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PubMedDate not supplied

Effect of different dietary carbohydrates on some hepatic dehydrogenases and total lipid during starvation and refeeding regimen.

Lipogenic capacity of various dietary carbohydrates starch, glucose sucrose and lactose was tested during ad lib feeding and starvation followed by refeeding. Sucrose was found to have maximal effect on hepatic total lipid and the enzymes in the study followed by glucose and sago while lactose was found to be toxic. Starvation resulted depression in the activities of various enzymes. The enzyme activity inducing effect was again exhibited by sucrose diet during ad lib and restricted refeeding followed by starvation.

Animals↗

PubMedDate not supplied

Effect of refeeding after starvation on basal and tolbutamide-stimulated insulin secretion and beta-adrenergic receptor function in the regulation of insulin release and lipolysis in obese patients.

Serum insulin, blood glucose and plasma free fatty acids (FFA) were determined in 14 subjects with a simple obesity under basal conditions and during the tests with tolbutamide, propranolol and epinephrine before and after fasting of 14 days duration, on restricted diet of 1300 kcal. After refeeding some changes in pancreatic B cells reactivity and an altered metabolic responsiveness to epinephrine and propranolol were found as compared to prefasting values. It may be concluded that after refeeding a further increment of beta-adrenergic function seems to contribute to accelerated lipid mobilisation and partly to increased insulin secretion.

Adult↗

PubMed1984

Influence of fasting and refeeding high forage and all-concentrate diets on beef heifers.

An 88% forage diet (F) and a corn-based all-concentrate diet (C) were fed to compare the influence of prior diet and rumen microbial inoculation on dietary intake and ruminal fermentation of heifers allowed to consume their diet ad libitum after a 4-d fast. Twelve ruminal-fistulated Angus heifers averaging 265 kg body weight were fed F ad libitum for 28 d, fasted for 4 d and refed F ad libitum for 21 d (period 1). After 21 d of refeeding, the heifers were fasted for 4 d and then fed C ad libitum for 60 d (period 2). After 60 d, the heifers were fasted for 4 d and refed C ad libitum for 35 d (period 3). The rumens of six heifers were inoculated (1) at the end of each fast with 2 l of ruminal fluid from two ruminal fistulated donor steers fed the corresponding postfast diet ad libitum. Six heifers were uninoculated (UI). The most severe digestive disturbance associated with any of the treatments was reduced feed intake. During the first week of refeeding the I heifers consumed more feed than UI heifers. Regardless of treatment 2 wk or more were required for heifers to return to before fast intake levels. If ruminal glucose accumulated to 10 mg/100 ml in the rumen for more than 7 h, then ruminal lactate accumulated to higher concentrations and for longer periods of time. Ruminal lactic acid accumulation is considered to be one of the main causes for reduced feed intake. When heifers were switched from F to C, they did not overeat to the point of causing complete feed refusals on subsequent days. However, even at low intakes, a reduction in feed intake occurred.

Ammonia↗

PubMed1984

Refeeding of fasting rats stimulates epithelial cell proliferation in the excluded colon.

The major postprandial factors known to influence epithelial cell proliferation in the colon are intraluminal factors. In this study, a transverse colostomy was created in rats in order to avoid the intraluminal stimulation of the distal colon after feeding. After a 48-h fasting period, the animals were refed whereas controls were kept fasted. Refed animals with their controls were killed at respectively 0, 8, 12, 18, and 24 h after the time of refeeding. Autoradiography of in vitro labeled mucosal samples was used for determining the proliferative parameters in the colonic crypts. The uptake of [3H]thymidine in mucosal scrapings was measured for estimating DNA synthetic activity. Refeeding increased the labeling index of the crypts (p less than 0.01) and the mucosal DNA synthesis (p less than 0.01) not only in the proximal colon but also in the excluded distal colon. The increase in labeling index was followed by a significant mitotic peak in both segments. These data indicate that direct intraluminal stimulation is not the only mechanism involved after feeding. There are other potent physiological stimulants of epithelial cell proliferation in the colon which are released postprandially.

Animals↗

PubMed1984

Effects of starvation and refeeding on the excretion of urinary steroid metabolites in mice with different genetic background.

Gas chromatographic steroid metabolic profiling procedures have been applied to investigations of the effects of starvation and refeeding in mice. Urinary steroid metabolites were quantitatively followed during the starvation-refeeding experiments for mice with different genetic backgrounds. Some quantitative alterations were noted for certain congenic strains of mice. The metabolites which exhibited such quantitative variations were tentatively identified by means of combined gas chromatography-mass spectrometry.

