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Types and complications of femoral neck fractures in children.

This multicenter collaborative study was undertaken to review the types and complications of femoral neck fractures in children. It is a retrospective clinical and radiological review of 108 femoral neck fractures. Cases originated from four different pediatric hospitals. All the patients had plain radiographs. Fractures occurred at all ages (one day to 18 years), and 63% of the patients were boys. Forty-nine fractures were traumatic; 37 were pathologic, 19 were insufficiency fractures; and three were fatigue fractures. Unless the underlying bone was abnormal, significant high velocity trauma, fall from a height or other severe violence was required to fracture the femoral neck. A unicameral bone cyst was the underlying lesion in 40% of pathologic femoral neck fractures and malignancy in 35%. Osteoporosis as in myelodysplasia, osteogenesis imperfecta and from other causes was responsible for 52% of insufficiency fractures. Because of the unique osseous and vascular anatomy of the femoral head and neck in the growing child, these fractures have a high incidence of complications. Complications included avascular necrosis 13%, premature closure of the epiphyseal plate 12%, varus deformity 8.3%, and nonunion 3.7%. Unless there is a clear history of significant violence, a cause for a femoral neck fracture should be sought, e.g. an underlying bone lesion or a metabolic bone disease. These fractures are rare, but are serious injuries since their complications may lead to a life-long disability.

Adolescent↗

[Suicidal methods--a comparison between East and West Germany. Epidemiological, forensic and sociomedical aspects].

A comparative study of the means of suicide in West and East Germany is extremely difficult both because of the data stock and the methodological questions that arise. This examination analyses means of suicide used during the following years: 1962-1964, 1987-1989 and 2000-2002. Accordingly, there is a similar pattern in both East and West for type of suicide committed and distinct developmental parallelism in applying the suicide methods. Certain means of suicide are more prominent (e. g. "hanging", "falling from a height") while others decrease in significance (e. g. "drowning"). No link was found between means of suicide and "society order". The use of a certain means of suicide depends on "availability", "existence" or "accessibility" of opportunities to commit suicide in the everyday environment. The same trend towards an increase of "hard" means of suicide was noted. The ways in which suicide is committed are becoming increasingly alike, but in the East it is apparent that people adhere more to "traditional" means of suicide.

Adolescent↗

[Foot injury as a rare cause of scendosporiosis with fetal outcome].

After an attempted suicide with a fall from a height of 5 m, a 33 year old male suffered a subarachnoidal haemorrhage, an instable fracture of the second lumbar vertebra as well as a soft-tissue decollément in the vicinity of the right heel. Despite surgical management, the comatose patient showed slow wound-healing of the heel, making revision-surgery necessary 10 days after the first treatment. Fungi were histologically recognised, and subsequent culturing identified Scedosporium apiospermum. Systemic antimycotic therapy with itraconazol (800 mg/d) was immediately initiated. Despite this, S. apiospermum was repeatedly found in wound swabs over the following 2 weeks. After 4 weeks, a radiographically verified osteomyelitis of the calcaneus was diagnosed and local debridement was once again performed. After 5 days, an MRI of the cranium suggested an abscess in the posterior horn of the left lateral ventricle. Itraconazol was altered to voriconazol (4 mg/kg body weight). Neurosurgical opening of the abscess and subsequent culturing once again showed S. apiospermum. CT-scans performed over the following period showed an increase in lesions in the brain suggestive for numerous abscesses. At 78 days after the initial trauma, the still comatose patient died due to a massive cerebral haemorrhage. Microbiological assessment of the soil at the site of injury revealed S. apiospermum.

Adult↗

[Pelvic ring injuries].

PURPOSE: Analysis of the trauma patient of fractures of the pelvic ring and classification according to AO/Tile. METHODS: 125 unselected patients (43 females, 82 males) were evaluated retrospectively by conventional x-ray, and CT examinations included follow-studies. RESULTS: Type-A fractures were seen in 36 (29%), Type-B fractures in 58 (46%), and Type-C fractures in 31 (25%) cases. Type-B and Type-C fractures mainly occurred in patients with traffic accidents and falls from great height. Type-A fractures were seen most often in patients with accidents at home or at work. However, in patients with complex fractures a classification concerning Type-B or Type-C fractures was difficult. SUMMARY: Based on CT criterias, in most patients a statement concerning the applied forces, the stability of the pelvic rim and the fracture type can be made.

Fractures, Bone↗

Epidemiology of minimal trauma rib fractures in the elderly.

