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On topical application of fluorides and its inhibiting effect on caries.

The observations of interest made in this investigation may be summarized as follows: 1. Conventional fluoride application by mouthrinsing with neutral NaF solution (0.025% daily for three weeks or three months; or 0.05% solution daily; or 0.2% solution weekly for three weeks) is found to result in only moderate and insignificant uptake of F in facial enamel surfaces. The gain is in the order of a hundred ppm within 10 to 15 microns' depth (as determined by an acid etching technique) and a few hundred ppm at 0.02 to 0.05 microns (according to pilot ion probe analysis). 2. Painting, at one week's interval for three weeks with 2% NaF (pH=5) solution and application of an APF-gel (Flura-Kerr 1.23% F) results in the significant uptake of a few hundred ppm F within the first 10 microns of the enamel. Painting with 2% NaF (pH=7), with 8% SnF2, or with 5% Na2PO3F solutions does not yield a significant gain in F in the first 10 microns of the facial enamel, as determined by the etching technique under similar conditions. 3. A varnish (Duraphat) containing 5% NaF (applied three times at weekly intervals) is found to deposit considerable amounts of fluorine in outer facial enamel. Within the first 10 microns gains of more than 1000 ppm F are detected by the etching technique. Uptakes of the order about 500 ppm F are seen even at depths beyond 10 microns; penetration of F is detected down to about 100 microns' depth. Ion probe experiments show a F gain of more than 2000 ppm at a depth of about 0.3 microns. 4. In teeth extracted one day after a single application of NaF varnish, the retained fluorine is higher than in teeth retained in oral environment for one or five weeks after application. This suggests that loss of F occurs particularly during the first days after treatment. 5. The varnish, when applied every six months in permanent dentition of 15 year old children, is cariostatic on all tooth surfaces. 6. The secondary ion microanalyzer ("ion probe") is a useful instrument for the study of fluorine concentrations in dental hard tissue, and provides a special approach to the outermost regions of enamel. 7. The ion probe renders quantitative F determinations in dental hard tissue; a calibration method is available when the positive secondary ion ratios CaF+/Ca+ or F+/Ca++ are recorded versus Ca++/Ca+.

Adolescent↗

The level and timing of systemic exposure to fluoride with respect to caries resistance.

Material related to water fluoridation and fluoride availability has been examined for changing patterns of fluoride intake by humans over recent years. The difficulty of separating systemic and topical fluoride action from water and foods from that found in fluoride agents used in preventive treatment programs is discussed. Recommendations are made that water fluoridation is a well-proven program and should be continued, but that fluoride supplementation programs under the control of the individual should be carefully evaluated and, if used, should be restricted to periods after the secretory stage of enamel formation is normally finished for anterior teeth, with supplements commenced during the pre-eruption maturation period and continuing until permanent tooth eruption is complete. Although supplements can also give a topical source to the teeth, depending on the way the supplement is consumed and the duration of time it is available in the mouth, other methods of topical fluoride provision are endorsed, and these should continue through life. It is suggested, in respect of epidemiology studies, that data collected before the availability of fluoride dentifrices in 1971 should be re-examined.

Animals↗

In vivo caries formation in enamel following argon laser irradiation and combined fluoride and argon laser treatment: a clinical pilot study.

OBJECTIVE: This in vivo pilot study investigated the role of argon laser irradiation and combined fluoride and argon laser treatment in accelerated natural caries development in sound enamel surfaces beneath plaque-retentive orthodontic bands. METHOD AND MATERIALS: Five patients (3 female, 2 male, ages 19 to 28 years) requiring tooth extraction prior to orthodontic treatment, participated in the study. Buccal surfaces were treated with either: (1) argon laser (250 mW for 10 seconds, ARGO-MOD); (2) topical fluoride (0.5% fluoride ion, Thera-Flur-N) followed by argon lasing; or (3) no treatment (control). Orthodontic bands with plaque-retentive slots on buccal surfaces were placed on the teeth slated for extraction (n = 14). Following a minimum of 5 weeks of intraoral exposure, the teeth were extracted for laboratory analysis. The teeth underwent serial longitudinal sectioning (12 sections per tooth). The sections were imbibed in water, and lesion depths were determined with each section, using polarized light microscopy. Comparisons were made among treatment groups (analysis of variance, Duncan's multiple range test for paired samples). RESULTS: Mean lesion depths were: 261 +/- 24 microm for the no treatment control group (n = 84 sections); 147 +/- 18 microm for the argon laser group (n = 24 sections); and 99 +/- 12 microm for the fluoride and argon laser group (n = 60 sections). Both the argon laser (44%) and the fluoride and argon laser groups (62%) had significant lesion depth reductions compared to controls. The addition of fluoride treatment prior to argon lasing resulted in a 32% reduction in lesion depth compared to argon laser treatment alone. CONCLUSIONS: Within this clinical pilot study, in vivo natural caries formation was affected significantly by a single exposure to low fluence argon laser irradiation. Topical fluoride treatment in combination with argon lasing provided an even greater degree of resistance against in vivo enamel caries development. A simple technique for reducing the caries susceptibility of enamel may be a clinical reality.