Animals↗

PubMed1982

Refeeding after acute gastroenteritis: a controlled study.

Children admitted with acute gastroenteritis were managed with clear fluids and then given either the standard graduated feeding regimen or an abrupt reintroduction of normal feeds. The rapid refeeding group lost less weight, went home sooner, and had no increase in complication rate. Rapid refeeding is a reasonable option in the management of acute gastroenteritis.

Acute Disease↗

PubMed1982

Effects on the rate of increase in fetal girth of refeeding ewes after short periods of severe undernutrition during late pregnancy.

A technique is described by which daily changes in the thoracic circumference (girth) of individual fetal sheep were observed during the last 60 to 70 days of pregnancy. The girth technique and a previously published method for measuring daily changes in the curved crown-rump length were both used to examine fetal growth responses when ewes were refed at 116 days of gestation after short periods of severe underfeeding. Refeeding ewes after nine or 16 days of severe underfeeding was associated in most cases with an immediate increase in fetal growth rate, whereas refeeding after 21 days had no effect on the rate in any fetus. Possible mechanisms underlying these effects are discussed. Using girth as an index the growth rates of individual lambs were measured before and after birth. There was a 3.3 fold increase in growth rate immediately after birth.

Animal Feed↗

PubMed1982

Bile acid excretion during drainage of extrahepatic cholestasis with refeeding of bile.

Hepatic and renal excretion of individual bile acid conjugates were studied in four patients with extrahepatic cholestasis during 3 weeks of percutaneous transhepatic drainage with bile refeeding. The study involved isolation and determination by gas chromatography-mass spectrometry of individual bile acids separated into glycine, taurine and sulphate conjugates simultaneously in bile, serum and urine. In bile cholic, chenodeoxycholic and deoxycholic acids were chiefly found as glycine or taurine conjugates and in high concentrations, which indicated a large capacity of the post-cholestatic liver to excrete these conjugates. A minor portion of cholic, chenodeoxycholic and deoxycholic acids and all of lithocholic and 3 beta-hydroxy-5-cholenic acids in the bile were recovered as sulphate conjugates. The biliary concentration of sulphated bile acids was low, but increased during drainage with refeeding of bile indicating a gradually more efficient hepatic elimination of sulphated bile acids. The urinary concentrations of the individual bile acid conjugates decreased when the biliary concentration increased.

Aged↗

PubMed1982

Effect of starvation and refeeding on the blood and liver of domesticated rabbits.

A group of male rabbits was starved for 7 days. Their blood samples were collected, before and after the starvation period. Six rabbits were slaughtered for the recovery of livers, while the rest were refed for the next 7 days, at the end of which their blood samples were collected and livers taken out for various analyses. After 7 days of starvation, the total leukocytic count, haemoglobin, bilirubin, proteins and glucose contents, and activities of alkaline phosphatase and glutamate pyruvate transaminase of blood serum decreased significantly, while its lactate dehydrogenase activity and cholesterol, total lipids and urea contents showed a significant increase. In liver, except for the bilirubin and glucose contents, all the biochemical components--RNA, DNA and total proteins included--showed highly elevated values. Refeeding of the starved rabbits tended to normalize most within 7 days. Although RNA, DNA, total proteins, cholesterol and urea contents did not reach the normal level in liver during this period, they were definitely less than those of the starved condition. The hepatic transaminases activities and lipid content in starved + refed livers were considerably decreased during the refeeding period. The histological parameters were slow to recover.

Animals↗

PubMed1980

The effect of refeeding after semistarvation on catecholamine and thyroid metabolism.

To investigate the effect of nutrition on catecholamine metabolism, four subjects were initially energy-restricted for three weeks and then refed a high-carbohydrate diet, salt intake being kept constant. Energy restriction was associated with a reduction in plasma noradrenaline, urinary excretion of 4-hydroxy 3-methoxymandelic acid (HMMA), serum triiodothyronine (T3), systolic and diastolic pressures, pulse and resting metabolic rate (RMR). Within 72 hours of refeeding there was a significant increase in the urinary excretion of HMMA, serum T3, blood pressure, pulse and the RMR. Thus catecholamine metabolism is affected both in semistarvation and during the first few days of refeeding.

Adult↗

PubMed1995

Effect of severe energy restriction and refeeding on thyroid hormones in bulls.

