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PubMedDate not supplied

[Immunomodulating effects induced by the regulators of energy metabolism and the exposure to heat and cold in case of toxic affection of the kidneys].

The injection of HgCl2 to Wistar rats results in the affection of the excretory renal function, the development of immunosuppressive properties of red blood cells and the depression of immunological functions. The exposure to heat in combination with the injection of thiamin and inosin caused normalization of the immunological parameters of the intoxicated animals. The exposure to cold aggravates the severity of the immunological abnormalities induced by the injection of HgCl2. Thiamin in combination with inosin and carnitin with biotin significantly weaken the immunological disorders caused by intoxication and cooling.

Animals↗
PubMed1988

Benefit of a 37 degree C extracorporeal circuit in plasma exchange therapy for selected cases with cold agglutinin disease.

Plasmapheresis is commonly advocated in cold agglutinin disease with life-threatening hemolysis. Some clinicians, however, are reluctant to use this therapy because of perceived technical problems and risks attendant with the temperature of the extracorporeal circulation. In this study we report our experience of two patients with severe life-threatening hemolysis and in whom plasma exchange was not feasible due to red blood cell autoagglutination in the extracorporeal circuit. A method is described involving the use of blood warmers and the Fenwal CS-3000 blood cell separator with its 37 degrees C centrifuge compartment. The use of plasma exchange in this manner is a safe and beneficial form of adjunctive therapy and should be considered for patients with cold agglutinin disease at risk for extracorporeal agglutination or hemolysis.

Adolescent↗
PubMedDate not supplied

[Splenic lympho-plasmocytic sarcomas discovered by exploratory laparotomy in 2 cases of cold agglutinin disease].

The 2 patients have cold agglutinin disease with lymphoid nodules in the bone marrow. A splenectomy was done because of the severity of the hemolytic anemia and because of the increasing splenomegaly. Tumoral nodules with the aspect of lymphoplasmocytic sarcoma or immunocytoma were discovered in the spleen. Those tumors can be considered either as a morphologic aspect of the cold agglutinin disease which is yet considered as a kind of chronic lymphoproliferative syndrom or as the proliferation of an other clone. In this hypothesis, the lymphoplasmocytic sarcoma habe the same signification that the Richter's syndrome in chronic lymphoid leukemia and that the sarcoma appearing in Waldenström's macroglobulinemia or in alpha heavy chain disease.

Abdomen↗