Acute interstitial nephritis secondary to esomeprazole.
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Nitric oxide can be generated by macrophages, as well as many other cell types, through a cytokine inducible isoform of nitric oxide synthase. Historically the effector functions ascribed to iNOS-generated NO have been the control of intracellular organisms and tumor cell cytotoxicity. However, there is a growing appreciation that iNOS generated NO can additionally play an important role in immunoregulation. In this review, the authors outline the effects of iNOS inhibition or genetic deletion on the expression of several autoimmune diseases and discuss potential mechanisms underlying the immunosuppressive effects of NO.
Sulpyrine is commonly used in Japan. We report a case of acute renal failure due to acute tubulointerstitial nephritis (ATIN), which we believe was associated with the use of sulpyrine.