Fifty-three Holstein-Friesian breeding bulls (944.99 +/- 14.59 kg) were fasted for 4 weeks. The influence of feeding on thyroid hormones was studied by comparing a starting point with a 4-week fasting period and a refeeding period. Blood samples were taken via a jugular vein catheter at 8:00 a.m. one day before, then once every week during, and two times after the fasting period. Plasma thyroxine (T4) and triiodothyronine (T3) levels were determined by direct radioimmuno-assay. The concentration of T4 and T3 decreased during fasting. The concentration of T3 increased after refeeding, but that of T4 did not. These data suggest that fasting is associated with a decrease in the peripheral conversion of T4 to T3 and, consequently, less T4 is converted into T3.

Animal Feed↗

PubMed1994

Concentrations of amino acids in plasma and whole blood in response to food deprivation and refeeding in healthy two-day-old foals.

Concentrations of amino acids in plasma and whole blood in response to 10 hours of food deprivation were determined in healthy 2-day-old foals (n = 8) and were compared with control values in foals of the same age (n = 8) allowed free access to suckle. In addition, response of concentrations of amino acids in plasma to 15 minutes of free-access suckling was determined at the end of the 10-hour period in both groups. Response of 13 amino acids in plasma of food-deprived foals was significantly (P < 0.05) different, compared with that in control foals. Concentrations of 3 amino acids (alanine, glycine, and phenylalanine) in plasma increased significantly (P < 0.05), whereas concentrations of 7 amino acids (asparagine, citrulline, histidine, ornithine, proline, tryptophan, and tyrosine) in plasma decreased significantly (P < 0.05) during food deprivation. Response of concentrations of 2 amino acids (glycine and histidine) in whole blood was significantly (P < 0.05) different from that in plasma of food-deprived vs control foals. Refeeding of food-deprived foals resulted in significantly (P < 0.05) different responses for concentrations of all but 2 amino acids (cystine and taurine) in plasma, compared with responses in controls. Changes in concentrations of amino acids in plasma and whole blood of foals in response to food deprivation are similar to those in foals with septicemia and in children with grade 1 or 2 kwashiorkor. The significantly different response of food-deprived foals to refeeding may be attributable to increased protein intake or altered physiologic state.

Amino Acids↗

PubMed1996

Refeeding activity of immature ticks of Ixodes persulcatus and transmission of Lyme disease spirochete by partially fed larvae.

The refeeding activity of immature ticks of Ixodes persulcatus was studied under laboratory conditions. BALB/c mice were used as blood sources. Feeding larvae and nymphs spontaneously detached themselves from parasitized mice when the mice were killed 1 or 2 days after tick exposure. Partially fed ticks were reexposed on other mice. Both larvae and nymphs were able to refeed on mice. The resultant engorged ticks normally molted to the next developmental stages. We also examined the transmission of the Lyme disease spirochete, Borrelia garinii, by bites of partially fed ticks. Larvae that had fed on infected mice for 1 or 2 days transmitted the spirochete to mice by refeeding.

Animals↗

PubMed1998

The effects of fasting and refeeding healthy volunteers on serum folate levels.

Fasting serum folate levels are commonly used in assessing folate status and also in estimating the bioavailability of synthetic folic acid and food folate. Previous work has shown that serum folate more than doubles in concentration during a 48 hour fast. Following a 24-hour standardisation procedure, serum and urinary folate levels were measured in nine healthy female volunteers fasting for 36 hours and in the first 6 hours during refeeding. Serum folate concentration increased from a mean of 14.8 ng/ml to 29.3 ng/ml during the 36 hour fast and fell to 22.1 ng/ml during the 6 hour refeeding period. The rise in serum folate concentration during the fast was negatively related to serum folate concentration at 0 hours fasting. It is hypothesised that the enterohepatic recirculation of folate plays an important role in the underlying physiological mechanism. These findings highlight the need to standardise energy intake to control for hepatic influences on folate metabolism in future studies assessing the bioavailability of folate in food.

Adolescent↗

PubMed1983

Effects of protein-calorie malnutrition and refeeding on fluorouracil toxicity.

