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PubMed2006

[Application of allogeneic bone in surgical treatment of benign bone neoplasm].

OBJECTIVE: To evaluate the clinical outcomes of allogeneic bone grafting for bone defect resulting from benign neoplasm resection and discuss the clinical application and bone defect repair mechanisms of allogeneic bone. METHODS: A retrospective review was conducted of 135 patients with benign neoplasm resection who received bone defect filling with the allogeneic bone graft. RESULTS: In the 104 patients with complete clinical follow-up data, 96 achieved bone union, 7 experienced relapses to require surgical intervention and 1 had severe infection to lead to failure of the operation. The mean time for bone union was 9.7 months, and during the follow-up, no viral disease in relation to the graft was found after surgery. CONCLUSION: Bone defect filling with allogeneic bone graft can be simple and safe in comparison with that with autograft or other biomaterials, and the bone healing time, infection rate and local tumor recurrence can be comparable with the autograft.

Adolescent↗
PubMedDate not supplied

[Selenium in blood serum and in tumors of patients with benign and malignant bone neoplasms].

The content of selenium in the serum and bones was compared in persons having no neoplasms and in patients with malignant and benign bone tumors. The mean level of selenium in the healthy femoral bone was 81 micrograms/kg, with more predominant accumulation in the epiphysis than in the metaphysis and diaphysis and with higher concentrations in the periosteum than in the cambial layer. The normal mean bone/serum selenium ratio was 0.74. This index varied 0.8 to 5.1 in patients with benign tumors and 2.3 to 10.0 in those with malignant tumors. Benign tumors were characterized by significant multiple variations of tumor selenium levels depending on the type of an abnormality with maximally observed values in giant-cell tumor. In patients with various osteosarcomas, the mean selenium content was decreased to 71% in the serum and increased up to 300% in the tumor. The examination of the impact of the type of non-adjuvant therapy on serum selenium levels in patients with bone tumors indicated a negative selenium effect in the application of radiation therapy and a positive selenium effect in the transfusion of bone marrow suspension and in the use of platidium or SAR-regimen therapy.

Adult↗
PubMed1992

Temporal bone neoplasms: a report on 20 surgically treated cases.

The surgical resection of neoplasms involving the petrous bone and surrounding areas in 20 patients is reported. Technical advances described include the total resection of several tumors previously considered inoperable due to involvement of dura and brain, petrous internal carotid artery (ICA), the vein of Labbé, and adjacent areas such as the clivus and the cavernous sinus. Areas of reconstruction after resection included the ICA, the seventh and 11th cranial nerves, and the cranial base, often requiring the use of vascularized flaps. There were no intraoperative deaths. Many patients experienced significant temporary morbidity related primarily to wound healing and to lower cranial nerve palsy; however, all but three patients (all with fast-growing malignancies) returned to their preoperative functional status. During a median follow-up period of 30 months (range 17 to 63 months), the 10 patients with benign tumors and slow-growing malignancies fared well, seven being alive and disease-free. The 10 patients with fast-growing malignancies fared poorly, only two being alive without disease. This outcome appeared to be related to tumor pathology and extent of invasion; both survivors harbored tumors confined to the petrous bone. An anatomical classification system of tumor spread is introduced, which should be considered concomitantly with tumor pathology.

Adolescent↗
PubMed1979

[Bone neoplasms].

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Bone Neoplasms↗
PubMed1996

[Archiving of pathologic-anatomic findings in bone diseases and bone neoplasms in individual databanks. Experiences of a new enterprise with applicable outcome].

In this paper my experience with a databank for cases with bone diseases is reported. All cases which had been diagnosed in the newly formed Department of Bone Pathology of the University of Hamburg since 1970 were registered in uniform fashion. Adapting the system to state-of-the-art network structures required a lot of personal and financial investment. This could not be accomplished by university resources alone, but only in cooperation with other research funds. Now 76,000 cases can be routinely accessed and scientifically analysed.

Bone Diseases↗