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Orientation-tuned spatial filters for texture-defined form.

Detection threshold for an orientation-texture-defined (OTD) test grating was elevated after adapting to an OTD grating of high orientation contrast. Threshold elevation was greatest for a test grating parallel to the adapting grating, and fell to zero for a test grating perpendicular to the adapting grating. We conclude that the human visual system contains an orientation-tuned neural mechanism sensitive to OTD form, and propose a model for this mechanism. We further propose that orientation discrimination for OTD bars and gratings is determined by the relative activity of these filters for OTD form.

Adaptation, Ocular↗

A second-order pattern reveals separate strategies for encoding orientation in two-dimensional space and space-time.

We measured the perceived spatial orientation of the low contrast regions of contrast modulated sine gratings. Subjects make systematic errors which depend upon the carrier spatial frequency and the angle between the carrier grating and the modulation. The results for the spatial orientation task are compared with a motion domain analogue. The difference in the pattern of results for these two tasks suggests there exist separate strategies for encoding orientation in two-dimensional space and space-time.

Contrast Sensitivity↗

Vestibular compensation and orientation during locomotion.

Body, head, and eye movements were studied in three dimensions while walking and turning to determine the role of the vestibular system in directing gaze and maintaining spatial orientation. The body, head, and eyes were represented as three-dimensional coordinate frames, and the movement of these frames was related to a trajectory frame that described the motion of the body on a terrestrial plane. The axis-angle of the body, head, and eye rotation were then compared to the axis-angle of the rotation of the gravitoinertial acceleration (GIA). We inferred the role of the vestibular system during locomotion and the contributions of the VCR and VOR by examining the interrelationship between these coordinate frames. Straight walking induced head and eye rotations in a compensatory manner to the linear accelerations, maintaining head pointing and gaze along the direction of forward motion. Turning generated a combination of compensation and orientation responses. The head leads and steers the turn while the eyes compensate to maintain stable horizontal gaze in space. Saccades shift horizontal gaze as the turn is executed. The head pitches, as during straight walking. It also rolls so that the head tends to align with the orientation of the GIA. Head orientation changes anticipate orientation changes of the GIA. Eye orientation follows the changes in GIA orientation so that the net orientation gaze is closer to the orientation of the GIA. The study indicates that the vestibular system utilizes compensatory and orienting mechanisms to stabilize spatial orientation and gaze during walking and turning.

Eye Movements↗

Population encoding of spatial frequency, orientation, and color in macaque V1.

1. We recorded local field potentials in the parafoveal representation in the primary visual cortex of anesthetized and paralyzed macaque monkeys with a multicontact electrode that provided for sampling of neural activity at 16 sites along a vertical penetration. Differential recordings at adjacent contacts were transformed into an estimate of current source density (CSD), to provide a measure of local neural activity. 2. We used m-sequence stimuli to map the region of visual space that provided input to the recording site. The local field potential recorded in macaque V1 has a population receptive field (PRF) size of approximately 2 deg2. 3. We assessed spatial tuning by the responses to two-dimensional Gaussian noise, spatially filtered to retain power only within one octave. Responses to achromatic band-limited noise stimuli revealed a prominent band-pass spatial tuning in the upper layers, but a more low-pass spatial tuning in lower layers. 4. We assessed orientation tuning by the responses to band-limited noise whose spectrum was further restricted to lie within 45 degrees wedges. The local field potential showed evidence of orientation tuning at most sites. Orientation tuning in upper and lower layers was manifest by systematic variations not only in response size but also in response dynamics. 5. We assessed chromatic tuning by the responses to isotropic band-limited noise modulated in a variety of directions in tristimulus space. Some lower-layer locations showed a nulling of response under near-isoluminant conditions. However, response dynamics in upper and lower layers depended not only on luminance contrast, but also on chromatic inputs. 6. Responses to near-isoluminant stimuli and to low-contrast luminance modulation were shifted to lower spatial frequencies. 7. We determined the extent to which various temporal frequencies in the response conveyed information concerning spatial frequency, orientation, and color under the steady-state conditions used in these studies. In each case, information is distributed in the response dynamics across a broad temporal frequency range, beginning at 4 Hz (the lowest frequency used). For spatial frequency the information rate remains significant up to at least 25 Hz. For orientation tuning and chromatic tuning, the information rate is lower overall and remains significant up to 13 Hz. In contrast, for texture discrimination, information is shifted to lower temporal frequencies.

Animals↗

Perceptual learning specific for orientation and spatial frequency.

