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PubMed1978

Uterine T-mycoplasma colonization in reproductive failure.

In 46 patients with a history of habitual abortion and in 18 women with primary unexplained infertility, samples from cervical mucus and endometrial tissue have been examined for presence of T-mycoplasma, and the results compared to those obtained among 45 control subjects. Colonization of T-mycoplasma in the cervix was found to be common in all patient groups (49 to 83 per cent), whereas colonization in the endometrium was found to be significantly more frequent among the habitual abortion patients (28 per cent) and the infertility patients (50 per cent) than among the control subjects (7 per cent). In all patients having T-mycoplasma-positive endometria the organism was also isolated from the cervix, thus indicating an ascending route for the colonization of the uterine cavity. Bacteria belonging to the normal vaginal flora were frequently co-isolated from the endometrial samples along with T-mycoplasma. The women with T-mycoplasma-positive endometria showed a high incidence of postabortion fever. Treatment with doxycycline eradicated T-mycoplasma from the cervix and the endometrium and apparently led to an improvement with respect to the outcome of the posttreatment pregnancies.

Abortion, Habitual↗
PubMed1975

Antibodies to spermatozoa. V. Antibody activity in human cervical mucus.

Efforts were made to seek sperm antibody activity in human cervical mucus (C.M.). A procedure of extraction was developed, as well as methods for measurement of total protein and of immunoglubulin level. The antibody testing was done by the Kibrick (K-B-M) and F-D methods. In clear contrast with negative control serum and negative C.M. samples, positive activity could be found in the C.M. extracts from several infertile women. Some of these manifestations were seen as positive K-B-M agglutination, whereas some were seen either as agglutination or immobilization in the F-D test; hence, three kinds of observation can be indicative of sperm antibody in extracts of cervical mucus.

Antibodies↗
PubMed1976

The interpretation and significance of the fractional postcoital test.

The investigation was designed to objectively determine the clinical usefulness of the fractional postcoital test. Forty-three normal subjects had midcycle cervical mucus collection at various times after insemination. There was a significant correlation between the number of motile sperm at the internal os level and the total sperm count within the cervical mucus. The median internal os count was 15 motile sperm per high-power field with a lower 95% confidence limit of five motile sperm per high-power field. Therefore, the fractional postcoital test is useful clinically as it is a physiologic indication of sperm transport in cervical mucus.

Adult↗
PubMed1976

Inadequate cervical mucus--a cause of "idiopathic" infertility.

The purpose of this study was to investigate and treat a group of patients referred for "idiopathic" infertility in whom no apparent cause for infertility, apart from inadequate cervical mucus, was found. Hormone investigations revealed that these patients could be divided into two groups: those with low sex steroid profiles despite apparent ovulation, and a second group with normal sex steroid profiles. All patients were treated with ovulation-inducing agents in an attempt to produce "controlled" ovarian hyperstimulation and an improved cervical mucus. Four of six patients conceived. The rationale behind the use of ovulation-inducing agents in this situation is discussed.

Adult↗