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Fetal cephalometry by ultrasound as a screening procedure for the prenatal detection of Down's syndrome.

Infants and children with Down's syndrome have a cephalic index (ratio of biparietal to occipitofrontal diameter) higher than that in normal children. To determine whether this difference is present and detectable by ultrasound measurement of the second-trimester fetal head, we calculated the cephalic indices for 308 normal fetuses and eight fetuses with a 47, +21 karyotype. The mean cephalic index in the fetuses with Down's syndrome (0.829, SD 0.033) was indistinguishable from that in the normal fetuses (0.825, SD 0.042). These data suggest that the documented difference in mean cephalic index between liveborn children with Down's syndrome and normal control children is not detectable in the mid-gestation fetus and that ultrasound cephalometry alone is unlikely to discriminate reliably between normal and affected fetuses.

Adult↗

Parental craniofacial morphology in cleft lip with or without cleft palate as determined by cephalometry: a meta-analysis.

OBJECTIVE: To integrate findings from previous cephalometric studies comparing the craniofacial complex of unaffected parents with cleft lip with or without cleft palate (CL/P) children to controls with no history of the disease. DESIGN: Meta-analysis of case-control cephalometric data. INCLUSION CRITERIA: Studies were selected if the unaffected parents of children with CL/P were included and were not combined with parents of children with isolated CP; quantitative data were obtained through cephalometry; the cephalometric variables used were not unique to a study; a case-control design was used; and the means and standard deviations for all variables were reported or could be calculated for both the experimental and the control group. OUTCOME MEASURE: Using raw data obtained from nine studies, mean weighted effect sizes with 95% confidence intervals were calculated for 28 cephalometric variables (mothers and fathers combined) or 18 variables (mothers and fathers separately). Heterogeneity statistics for the effect sizes were also calculated. RESULTS: In general, unaffected parents of children with CL/P possessed significantly wider interorbital, nasal cavity and upper facial dimensions, narrower cranial vaults, longer cranial bases, longer and more protrusive mandibles, shorter upper faces and longer lower faces compared with controls. Increased width of the nasal cavity was the most robust finding. Significant effect size heterogeneity was observed in roughly half of the variables examined. CONCLUSION: Unaffected parents of children with CL/P are characterized by a suite of consistent, yet subtle, craniofacial differences, which could indicate an underlying genetic liability.

Case-Control Studies↗

Effect of obesity and erect/supine posture on lateral cephalometry: relationship to sleep-disordered breathing.

Craniofacial and upper airway anatomy, obesity and posture may all play a role in compromising upper airway patency in patients with the sleep apnoea/hypopnoea syndrome. The aim of this study was to investigate the relationship between obesity, facial structure and severity of sleep-disordered breathing using lateral cephalometric measurements and to assess the effect of body posture on cephalometric measurements of upper airway calibre variables in obese and non-obese subjects. Lateral cephalometry was carried out in erect and supine postures in 73 awake male subjects randomly selected from patients referred for polysomnography who had a wide range of apnoea/hypopnoea frequencies (1-131 events x h sleep(-1)). Subjects were divided into non-obese (body mass index (BMI) < 30 kg x m(-2); n=42) and obese (BMI > or = 30 kg x m(-2); n=31) groups. Significant but weak correlations were found between apnoea/hypopnoea index (AHI) and measurements reflecting upper airway dimensions: uvular protrusion-posterior pharyngeal wall (r=-0.26, p<0.05) and hyoid-posterior pharyngeal wall (r=0.26, p<0.05). Multiple regression using both upper airway dimensions improved the correlation to AHI (r=0.34, p=0.01). Obese subjects had greater hyoid-posterior pharyngeal wall distances than non-obese subjects, both erect (42+/-5 versus 39+/-4 mm, respectively (mean+/-SD) p<0.01) and supine (43+/-5 versus 40+/-4 mm, p<0.05). Skeletal craniofacial structure was similar in obese and non-obese subjects. In conclusion, measurements reflecting upper airway size were correlated with the severity of sleep-disordered breathing. Differences in upper airway size measurements between obese and non-obese subjects were independent of bony craniofacial structure.

