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Results for “Reinforcement Schedule”

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At least 523 records · Page 29Linked to original sources

PubMed1995

Buprenorphine increases intake of freely available and operant-contingent food in satiated rats.

Opiate administration increases short-term free feeding in satiated rats. The feeding effects of the mixed opioid receptor agonist/antagonist buprenorphine were examined in both free-feeding and operant chamber paradigms. Buprenorphine (0.1 and 0.3 mg/kg) produced significant increases in short-term free feeding (i.e., 4 h), an effect enhanced by repeated administration. Buprenorphine's effects on operant responding were examined in satiated rats using a fixed ratio (FR) 80 (initial pellet) FR 3 (subsequent pellets) reinforcement schedule. Buprenorphine (0.03-0.3 mg/kg) decreased latency to begin responding for food, and increased total number of pellets consumed in a 1-h session. Increases in food intake relative to control were caused by continued responding for food as sessions progressed. Naloxone suppressed both the free-feeding and operant-contingent intake induced by buprenorphine. Thus, buprenorphine increases both freely available and lever-press contingent food intake.

Animals↗

PubMed1983

Quantification of rats' behavior during reinforcement periods.

What is treated as a single unit of reinforcement often involves what could be called a reinforcement period during which two or more acts of ingestion may occur, and each of these may have associated with it a series of responses, some reflexive, some learned, that lead up to ingestion. Food-tray presentation to a pigeon is an example of such a "reinforcement period." In order to quantify this behavior, a continuous-reinforcement schedule was used as the reinforcement period and was chained to a fixed-ratio schedule. Both fixed-ratio size and reinforcement-period duration were manipulated. Rats were used as subjects, food as reinforcement, and a lever press as the operant. Major findings included (a) a rapid decline in response rates during the first 15 to 20 seconds of the reinforcement periods, and (b) a strong positive relationship between these response rates and the size of the fixed ratio. Also revealed was a short scallop not normally found in fixed-ratio response patterns, whose length was a function of fixed-ratio size and reinforcement-period duration. It is suggested that rapidly fluctuating excitatory processes can account for many of these findings and that such processes are functionally significant in terms of behavioral compensation.

Journal Article↗

PubMed1984

Pentobarbital self-administration in rhesus monkeys: drug concentration and fixed-ratio size interactions.

Performances of three rhesus monkeys were reinforced by the oral delivery of pentobarbital and studied as functions of fixed-ratio size and drug concentration. Pentobarbital solutions and water were concurrently available on identical reinforcement schedules from separate liquid-delivery systems during 3-hour sessions. Under a fixed-ratio 16 schedule of drug availability, a descending series of drug concentrations was tested (4, 2, 1, 0.5, 0.25, 0.125, and 0.0625 mg/ml, followed by a retest at 4 mg/ml). Partial concentration series beginning with the highest concentration were repeated with fixed-ratios of 32 and 64, with a fixed-ratio 128 for two monkeys, and with fixed-ratio 256 for one. At each fixed-ratio value, response rate and number of drug deliveries were inverted U-shaped functions of pentobarbital concentration. Drug intake (mg/kg/session) increased directly with drug concentration. As the fixed-ratio size was increased, the number of liquid deliveries decreased. For each drug concentration, when the numbers of drug deliveries at fixed-ratios of 32, 64, and 128 responses were plotted as percentages of those obtained at fixed-ratio 16, the following orderly relationship emerged: the higher the drug concentration, the less that drug deliveries were decreased by increases in fixed-ratio size. This relationship indicates an increase in reinforcing efficacy with increases in pentobarbital concentration.

Animals↗

PubMed1979

Effects of methylphenidate on schedule dependent and schedule induced behavior.

The effects of methylphenidate, 1.5, 3.0, 6.0 and 12.0 mg/kg, on lever pressing, schedule induced licking, and drinking were studied. The generator schedule was a fixed interval 1 min food reinforcement schedule. The effects were assessed when animals were reduced to 80% body weight by partial food deprivation and when allowed to recover body weight under conditions of ad lib eating. Results indicate that under body weight conditions methylphenidate significantly decreases schedule induced licking and drinking but does not affect lever pressing.

Animals↗

PubMedDate not supplied

Cross-dependence on ethanol and pentobarbital in rats reinforced on diazepam.

Cross-dependence on ethanol and pentobarbital was studied in rats reinforced on diazepam, using an intravenous self-administration method. Five rats were allowed to self-administer diazepam 2.0 mg/kg per injection intravenously by pressing a lever on a continuous reinforcement schedule over a 20 day period. The total daily dose of diazepam delivered reached 50 mg/kg/day. Thereafter, ethanol (50 or 100 mg/kg per injection) and then pentobarbital (6 mg/kg per injection) were substituted for diazepam for 3 and 2 days, respectively. During these substitution periods, responding for self-administration, food intake and body weight were recorded. When ethanol was substituted, self-administration responding increased and then decreased. Food intake and body weight also decreased during this period. These changes during the ethanol substitution session resembled those observed during withdrawal sessions. In contrast, when pentobarbital was substituted, no significant changes in self-administration responses, food intake or body weight were seen. These findings suggest that diazepam produces cross-dependence on pentobarbital, but not on ethanol at the doses used in this experiment.

Animals↗

PubMed1986

Fixed and variable ratios and delays: further tests of an equivalence rule.

A discrete-trial procedure was used to measure pigeons' choices between fixed and variable ratio schedules and between fixed and variable delays before reinforcement. A peck at a green key produced a reinforcement schedule that was constant within a condition but varied across conditions. A peck at a red key produced a ratio schedule (or, in other conditions, a simple delay) whose size was increased or decreased many times a session, depending on the subject's previous choices. The purpose of these adjustments was to estimate an indifference point--a ratio size (or delay duration) at which the subject chose each key about equally often. The results were used to test a simple "equivalence rule" for choices between fixed and variable schedules (Mazur, 1984). This rule, which was applied without using free parameters, predicted the major trends in the obtained indifference points from both ratio and delay conditions. However, some small but consistent deviations from the predictions were apparent. Better predictions were generated with a more complex equation, which included parameters reflecting the subjects' sensitivities to delay of reinforcement and to events of different probabilities. It was concluded that a successful equivalence rule must include parameters that can be adjusted to describe the effects of delay and probability in a given experimental setting. Once these parameters are estimated, however, choices involving both fixed and variable delays and fixed and variable ratios can be accurately predicted with the same equation.

Animals↗

PubMed2002

Behavioral contrast redux.

Behavioral contrast is defined as a change in response rate during a stimulus associated with a constant reinforcement schedule, in inverse relation to the rates of reinforcement in the surrounding stimulus conditions. Contrast has at least two functionally separable components: local contrast, which occurs after component transition, and molar contrast. Local contrast contributes to molar contrast under some conditions, but not generally. Molar contrast is due primarily to anticipatory contrast. However, anticipatory contrast with respect to response rate has been shown to be inversely related to stimulus preference, which challenges the widely held view that contrast effects reflect changes in stimulus value owing to the reinforcement context. More recent data demonstrate that the inverse relation between response rate and preference with respect to anticipatory contrast is due to Pavlovian contingencies embedded in anticipatory contrast procedures. When those contingencies are weakened, anticipatory contrast and stimulus preference are positively related, thus reaffirming the view that the reinforcing effectiveness of a constant schedule is inversely related to the value of the context of reinforcement in which it occurs. The underlying basis of how the context of reinforcement controls reinforcement value remains uncertain, although clear parallels exist between contrast and the effects of contingency in both Pavlovian and operant conditioning.

Animals↗

PubMed1968