Several examples of 'perceptual learning' (improvement of some perceptual task with practice) have been reported. These studies are of great interest for neurological research because they demonstrate plasticity of the nervous system. Even for apparently basic perceptual tasks, such as visual acuity or vernier acuity, practice can facilitate a neural change which enhances performance. One question in this field is where does this learning occur? Indications about the possible neural site of a learning process may be derived from its specificity for some particular stimulus parameters. For instance, there is a hint that learning in global stereopsis may occur at a stage where visual information is processed by mechanisms selectively sensitive to different stimulus orientations. We report here an experiment on perceptual learning in the discrimination of gratings of different waveform. Our findings show that learning is specific for both the orientation and the spatial frequency of the practice stimulus.

Discrimination, Psychological↗

Effects of stimulus orientation on spatial frequency function of the visual evoked potential.

Visual performance is better in response to vertical and horizontal stimuli than oblique ones in many visual tasks; this is called the orientation effect. In order to elucidate the electrophysiological basis of this psychophysical effect, we studied the effects of stimulus orientation on the amplitudes and latencies of visual evoked potentials (VEPs) over different spatial frequencies of the visual stimulation. VEPs to sinusoidal gratings at four orientations (vertical, horizontal, and oblique at 45 degrees and 135 degrees) with eight spatial frequencies (0.5-10.7 cycles/deg) at reversal rates of 1 Hz and 4 Hz were recorded in nine subjects. At 1-Hz stimulation, the amplitude and latency of P100 were measured. At 4-Hz stimulation, VEPs were Fourier-analyzed to obtain phase and amplitude of the second harmonic response (2F). At 1-Hz stimulation, P100 latencies were decreased for oblique stimuli compared with those for horizontal and vertical stimuli at lower spatial frequencies. Conversely, those for oblique stimuli were increased compared with those for horizontal and vertical stimuli at higher spatial frequencies. At 4-Hz stimulation, spatial tuning observed in 2F amplitude of the oblique gratings shifted to lower spatial frequencies when compared with those of vertical stimulation. The alteration of the VEP spatial frequency function caused by the oblique stimuli was in good agreement with the orientation effect observed in psychophysical studies. Our study may have a clinical implication in that VEP testing with stimuli in more than one orientation at slow and fast temporal modulations can be useful in evaluating neurological disease affecting the visual system.

Adult↗

Study on experimental motion sickness in children.

To clarify the characteristics of motion sickness in children we investigated autonomic nervous symptoms and instability evoked by walking while wearing horizontally reversing goggles in 90 children aged 4 to 15 years. Kindergarten children had hardly any autonomic nervous symptoms except headache; however, they often fell, could not stand up or move, and exhibited a to-and-fro deviation gait. Although the frequency and severity of sickness gradually increased during growth, the severity of gait disorder became milder as age increased. On the basis of these findings it seems likely that functions which perceive disorder of spatial orientation and action are immature in young children, and once spatial orientation is impaired, instability becomes very severe, since inadequate control is not stopped by an alarm function against disorientation.

Adolescent↗

Differential roles for visuospatial and verbal working memory in situation model construction.

Two experiments investigated the processing of the spatial and causal dimensions of situation models. In Experiment 1, participants read texts varying in spatial and causal demands while responding to on-line spatial and causal probes. Experiment 2 used the same design, but used texts that more tightly integrated spatial and causal information. In both experiments, spatially oriented dependent measures were generally influenced by spatial, but not causal, demands, whereas causally oriented measures were influenced by causal, but not spatial, demands. In addition, spatially oriented dependent measures were generally correlated with a measure of spatial working memory capacity, whereas causally oriented measures were correlated with a measure of verbal working memory capacity. These results indicate that spatial and causal dimensions of situation models are maintained and elaborated independently in different working memory subsystems.

Adult↗

Orienting a spatial attention--its reflexive, compensatory, and voluntary mechanisms.

Attention is a mechanism to select sensory information. It is a modulatory process which normally cannot be observed as overt responses. We have studied spatial attention using a new visual illusion of motion--line-motion effect: a line, which was presented physically at once, was perceived to be drawn from one side when attention was captured to that side of the line by a preceding visual cue stimulus. This effect was due to acceleration of visual information processing at the locus of attention. The motion illusion was produced by both stimulus-induced (bottom-up) and voluntary (top-down) attention, which suggested that the two kinds of attention act on relatively early stages of visual processing. The objective of this study was to examine how various modes of spatial attention might be represented and reorganized in the brain. Using the induction of illusory line motion as a measure we found that: (1) once attention is captured by a moving object, it follows the object as it moves; and (2) attention moves with a saccade in the retinal coordinates such that its focus remains fixed in space. We then asked whether attention acts across different sensory modalities. We found that both auditory and somatosensory cues induced focal visual attention in space where the cue was presented. Based on these findings we propose a model which would allow (1) matching of visual spatial information obtained across saccades, and (2) matching of spatial information obtained in different sensory modalities.

