[Mechanisms of synchronization of cerebral cortex biopotentials. 3. Analysis of the synchronization effect of biopotentials recorded directly from the cortex].
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Cyclic discharges occurring during prolonged low-frequency electric stimulation of the cortical surface were studied in the rat neocortex by means of K+ selective microelectrodes. Duration of excitation cycles and intervals between them depended on the parameters of stimulation. Surface potential shift reached 4-5 mV and [K+]0 increased to 8-10 mM. The cyclic excitation process was not self-sustained and stopped just after the current was switched off. Small doses of nembutal (10-20 mg/kg) increased both the threshold for the cyclic process onset and duration of the intervals between the active phases. Higher nembutal doses (30-40 mg/kg) abolished cyclic excitation for 2-3 hours. This model of cyclic discharges is supposed to be useful for investigation of the mechanism of seizure activity and of the effect of antiepileptic drugs.
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