We determined the secular trends in the number and incidence of the elderly's minimal trauma rib fractures (typically caused by a fall from standing height or less) in Finland in 1970-1994 by collecting from the National Hospital Discharge Register all patients aged 60 years or more who were treated in Finnish hospitals in 1970-72, 1974-75, 1978-80, 1983-85, 1988-89, and 1991-94 for first rib fracture. The age-adjusted incidence of fractures slightly increased in both sexes, from 36 (1970) to 40 (1994) in women, and from 63 to 71 in men; in younger patients (aged 20-49 years) this incidence decreased from 10 to 6. The age-specific incidences increased especially in women aged 85 years and over, from 108 (1970) to 251 (1994). If this trend continues, the total number of hospital-admitted, minimal trauma rib fractures in Finnish elderly will increase from 576 (1994) to almost 1000 in the year 2010. We conclude that the number of the elderly's minimal trauma rib fractures is increasing in Finland, largely due to the increasing number of elderly in the Finnish population. Therefore, effective preventive measures are needed to keep this problem under control.

Adult↗

Conservative treatment of fractures of the thoracolumbar spine.

We reviewed 48 patients with thoracolumbar fractures treated conservatively between 1988 and 1999. The average follow-up was 77.5 (31-137) months and average patient age (23 women, 25 men) was 46 (18-76) years. Twenty-nine patients suffered a fall from a height and 13 patients were injured in traffic accidents. Thirty-two patients had compression-type fractures and 16 burst-type fractures. There were no neurological deficits. Twenty-nine patients were treated by orthosis, 13 by body cast and six by bed rest. In addition to pain and functional scoring, we measured a number of radiographic parameters at the time of admission and at latest follow-up and compared the values. In patients with compression fractures there were significant changes in scoliosis angle and wedging index (p<0.05). The mean pain score was 1.66 and mean functional score 1.03. In patients with burst fractures, vertebral index, wedging index and height loss increased after treatment (p<0.05). The mean pain score was 1.26 and functional score 0.93. Compression fractures with kyphosis angle <30 degrees are supposed to be stable and can be treated conservatively. If the kyphosis angle is more than 30 degrees, magnetic resonance imaging (MRI) should be performed, and if the posterior ligamentous complex is damaged, surgery should be considered. In burst fractures, MRI should always be performed and conservative treatment should only be considered if there is no neurological deficit and the ligaments are intact.

Adolescent↗

Epidemiology of hip fractures in Belgrade, Serbia Montenegro, 1990-2000.

INTRODUCTION: This study retrospectively determined the incidence rates of hip fractures in Belgrade, Serbia and Montenegro, during the period 1990-2000. MATERIALS AND METHODS: All patients with hip fractures treated at all Belgrade hospitals were identified from the Republic of Serbia's Ministry of Health National Health Care database. Patient demographics, type of hip fracture, and details of the mechanism of injury were collected. The annual incidence rates were calculated with interpolation according to the Belgrade population census of 1991 and 2002. RESULTS: There were a total of 8,904 hip fractures with a mean annual incidence of 51.7 per 100,000 adults (62.2 females and 35.5 males). Mean age at the time of fracture was 67 years (72.6 for females and 59.3 for males), with 64.7% of all fractures occurring in women. There was a significant increase in hip fracture incidence rates over the observed period in females (P = 0.006), but not in males (P = 0.962). Trochanteric fractures predominated, accounting for 53% compared with cervical fractures. In patients over 50 years of age there was an exponential increase in the incidence of hip fractures in both sexes; though more so in females. 91% of hip fractures occurred in these older patients with incidence rates of 143.6 per 100,000 (185.9 for female and 92.2 for male patients). The most common mechanism of injury in the older group was low-energy trauma (70.3%) resulting from a fall from standing height onto a flat surface (same level). Standardizing incidence rates in the older age group to the US 1985 white population gave values of 228 per 100,000 females and 96 per 100,000 males. These incidence rates are similar to those reported in Italy, France and Great Britain, but lower than those in Scandinavian countries. CONCLUSION: In view of growing population numbers and an increase in the proportion of patients aged over 60 years, we can expect an increase in the prevalence of osteoporosis and an increase in the incidence of fragility hip fractures in the future, with resource implications.

Adolescent↗

Voice monitoring to measure emotional load during short-term stress.

