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Complications of continuous-wear soft contact lenses in a nonreferral population.

Serious corneal complications occurred in an otherwise successful experience with continuous-wear soft contact lenses (SCLs) for aphakic correction. One hundred twenty eyes were fit, and 92% attained visual acuity of 20/40 or better. Severe corneal complications were observed in 13 eyes, including bacterial ulcers (six), apical erosions (three), and severe superficial vascularization (four). Corneal ulcers occurred in nondiabetic as well as diabetic subjects. Continuous-wear SCLs are not innocuous; as for any other drug or device, continuous, long-term medical supervision is necessary to minimize potentially severe complications and visual loss.

Adult↗

Clinical performance of a disability glare tester.

A glare tester was described previously and was found, in the presence of cataracts, to be almost twice as predictive as was Snellen measurement for determining visual acuity outdoors. The current study tests the reproducibility of glare test scores and the influence of refractive error and contrast sensitivity on such scores when used in a clinical environment. Although the effects of visual acuity and impaired contrast sensitivity were found to be statistically significant components of glare test scores, the magnitudes of their effects were found to be clinically insignificant. Sequential retesting of physiologically stable eyes or, in the case of progressive cataracts, within intervals short enough to preclude discernible lenticular changes indicated that, for the most part, reproducibility of glare testing was comparable to that of visual acuity testing.

Adult↗

Delayed nonexpulsive suprachoroidal hemorrhage.

Eight cases of delayed nonexpulsive suprachoroidal hemorrhage occurred after filtering operations in aphakic eyes. Sustained hypotonia resulting in serous choroidal detachments, scleral infolding, or both was observed prior to the hemorrhage in seven of the eight eyes. The prognosis was related to the extent of the hemorrhage and possibly to whether or not surgical drainage was performed. Only one of the five patients with massive hemorrhages recovered visual acuity better than hand motions; that patient had undergone prompt surgical drainage of the suprachoroidal blood.

Aged↗

Analysis of corneal thickness and endothelial cell density in pseudophakic and aphakic patients undergoing penetrating keratoplasty.

We studied the effects of the presence or location of an intraocular lens on 54 eyes with a penetrating keratoplasty. Endothelial cell density and corneal thickness measurements were compared in the four subgroups (14 aphakic, 14 anterior chamber lenses, 11 iris-supported lenses, and 15 posterior chamber lenses), using analysis of covariance, with the covariable being months since transplant. There was no statistical difference in these parameters among the four groups. The correlation between endothelial cell density and postoperative time (P less than .0022) and between corneal thickness and elapsed time (P less than .05) was, however, significant in all categories. Based on our analysis, we believe the presence or location of an intraocular lens is not detrimental to the corneal endothelium in penetrating keratoplasty.

Aphakia, Postcataract↗

Slit-lamp fluid-gas exchange and other office procedures following vitreoretinal surgery.

Many complicated postoperative vitreoretinal cases require reoperations. It is possible to perform some of these procedures outside the operating room. We describe examining room techniques for fluid-gas exchange, fluid and gas aspiration, and adherent vitreous strand removal. We also discuss a slit-lamp technique for using sodium hyaluronate (Healon) following fluid-gas exchange to eliminate optical distortion from endothelial striae.

Anesthesia, Local↗

Histopathology of a case of epikeratophakia (aphakic epikeratoplasty).

An epikeratoplasty button was removed by penetrating keratoplasty 31 months following an aphakic epikeratoplasty. The epithelium over the donor cap was thickened with numerous surface abnormalities. Bends and fractures in the donor Bowman's membrane were found throughout the length of the specimen. A significantly decreased number of keratocytes were found in the anterior half of the donor lenticule; the posterior half of the lenticule was acellular. The interfibrillar collagen distance of the donor lenticule was significantly increased compared with that of the recipient host cornea. The central thickness of the lenticule increased the total corneal thickness by 56%. Abnormal keratocytes were found in the underlying recipient corneal stroma. Based on this study, the histopathologic features of epikeratoplasty appear to be similar to those documented in the other lamellar refractive surgical procedures of keratophakia and keratomileusis.

Adult↗

Keratometric and refractive results of pediatric epikeratophakia.

Keratometric and refractive results of pediatric epikeratophakia showed that patients under 1 year of age had steeper corneas preoperatively and required more correction, as estimated by the Sanders-Retzlaff-Kraff regression formula. The average spherical equivalent of refractive error six months postoperatively was +6.92 +/- 4.67 diopters in patients under 1 year, and -0.72 +/- 4.22 D in patients over 1 year. Three of 14 younger patients and 35 of 54 older patients were within 3 D of emmetropia. Since March 1982, significant undercorrection has occurred only in patients 6 months old or younger. Younger children achieved an average of 46% of the predicted change in corneal curvature, while older children achieved 85%. Also, the Sanders-Retzlaff-Kraff formula may be inaccurate in estimating powers for younger children. Therefore, we recommend at this time that epikeratophakia be used as a secondary procedure in neonates with congenital cataracts.

Age Factors↗

Long-term follow-up of refractive and keratometric results of pediatric epikeratophakia.

