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PubMed1971

Morphological transformation of mouse and rat embryo cells in vitro by an agent from S37 ascites tumour.

When normal rat and mouse embryo cells were treated with a cell free extract of S37 ascites tumour, morphological transformations occurred in both. The transformed cells readily induced lymphosarcoma-type tumours in the mice inoculated when newborn or young adults (8-12 weeks old), but not so readily in rats.Various tests carried out with these cells strongly indicate the presence of an oncogenic and transmissible agent in S37 ascites tumour. This agent appears to be related to mouse sarcoma virus isolated from animals with Moloney leukaemia but differs in only producing characteristic lymphosarcoma-type tumours.

Age Factors↗
PubMed1982

Primary pulmonary sarcomas: etiology, clinical assessment and prognosis with a comparison to pulmonary carcinomas--a review of 41 cases and 394 other cases of the literature.

Primary sarcomas of the lungs occur at frequencies of 1:100, as compared with carcinomas reported in our retrospective studies covering 394 cases reported in the literature from 1957 to 1972 and 41 cases from 1957 to 1974. The average age was 45 years, the disease usually occurred between the ages of 35 and 65, the peak being between 45 and 60 years. Distribution between sexes was much the same as that seen in general. X-ray with rapid thoracotomy provided the best clinical results. The literature showed a postoperative survival time of 5 years in 19% and 44% of our own cases. The general metastasis, haematologenous and lymphogenous were more or less equal and recidive tendency in 7% essentially varied, as related to the single histological forms. Lymphosarcomas (28.6%) were the most frequent, the group of spindle-celled sarcomas, inclusive of leiomyosarcomas, occurred in 40%. Histological maturity of the tissues and the prognosis according to active therapy were in parallel. A comparison of 41 primary sarcomas of the lungs with the 192 cases of carcinomas seen in our clinic showed no connection between sarcomas of the lungs and smoking of cigarettes, pollution of the environment, industrial toxins or chronic bronchitis. These findings relate to the peripheral localization as well as to the lack of incidence among men, with regard to pulmonary adenocarcinomas. An overall view of the characteristics led to the assumption of a probable endogenous tumour. A summarization of the characteristics of pulmonary sarcomas and carcinomas revealed the role of primary sarcomas in the total complex of malignant tumours of the lungs.

Adolescent↗
PubMedDate not supplied

Effect of rabbit strain on activity level and cytotoxicity of serum complement. III. Comparison of four tumor target cells.

Serum samples from about 10 males and 10 females from each of 15 genetically defined strains of rabbits and from one hybrid were tested as sources of complement for the microtiter lymphocytotoxicity test using tumor cells from SaI-A, 6C3HED-A, BW5147, and L-cells as target cells. The tumor cells were tested with appropriate H-2 antisera. Results indicated strain differences particularly evident when the target cells were eithter 6C3HED-A or L-cells. BW5147 worked well with most all strains and SaI-A was extremely demanding of all strains of rabbits. However, strains IIIC/J, IIIVO/J and the F1 hybrid between them were still among the six best strains when tested against the tumor cells as they were when tested against the lymph nodes in previously published data. Strain WH/J which carries the gene, ha, for hereditary lymphosarcoma, proved to be a good complement source with SaI-A and 6C3HED-A, both sarcoma in nature. However, it was not a good complement source with BW5147, a lymphatic leukemia, or L-cells. This is possible evidence for a common tumor antigen associated with lymphosarcoma.

Animals↗
PubMed1975

Fine structure of primary reticulum cell sacroma of the brain.

An electron microscopic study was made on two cases of reticulum cell sarcoma (microglioma) of the brain. In both, the tumour was composed of several type of cells; cells with an undifferentiated appearance and cells with ultrastructural features of the reticulum cell and histiocyte. There seemed to be no significant difference in the fine structure between the tumour cells in reticulum cell sarcoma of the brain and extracerebral forms. The ultrastructures of a lymphosarcoma of the spinal epidural space was also examined and resembles that of such tumours occurring elsewhere in the body.

Adult↗
PubMed1976

Antibacterial and antitumor activity of some derivatives of ureidosuccinic acid.

The effect of several derivatives of ureidosuccinic acid on the growth of Escherichia coli 387, Staphylococcus aureus strain 209 and its mutant UV-2, Sarcina lutea, Candida tropicalis and Neurospora crossa 9863 as pre-screening systems for antitumor activity was studied. It was found that dihydrazide of D,L-ureidosuccinic acid (DHUA) had a marked antibacterial activity. The inhibitory effect of DHUA on N. crassa could not be removed by aspartic acid, ureidosuccinic acid, dihydroorotic acid, orotic acid, uracil or cytosine. DHUA suppressed the growth of Myeloma P-8 by 38%, that of Sarcoma 180 by 12% and that of Yoshida sarcoma by 19%. No effect was found on the growth of Lymphosarcoma Pliss.

Antineoplastic Agents↗
PubMed1976

Spinal cord compression in malignant lymphoma. Treatment and results.

The natural history, treatment, and results of 73 spinal cord compressions caused by malignant lymphomas are analyzed. It is found that the spinal cord compression caused by malignant lymphomas is generally a late manifestation of the illness, although primary or early involvements are occasionally seen. In our study, reticulum cell sarcoma is the most frequently variety followed by Hodgkin's disease and lymphosarcoma. The dorsal spinal cord is the most frequently involved segment and pain, weakness, and paresthesia are cardinal symptoms. Radiation treatment delivered in the early phase of the compression is commonly successful in reversing the neurologic symptoms and a dose above 2500 rads appears to be optimal for local control of disease. The low incidence of cerivcal cord compression in Hodgkin's disease patients may be related to frequent manifestation and irradiation of the neck nodes in these patients. Early detection of disease in the deep seated areas along the spinal cord and irradiation of these areas may prevent progression of tumor to the epidural space.

Adolescent↗