Adult↗

Dietary fluoride supplements for Nebraska's children--the role of the physician.

1. All children should receive one form of systemic fluoride and appropriate forms of topical fluoride. 2. If a child is not receiving optimally fluoridated water, the physician or dentist should prescribe dietary fluoride supplements (tablets or drops). 3. The correct dosage must be determined based on patient age and fluoride content of the patient's main water source(s). 4. Special attention is necessary concerning fluoride intake for children breast-feeding or consuming infant formula. 5. To arrive at the correct fluoride dose, these steps should be followed: A. Always have a sample of the main drinking water source (usually home water) analyzed for the fluoride content before prescribing a fluoride supplement, if you do not have other specific knowledge of water fluoride content. The Laboratory Division of the Nebraska State Department of Health provides water fluoride assay services. B. When the fluoride content of the water has been determined, the fluoride level and the child's age should be matched on Table 1 to arrive at the correct supplement dose. 6. The Division of Dental Health of the Nebraska State Department of Health can provide lists of communities and schools in Nebraska that are optimally fluoridated.

Adolescent↗

Dietary fluoride supplements for Tennessee's children: the role of the physician.

1. All children should receive some form of systemic fluoride and appropriate forms of topical fluoride. 2. If a child is not receiving optimally fluoridated water, the physician or dentist should prescribe a dietary fluoride supplement as tablets or drops. 3. The correct dosage must be determined, based on patient age and fluoride content of the patient's drinking water. 4. Special attention is necessary concerning fluoride intake for children breast-feeding or consuming infant formula. 5. To arrive at the correct fluoride dose, these steps should be followed: (A) Whenever you do not have specific knowledge of water fluoride content, have a sample of the main drinking water source (usually home water) analyzed for the fluoride content before prescribing a fluoride supplement. (B) When the fluoride content of the water has been determined, the fluoride level and the child's age should be matched on Table 1 to arrive at the correct supplement dose. 6. The Fluoridation Program of the Tennessee Division of Water Supply can provide lists of communities and schools in Tennessee that are optimally fluoridated.

Child↗

Oral health of individuals aged 3-80 years in Jönköping, Sweden in 1973, 1983, and 1993. I. Review of findings on dental care habits and knowledge of oral health.

The aim of the present study was to compare data on dental care habits and knowledge of oral health in three cross-sectional studies carried out in 1973, 1983, and 1993. The 1973 study constituted a random sample of 1000 individuals evenly distributed in the age groups 3, 5, 10, 15, 20, 30, 40, 50, 60, and 70 years. The same age groups with addition of a group of 80-year-olds were included in the 1983 and 1993 studies which comprised 1104 and 1078 individuals, respectively. A questionnaire (23-101 questions) about dental care habits and knowledge of oral health was used in connection with a clinical and radiographic examination. The same questions were used in all the three studies. An addition to the 1993 investigation was questions concerning ethnographic background. In 1993 approximately 95% of all individuals were visiting the dentist on a regular basis every or every second year. The 30-year-olds, however, did not visit a dentist as regularly in 1993 as in 1983. The 70- and 80-year-olds visited a dentist more regularly in 1993 than in 1983. An increased number of adults in all age groups, except for the 70-year-olds, received their dental care in the Public Dental Service in 1993 compared to 1983 and 1973. Most 40-year-olds and older, however, received their dental care by private practitioners. About 80% of all adults in 1993 were enrolled in a recall system on the dentist's initiative while in 1973 most appointments were based on the patient's own initiative. The number of individuals who felt discomfort at the prospect of an appointment with the dentist was more or less the same in 1973, 1983, and 1993. The knowledge of the etiology of dental diseases has not changed much between 1973 and 1993. The frequency of toothbrushing has increased since 1973 and in 1993 more than 95% of all individuals brushed their teeth daily. The use of dental floss and toothpicks as well as disclosing tablets decreased in 1993 compared to 1983. Almost all individuals in 1993 used fluoride toothpaste. The use of topical fluorides and fluoride tablets in children had decreased considerably in 1993 compared to 1983.

Adolescent↗

Professionally applied and prescribed fluoride products.