To examine the long-term stability of epikeratophakia and its effect on the development of young eyes, the change in corneal curvature and refractive error over time were reviewed in pediatric patients who underwent epikeratophakia for optical correction of aphakia. Over an average follow-up time of 28.0 months, corneal curvature flattened by 1.15 diopters, or 0.53 D/yr. The average change in refractive error was -2.81 D over 23.6 months, or 1.49 D/yr. Patients younger than 1 year of age at surgery became significantly more myopic over the period of follow-up (4.75 D) than patients older than 1 year of age at surgery (2.24 D). These changes are consistent with the corneal flattening and increase in axial length expected from normal growth. Aphakic infants corrected to emmetropia with epikeratophakia will likely require correction of myopia in later childhood.

Aphakia, Postcataract↗

Epikeratophakia for pediatric aphakia.

We used epikeratophakia for rehabilitation in 11 contact lens-intolerant aphakic children aged 9 months to 14 years. Minimum follow-up was five months; the longest was 12 months. There were no graft failures, and no patients were unavailable for follow-up. Objective postoperative overrefractions on all patients revealed that an average of 93% of the desired correction was obtained. Residual corrections ranged from -3.75 diopters spherical equivalent to +2.87 D. Nine of the 11 children were of verbal age; their spectacle visual acuities averaged 20/50, with a range of 20/20 to 20/80. Preverbal children all tolerated occlusive therapy, although accurate visual acuities could not be obtained. Our early results with this modality as therapy for monocular aphakia in the pediatric population have demonstrated improvement in visual function in all patients to date.

Adolescent↗

Prevention and management of delayed suprachoroidal hemorrhage after filtration surgery.

We report two new cases of massive delayed nonexpulsive suprachoroidal hemorrhage (DNSH) following a filtering operation in the aphakic eyes of elderly patients with glaucoma. A timely surgical drainage resulted in full recovery of preoperative visual acuity in both of our patients. As we combine our cases with a series of 18 similar cases of others in the literature, the following conclusions emerge. Limited DNSH does not require surgical intervention for a favorable visual outcome. Massive DNSH, however, requires timely and appropriate surgical intervention to achieve a favorable visual outcome and to avoid persistent hypotony. The most effective surgical intervention is drainage of the suprachoroidal hemorrhage and re-formation of the anterior chamber, but without concomitant vitrectomy. In both limited and massive DNSH, the final visual outcome is not determined by the worst vision at the time of DNSH. Some of the known and suspected risk factors of DNSH following filtering surgery are old age, aphakia, postoperative hypotony, a history of vitreous manipulation or complication, general anesthesia, increased venous pressure, use of fluorouracil, and high myopia. In view of these risk factors, we recommend several preventive measures for decreasing the incidence of DNSH following filtering surgery.

Aged↗

Intravitreal vancomycin. Retinal toxicity, clearance, and interaction with gentamicin.

Some of the gram-positive isolates from exogenous bacterial endophthalmitis cases treated at our institution have been found to be resistant to either cefazolin sodium, gentamicin sulfate, or both. However, all of these isolates have been sensitive to vancomycin. These findings prompted us to reevaluate the retinal toxicity and clearance of intravitreal vancomycin in pigmented rabbits. Doses up to 2 mg were found to be nontoxic in phakic and aphakic-vitrectomized eyes. Clearance was determined in phakic and aphakic-vitrectomized rabbit eyes with or without intact lens capsules. The antibiotic was cleared most slowly in phakic eyes. Aphakic-vitrectomized eyes without an intact lens capsule cleared antibiotic most rapidly, while aphakic-vitrectomized eyes with intact capsules exhibited an intermediate clearance rate. In addition, the interaction between vancomycin and gentamicin on gram-positive endophthalmitis isolates was found to be additive or synergistic depending on the bacterial species. Based on these data, we recommend the combination of vancomycin and an aminoglycoside as the initial antibiotic therapy for exogenous bacterial endophthalmitis.

Animals↗

Use of posterior chamber lenses in pseudophakic bullous keratopathy.

The occurrence of pseudophakic bullous keratopathy following anterior chamber intraocular lens implantation is well documented. At the time of penetrating keratoplasty and anterior chamber intraocular lens removal, we attempt to reimplant a posterior chamber lens whenever possible because of the complications associated with anterior chamber lenses. We developed a technique to exchange an anterior chamber lens with a posterior chamber lens during penetrating keratoplasty. The intraocular lens loops are inserted in the ciliary sulcus and the optic is sutured to the iris.

Anterior Chamber↗

Theoretical vs empirical prediction of aphakic refraction.

The aphakic refraction was predicted from preoperative and postoperative keratometry and axial length determinations in 43 patients subjected to cataract extraction without intraocular lens implantation using a theoretical and an empirical (Sanders, Retzlaff, Kraff [SRK]) method of calculation. The error (mean +/- SD; observed value minus expected value) of the theoretical vs the empirical method was 0.02 +/- 0.76 diopters (D) vs 0.66 +/- 0.72 D, respectively, when the preoperative data were used in the calculations, and 0.21 +/- 0.80 D vs 0.84 +/- 0.79 D, respectively, when the postoperative data were used in the calculations. The mean error was significantly different from zero (predicted values were lower than observed values) for the SRK method but not for the theoretical method. The mean error of the SRK method could be eliminated by adjusting the offset constant in the regression formula.

Aged↗

The removal of silicone oil from the anterior chamber in phakic eyes.

The appearance of large silicone oil globules in the anterior chamber of phakic eyes leads to serious intraoperative and postoperative problems. Using hyaluronate sodium, the silicone can be safely removed from the anterior chamber, the crystalline lens may be saved, and the posterior segment procedure can be completed.

Anterior Chamber↗