Adult↗

A method for three-projection infant cephalometry.

OBJECTIVE: To assess morphology and growth in infants and children with craniofacial anomalies based on comprehensive digitization of radiographic films in three, mutually orthogonal projections. METHOD: The method consists of (1) acquisition of radiographic films in a highly standardized three-projection (lateral, frontal, and axial) cephalometer, (2) marking and digitization of a total of 279 anatomical landmarks in the three projections, and (3) computation and presentation (tabular and graphical) of 356 linear and angular variables describing the craniofacial morphology, including soft tissue. Computation of statistical entities describing a patient, a group of patients, the differences between patients or groups of patients was carried out. Error assessment of the method involved investigation of error distribution among a number of error sources. Duplicate digitization of radiographic films from 30 randomly selected patients, and from 10 dry skulls, was carried out to determine the errors contributed by the procedure of landmark digitization and the distribution of error among landmarks and variables, as well as between projections. RESULTS: The average error due to landmark digitization, s(i), determined by duplicate digitization and calculated by use of Dahlberg's formula was 0.8 mm for linear variables and 1.6 degrees for angular variables. CONCLUSION: This method of infant cephalometry has been shown to be highly accurate and reproducible, and it adds significant new potential for, e.g., asymmetry detection, population comparison, and growth measurements compared to other cephalometric techniques due to its standardized acquisition and digitization protocol, inclusion of an axial projection, and the large number of well-defined landmarks and variables involved.

Cephalometry↗

[Examination of low palatal arch with long low hanging soft palate in obstructive sleep apnea syndrome and cephalometry].

In order to clarify morphological abnormalities of the upper airway in patients with obstructive sleep apnea syndrome (OSAS), and to predict the severity as well as the effect of surgery, we statistically examined the relationship between the degree of low palatal arch and the result of cephalometry in 45 adult male patients with OSAS who underwent uvulopalatopharyngoplasty. The patients were divided into 3 types, A, B and C, according to the degree of low palatal arch on inspection, and type C was regarded as having a low palatal arch with a long low-hanging soft palate. It was found that (1) type C patients showed a higher preoperative apnea index and lower minimal blood oxygen saturation, suggesting a serious condition. (2) In type C patients, the long axis (PNS-H) of the airway was larger, and the oral area was smaller. The area of the entire tongue, especially the upper half of the tongue, was larger than that in patients of other types. Type C patients were further divided into 3 subtypes: (1) those with a substantially long low-hanging soft palate; (2) those with a long low-hanging soft palate and large tongue; and (3) those in whom the large tongue is the main factor for the apparent low-hanging soft palate. These subtypes should be confirmed by cephalography before treatment for effective surgical results.

Adult↗

Ultrasonic cephalometry: Its use in estimating fetal weight.

Data on 100 consecutive patients delivering within 1 week after ultrasonic cephalometry measurement were reviewed to assess the weight-predicting potential of three known formulas. With Thompson's formula, 78% of infant weights fell within a range of 350 g, the absolute mean error for the 100 cases being 267 g. Excluding cases of fetal malnutrition, when the biparietal diameter (BPD) obtained was 8.3 cm or more, all newborn babies weighed more than 2000 g, and with a BPD of 8.7 cm or more they all exceeded 2500 g. Ninety percent of newborn babies in whom the in utero BPD was 9.1 cm or more weighed more than 3000 g. These values compared very favorably with those from other series and, thus, demonstrate the usefulness of this type of assessment.

Birth Weight↗

[The importance of ultra-sound cephalometry for the prediction of the date of delivery--a contribution to the assessment of duration of pregnancy (author's transl)].

On the basis of some statistical data ultrasound cephalometry for the prediction of term is discussed. These data should be considered when providing socalled test-graphs. The usefulness of the author's own standard graph is examined. Prediction with the biparietal diameter is not much less exact than after the rule of Naegele. Accuracy of prediction can be much improved by using both methods together, starting from the averages of both.

Cephalometry↗

[Three-dimensional imaging and cephalometry of cranio-facial asymmetry].