The US regulatory process relative to the marketing of sodium fluoride dietary supplements and professionally applied topical fluorides is examined with regard to interactions of ADA, NIH, academia, and the FDA, as well as resultant effects on industry, practitioners, and patients. Restrictions on noncaries use of fluoride limit commercial claims, but not professional practice. Prenatal fluoride supplements are still unapproved. Finally, the effects of generic competition and the regulatory process on costs, sales, quality of professional fluoride products and on new product research are discussed.

American Dental Association↗

Cariostatic efficacy of the combined use of fluorides.

There is ample evidence documenting that simultaneous use of several fluoride application techniques results in an enhanced cariostatic effect. A formula is presented which estimates the combined cariostatic efficacy of such multiple usage. For simultaneously applied topical fluorides, the formula seems to overestimate the combined efficacy. Both higher frequency of use and higher concentration result in increased topical fluoride efficacy. Within narrower limits, higher concentrations of fluoride in water or salt also enhance efficacy. The rapid and substantial decline of caries prevalence in some highly industrialized countries may, in part, be attributed to multiple fluoride usage, but other factors must also have exerted a beneficial effect.

Cariostatic Agents↗

Demineralization and remineralization of dental enamel.

Experimentation in vitro using organic acid buffers as demineralizing media shows that caries-like lesions can be obtained which are very similar in morphology and developmental stages to early lesions formed naturally under oral conditions. The use of these chemical systems and of mechanistic models advanced to explain the unique histological features of incipient caries have yielded a good understanding of the processes involved in caries formation. The study of natural and induced factors influencing the demineralization process has been greatly facilitated by the use of bacteriological systems in which demineralization is produced by direct colonization of cariogenic microorganisms on the surfaces of extracted teeth. Comparison of results obtained with these latter systems and with chemical systems has allowed us, for example, to elucidate the mechanism by which acquired salivary pellicles and fluoride topical solutions decrease the rate of enamel demineralization. The pellicle retards transport of matter across the enamel surface, whereas the fluoride topical solutions decrease the cariogenicity of the colonizing bacteria.

Acids↗

The cariostatic mechanism of fluoride.

The benefits of using fluoride to prevent caries have been known for many years, but a complete understanding of this mechanism is still being researched. The fluoride concentration in the apatitic structure of enamel does not have as significant an effect on reducing caries as a continuous presence of fluoride in the plaque liquid. Concentrated, topical fluoride agents (such as in toothpaste, fluoride mouth rinses, gels, or varnishes) have a different mechanism of fluoride protection than low-concentration applications (such as fluoridated water). In initial caries lesions and plaque, concentrated agents form globules of a calcium fluoride-like material on the enamel surface. This material is fairly insoluble, possibly because it is coated with phosphates or proteins. This mechanism explains how the topical application of a fluoride varnish, two or three times a year, can result in caries reduction.

Apatites↗

Root surface caries--an overview of aetiology, prevalence, prevention, and management.

Root surface caries is a specific clinical entity which has been receiving increasing attention in recent years. It has a complex, multi-factorial aetiology, but all the causal factors, and their relative contributions, are not yet clear. There appears to be a role for one or more microbiological agents, particularly in association with a diet involving frequent ingestion of fermentable sugars. Gingival recession is almost certainly a pre-requisite for the development of root surface caries, but intra-oral, site-specific differences in prevalence confuse the picture. Figures of between 20 and over 70 percent for gross prevalence have been reported, with demonstrated attack rates of between 15 and 28 percent of susceptible surfaces being affected. Difficulties in diagnosis may limit the reliability of these figures. The prevention of root surface caries is a two-phase process; the initial emphasis is on the prevention of gingival recession, and the later approach involves measures aimed at reducing the frequency of intake of known cariogenic foodstuffs, and increasing the resistance of susceptible root surfaces with topical fluoride. Medicines which can cause dry mouth must also be examined. The treatment of root surface caries involves a range of procedures, from topical fluoride to multi-surface, glass ionomer cement restorations.

Dental Caries↗

Potential remineralization of demineralized enamel after application of fluoride varnish.

PURPOSE: To evaluate remineralization effects of a topical fluoride varnish applied over a caries-like lesion compared to around a caries-like lesion. METHODS: Caries-like lesions were created on 30 molar surfaces. Sections were cut through each lesion, photographed under polarized light microscopy, and quantitated with a computerized imaging system. The sections were repositioned with only the lesion exposed. Half were painted with a 5% NaF varnish, including the surface of lesion. The remaining half were painted excluding the surface of the lesion. The sections were placed in artificial saliva for 30 days, re-photographed and re-quantitated. RESULTS: Using a student t-test for analysis, the results demonstrated the mean (+/- S.E.) percent remineralization of lesion size to be 10.8 (4.8) for lesions completely covered by the fluoridated varnish and 9.5 (2.9) for lesions that had the fluoridated varnish surrounding the lesion. Both application techniques indicated remineralization effects, yet there was no significant difference between the two application techniques evaluated in this study (P < 0.05). The data from this in vitro study indicated that there was no significant difference in methods of application for fluoridated varnish. Both application techniques demonstrated effective remineralization.