It is well known that there is a relationship between the voice the human emotional status. Previous studies have demonstrated that changes of fundamental frequency ( f(0)), in particular, have a significant relationship with emotional load. The aim of the present study was to investigate how f(0) changes in response to an unknown emotionally stressful task under real-life conditions. A further question was whether repetitions of this task lead to an adaptation of f(0), indicating a lower emotional load. The participants of this study included 26 healthy males. f(0) and heart rate ( f(c)) were recorded for baseline testing (BLT) under relaxed laboratory conditions. Then the participants were asked to negotiate a natural obstacle by way of sliding down a rope hanging from a handlebar without any safety provisions, thus being exposed to the danger of a fall from a height of up to 12 m into shallow water (guerrilla slide I, GSI). The task was repeated after 30 min (GSII) and after 3 days of physical strain (GSIII). Immediately before starting the task the participants were asked to give a standardised speech sample, during which f(c) was recorded. The mode value of f(0) ( f(0,mode)) of the speech samples was used for further analysis. The mean (SD) value of f(0,mode) at BLT was 114.9 (14.8) Hz; this increased to 138.8 (19.6) Hz at GSI ( P<0.000), decreased to 135.9 (19.6) Hz at GSII and to 130.0 (21.5) Hz at GSIII ( P=0.012). The increase in f(c) was significantly different from BLT to GSI ( P<0.000). The repetitions of the task did not produce significant changes in f(c). It was shown that f(0,mode) is a sensitive parameter to describe changes in emotional load, at least in response to short-term psychoemotional stress, and seems to throw light upon the amount of adaptation caused by increased experience.

Adult↗

Endovascular treatment of a direct post-traumatic carotid-cavernous fistula with electrolytically detachable coils.

Carotid-cavernous fistulae are abnormal communications between the internal carotid artery and venous compartments of the cavernous sinus. Fistulae are uncommon but well-documented sequelae of craniofacial trauma. The characteristic clinical presentation includes ocular pain, chemosis, exophthalmus and visual disturbances. We report on a 28-year-old man with a history of severe craniocerebral injury, including multiple craniofacial fractures resulting from a fall from a height of approximately 6 meters, who was surgically treated one year ago. Two months before presentation, the patient began to exhibit progressive chemosis, proptosis, eyelid swelling, diplopia and exophthalmus. Computerized tomography and computerized tomographic angiography revealed findings consistent with a carotid-cavernous fistula of the right side of the cavernous sinus with dilatation of the right ocular vein. Digital subtractional angiography of the right internal carotid artery revealed a fistula between the cavernous part of the artery and the right cavernous sinus. There was only minimal blood flow in the supraclinoid part of the internal carotid artery because of the high pressure within the fistula. Our decision was to try to occlude the fistula by means of endovascular embolization. The origin of the fistula in the internal carotid artery was successfully obliterated with seven electolytically detachable coils. Control digital subtractional angiography at the end of the procedure demonstrated minimal residual flow through the fistula. Two months after the treatment, angiographic control revealed complete obliteration of the fistula. Clinical examination showed total resolution of signs and symptoms of a carotid-cavernous fistula. Endovascular transarterial embolization of carotid cavernous fistulae is a widely accepted, safe and successful treatment option. In the case that we describe we occluded the fistula and right cavernous sinus with electrolytically detachable coils that we could place into the sinus. Other endovascular treatment options include the use of detachable balloons, stent placement, transvenous embolization or surgical ligation of the fistula.

Adult↗

Reliability of vacuum phenomenon in the sacroiliac joint as a sign of traumatic injury.

OBJECTIVE: To determine whether a vacuum phenomenon in the sacroiliac joint is a reliable sign of pelvic injury in trauma patients. MATERIALS AND METHODS: Prospective data were collected over a 1-year period for 107 patients with pelvic trauma and 104 nontrauma patients. Age ranges were 13-93 years in the trauma group and 19-83 years in the nontrauma group. All the patients had pelvic CT scans. The cases were assessed with regard to gas in the sacroiliac joint, osseous pelvic injuries, and mechanism of injury, and demographic data were analyzed. Injuries were caused by motor vehicle accidents in 67 cases, pedestrians being struck by a motor vehicle in 20, falling from a height in 18, gunshot wound in 1, and crush injury in 1. The indications for CT scan in the nontrauma patients were pain in 33 cases, infection in 31, cancer in 29, transplant in 5, bleeding in 4, and abnormal liver function tests in 2. RESULTS: Gas in the sacroiliac joint was present in 11 out of 107 trauma patients (10%) and 12 out of 104 nontrauma patients (12%). There was no statistical difference in the incidence of the vacuum phenomenon between the two patient populations according to the Chi(2) test. Degenerative sacroiliac changes were evident in 18 out of 107 trauma patients (17%) and 32 out of 104 nontrauma patients (41%). CONCLUSION: Gas in the sacroiliac joint is not a reliable indicator of sacroiliac joint injury.