The 75th meeting of the French Orthodontics Society will be held in Biarritz May 8-9-10-11 2002. The main topic for discussion will be: "facial asymmetry". During the meeting, authors will present study of facial asymmetries using a new innovative three-dimensional cephalometry. The method combines CT scans data, anatomical landmarks and mathematical tools to create, using the "Cepha" software, a 3D model of the human face. Balance and symmetry of the model are stable enough to define normality for each individual even with different ethnic and cultural origins. Unbalance and asymmetry characterize pathologies. Follow up shape and size of models allows growth prediction and modeling. The model is in the process of becoming the indispensable reference for all those who are interested in studying the human face: Orthodontics, Surgery, Anatomy, Anthropology, Plastic surgery, Forensic Medicine.

Cephalometry↗

[A new cephalometric analysis of the profile. 1. Anatomic bases, cephalometry].

Through a revision of the classical anatomy of the exocranial skull base, the authors present of a new exobasicranial plan in cephalometry, the Nasion-Glenion (or Porion plane). The median part of the base devoted to ventilation goes from the Nasion to the spheno-occipital synchondrosis, joining two essentially cartilaginous sites. The lateral parts, with manducatory functions, extend from supra-orbital rim to glenoid fossa and are mainly membranous. Pterygoid processes belong to the facial squeleton. Dental and growth axes are projected on the new exobasicranial base. Facial structures are analyzed in four planes, perpendicular to Francfort plane (facial cutaneous plane, premaxillary plane, postmaxillary plane, craniocervical plane).

Cephalometry↗

[Development of a computerized automatic identification system for use in cephalometry].

OBJECTIVE: To establish the automatic X-ray cephalometric analysis system to simplify cephalometric steps and to provide a convenient and reliable method for cephalometric analysis. METHODS: The system which was programmed by visual-c language, and graphics and image processing techniques and artificial intelligence were used. The techniques related to computer digital image processing and pattern recognition such as Median filtering, Histogram equalization, Laplacian and Canny edge detection were introduced. It could automatically outline the contour lines of the hard and soft tissues by establishing the templates of the variable anatomical structures. RESULTS: The following functions were established: (1) automatically outlining the contour lines of the soft tissues. (2) automatically recognizing, measuring and analysing the landmarks of soft tissues. (3) automatically recognizing porion, sella and the landmarks of the mandible. (4) automatically building the contour lines of the hard tissues. In brief, the system used the more advanced methods, calculated more precisely and saved more time and energy than other systems. CONCLUSION: The system is a more convenient and precise tool in cephalometry.

Cephalometry↗

[Cephalometry study of craniofacial and upper airway in boys with OSAS].

OBJECTIVE: The purpose of the study was to find out craniofacial and upper airway characteristics of boys with OSAS. METHODS: Craniofacial and upper airway morphology was studied by computerized cephalometric analysis in 7 mixed dentition boys with OSAS and 29 healthy boys. RESULTS: The main differences of OSAS patients were shown as follows: longer dimension of cranial base with clockwise rotation of palate plane and mandibular plane, increased height of the tongue, inferiorly displaced hyoid bone, decreased sagittal dimension of upper airway in soft palate level and tongue base level. In addition, the tongue and soft palate occupied a larger portion of the oropharyngeal area. CONCLUSION: Patients with OSAS presented multiple abnormalities in craniofacial and upper airway. Cephalometry can be useful in diagnosis and determining the appropriate treatment for OSAS patients.

Cephalometry↗

[Morphology of the soft palate in normal humans with digital cephalometry].

OBJECTIVE: To study the morphology of the soft palate in normal humans with digital radiography and to provide the references for therapy of the cleft. METHODS: 106 normal people were involved. The morphology of the soft palate was observed with digital cephalometry. RESULTS: All static images of soft palate could be divided into six types: Shuttle-shaped, crescent-shaped, strip-shaped, S-shaped, hamulus-shaped and anomalous shaped. The dynamic image was knee-shaped. CONCLUSION: The morphology of the soft palate is varied.

Cephalometry↗

[Processing of cephalometry: Delaire's architectural and structural analysis].

