Structural biology. Adaptation of SARS coronavirus to humans.
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OBJECTIVE: To study the mechanism of subclinical damage and repairing process of peripheral nerves during gradual tibial lengthening. METHODS: Histological investigation, electrophysiological examination of tibial nerve and GAP-43 mRNA expression of sciatic nerve related spinal cord and ganglion were observed in 10%, 20%, 30%, 40% lengthening, and at 2, 4, 8 weeks phases after 40% limb lengthening in 80 rabbits. RESULTS: With the increase of elongation, severer and more obvious nerve damage and stronger expression of GAP-43 mRNA happened. However, nerve regeneration occurred synchronously and the changes recovered gradually within 8 weeks. CONCLUSION: Damage of the peripheral nerves is common during limb lengthening. But, it is temporary and recoverable in case the lengthening rate is < 1 mm/d.
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A total of 192 patients with Bell paralysis were studied. In 32 a technique of biofeedback training was applied to accelerate the restoration of mimetic muscles with EMG feedback. Clinical and electrophysiological data confirmed the efficiency of this technique in terms of considerably accelerated rehabilitation.
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The influence of social alterations on the treatment effectivity and social adaptation of 1350 epileptic patients was followed up in 1981-1993. It is shown that during the period of social stability clinical observation of such patients was quite satisfactory. Therapeutic response reached 98.2% at invalidity rate 0.2% in 1989. On the contrary, during period of social instability 10.8% of patients did not resolve any treatment, the effectiveness of the treatment lowered to 76.6%, remission failure occurred in 6%, and the percent of the invalids increased to 5.6% of patients. The recommendations are given concerning adaptation of epileptics to new social conditions.
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Adaptation is a central precept of biology; it provides a framework for identifying functional significance. We equate mammalian development with adaptation, by viewing the developmental sequence as a series of adaptations to a stereotyped sequence of habitats. In this way development is adaptation. The Norway rat is used as a mammalian model, and the sequence of habitats that is used to define its adaptive-developmental sequence is (a) the uterus, (b) the mother's body, (c) the huddle, and (d) the coterie of pups as they gain independence. Then, within this framework and in relation to each of the habitats, we consider problems of organismal responses to altered gravitational forces (micro-g to hyper-g), especially those encountered during space flight and centrifugation. This approach enables a clearer identification of simple "effects" and active "responses" with respect to gravity. It focuses our attention on functional systems and brings to the fore the manner in which experience shapes somatic adaptation. We argue that this basic developmental approach is not only central to basic issues in gravitational biology, but that it provides a natural tool for understanding the underlying processes that are vital to astronaut health and well-being during long duration flights that will involve adaptation to space flight conditions and eventual re-adaptation to Earth's gravity.