Mice were used to study the effects of protein-calorie malnutrition and its reversal on granulocyte-macrophage production and fluorouracil's toxic effect on bone marrow. An in vitro quantitative clonal culture technique for bone marrow granulocyte-macrophage progenitor cells (GM-CFC) was used. Animals on a protein-free but otherwise complete diet for ten days had a significant contraction in total marrow cellularity and GM-CFC numbers paralleling the animal's weight loss. The acute toxic effect of fluorouracil on bone marrow was not increased in protein-deprived animals. On refeeding, there was a biphasic response in the degree of toxic effect on marrow. Animals refed for one day had significantly increased fluorouracil-related marrow abnormalities. However, animals refed for four days, when marrows were repleted, were partially protected from the drug's cytotoxic effects. The increased sensitivity in mice refed for one day was related to more GM-CFC in active DNA synthesis.

Animals↗

PubMed1997

Persistence of binge-eating patterns after a history of restriction with intermittent bouts of refeeding on palatable food in rats: implications for bulimia nervosa.

OBJECTIVE: To test the hypothesis that experience with food restriction produces persistent binge eating. The Minnesota semistarvation experiment and studies of prisoners-of-war show that chronic food restriction produces dramatic changes in eating behavior (including binge eating) that endure decades after restriction has ceased. Bulimia nervosa patients who restrict also binge. Restriction may be a risk factor in the etiology of binge eating and bulimia. METHOD: Animals were subjected to four different patterns of 12-week restriction-refeeding cycles. The rats were either food restricted (dieting) or not restricted and refed regular or palatable food (binging). RESULTS: Thirty days after normalization (full feeding, no restriction cycling), rats with a history of cycles of restriction and hyperphagia continued to exhibit persistent binge eating. This effect was shown particularly with palatable food, in stated conditions, and in response to acute 24-hr deprivation. DISCUSSION: Results from this animal model implicate restriction and overeating on palatable food as biological determinants of binge-eating behaviors, including bulimia nervosa.

Animals↗

PubMed1981

The effects of refeeding after varying periods of neonatal undernutrition on the morphology of Purkinje cells in the cerebellum of the rat.

Undernutrition of the rat for the first 30 days of postnatal life is known to permanently alter Purkinje cell (PC) dendritic morphology. The effects of earlier nutritional rehabilitation have not previously been determined. Neonatal rat pups were undernourished by limiting their access to the lactating dam. After 10, 15, or 20 days of food restriction, animals were either killed for histological comparison with normally fed controls, or provided with ad libitum food until 80 dpp, and then killed. Network analysis of Golgi Cox impregnated PCs from the undernourished animals revealed alterations in dendritic length, segment frequency, and branching pattern, which first became apparent at 15 dpp, accompanied by a reduction in the number of granule cells (GCs) per PC. If undernourished animals were refed from 10 or 15 days, however, the total lengths and segment frequencies of their PC trees were indistinguishable from those of controls at 80 dpp, although the 15-day group showed persistent topological alterations. The GC:PC ratios of these refed groups were also found to be similar to those of the controls. In animals refed after 20 days of undernutrition, network size remained reduced, as did the GC:PC ratio. The different degrees of recovery of PC dendritic field parameters recorded in the refed animals could be related either to enhanced GC replication afforded by refeeding, or to the existence of intrinsic mechanisms which limit the growth capacity of the PC dendrites.

Animals↗

PubMed1979

Selective high metabolic lability of uridine, guanosine and cytosine triphosphates in response to glucose deprivation and refeeding of untransformed and polyoma virus-transformed hamster fibroblasts.

Sugar deprivation of hamster fibroblasts (NIL) affected the steady state levels (pool sizes) of cellular acid soluble nucleotides in the folloing fashion: the pools of UTP, GTP and CTP decreased to a much greater extent than the cellular ATP pools, with the UTP pools undergoing the most dramatic reduction. Sugar deprivation of polyoma-transformed NIL cells (PyNIL) yielded even sharper decreases in the nucleoside triphosphate pools with relative changes similar to those of the untransformed cells. Inhibition of protein synthesis by cycloheximide, initiated at the onset of (and continued during) sugar deprivation, prevented the reduction in pool sizes and yielded values slightly higher than those observed for pool sizes in cells cultured in sugar-supplemented medium. Refeeding glucose to sugar-depleted hamster fibroblasts led to rapid increases (within 1 hour) in the UTP and CTP pools to levels well above the pool sizes observed in cells which were continuously cultured (16 hours) in sugar supplemented medium. Feeding NIL or PyNIL cells with fructose instead of glucose as the only hexose source did not appreciably affect any of the ribonucleoside triphosphate pool sizes. Measurements of hexose uptake by NIL and PyNIL cells under a variety of conditions suggest that hexose transport is not regulated by the total cellular pools of ATP or any of the other ribonucleoside triphosphates.

Animals↗