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At least 505 records · Page 28Linked to original sources
PubMed1993

[Serum soluble CD23 and soluble CD25 in bronchial asthmatic patients].

Serum sCD23 and sCD25 levels in asthmatic patients and healthy subjects were assayed. Serum sCD23 levels in asthmatic patients were significantly higher than those in healthy subjects (p < 0.05). Serum sCD25 levels in asthmatic patients were also significantly higher than those in healthy subjects (p < 0.02). There was a significant correlation between serum sCD23 and sCD25 levels in asthmatic patients (r = 0.52, p < 0.001). It is well known that sCD23 and sCD25 levels are regulated by different cytokines, and this study suggests that T cells play important roles in the pathogenesis of asthma.

Adult↗
PubMed1993

[Serum levels of soluble CD25 (soluble interleukin 2 receptor) in asthmatic patients].

Serum sCD25 levels were measured in 64 asthmatic patients and 22 healthy subjects by enzyme-liked immunosorbent assay. Serum sCD25 levels in the asthmatic patients were significantly higher than those in the healthy subjects (p < 0.02). Serum sCD25 levels in the asthmatic patients during attack were slightly higher than in those in remission, but there was no significant difference between the two groups. We studied changes of serum sCD25 level in 13 asthmatic patients in remission and during attack and found that serum sCD25 levels were significantly higher during attack than in remission (p < 0.02). Serum sCD25 levels in the asthmatic patients undergoing steroid therapy were significantly lower than in those who were not (p < 0.05). The significance of serum sCD25 in bronchial asthma still remains unclear, but these results suggest that T cells play an important role in bronchial asthma.

Adult↗
PubMed1997

Interleukin-6, soluble interleukin-2-receptor and soluble interleukin-6-receptor in sera of patients with rheumatoid arthritis: influences of disease activity and drug therapy.

Cytokines and their receptors play a fundamental role in the development and maintenance of the inflammatory process in rheumatoid arthritis (RA). The purpose of this study was to evaluate sIL-2R, sIL-6R and IL-6 levels in the sera of 48 RA patients and to correlate them with disease activity, indicators of inflammatory process as ESR and CRP, and drug treatment modalities. IL-6 and sIL-2R levels were positively correlated with disease activity, ESR and CRP. No correlation between sIL-6R levels and these markers were observed. Our results suggest that different drug therapies have a decisive influence on the levels of selected cytokines. All investigated disease-modifying antirheumatic drugs (DMARDs) were able to reduce the IL-6 level significantly. Non-immunosuppressive DMARDs decreased the amount of circulating sIL-2R more than immunosuppressive drugs. Treatment with methotrexate resulted in a significant reduction of circulating levels of sIL-6R compared to azathioprine therapy. Under low dose glucocorticoid therapy, significantly lower levels of sIL-6R were found than in patients without glucocorticoids. In conclusion, the results provide some arguments in favour of combined drug therapies, which might possibly enhance the effectiveness of RA therapy.

Adult↗