Adaptation, Physiological↗

Orienting attention based on long-term memory experience.

Attentional orienting and memory are intrinsically bound, but their interaction has rarely been investigated. Here we introduce an experimental paradigm using naturalistic scenes to investigate how long-term memory can guide spatial attention and thereby enhance identification of events in the perceptual domain. In the task, stable memories of objects embedded within complex scenes guide spatial orienting. We compared the behavioral effects and neural systems of memory-guided orienting with those in a more traditional attention-orienting task in which transient spatial cues guide attention. Memory-guided attention operated within surprisingly short intervals and conferred reliable and sizeable advantages for detection of objects embedded in scenes. Event-related functional magnetic resonance imaging showed that memory-guided attention involves the interaction between brain areas participating in retrieval of memories for spatial context with the parietal-frontal network for visual spatial orienting. Activity in the hippocampus was specifically engaged in memory-guided spatial attention and correlated with the ensuing behavioral advantage.

Adult↗

Dissociation of the contributions of the prefrontal cortex and dorsomedial thalamic nucleus to spatially guided behavior in the rat.

Rats with lesions of the medial frontal cortex or dorsomedial nucleus of the thalamus (MD) were studied in two spatial localization tasks: the Morris water task and the 8-arm radial arm maze. Rats with medial frontal lesions failed to learn to swim from different locations to a hidden platform located at a specific place in a large tank (Morris task) and were impaired at learning the location of reward in the radial arm maze. Rats with MD lesions were not impaired at spatial orientation in either task. The results provide the first unequivocal evidence of a spatial orientation deficit following frontal lesions and lend support to the notion that the frontal cortex forms part of a 'spatial mapping system'. The results suggest that although MD is the major afferent to the frontal cortex, it does not provide necessary spatially-relevant input.

Afferent Pathways↗

ST-vector orientation and location of myocardial perfusion defects during exercise.

In 34 patients with chest pain the spatial orientation of the ST-vectors in the exercise electrocardiogramm 30 and 80 msec after the end of QRS were compared with the location of exercise induced local defects of myocardial uptake of 201Tl. The following results were obtained: 1. The sensitivity and specifity of myocardial perfusion imaging after exercise were the same as those of exercise electrocardiograms; 2. No relation could be observed between the location of reduced 201Tl uptake during exercise and the spatial orientation of the ST-vectors.

Angina Pectoris↗

Vestibular ataxia following shuttle flights: effects of microgravity on otolith-mediated sensorimotor control of posture.

Orbital spaceflight exposes astronauts to an environment in which gravity is reduced to negligible magnitudes of 10(-3) to 10(-6) G. Upon insertion into earth orbit, the abrupt loss of the constant linear acceleration provided by gravity removes the otolith stimulus for vestibular sensation of vertical orientation constantly present on Earth. Since the central nervous system (CNS) assesses spatial orientation by simultaneously interpreting sensory inputs from the vestibular, visual, and proprioceptive systems, loss of the otolith-mediated vertical reference input results in an incorrect estimation of spatial orientation, which, in turn, causes a degradation in movement control. Over time, however, the CNS adapts to the loss of gravitational signals. Upon return to Earth, the vertical reference provided by gravitational stimulation of the otolith organ reappears. As a result, a period of CNS readaptation must occur upon return to terrestrial environment. Among the physiological changes observed during the postflight CNS readaptation period is a disruption of postural equilibrium control. Using a dynamic posturography system (modified NeuroCom EquiTest), 16 astronauts were tested at 60, 30, and 10 days preflight and retested at 1 to 5 hours, and 8 days postflight. All astronauts tested demonstrated decreased postural stability immediately upon return to Earth. The most dramatic increases in postural sway occurred during those sensory conditions in which both the visual and proprioceptive feedback information used for postural control were altered by the dynamic posturography system, requiring reliance primarily upon vestibular function for control of upright stance. Less marked but statistically significant increases in sway were observed under those conditions in which visual and foot support surface inputs alone were altered.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

Audio-visual dynamic remapping in an endogenous spatial attention task.

