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Measuring the attentional speed-up in the motion induction effect.

Motion induction is the illusory motion within an elongated stimulus, such as a bar or a line, when it is preceded by a priming stimulus next to one of its ends. Motion is away from this primer. The presentation of two priming spots at both ends of a stimulus bar results in motion away from both spots with a collision in the center of the bar. With a sufficiently long delay between the spots, motion will be seen only as away from the second spot. Similarly, in a bar with a luminance gradient an illusory motion is perceived as away from the high-luminance end, presumably due to the known dependence of neural processing speed on luminance. In the present study, these two illusory motions were made to oppose each other. The particular luminance gradient which would just cancel the motion induction effect when motion is seen optimally as away from the second spot (cancellation gradient) was determined, resulting again in a collision near the center of the bar. Furthermore, the luminance dependence of the reaction time to stimulus detection was measured in a separate experiment. Thus for each observer, the processing time difference associated with the cancellation gradient was established. This delta t then gives the amount of time by which processing is speeded up in motion induction due to the priming spot. In a simple model of motion processing it can also be identified as the built-in delay delta t of a typical Reichardt-type motion detector. With the present conditions, it varied between 14 and 19 msec for different observers for a bar length of 5.3 deg. In this way, we show not only that the priming effect in motion induction can be understood as a speed-up of neural processing, but also provide a way of measuring the times involved. In additional experiments, we examined the effect of bar length and luminance profile. These results allow us to estimate the gradients of the attentional fields.

Attention↗

Working memory deficits in chronic fatigue syndrome: differentiating between speed and accuracy of information processing.

To examine the relative influence of speed of information processing versus working memory ability, CFS participants with psychiatric comorbidity (CFS-Psych) and CFS without a psychiatric history (CFS-noPsych) were examined on tests of visual and auditory processing speed and visual and auditory working memory. Compared to healthy controls (HC) and a group of participants with rheumatoid arthritis (RA), the CFS-noPsych group displayed significantly reduced performance on tests of information processing speed, but not on tests of working memory. No significant differences were observed between the CFS-Psych group and any other group in the study. The implications of group heterogeneity on the understanding of cognitive impairment in CFS are discussed.

Adult↗

Neurobehavioral performance of adult and adolescent agricultural workers.

There are many occupational hazards associated with working in agriculture including risk of injury and exposure to pesticides. Research examining neurobehavioral effects of pesticide exposure have focused primarily on the acute effects in adults working in agriculture. Organophosphate poisoned populations have shown a consistent pattern of deficits when compared to a non-exposed or non-poisoned population on measures of motor speed and coordination, sustained attention, and information processing speed. Fewer studies have examined the effect of long-term low-level exposure on nervous system functioning in agricultural workers. Pesticides are thought to pose a considerably higher risk to children than to adults, yet little is known about the extent or magnitude of health problems related to occupational exposure to pesticides in children and adolescents. The present study compared the neurobehavioral performance of adolescents and adults working in agriculture and examined the impact of years working in agriculture on neurobehavioral performance. One hundred seventy-five Hispanic adolescent and adults completed a neurobehavioral test battery consisting of 10 computer-based tests measuring attention, response speed, coordination and memory. Age, gender, school experience, and years working in agriculture all impacted performance on the neurobehavioral tests. Comparison of adult and adolescents did not reveal decreased neurobehavioral performance in adolescents. On several tests the adolescents performed better than adult counterparts. The adolescents and adults were engaged in comparable agricultural working environments at the time of the neurobehavioral testing. These findings suggest that, at the time of exposure to pesticides, adolescents are not more vulnerable to the effects of working in agriculture. Evidence from this study suggests that cumulative exposure to low levels of pesticides over many years of agricultural work is associated with neurological impairment as measured by the Selective Attention, Symbol-Digit, Reaction Time tests. Experience handling pesticides was also associated with deficits in neurobehavioral performance.

Adolescent↗

Improving language and literacy is a matter of time.

