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At least 523 records · Page 29Linked to original sources
PubMed1976

[Neuroleptics and continuous measurement of intracranial pressure].

Neurosurgical patients, whether injured or not, have benefited in recent years from a new technique of supervision, measurement of thr intracranial pressure (ICP). Thus, measurement of a pressure figure and its course, gives precious information, both diagnostic and therapeutic. Various techniques of measurement are now proposed. We chose, for special reasons, measurement of the ICP within the ventricle. A catheter is introduced into the ventricle through a trephine hole. It is linked by a liquid column to a recording system (cathode oscilloscope, ink writer or magnetic tape). A slow inscriber permits continuous recording of the ICP for several days or even weeks. In view of the narrow dependency of the ICP on other physiological parameters, it seemed to us essential to record simultaneously 5 other parameters, the temperature, the blood pressure, the central venous pressure, the heart rate and the respiratory ventilation, by measurement of FeCO2 (capnography). Several forms of treatment have been proposed to bring down a raised ICP (greater than 15 mm Hg), e.g. osmotic diuresis, hyperventilation, corticosteroid therapy. Removal of CSF by ventriculalar catheter, sometimes permits one to pass over the critical period. It was in this background that we attempted to analyse the effect of neuroleptics on the ICP, without attempting to explain their mechanism of action. Our study was of 10 patients with cranial trauma, of both sexes, aged from 14 to 60 years. The intracranial pressure was measured within the ventricle and correlated with the other physiological parameters. When the ICP was normal, e.g. primary lesion of the brain stem, administration of neuroleptics such as chlorpromazine 100 mg IV/24 hours, or levopromazine 50 mg IV/24 hours, does not modify the value of the ICP. On the other hand, in the case of raised intracranial pressure due to contusion with cerebral oedema, for example, the administration of neuroleptic drugs seems to provide a very slight reduction in this pressure. It would be interesting to measure, at the same time as the ICP, the cerebral blood flow.

Adolescent↗
PubMed1991

[Malignant neuroleptic syndrome in a 15-year old girl after a single injection of a high-dose neuroleptic].

The malignant neuroleptic syndrome is a rare and fatal iatrogenic syndrome which requires rapid and effective symptomatic treatment in a somatic hospital, possibly in an intensive care unit. Relatively little medicine (neuroleptics) is employed in child psychiatry and the syndrome is, therefore, rare in child psychiatric departments. A well-defined syndrome is concerned and it is important to be able to recognise and diagnose this.

Adolescent↗
PubMed1975

[Anesthesia in reoperations in abdominal surgery].

Fifty one patients from different surgical units, hence anesthetized by different anaesthesists, underwent reinterventions in abdominal surgery. The indications for the first intervention essentially involved the supra-mesocolic region of the abdomen (62 out of 100 cases). The operative risk during the first intervention was on the average 18 pour cent. The protocol of the first anaesthesia which was known in 42 cases, was of the narco-ataralgestic type. The date of the return to the operation table varied from 1 to 60 days. The state of the patients was in general catastrophic (organic renal failure, acute respiratory failure). Here again the anaesthesia was of the narco-ataralgesic type but the choice of drugs varied depending on the patients' state. However non significant difference was noted in the average hourly drug consumption between the two interventions. Apart from one circulatory arrest during induction, in one patient with hemorrhagic shock, no death was attributable to the anesthetic technique. The authors, using these findings, attempt to pick out a practical line of behaviour.

Abdomen↗
PubMedDate not supplied

[Effect of drugs possessing antialcoholic activity on ethanol pharmacokinetics].

Furazolidone, lithium carbonate, chlorprotixen and pyrroxan exert different effects on ethanol pharmacokinetics. Furazolidone decreases clearance of ethanol, increases its half-life with a simultaneous reduction of blood acetaldehyde concentration. Pyrroxan increases clearance and maximal concentration of ethanol. Chloprotixen effect is characterized by a concurrent increase of ethanol and acetaldehyde concentrations in the first hours after ethanol administration. Lithium carbonate produces no significant changes in ethanol pharmacokinetic parameters.

Acetaldehyde↗
PubMed1979

[Psychiatric intensive therapy after acute alkaloid withdrawal syndrome].

Two groups of patients (nine patients each) were treated for acute alcaloid-withdrawal-syndromes. One group was given peroral neuroleptic medication, the other was treated by neuroleptic cocktail administered via vena subclavia catheter. By statistic comparison of the two methods the superiority of the latter could be shown in that duration of withdrawal, the syndrome itself and hallucinatory transitional psychoses could be drastically reduced. A suitable prescription and dosages of the neuroleptic cocktail are presented. The results are compared to the ones in current literature.

Adolescent↗