Several studies on cross-modal attention showed that remapping processes between sensory modalities occur in the spatial orienting of attention. One hypothesis that accounts for such links is that spatial attention operates upon representations of common locations in the external space. However, convincing evidence only exists for cross-modal links in spatial orienting, leaving the dynamics of these effects unexplored. Four experiments were designed to cope with this issue by having participants being involved in an endogenous orienting task to visual and auditory target stimuli. Targets on invalid trials were embedded into two different kinds of sequences of stimuli: (1) long sequences, wherein three valid trials in one modality preceded the invalid trial in the other modality; (2) short sequences, wherein only one valid trial in one modality preceded the invalid trial in the other modality. Results revealed modality-specific meridian effects in the short sequences, and a significant decrement of the modality-specific meridian effect in the long sequences. The results of these experiments indicate that cross-modal links in visual and auditory spatial attention are based on representations of common locations in the external space across sensory modalities. Moreover, the results strongly support the hypothesis that representations of space are dynamically built and updated according to task demands.

Acoustic Stimulation↗

Fast algorithm for estimation of the orientation term of a general quadrature transform with application to demodulation of an n-dimensional fringe pattern.

The spatial orientation of fringes has been demonstrated to be a key point in reliable phase demodulation from a single n-dimensional fringe pattern, regardless of the frequency spectrum of the signal. Recent publications have shown a general method for determination of the orientation factor by use of a regularized phase-tracking (RPT) algorithm. We propose a generalization of a RPT algorithm for estimation of the spatial orientation in a general n-dimensional case. The proposed algorithm makes use of a simplified cost function that remains one dimensional regardless of the dimension of the problem. This makes the calculation faster than with a standard RPT algorithm, with which it is necessary to minimize an n + 1-dimensional cost function for each point of the sample space. We have applied the method to the three-dimensional demodulation of a time-evolving fringe pattern, with good results.

Journal Article↗

Two firing patterns in the discharge of complex cells encoding different attributes of the visual stimulus.

The activity of complex neurones of area 17 was recorded in anaesthetized cats in response to sinusoidal drifting gratings of various orientations, spatial frequencies and contrasts. The responses of complex cells present two different firing patterns: spikes organized in clusters and spikes which do not show this organization ("isolated spikes"). The clustered component is the only one in the complex cell discharge which is tuned for spatial frequency and orientation, while the isolated spike component is correlated with the contrast of the stimulus.

Animals↗

The homeobox gene lim-6 is required for distinct chemosensory representations in C. elegans.

The ability to discriminate between different chemical stimuli is crucial for food detection, spatial orientation and other adaptive behaviours in animals. In the nematode Caenorhabditis elegans, spatial orientation in gradients of soluble chemoattractants (chemotaxis) is controlled mainly by a single pair of chemosensory neurons. These two neurons, ASEL and ASER, are left-right homologues in terms of the disposition of their somata and processes, morphology of specialized sensory endings, synaptic partners and expression profile of many genes. However, recent gene-expression studies have revealed unexpected asymmetries between ASEL and ASER. ASEL expresses the putative receptor guanylyl cyclase genes gcy-6 and gcy-7, whereas ASER expresses gcy-5 (ref. 4). In addition, only ASEL expresses the homeobox gene lim-6, an orthologue of the human LMX1 subfamily of homeobox genes. Here we show, using laser ablation of neurons and whole-cell patch-clamp electrophysiology, that the asymmetries between ASEL and ASER extend to the functional level. ASEL is primarily sensitive to sodium, whereas ASER is primarily sensitive to chloride and potassium. Furthermore, we find that lim-6 is required for this functional asymmetry and for the ability to distinguish sodium from chloride. Thus, a homeobox gene increases the representational capacity of the nervous system by establishing asymmetric functions in a bilaterally symmetrical neuron pair.

Animals↗

Cognitive efficiency in alcoholics and polysubstance abusers.

Previous studies have found alcoholics to be impaired on tests of cognitive efficiency. However, it is unclear to what extent individuals who abuse drugs in addition to alcohol exhibit similar deficits. To answer this question, 63 healthy control subjects were compared with 40 individuals who abused alcohol only, 24 individuals who abused alcohol and stimulants, 16 individuals who abused alcohol and marijuana, and 41 individuals who abused alcohol and depressants/narcotics, or alcohol and two or more other drugs. All subjects were administered tests of short-term memory, spatial orientation, visual-spatial perception, and problem-solving. Results from the study indicated that control subjects and individuals who abused both alcohol and marijuana performed significantly better than the other groups on most tests. These results were not attributable to differences on measures of affect or chronicity of alcohol consumption.

Adult↗