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At least 505 records · Page 28Linked to original sources
PubMed1990

[A case of a blue nevus of the palate].

A rare case of palatal blue nevus is reported. Nearly 200 cases of oral melanocytic nevi are reported in the literature, but histological data are often not given. In view of the difficulties encountered in clinical differential diagnosis, above all with reference to malignant melanoma, nevus lesions should be removed from the oral mucosa.

Adult↗
PubMed1990

[Adult type rhabdomyoma of the soft palate: pathology of 2 cases with review of the medical literature].

In this paper, the authors report two cases of adult type rhabdomyomas of the soft palate. This tumor is composed of striated muscle cells containing striations and intracytoplasmic rod-shaped inclusions. In specimens already fixed in aqueous fixators (formalin...), some tumor cells presented a fixation artefact and displayed the morphology of so-called "spiderweb cells". Adult type rhabdomyoma is a real tumor. Total surgical removal is sufficient to cure the patient of this tumor in most cases.

Adult↗
PubMed1990

Immunohistochemical localization of filaggrin in benign and malignant lesions of the human oral mucosa.

Filaggrin is a protein normally present in the granular and horny layer of stratified squamous epithelia. We studied the presence of this protein in 83 benign lesions and in 73 cases of malignant epithelial tumours of the oral cavity and investigated its possible role as an immunohistochemical marker. The immunohistochemical technique was based on the P.A.P. method. The results in benign lesions show a distribution of filaggrin similar to that observed in the normal mucosa. By contrast, an irregular distribution of filaggrin is observed in areas of leukoplakia with parakeratosis and in papillomas. In malignant lesions the expression of this protein is closely related to the degree of differentiation of the cellular elements, being positive in more differentiated and negative in anaplastic areas. Therefore in some types of benign lesions filaggrin testifies an alteration of the normal process of keratinization. Filaggrin is more significant in malignant lesions in which its presence if any permits an evaluation of the degree of differentiation of the tumour.

Carcinoma, Squamous Cell↗
PubMed1990

Lip and intraoral tumours: a local perspective.

Lip and intra-oral cancer is an uncommon disease in Singapore among the local population. The incidence is less than 1.5% of all cancers reported to the Singapore Cancer Registry which recorded a total of 18,049 cases of all types of cancer in a 5-year period from 1978 to 1982. The Department of Plastic Surgery at Singapore General Hospital has been conducting a multidisciplinary clinic for the management of head and neck tumours since 1984. The results of the distribution, age, sex and racial differences, risk factors and modalities of treatment of the various types of cancer affecting the lip and intraoral region were analysed in a prospective study. A total of 69 cases were analysed and of these 59 (85.5%) were squamous cell carcinoma (SCC) of varying grades of malignancy, the remaining comprising adenoidcystic and mucoepidermoid carcinoma, malignant melanoma and a single case of ameloblastoma. A number of predisposing factors such as smoking, alcohol and the chewing of betel nuts could be identified in the history of patients suffering from cancers involving the buccal mucosa and tongue. As the numbers involved in non-SCC are small in this study, the discussion will be confined to patients presenting with squamous cell carcinoma only.

Adult↗
PubMed1990

[Carcinoma in situ of soft palate].

A case of carcinoma in situ in the soft palate in a 46-year-old man, heavy smoker, is presented. Six month's previously the patients own dentist discovered a rash in the soft palate, but no biopsy was taken until 6 months later when the patient was referred to the Dental Department, University Hospital, Copenhagen. The patient was referred to an oncologic department for evaluation. As radiation therapy was not indicated, surgery was performed. This included removal of the soft palate, tonsil and tonsil fossae. The patient had a palate plate done to relieve problems with swallowing. Patients with a long history of heavy smoking and oral lesions with suspicion for malignancy should always immediately after recognition of the lesion have more intensive examination and this should include a biopsy to establish a reliable diagnosis.

Carcinoma in Situ↗
PubMed1987

[The problem of double abnormalities].

Twin monsters are rare obstetrical events. The article reports on the course and the termination of pregnancy of a fetus with epignathus (non separated asymmetrical twin monster) and a fetus with thoracopagus (non separated symmetrical twin monster). In this connection the importance of an early prenatal diagnosis is discussed.

Abnormalities, Multiple↗
PubMed1989

Application of nasopharyngoscopy and videofluoroscopy in the fabrication of a speech aid for soft palate defects.

Conventional methods of speech aid fabrication have little control over the pharyngeal extension or over the adequacy of the velopharyngeal closure. These limitations can be overcome by using a nasopharyngoscope, which provides the operator with direct vision during the molding of the pharyngeal section. Likewise, the use of a videofluoroscope also permits visualization of the prosthesis in relation to the surrounding structures during various activities, and is equally valuable in the evaluation of the velopharyngeal mechanism. In both instances, the evidence of inadequate closure could be seen as mucus bubbling or refluxing of barium from the junction of the prosthesis with the soft palate defect. Also the standard Mandarin phrases used in the speech test and the advantages of nasal endoscopy over oral endoscopy are discussed.

Adult↗
PubMed1977

Critical review of biopsy and cytologic examination of oral cancer.

The value of cytologic diagnosis has been highly estimated since Papanicolaou introduced cytologic study into various clinical fields as a diagnostic tool. In this paper the causes of errors in diagnosis, particularly the false negative case which occurs more frequently than false positive cases are critically reviewed. Four false negative cases, including one case subsequently diagnosed as positive by a direct imprint smear taken from its biopsy section, are presented in detail and possible causative factors for misinterpretation discussed and summarized, comparing the results with those previously reported by Watanabe et al (1959) and Watanabe (1968). In the 24 cases reviewed in this article false negative diagnoses were made in 12-5 per cent and in summarizing the results with the previous reports they averaged 14-5 per cent. False negative cases could be reduced by careful attention to the elimination of the causative factors which have been described.

Adult↗
PubMed1989

[The temporalis muscle fascia flap for covering defects in the oropharynx. Report of 4 years experiences with 26 cases].

The temporalis muscle flap has proved its usefulness in the reconstruction of extensive oropharyngeal defects in the last 4 years in 26 patients. Although the functional qualities of the reconstructed area are not as superb as jejunal mucosa, due to a certain fibrosis of the muscle-fascia flap, much less surgical effort is required with this flap, since it is situated in the vicinity of the defect. Moreover, its short vascular pedicle guarantees the safe taking of the flap. The cosmetic alteration caused by the flattening of the temporal fossa is considerably attenuated with the replantation of the zygomatic arch. Especially in the multimorbide oropharyngeal cancer patient, the temporalis muscle flap with its reasonable surgical effort and its reliability represents a valuable alternative in the reconstruction of extensive defects.

Fascia↗