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PubMed2002

An Unusual Case of Motor and Vocal Tics With Obsessive-Compulsive Symptoms in a Young Adult With Behcet's Syndrome.

Behcet's disease is a chronic relapsing-remitting, multi-system inflammatory disorder of unknown etiology, characterized by recurrent oral and genital ulcers, uveitis, and skin lesions. The most common central nervous system findings are demyelization and perivascular cell infiltration; meningoencephalitis, cerebral atrophy, and vascular thrombosis may also occur. Neuropsychiatric symptoms may include: paroxysmal dystonia, parkinsonism, delirium, hallucinations, and behavioral disturbances. We report an unusual case of explosive onset of motor and vocal tics with obsessive-compulsive symptoms in a 22-year-old male with Behcet's disease. The putative roles of infection and autoimmune mechanisms in the pathogenesis of tics and obsessive-compulsive symptoms are explored.

Journal Article↗
PubMed1998

[Behcet syndrome].

We present a survey of Behçet's syndrome based on three case reports and a review of the literature. Behçet's syndrome is a systemic connective tissue disease affecting arteries and veins. The basic pathological findings are vasculitis, aneurysms and thrombosis. The disease is rarely observed in Norway, but occurs rather frequently in Turkey and Japan. It affects males and females, most often in the age group 20-35 years. The main clinical manifestations are oral and genital aphthae and eye inflammation. The disease may also involve a number of other organs. Depending on the severity of the disease, corticosteroids and immunosuppressive agents are employed.

Adult↗
PubMedDate not supplied

[Neurological Behcet syndrome. Presentation of three cases].

INTRODUCTION: Behçet's disease is a multisystemic illness in which neurological abnormalities are seen in 5-48% of cases. CLINICAL CASES: We present 3 patients (2 men and 1 women) diagnosed as having Behçet's disease, according to the criteria of the 'International Study Group for Behçet's Disease' of 1990. We describe the clinical findings in these patients, the results of investigations done (MR or CT, evoked potentials-PEV, PESS, PEATC-EEG, ECN, CSF and neuropsychological tests), their course and response to treatment with hyperimmune human gammaglobulim at a dose of 400 mg/kg body weight in 2 patients. All three patients had repeated episodes of meningitis and alterations of the cranial nerves; two patients had epileptic seizures and two had signs of cerebellar disorders and dementia at some time during their illness. One patient died and the other two survived with severe disabilities. Cranial CT showed a cerebral infarct in one patient; evoked potentials showed axon damage in the two patients in whom this was studied. In the only patient in whom ECN was done, signs of axonal polyneuropathy were found. In all three patients there was pleocytosis in the CSF. In the patients in whom hyperimmune human gammaglobulin was given, the results were: one improved after this treatment; in the other there was clinical deterioration, but this was considered to be secondary to a curettage done the day before. CONCLUSION: The presence of neurological findings in Behçet's disease not caused by cerebral vein thrombosis worsens the prognosis of these patients.

Adult↗
PubMed1955

BEHCET'S syndrome.

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Behcet Syndrome↗
PubMed1976

A case of vasculo-Behcet's syndrome.

A case of Behcet's syndrome with vascular complications is presented. This case had a familial occurrence of Behcet's syndrome. His vascular complications were deep vein thrombophlebitis of both legs, aneurysms of the left common iliac artery and the left femoral artery and the occlusion of the left subclavian artery. He was successfully operated on for the aneurysms. This paper discusses the problems accompanying the aneurysm of Behcet's syndrome. The authors pointed out that the subclavian steal syndrome may be diagnosed as neuro-Behet's syndrome and stressed the importance of vascular survay in Behcet's syndrome when the patient complaints of thrombophlebitis.

Aneurysm↗
PubMedDate not supplied

Behcet's syndrome.

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Arteries↗
PubMed1950

Behcet's syndrome.

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Behcet Syndrome↗
PubMed1977

Platelet function, blood coagulation and fibrinolysis in Behcet's syndrome.

In 10 patients with Behcet's syndrome, various parameters of platelet function, blood coagulation and fibrinolysis were studied. With varying frequency the following abnormalities were found: increased retention of platelets in glass bead column, reduced platelet aggregation to low concentrations of adenosine diphosphate, elevated plasma levels of fibrinogen concentration and factor VIII activity, increased plasma antiheparin activity and impairment of fibrinolytic activity. The above abnormalities were found long after the last thrombotic episode and were more frequent in patients with a history of thrombophlebitis. It is suggested that certain hemostatic abnormalities accompany or form part of Behcet's syndrome and that they are related to the thrombotic complications characteristic of this syndrome.

Adenosine Diphosphate↗