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[The Beilstein CrossFire Information System and its use in pharmaceutical chemistry].

The Beilstein CrossFire database system is one of the most popular, most extensive, and most accomplished systems presenting information about chemical substances, including drugs, and covering the basic identification, physico-chemical, ecological, and pharmacological data. The present article offers an overview of historical evaluation of the Beilstein CrossFire database system, beginning from its founder Prof. Friedrich Conrad Beilstein till the most recent prospects about the connection of classical data with full-text databases. The article also offers a review of the development of electronic information systems in the Slovak Republic, a definition of basic functionality of the Beilstein CrossFire database system, and an example of targeted selection of active substances structurally similar to novel COX-2 inhibitors having an approved anti-inflammatory activity.

Chemistry, Organic↗

[Pharmaceutical chemistry of major analgesics].

The paper represents the 5th part of a series about agents acting on the central nervous system. This time the major analgesics are surveyed. As previously, the material is divided into chapters of hystory-preparation; structure-properties-activity; therapeutical use; analysis.

Amino Acid Sequence↗