Developmental deficits that affect speech perception increase the risk of language and literacy problems, which can lead to lowered academic and occupational accomplishment. Normal development and disorders of speech perception have both been linked to temporospectral auditory processing speed. Understanding the role of dynamic auditory processing in speech perception and language comprehension has led to the development of neuroplasticity-based intervention strategies aimed at ameliorating language and literacy problems and their sequelae.

Animals↗

Spatial-temporal characteristics of perceptual organization following acquired brain injury.

OBJECTIVE: To assess characteristics of perceptual organization following brain injury. RESEARCH DESIGN: A repeated measures between groups design. METHODS: Perceptual thresholds were compared between 10 persons with brain injury and 10 demographically matched healthy control subjects. Ten young control subjects were also tested to evaluate effects of normal ageing on these processes. Participants viewed stimuli on a computer monitor in which regularities existed in either the spatial or temporal domain. Psychophysical measurements were made of perceptual thresholds, as well as time required to process stimuli. RESULTS: Relative to age-matched control subjects, patients were impaired on all measures, with greatest deficits in conditions that contained a temporal component. Impairment did not occur with normal ageing. CONCLUSIONS: These results reflect cognitive impairment resulting from reduced cortical integrative function as well as reduced information processing speed. Such deficits at this level of processing likely impact subsequent perceptual function, such as object recognition.

Adolescent↗

Cognitive dysfunction in schizophrenia: a new set of tools for the assessment of cognition and drug effects.

Cognitive impairment in schizophrenia must be seen as a disturbance of cortico-sub-cortical connectivity with a neurotransmitter imbalance in a circuitry system, which connects thalamic input with prefrontal processing and supplementary motor cortex and basal ganglia output. The concept of maze-solving behaviour as a continuous cognitive task evoking a conflict between prefrontal cortex and basal ganglia activity is explained and introduced to distinguish between the effects of D2 blocking agents and substances with a predominant 5HT2A receptor affinity, such as clozapine and risperidone. Complex mazes show a cognitive deficit in untreated schizophrenic patients that are impaired by conventional and improved by atypical antipsychotic substances. Processing speed improves most on clozapine, while parallel processing is best supported by the non-sedative atypical substance risperidone. Maze paradigms are presented.

Antipsychotic Agents↗

The Ruff 2 and 7 Selective Attention Test: a neuropsychological application.

The neuropsychological application of the Ruff 2 and 7 Selective Attention Test as a measure of visual selective attention was investigated. The instrument was constructed as a paper-and-pencil approach to evaluate sustained attention utilizing different distractor conditions in the study of voluntary or intentional aspects of attention. Four patient groups with cerebral lesions confined to either the right or left anterior or left or right posterior region (ns = 8, 8, 8, 6) were studied. Patients with right-hemispheric lesions showed a greater over-all reduction in processing speed independent of the serial or parallel processing mode in comparison to individuals with left-sided lesions. Furthermore, as predicted, the two groups with anterior brain damage showed a larger discrepancy between serial and parallel processing modes than patients with posterior lesions. Specifically, the right frontal cases showed the greatest differential of accuracy on the serial and parallel tasks.

Adult↗

[Intervention in dyslexic disorders: phonological awareness training].

Taking into account the systems for the treatment of brain information when drawing up a work plan allows us to recreate processing routines that go from multisensory perception to motor, oral and cognitive production, which is the step prior to executive levels of thought, bottom-up and top-down processing systems. In recent years, the use of phonological methods to prevent or resolve reading disorders has become the fundamental mainstay in the treatment of dyslexia. The work is mainly based on phonological proficiency, which enables the patient to detect phonemes (input), to think about them (performance) and to use them to build words (output). Daily work with rhymes, the capacity to listen, the identification of phrases and words, and handling syllables and phonemes allows us to perform a preventive intervention that enhances the capacity to identify letters, phonological analysis and the reading of single words. We present the different therapeutic models that are most frequently employed. Fast For Word (FFW) training helps make progress in phonematic awareness and other linguistic skills, such as phonological awareness, semantics, syntax, grammar, working memory and event sequencing. With Deco-Fon, a programme for training phonological decoding, work is carried out on the auditory discrimination of pure tones, letters and consonant clusters, auditory processing speed, auditory and phonematic memory, and graphophonological processing, which is fundamental for speech, language and reading writing disorders. Hamlet is a programme based on categorisation activities for working on phonological conceptualisation. It attempts to encourage the analysis of the segments of words, syllables or phonemes, and the classification of a certain segment as belonging or not to a particular phonological or orthographical category. Therapeutic approaches in the early phases of reading are oriented towards two poles based on the basic mechanisms underlying the process of learning to read, the grapheme phoneme transformation process and global word recognition. The interventionalist strategies used at school are focused on the use of cognitive strategy techniques. The purpose of these techniques is to teach pupils practical strategies or resources aimed at overcoming specific deficiencies.

