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At least 505 records · Page 28Linked to original sources
PubMed2006

Plasma acceleration above martian magnetic anomalies.

Auroras are caused by accelerated charged particles precipitating along magnetic field lines into a planetary atmosphere, the auroral brightness being roughly proportional to the precipitating particle energy flux. The Analyzer of Space Plasma and Energetic Atoms experiment on the Mars Express spacecraft has made a detailed study of acceleration processes on the nightside of Mars. We observed accelerated electrons and ions in the deep nightside high-altitude region of Mars that map geographically to interface/cleft regions associated with martian crustal magnetization regions. By integrating electron and ion acceleration energy down to the upper atmosphere, we saw energy fluxes in the range of 1 to 50 milliwatts per square meter per second. These conditions are similar to those producing bright discrete auroras above Earth. Discrete auroras at Mars are therefore expected to be associated with plasma acceleration in diverging magnetic flux tubes above crustal magnetization regions, the auroras being distributed geographically in a complex pattern by the many multipole magnetic field lines extending into space.

Journal Article↗
PubMed1982

New neutron sources.

This paper describes the latest developments in neutron sources developed for fast neutron therapy. Two approaches have been taken using cyclotrons and D-T generators. For cyclotrons the proton on beryllium reaction is now preferred since smaller cyclotrons for a given neutron penetration can be used. Optimization of target thickness and filtration is necessary to obtain maximum beam penetration. D-T generators have been developed either as multi-beam accelerators or using ultrapure techniques to obtain maximum neutron output.

Fast Neutrons↗
PubMed1985

History of microwave electron linear accelerators for radiotherapy.

Some of the far reaching contributions of Henry S. Kaplan are described which helped launch the development, improvement, and widespread use of microwave electron linear accelerators in radiotherapy. These are presented in historical relationship to the fundamental inventions and developments upon which modern medical accelerator technology is based.

England↗
PubMed2005

Targeting accuracy of an image guided gating system for stereotactic body radiotherapy.

Recently, a commercial system capable of x-ray image guided patient positioning and respiratory gated delivery has become available. Here we describe the operational principles of this system and investigate its geometric targeting accuracy under controlled conditions. The system tracks breathing via infrared (IR) detection of reflective markers located on the patient's abdomen. Localization kilovoltage (kV) x-rays are triggered from within the gated delivery window portion of the breathing trace and after positioning, the tumour will cross the linac isocentre during gated delivery. We tested geometric accuracy of this system by localizing and delivering gated fields to a moving phantom. Effects of phantom speed, gating window location, timing errors and phantom rotations on positioning and gating accuracy were investigated. The system delivered gated fields to both a moving and static phantom with equal accuracy. The position of the gating window affects accuracy only to the extent that an asymmetric breathing motion could affect dose distribution within its boundaries. Positioning errors were found to be less then 0.5 +/- 0.2 mm for phantom rotations up to 5 degrees. We found and corrected a synchronization error caused by a faulty x-ray duration setting and detected a 60 +/- 20 ms time delay in our linear accelerator.

Calibration↗
PubMed2006

Activation processes in a medical linear accelerator and spatial distribution of activation products.

Activation products have been identified by in situ gamma spectroscopy at the isocentre of a medical linear accelerator shortly after termination of a high energy photon beam irradiation with 15 x 15 cm field size. Spectra have been recorded either with an open or with a closed collimator. Whilst some activation products disappear from the spectrum with closed collimator or exhibit reduced count rates, others remain with identical intensity. The former isotopes are neutron-deficient and mostly decay by positron emission or electron capture; the latter have neutron excess and decay by beta(-) emission. This new finding is consistent with the assumption that photons in the primary beam produce activation products by (gamma, n) reactions in the treatment head and subsequently the neutrons created in these processes undergo (n, gamma) reactions creating activation products in a much larger area. These findings are expected to be generally applicable to all medical high energy linear accelerators.

Electrons↗
PubMed2001

Determination of personal dose equivalents in accelerator radiation fields.

Values for the dose equivalent are required for radiation protection purposes, but determination of such values can be quite difficult for high energy radiations. The accurate determination of personal dose equivalents in accelerator radiation fields requires the propel use of appropriate radiological quantities and units, knowledge of the dose equivalent response of the personal dosemeters used, measurement or calculation of the fluence spectrum in the workplace and the fluence spectrum of the reference radiation used to calibrate the dosemeters, in addition to knowledge of the appropriate fluence-to-dose equivalent conversion coefficients. This information can then be used to select the appropriate dosemeters, set up the optimum calibration conditions, or to establish correction factors that account for differences in the calibration and workplace fluence spectra. High energy neutrons account for a significant fraction of the dose equivalent received by workers at accelerator facilities, and this work discusses the procedures and methods needed to determine dose equivalent produced by neutrons in the vicinity of high energy particle accclerators.

Calibration↗
PubMed1993

Evaluation of a new high-density shielding material.

A new high-density material is evaluated for use as shielding at medical radiation therapy facilities. The substance is supplied in the form of prefabricated interlocking blocks that contain steel scrap as the aggregate in a matrix of Portland cement. This material, called Ledite by its manufacturer, permits the dimensions of radiation therapy room walls to be reduced by a factor of approximately 2 when compared with rooms made from ordinary concrete. The neutron absorption required for high-energy linear accelerators is present.

Construction Materials↗
PubMed2001

Titanium particles stimulate bone resorption by inducing differentiation of murine osteoclasts.

BACKGROUND: Loosening of orthopaedic implants is mediated by cytokines that elicit bone resorption and are produced in response to phagocytosis of implant-derived wear particles. This accelerated bone resorption could be due to increased osteoclastic activity, survival, or differentiation. Although a number of in vitro studies have shown that wear particles increase osteoclastic activity, the increase was less than twofold in all cases. The objective of the current study was to test the hypothesis that wear particles stimulate bone resorption by inducing osteoclast differentiation. METHODS: Conditioned media were prepared from murine marrow cells or human peripheral blood monocytes incubated in the presence or absence of titanium particles. The effects of conditioned media on osteoclast differentiation were examined with use of a recently developed assay in which osteoclast precursors are co-cultured with mesenchymal support cells. RESULTS: The present study showed that titanium particles induced both murine marrow cells and human peripheral blood monocytes to produce factors that stimulated osteoclast differentiation. The mean increase in osteoclast differentiation was 29.3+/-9.4-fold. The stimulation of osteoclast differentiation led to a parallel increase in bone resorption. The amount of stimulation was regulated in a dose-dependent manner by the concentration of both titanium particles and conditioned media. The stimulation of osteoclast differentiation required interactions between the cells and the particles themselves and, therefore, was not due to metal ions, soluble contaminants released from the particles, or submicrometer particles. In contrast, conditioned media from control cells incubated in the absence of titanium particles had no detectable effect on any of the examined parameters. CONCLUSIONS: The present study showed that titanium particles stimulate in vitro bone resorption primarily by inducing osteoclast differentiation. In contrast, the titanium particles had only small effects on osteoclast activity or survival.

Adult↗