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PubMedDate not supplied

[The use of the alpha-glucosidase inhibitor acarbose for the treatment of type-2 diabetes mellitus in secondary sulfanilamide resistance].

Efficacy was studied of acarbose in patients with type II diabetes mellitus during the development of secondary sulfamide resistance. 63 patients were evaluated. Studies were made involving glycemia on an empty stomach, postprandial glycemia and 24-h glucosuria in order that we might learn about the above drug's efficacy. High confidence level decrease in postprandial glycemia was recorded as was significant reduction in diurnal glucosuria.

Acarbose↗
PubMed1997

Spectroscopic, Magnetic, and Electrochemical Studies of a Dimeric N-Substituted-Sulfanilamide Copper(II) Complex. X-ray and Molecular Structure of the Cu(2)(sulfathiazolato)(4) Complex.

A copper(II) complex of formula Cu(2)(stz)(4) (stz(-) = sulfathiazolato) has been synthesized and characterized by single-crystal X-ray diffraction. The compound crystallizes in the orthorhombic system, space group P2(1)cn with a = 10.595(7) Å, b = 14.274(3) Å, c = 29.65(1) Å, and Z = 4. The structure consists of dinuclear copper(II) units which contain four sulfathiazolato ligands bridging the metal ions through a nonlinear NCN group. The copper atoms are four-coordinated, the chromophore being CuN(4). The Cu.Cu bond distance is 2.671(2) Å. Magnetic susceptibility data in the temperature range 7-300 K show the occurrence of intramolecular antiferromagnetic coupling with 2J = -61.5 cm(-1). This low exchange energy value has been analyzed and rationalized through extended Hückel calculations. EPR spectra at X- and Q-band frequencies show the signals corresponding to a dinuclear entity, being the zero-field splitting parameter, D = 0.230 cm(-1).

Journal Article↗