Child↗

Color naming deficits and attention-deficit/hyperactivity disorder: a retinal dopaminergic hypothesis.

BACKGROUND: Individuals with Attention-Deficit/Hyperactive Disorder (ADHD) have unexplained difficulties on tasks requiring speeded processing of colored stimuli. Color vision mechanisms, particularly short-wavelength (blue-yellow) pathways, are highly sensitive to various diseases, toxins and drugs that alter dopaminergic neurotransmission. Thus, slow color processing might reflect subtle impairments in the perceptual encoding stage of stimulus color, which arise from hypodopaminergic functioning. PRESENTATION OF HYPOTHESES: 1) Color perception of blue-yellow (but not red-green) stimuli is impaired in ADHD as a result of deficient retinal dopamine; 2) Impairments in the blue-yellow color mechanism in ADHD contribute to poor performance on speeded color naming tasks that include a substantial proportion of blue-yellow stimuli; and 3) Methylphenidate increases central dopamine and is also believed to increase retinal dopamine, thereby normalizing blue-yellow color perception, which in turn improves performance on the speeded color naming tasks. TESTING THE HYPOTHESIS: Requires three approaches, including:1) direct assessment of color perception in individuals with ADHD to determine whether blue-yellow color perception is selectively impaired; 2) determination of relationship between performance on neuropsychological tasks requiring speeded color processing and color perception; and 3) randomized, controlled pharmacological intervention with stimulant medication to examine the effects of enhancing central dopamine on color perception and task performance IMPLICATIONS OF HYPOTHESIS: If substantiated, the findings of color perception problems would necessitate a re-consideration of current neuropsychological models of attention-deficit/hyperactivity disorder, guide psycho-education, academic instruction, and require consideration of stimulus color in many of the widely used neuropsychological tests.

Journal Article↗

Cognitive processes in the development of TOL performance.

Components of executive function continue to develop through adolescence. There is limited knowledge of how these cognitive components impact complex cognitive function requiring their integration. This study examines the development of response planning, a complex cognitive function, and the contributions of selected cognitive processes, including speed of processing, response inhibition, and working memory to its development. We tested 100 healthy 8-30 year old individuals with a computerized version to the Tower of London (TOL) task and cognitive oculomotor tests including the visually guided saccade, oculomotor delayed response, and antisaccade tasks. Speed of processing, response inhibition, working memory, and TOL performance all demonstrated maturation in adolescence. While all processes were correlated with the development of TOL performance, antisaccade performance showed the strongest association indicating an important role for response inhibition in planning. These results indicate that the development of converging cognitive processes in adolescence, including response inhibition and working memory, support response planning and may serve as a model for the development of performance in other complex problem solving tasks.

Adolescent↗

Facial identity and facial emotions: speed, accuracy, and processing strategies in children and adults.

