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PubMedDate not supplied

Effects of the nonsteroidal anti-inflammatory compounds Lonazolac Ca, indomethacin and NDGA on inflammatory mediator generation and release from various cells.

The effects of Lonazolac calcium in modulating histamine release, leukotriene and 12-HETE generation and PAF metabolism from various cells were compared with the cyclooxygenase and lipoxygenase inhibitors indomethacin and nordihydroguaiaretic acid (NDGA). For histamine release cells were stimulated with Ca ionophore, A23187. The release of histamine from human basophils was significantly decreased after preincubation of the cells with Lonazolac Ca. Lonazolac Ca and NDGA were equally potent and their activity exceeded that of indomethacin. Preincubation of human polymorphonuclear leukocytes (PMN) with Lonazolac Ca, indomethacin and NDGA at high concentrations led to an inhibition of leukotriene generation induced by either the Ca ionophore or opsonized zymosan. Different concentrations were required for inhibiting the enzymatic and the non-enzymatically generated leukotrienes. Lonazolac Ca was more potent than indomethacin. Incubation of PMN with Lonazolac calcium modulated the metabolism of exogenously added 3H-PAF and 3H-lyso-PAF. In comparison with NDGA. Lonazolac Ca affected different enzymes of the PAF metabolism.

12-Hydroxy-5,8,10,14-eicosatetraenoic Acid↗
PubMed1984

Patterns of adnexal inflammatory damage: Chlamydia, the intrauterine device, and history of pelvic inflammatory disease.

In a study of 204 consecutive infertile couples, 58 women with adnexal abnormalities consistent with prior pelvic infection were identified. The status of those 58 subjects with respect to prior pelvic infection, prior intrauterine device use, and serologic evidence of past chlamydial infection was correlated with the types of adnexal abnormalities identified. Women with serologic evidence of past chlamydial infection were more likely to exhibit severe adhesions and hydrosalpinx formation, and hydrosalpinx formation was related to a history of clinically detected pelvic infection.

Chlamydia Infections↗