Journal Article↗

Multidetector CT in shoulder fractures.

The aim of this study was to assess the multi-detector computed tomography (MDCT) findings in acute shoulder traumas compared to radiographic findings in patients referred to a level one trauma center. Two hundred and ten patients (128 male, 82 female, age 16-95 years, mean age 51.7 years) underwent shoulder MDCT due to acute trauma. Three main mechanisms of injury were established: falling (113 patients, 54%), traffic accidents (36 patients, 17%) and falling from a height (12 patients, 6%). Based on MDCT, a total of 311 fractures--152 in the scapula and 159 in the proximal humerus--occurred in 191 (91%) of the 210 patients. The two most common occult fractures were lesser tubercle and coracoid process fractures. In 20 (63%) of the patients with a comminuted fracture of proximal humerus the exact number of fracture fragments was underestimated in radiographs. MDCT with multiplanar reconstructions (MPR) is a recommended complementary examination in patients with complex proximal humerus fractures where the extent of the fractures and the position or origin of dislocated fragments is not clear on radiography. This may increase the accuracy of the fracture classification and reveal occult fractures in other parts of the shoulder.

Adolescent↗

The depolarizing action of 5-HT on mammalian non-myelinated nerve fibres.

The effects of 5-hydroxytryptamine (5-HT) on nerve fibres in the rabbit cervical vagus and on the sciatic nerve "in vitro" were studied by the single sucrose-gap technique. The addition of 5-HT to the Locke solution bathing the vagus nerve induced rapid depolarization and a fall in spike height at the threshold concentration of 1 X 10(-7) M. In most cases the depolarizing effect was completely reversed by washing 5--10 min while in about 40% of the preparations the action potential amplitude remained 10--30% below the control level. These effects were dose-related up to a maximum concentration of 3 X 10(-5) M. Tachyphylaxis was not observed when the drug was added at 12--15 min intervals. Depolarization was abolished by perfusing the nerve with sodium-free medium or by previous exposure to lidocaine (10(-3) M). External hyperpolarizing currents (10(-7) to 10(-6) A) were not able to restore the action potential amplitude. Cyproheptadine (50 micron), which was found to have a slight local anesthetic action, reduced the 5-HT-induced depolarization by 20--30%. Methysergide (50 micron), a more specific 5-HT antagonist, did not affect the action of 5-HT. 5-HT was inactive when applied to the myelinated fibres of the sciatic nerve. Our results indicate that 5-HT-induced depolarization appears to be related to an increase in the resting sodium permeability of nerve fibres.

Action Potentials↗

A dose-ranging study of the efficacy and safety of azelastine nasal spray in the treatment of seasonal allergic rhinitis with an acute model.

BACKGROUND: Oral azelastine, a nonsteroidal antiinflammatory respiratory investigational drug has demonstrated activity in the treatment of allergic rhinitis and asthma with a good safety profile. METHODS: Azelastine nasal spray was compared with sustained-release oral chlorpheniramine maleate and placebo for efficacy and safety in the treatment of seasonal allergic rhinitis in a double-dummy, two-center, 2-day, double-blind, randomized, dose-ranging, parallel-groups, onset and duration of action study. Two hundred sixty-four subjects reported to an outdoor park on Saturday morning during the height of the fall pollen season and remained there for 8 hours that day and the next to ensure maximal exposure to seasonal aeroallergens. Symptom diary cards were collected hourly Saturday from 8:00 AM to 10:00 AM (baseline period). Subjects who had sufficient symptoms were randomized into five groups and received medication at 10:00 AM and 10:00 PM on Saturday and at 10:00 AM on Sunday: azelastine 0.1% (1 spray [0.12 mg] per nostril every 12 hours, 2 sprays per nostril every every 12 hours, or 2 sprays per nostril once daily), Chlor-Trimeton Repetabs (12 mg twice daily), or placebo (twice daily). Diary cards were completed hourly (11:00 AM to 4:00 PM) and at 6:00, 8:00, and 10:00 PM on Saturday and again hourly on Sunday (from 8:00 AM to 4:00 PM) to evaluate rhinitis symptoms and adverse events. RESULTS: Two hundred fifty-nine subjects completed the study. The groups that received 2 sprays of azelastine per nostril once and twice daily and the chlorpheniramine group had statistically significantly more improvement in total rhinitis symptoms than the placebo group without serious adverse events. CONCLUSIONS: This study supports a once to twice daily dosing regimen for 2 sprays of 0.1% azelastine in the acute treatment of allergic rhinitis with onset of action within 2 to 3 hours.