Cariostatic Agents↗

Maxillary incisor palatal erosion: no correlation with dietary variables?

The objectives of the study were to examine a relationship between tooth erosion affecting the palatal aspects of permanent maxillary central incisors with dietary, behavioral and medical variables. The methods included, 251 schoolchildren aged 11 to 13 years were recruited to participate. Each subject had dental impressions of the palatal aspects of both upper central incisors recorded at baseline, 9 and 18 months intervals. From these, electroconductive replicas were fabricated, mapped and compared using a surface matching technique. At the end of the study all participants underwent a structured interview that sought to assay the level of potential erosive dietary, behavioral and medical risk factors. Correlation analyses of the responses given in the final structured interview with the degrees of palatal tooth substance loss (both previous and measured) were under taken. The results showed: (1) The degree of previous erosion did not predict the level of measured ongoing erosion. (2) Brushing the teeth more frequently with fluoridated toothpaste correlated significantly with lower levels of ongoing erosion (P = 0 011). It was concluded that: (1) Evidence of previous palatal erosion did not predict future erosion. (2) The application of topical fluoride as a by-product of tooth brushing may provide an element of protection against palatal erosion. (3) In view of the lack of correlation between exposure to potential risk factors and the level of ongoing palatal tooth surface loss in this study, other factors (such as an individual's susceptibility and salivary buffering power) may well be more important predictors. The clinical relevance included: Preventive advice to patients with dental erosion should not only include the use of topical fluoride, in the form of toothpaste, but recognize individual susceptibility to this condition.

Adolescent↗

Caries reductions related to the use of fluorides: a retrospective cohort study.

AIM: To test whether topical fluoride regimes provided additional caries protection to the first molar teeth of children exposed to fluoridated toothpaste and optimally fluoridated water supplies. PARTICIPANTS AND METHODS: This two-year retrospective cohort study included 660, 8-year-old-children. A cluster sampling technique was used to select three groups of 220 children. Group 1 was selected from schools using fluoride mouthrinses (Programme 1). Group 2 was selected from schools applying fluoride gel (APF 1.23%) in addition to the weekly fluoride mouthrinse (Programme 2). Oral health education and oral hygiene instruction were provided to both groups. The control group was selected from schools in the same area that had not adopted any oral health preventive programme. All children were exposed to optimally fluoridated water and fluoridated toothpaste for the last two years or more. Participants were examined for DMFS scores of their first molars using WHO criteria by one examiner (MLRS). RESULTS: The percentage caries free children in Control, Programme 1 and Programme 2 were 55%, 65% and 65.5%, respectively. The differences between Programme 1 and 2 in relation to the Control Group were statistically significant (P < 0.05). There was no difference between Programme 1 and 2 (P = 0.92). CONCLUSIONS: Weekly fluoride rinsing combined whether or not with fluoride gel applications once every three months, provided additional caries-preventive benefits to children with high levels of caries and exposed to optimally fluoridated drinking water and toothpaste. There was no difference in caries levels between children having fluoride rinses and those having fluoride rinses and fluoride gel.

Acidulated Phosphate Fluoride↗

No effect of waxed dental floss on enamel fluoride uptake or on enamel dissolution changes.

Enamel specimens were flossed in vitro with "waxed" dental floss and then treated with water, Act, Meridol, or Elmex Gel to evaluate the effect of "waxed" floss on the enamel fluoride uptake and on the enamel dissolution rate. The flossed and treated enamel was etched 4 times successively in 2N HCl for 5, 10, 15 and another 15 s. The concentrations of fluoride, calcium and phosphorus were assayed in the etching solutions. The enamel fluoride concentration was significantly increased in only the first layer of the Elmex Gel group compared to the other 3 groups. Respective etching depths were similar for the water, Act and Elmex Gel groups. However, the first layer in the Meridol group was less etched than that in the 3 other groups. This study showed that "waxed" dental floss did not compromise the fluoride uptake by surface enamel after treatment with a concentrated acidic topical fluoridating agent. Moreover, previously reported results showing that Meridol solution containing SnF2 and amine fluoride 297 significantly decreased the in vitro dissolution rate of enamel were confirmed by the present study. Even though the enamel was first treated with "waxed" dental floss, the SnF2/amine fluoride 297 still produced a decreased enamel dissolution rate.

Acid Etching, Dental↗