest between the 5th and 7th day. There was a following drop with both types of cells, and by the 15th day the initial level was reached.

Animals↗
PubMed1996

[Paraproteins and lymphoma in HIV positive patients].

BACKGROUND AND AIM: Compared to healthy subjects there is a higher incidence of monoclonal immunoglobulins (= paraproteins = PP) in patients infected with the human immunodeficiency virus (HIV). High-grade B-cell non-Hodgkin's lymphomas (NHL) are the second most common neoplasms in these patients. Our aim was to determine whether paraproteins would be of diagnostic significance regarding an underlying or developing NHL. PATIENTS AND METHODS: The sera of 202 HIV-positive patients were tested for the presence of monoclonal or oligoclonal bands by using high-resolution-electrophoresis (HRE) and immunofixation (IFX). We also examined immunoglobulin concentrations, leucocyte count, lymphocyte count, CD4 lymphocyte count and CD4/CD8-ratio and collected clinical data. RESULTS: Paraproteins were detected in 26 (12.8%) of the patients. 84.6% of PP were IgG, in 80.7% associated with a kappa light chain. Patients with monoclonal or oligoclonal bands developed NHL significantly more often compared to those without PP (16.7% and 2.8%, respectively (p < 0.05%)). The CD4 count was significantly higher in patients with PP. There was no difference in levels of immunoglobulins, leucocyte count, lymphocyte count and CD4/CD8-ratio. The prevalence of PP was equally distributed in patients at different CDC-stages of HIV-infection. Common acute systemic infections like pneumocystis carinii pneumonia (PCP), toxoplasmosis, mycobacteriosis or cytomegalovirus (CMV) infection were not associated with paraproteins. CONCLUSION: We conclude that paraproteins could indicate the presence of a non-Hodgkin's-lymphoma.

AIDS-Related Opportunistic Infections↗
PubMed1978

[Influence of plasmaphoresis on total and T-lymphocyte count (author's transl)].

For more than one year 30 plasma donors were tested as to their influence on leukocytes, lymphocytes and SRBC-rosette-forming-T-lymphocytes. None of the donors, even under long-term observation and with more than 40 double plasmaphoreses per year, showed any significant changes in the above-mentioned data. The general level of lymphocytes and SRBC-rosette-forming is individually fixed, and there is a definite correlation between these two factors. This individual level is also uninfluenced by frequent plasmaphoreses.

Adult↗
PubMed2004

Comparison of CD4 and CD8 lymphocyte counts in HIV-negative pulmonary TB patients with those in normal blood donors and the effect of antitubercular treatment: hospital-based flow cytometric study.

BACKGROUND: This study was designed to flow cytometrically determine baseline and sequential values of CD4 and CD8 lymphocyte subsets in patients without the human immunodeficiency virus and with pulmonary tuberculosis (TB) and to correlate these values with those obtained from normal male blood donors and with the radiologic extent of disease and response to therapy. METHODS: We studied 39 male patients without the human immunodeficiency virus and with sputum positive for pulmonary TB who had been admitted to Military Hospital (Cardiothoracic Center) in Pune, India. Clinical, laboratory, and radiologic evaluations of these patients were done. Hematologic parameters were assessed by an automated hematology cell counter (AcT*Diff, Coulter), and T-cell subsets (CD4 and CD8) were determined flow cytometrically (EPICS-XL, Coulter). RESULTS: CD4 counts and percentages of CD4 were significantly lower, but CD8 values were normal, in patients with pulmonary TB when compared with values obtained in normal blood donors. The CD4/CD8 ratio was significantly lower in patients with TB. The CD4 counts normalized with antitubercular treatment. The radiologic extent of disease did not correlate well with the immune parameters studied. CONCLUSIONS: TB is a reversible cause of CD4 lymphocytopenia and is associated with normal numbers of CD8 cells. The radiologic extent of disease does not seem to determine the immune response.

Adult↗
PubMed1987

[The T mu- and T gamma-lymphocyte count and their ratio in patients with brucellosis of various focal natures].

The content of T mu- and T gamma-lymphocytes and their ratio in patients having subacute and chronic brucellosis with different foci of infection have been studied. The relationship between the decrease in the levels of T mu- and T gamma-cells and the clinical form of the disease and its clinical manifestations, such as polyarthritis, has been established. Manifestations of disturbances in the T mu-cell/T gamma-cell ratio were more pronounced in patients with subacute brucellosis in whom the lesions of the osteoarticular system prevailed. The detected changes in the counts of immunoregulatory cells in brucellosis are assumed to be of pathogenetic importance.

Adolescent↗
PubMed1994

The use of proliferating cell nuclear antigen (PCNA) expression and intraepithelial lymphocyte count in the differential diagnosis of inflammatory bowel disease.

Colonic biopsies of 283 patients with Crohn's disease (CD), ulcerative colitis (UC), infectious colitis (IC) lymphocytic colitis (LC) and controls for patients with either CD or UC, matched for age and sex, were evaluated with respect to the number of intraepithelial lymphocytes (IEL) and PCNA (cyclin) positive crypt epithelia. The IEL count of patients with LC differed significantly from all other patient groups, indicating that this condition bears no relation to the other diseases. Our patients with histologic diagnosis of LC had no uniform clinical presentation and the significance of this characteristic increase in IEL is unclear. The mean value of PCNA positive crypt epithelia in the lower crypt half was significantly higher in UC patients than in CD patients. PCNA counts in patients with IC or LC were not different from values in UC patients. PCNA counts in CD patients overlapped frequently with those in UC patients. This parameter thus fails to distinguish between CD and UC in individual patients and, though not investigated by us, is unlikely to be effective in the differential diagnosis in patients with a provisional diagnosis of indeterminate colitis.

Adult↗