This work purpose a performing system for the Cephalometry: Cephor a software for Delaire's analysis. From a radiography, we draw outlines on graphic tablet. Following in a short time, we obtain results: precise diagnosis permitting to establish a care plan. This care plan is indicated on the screen where we can simulate correction from a choised therapeutic (osteotomy for example). Moreover, this soft ware allows to survey numerically and graphically a treatment, allows to use others methods (Tweed, Ricketts, Steiner). Technological advantages rest on a hard gain of time and a precision gain. The large handiness of this system allows reproducible measures easily. Therefore, we own with this software an improvement and a performing system.

Cephalometry↗

The reproducibility and the validity of landmarks for the antero-inferior part of the maxilla in radiographic cephalometry.

Two possible landmarks, C1 and C2, were evaluated as alternatives to the A point (subspinale), in lateral radiographic cephalometry. The landmarks were determined on tracings of 25 straight lateral radiographs. Horizontal and vertical coordinates were recorded for C1 and C2, and also for point A, and the incisor edge and apex. The reproducibilities of the landmarks were determined by statistical analyses of the differences between landmark determinations on repeated tracings. Regression analyses were used to evaluate the validity of measurements on C1 and C2 in relation to corresponding measurements on the A point. In addition, the influences of upper incisor inclinations and of alveolar process inclinations on validity were investigated by regression analyses and analytical geometry, respectively. The reproducibility of all landmarks including C1 and C2 was high (correlation coefficients above 0.985). Both C1 and C2 were strongly correlated with point A (adjusted R2 values from 82 to 85 per cent). The inclination of the lingual aspect of the alveolar process may change from an alteration of the incisor inclination. When this happens, the positional change of C2 horizontally is smaller than the change of C1. Therefore, C2 appears to be the more valid landmark for horizontal measurements. The designation suggested for this landmark is C.

Alveolar Process↗

Sex determination by discriminant function analysis of lateral radiographic cephalometry.

The present work is an attempt to develop a new method to determine sex from the skull with lateral radiographic cephalometry and discriminant function analysis. The superciliary ridges, frontal sinuses, external occipital protuberance, and mastoid processes were adopted as objects of lateral radiographic cephalometric measurements. With discriminant functions created from 18 established cephalometric variables, a total of 100 cases were classified into two sexual groups with 100% accuracy in a random sample of Taiwanese adults. Therefore, we may obtain a much greater reliability of sex determination from skulls according to this newly developed technique.

Adult↗

Radiographic cephalometry of the facial profile.

Radiographic cephalometry is a biomorphological measuring method used in the prosthodontics as well, and for the facial profile analysis of persons with complete dentures. The purpose of this examination was to objectivize the facial esthetics in patients with complete dentures. The measurements were taken from LL X-ray radiographs obtained by the apparatus "Ortoceph 10" (Siemens, Bensheim, Germany). On the sample of 80 subjects a convexity angle of facial bone structures (N-A: A-Pg) and profile angle of soft facial tissue (ft-unt: lnt-ct) have been examined. The subjects were divided into a group with upper and lower complete dentures (20 males and 20 females) and a group with natural teeth of eugnatic characteristics (20 male and 20 female). The measurements were taken by standard protractor at 0.5% precision. The statistical analysis within and among groups has been made by F-test and t-test respectively. The results showed that the bone structure convexity angle span a range between 0 degree and 5.5 degrees (X = 2.5 degrees), and the facial profile angle between 139.5 degrees and 155 degrees (X = 149 degrees) in persons with complete dentures. In persons with natural teeth the values of bone structure convexity angles span a range between -0.5 degree and 4.8 degrees (X = 2 degrees), and the facial profile angle between 136 degrees and 155.5 degrees (X = 151 degrees). The results of tests proved that there were no statistically significant differences in examined variables between persons with natural teeth and those with complete dentures (p > 0.05). The conclusion is that clinical methods of determining the vertical and horizontal intermaxilliary relations used in the designing procedures of complete dentures were reliable enough in reconstruction of examined angles of soft and hard facial profile structures.

Case-Control Studies↗