As yet, nearly all studies in face and facial affect recognition typically provide only data on the accuracy of processing, invariably also in the absence of reference data on abstract information processing. In this study, accuracy and speed of abstract visuo-spatial processing, face recognition, and facial emotion recognition were investigated in normal school children (7-10 years) and adults (25+/-4 years). In the age range of 7-10 years, accuracy of facial processing hardly increased, while speed did substantially increase with age. Adults, however, were substantially more accurate and faster than children. Differences between facial and abstract information processing were related to type of processing strategy, that is, configural or holistic processing versus featural or piecemeal processing. Improvement in task performance with age is discussed in terms of an enhanced efficiency of the configural organization of facial knowledge (facial information processing tasks), together with a further increase in processing capacity (all tasks). The differential developmental course of speed and accuracy levels indicates that speed is a more sensitive measure when children get older. Moreover, it also suggests that speed of performance, in addition to accuracy, might be successfully used in the assessment of clinical deficits, as has recently been demonstrated in children with autistic disorders of social contact.

Adult↗

The genetic basis of the relation between speed-of-information-processing and IQ.

The relationship of speed-of-information-processing (SIP), as derived from reaction times (RTs) on experimental tasks, and intelligence has been extensively studied. SIP is suggested to measure the efficiency with which subjects can perform basic cognitive operations underlying a wide range of intellectual abilities. Observed phenotypic correlations between RT and IQ typically are in the -0.2 to -0.4 range, and the question is addressed to what extent this relationship is determined by genetic or environmental influences. In a group of Dutch twins the heritabilities for RT tasks at age 16 and 18 years were estimated longitudinally and the nature of the RT-IQ relationship was investigated. At age 16 years heritabilities for a simple reaction time (SRT) and choice reaction time (CRT) were 64 and 62% and the average phenotypic correlations between the RTs and IQ, assessed by the Raven standard progressive matrices, was -0.21. At the second test occasion lower heritabilities were observed for the RTs, probably due to modifications in administration procedures. The mean correlations between the RTs and WAIS verbal and per formal subtests were -0.18 and -0.16. Multivariate genetic analyses at both ages showed that the RT-IQ correlations were explained by genetic influences. These results are in agreement with earlier findings (Baker et al., Behav Genet 1991;21:351-67; Ho et al., Behav Genet 1988;18:247-61) and support the existence of a common, heritable biological basis underlying the SIP-IQ relationship.

Adolescent↗

A simple clinical assessment of attention in schizophrenia.

Although attentional dysfunction is considered a predominant feature of schizophrenia, it is seldom quantitatively assessed in clinical practice. A simple paper-and-pencil test of selective attention (Ruff et al., 1986) provides a 5-min assessment with theoretical relevance for schizophrenia. Thirty schizophrenic subjects performed the 2 and 7 Selective Attention Test, which measures speed and accuracy, and compares controlled and automatic information processing. Ninety percent of the subjects displayed automatic processing. Speed was severely impaired, and accuracy was less so. Sixty-seven percent of the schizophrenic subjects performed in the normal range (+/-1 SD) for accuracy, but only 23% scored in the normal range for speed. Speed and accuracy were moderately correlated. Although theories of a lateralized deficit were not supported, the results are consistent with a hypothesized frontal lobe dysfunction. The automatic processing demonstrated may represent old learning. Poor controlled processing may preclude the acquisition of automatic functioning. This selective attention test may provide a measure of severity of cognitive impairment relevant to daily life functioning.

Adult↗

Verbal knowledge and speed of information processing as mediators of age differences in verbal fluency performance among older adults.

Age-related declines in verbal fluency among a large sample of older adults were investigated. Background variables, verbal knowledge, and speed of processing were examined as predictors of verbal fluency and as mediators of age effects. As expected, age-related declines were greater on the excluded letter fluency task than on the initial letter fluency task. Verbal knowledge was a better predictor of initial letter fluency than speed of processing, whereas the reverse was true for excluded letter fluency. However, speed of processing accounted for more of the age-related variance in both fluency measures than the other predictors. There was no evidence of verbal knowledge compensating for age-related declines in verbal fluency. Results suggest that verbal fluency performance is well maintained in late life and that any age-related decline appears to be mainly due to declines in speed of information processing.

Aged↗

Chest radiography: a survey of techniques and exposure levels currently used.