Administration, Intranasal↗

Regulation of thyroid follicular volume by bidirectional transepithelial ion transport.

Previous studies have shown that thyroid cells in monolayer culture exhibit bidirectional ion transport comprising apical-to-basal amiloride-sensitive Na+ transport and oppositely directed bumetanide-sensitive Cl- transport. We have now investigated the role of ion transport in the regulation of thyroid follicular size using follicular primary porcine thyroid cell cultures. Bumetanide (10 microM) added at the beginning of culture inhibited the formation of follicular lumina and caused a fall in follicle height when added to 3-day-old cultures. In contrast, phenamil (1 microM; an amiloride analog) increased follicle size both in freshly isolated and 3-day-old cultures. The effect of bumetanide was prevented by the prior addition of phenamil. Micropuncture studies showed that follicles had a lumen-negative, basal-positive transepithelial potential difference which was progressively reduced in magnitude by the serial addition of bumetanide (10 microM) and phenamil (1 microM). We conclude that thyroid follicles possess a bidirectional ion transport system which transports Na+ in an apical-to-basal direction and Cl- in the opposite direction. The balance between these two processes determines net solute flux and hence follicular size. A physiological role of ion transport in the thyroid may be to regulate follicular volume suggesting that abnormalities of ion transport may be responsible for disorders of follicular size.

Animals↗

Abdominal wall hematoma: case report and subject review.

Presented is a case of abdominal wall hematoma following a fall from a height of 20 feet. This emergency department course illustrates the diagnostic dilemma that frequently accompanies this entity. The patient was discharged from the hospital without further complication following an extensive workup and 48 hours of observation. Pathophysiology, evaluation, and treatment are then discussed in detail.

Abdominal Muscles↗

Defenestration and dehiscence: suicide or homicide?

Wound rupture or dehiscence is usually encountered clinically following failure of healing after surgery or less often after major trauma. This article describes a case of wound dehiscence resulting from a fall from a height. In this incident there was initial uncertainty concerning the manner of death. In view of a gaping abdominal wound, the police officers first on the scene were suspicious that the deceased had been the victim of an assault.

Journal Article↗

Maxillofacial fracture repairs.

Oral trauma remains a common presentation in a small animal practice. Most fractures are the result of vehicular accidents. Among other causes are falls, kicks, gunshots wounds, and encounters with various hard objects ranging from baseball bats and golf clubs to horse hooves and car doors. Next in popularity are dog fights, especially when a large dog and a small dog are involved, and fights with other animals. With cats, falls from various heights are responsible for a large percentage of presentations.

Animals↗

Shaken baby syndrome: a biomechanics analysis of injury mechanisms.

Traumatic infant shaking has been associated with the shaken baby syndrome (SBS) diagnosis without verification of the operative mechanisms of injury. Intensities for SBS have been expressed only in qualitative, unsubstantiated terms usually referring to acceleration/deceleration rotational injury and relating to falls from great heights onto hard surfaces or from severe motor vehicle crashes. We conducted an injury biomechanics analysis of the reported SBS levels of rotational velocity and acceleration of the head for their injury effects on the infant head-neck. Resulting forces were compared with experimental data on the structural failure limits of the cervical spine in several animal models as well as human neonate cadaver models. We have determined that an infant head subjected to the levels of rotational velocity and acceleration called for in the SBS literature, would experience forces on the infant neck far exceeding the limits for structural failure of the cervical spine. Furthermore, shaking cervical spine injury can occur at much lower levels of head velocity and acceleration than those reported for the SBS. These findings are consistent with the physical laws of injury biomechanics as well as our collective understanding of the fragile infant cervical spine from (1) clinical obstetric experience, (2) automotive medicine and crash safety experience, and (3) common parental experience. The findings are not, however, consistent with the current clinical SBS experience and are in stark contradiction with the reported rarity of cervical spine injury in children diagnosed with SBS. In light of the implications of these findings on child protection and their social and medico-legal significance, a re-evaluation of the current diagnostic criteria for the SBS and its application is suggested.

Acceleration↗