In diagnostic radiology, the routine measurement of exposure levels for a reference patient is an important part of an effective quality assurance program. In the United States, chest radiography is the most frequent examination and has the lowest exposure level of all radiologic examinations. We estimated the amount of exposure an average patient received from both manual and automatic exposure-controlled radiographic techniques by using a "patient-equivalent" chest phantom during measurements. A densitometric procedure was used to assess processor performance. The mean exposure from 194 chest systems was 20 mR (5.16 X 10(-5) C/kg); the mean film density, 1.38; and the mean processing speed, 108. It is interesting to note that a wide range of radiographic techniques, processing conditions, and screen-film speeds are currently being used. With the information given in our study, investigators can begin to identify the problems that lead to unusual exposure levels and, perhaps, poor image quality.

Animals↗

Phonological neighbors speed visual word processing: evidence from multiple tasks.

The author investigated the role of phonological neighborhood on visual word recognition. Using a lexical decision task, the author showed in Experiment 1 that words with large phonological neighborhoods were processed more rapidly than those with smaller phonological neighborhoods. This facilitative effect was obtained even when the nonword fillers had the same number of phonological neighbors as the words. This finding indicates that phonological neighbors speed processing within the phonological system. In the next 2 experiments, this claim was further tested using the naming and semantic categorization tasks. In both experiments, the effect of phonological neighborhood was found to be facilitative. The results across all 3 experiments indicate that phonology is central to visual word recognition and that phonological neighborhood provides a reliable measure of phonological processing.

Humans↗

Auditory ERPs to non-target stimuli in schizophrenia: relationship to probability, task-demands, and target ERPs.

The effects of task demands and stimulus probability on the N1 and P2 components of the auditory event-related potential (ERP) to non-target stimuli were investigated in normal and medicated schizophrenic subjects. Subjects either read a book while tones were presented, or counted the rare (low probability) tones in an auditory oddball paradigm. The mismatch negativity to rare tones in the reading condition was present, and did not differ between groups. N1 amplitude was smaller in schizophrenic patients in all conditions. When subjects counted the rare tones, the amplitude and latency of P2 increased. This task-related effect on P2 was much greater in control than in schizophrenic subjects. Difference ERPs were used to better characterize the effect of task demands by subtracting the ERP in the reading condition from the ERP in the counting condition. The difference ERP consisted of a negative deflection at 182 ms, and a positive deflection at 276 ms, which were both reduced in schizophrenic subjects. N2 and P3 amplitude to target stimuli were reduced in patients as well, but these abnormalities were uncorrelated with N1 and P2 abnormalities to non-target stimuli. Despite automatic registration of stimulus mismatch, and normal processing speed, patients showed deficient task-related modulation of processing to both non-target and target stimuli. Reduction of N1 amplitude in schizophrenia occurs regardless of task demands, and may reflect a chronic, early-stage disturbance in information processing.

Acoustic Stimulation↗

Impact of ADHD on the neurocognitive functioning of adolescents with bipolar disorder.

BACKGROUND: Pediatric Bipolar Disorder (BD) has been associated with a number of neurocognitive deficits not dissimilar to ADHD. This study compared neuropsychological profiles of 4 groups of adolescents (14-17 years): 41 Normal Controls (NC), 30 ADHD, 12 BD and 12 combined (BD+ADHD). METHODS: Participants were identified according to a standardized protocol (WASHU-KSADS mood section, K-SADS-PL and Conners Scales) and completed tests of processing speed, memory, executive functioning, set shifting, and inhibition. ADHD adolescents on stimulant medication did not take it on the day. RESULTS: After controlling for covariates, the ADHD-only and combined groups were most impaired, including processing and naming speed, working memory, and response inhibition. The ADHD-only group showed specific impairment in naming objects, numbers and letters than the NC and showed greater deficits than the BD-only group on tests of naming speed. The combined group showed greatest deficits in verbal memory and inhibitory control. Other than working memory, there were no differences between the BD-only and NC groups. Removal of BD-NOS did not impact on the results. CONCLUSIONS: This study failed to find broad neurocognitive deficits in BD-only adolescents. Only those with comorbid ADHD showed cognitive deficits, highlighting the impact ADHD may have on neurocognitive functioning of BD.

Adolescent↗