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[Examination of confusion loci in acquired color vision deficiency with surface color].

Miscellaneous color vision tests were performed on 66 eyes in 46 acquired blue-yellow deficiency cases, in which the deficiency resembled congenital tritanopia. The confusion loci converged at a point on the short wavelength side of the spectrum in central chorioretinopathy, diabetic retinopathy, branch retinal vein occlusion, retinal pigmentary degeneration, and macular degeneration. However, the confusion loci of glaucoma differed from those of the other 5 diseases of the retina. They crossed the purple boundary, showing a unique tendency among the diseases exhibiting acquired blue-yellow deficiency. In these diseases, except in chorioretinopathy, no correlation was observed between visual acuity, visual field and color confusion.

Adult↗

[Examination of central vision. Visual acuity, contrast sensitivity, color vision].

In the neurophysiological organization of the visual system, form, color, movement, and depth perception are processed separately. Therefore, sensorial examination methods should test each of these basic functions separately, since they may be affected individually or to different extents by pathologic processes. For diagnosis the limit of visual acuity, i.e., the capacity for discrimination must be searched for, using Paliaga's "limits method". Visual acuity can also be tested in infants by the preferential looking method. Contrast sensitivity is tested using sinusoidal grid patterns of varying contrast and spatial frequency. In routine practice, however, this is usually achieved more easily with acuity cards on which contrast is reduced in several stages. The "two-equation method" is a colorimetric test combining two metameric matches, red + green = yellow, and blue + green = cyan, for testing color vision. The test requires an anomaloscope or anomalometer with four light channels. With this method it is possible to test the "red", "green", and "blue" cones and the "red-green" and "blue-yellow" opponents. The test provides a qualitative and quantitative evaluation of color vision disorders. If no colorimeter is available, classic printed test can be used. However, they might never achieve the same qualitative and quantitative precision.

Color Perception Tests↗

[Physical models of color vision].

Models of color vision are discussed on the basis of determining the difference between the signals of sensors of white (rods) and color (cones) vision. It was shown that the whole optical spectrum (RGB) can be obtained, provided only two and four types of sensors are used within a three-component model of color detection. The described models provide for comprehensive explanations to extensive experimental data on color vision.

Color Perception↗

Molecular basis for color vision.

Amino acid sequences of four kinds of chicken cone pigments and two kinds of nocturnal gecko visual pigment were determined. Calculations of amino acid identities indicate that gecko pigments should be cone pigments. A phylogenetic tree of visual pigments constructed demonstrated that cone pigments evolved earlier than rod pigments (rhodopsins), indicating that daylight vision including color vision appeared earlier than twilight vision. The divergence of cone pigments to rhodopsins would be caused by replacing basic amino acid residues to acidic ones according to net charge calculations. A comparison between chicken rhodopsin and cone pigments (chicken green and red) displayed that the cone pigments are faster in regeneration from 11-cis retinal and opsin, faster in formation of meta II-intermediate and shorter in lifetime of meta II-intermediate than rhodopsin. These facts would partly explain the rapid dark adaptation, the rapid light response and the low photosensitivity of cones compared with rods. In comparison with di- and tri-chromatic color visions, chicken tetra-chromatic vision was discussed on the basis of both absorption spectra of cone pigments and filtering effect of oil droplets.

Animals↗

Clinical implications of color vision research.

The attributes of color and the mechanisms underlying normal and defective color vision are reviewed. The clinical implications of some research efforts bearing on congenital and acquired color defects, peripheral color vision, and the influence of photostable pigments on color vision and color vision tests is presented. This presentation is intended to illustrate how selected avenues of research have contributed to our understanding of color vision and to demonstrate the clinical utility of that research.

Color Perception↗

Numbers and ratios of visual pigment genes for normal red-green color vision.

Red-green color vision is based on middle-wavelength- and long-wavelength-sensitive visual pigments encoded by an array of genes on the X chromosome. The numbers and ratios of genes in this cluster were reexamined in men with normal color vision by means of newly refined methods. These methods revealed that many men had more pigment genes on the X chromosome than had previously been suggested and that many had more than one long-wave pigment gene. These discoveries challenge accepted ideas that are the foundation for theories of normal and anomalous color vision.

Base Sequence↗

Testability of a color vision screening test in a population with mental retardation.

PURPOSE: The purpose of this study was to determine the testability of the "Co or Vision Testing Made Easy" color vision test, marketed as a screening test for young children, in a population of individuals with mental retardation. The test uses simple geometric figures that are easily identified. Previously, the test has demonstrated validity as a measure of color deficiency. METHODS: The test was presented to Special Olympic athletes, who are individuals with mental retardation or significant developmental delay, at four sites: the 1997 World Winter Games in Toronto, Canada; the Texas Summer Games in Houston, Texas; the Massachusetts Summer Games in Boston, Massachusetts; and Regional European Swim Competition in Seville, Spain. The criteria for passing was 8 correct responses on the first trial or 9 of 9 on the second attempt. RESULTS: Testability in Toronto, Canada; Houston, Texas; and Seville, Spain was high--95.5%, 98.7%, and 95.7%, respectively. Testability, however, dropped to 78.8% during the Boston, Massachusetts screening. There was no apparent difference in the testing environment that would account for the difference. The overall rate of testability was 93.2% for the 1078 athletes screened. The frequency of males identified as color deficient was similar to that expected in the general population; only two females (in Spain) failed the color vision screening. CONCLUSIONS: The "Color Vision Testing Made Easy" color vision test was successfully completed by a very high percentage of Special Olympics athletes. These results suggest that this test is useful in screening this population for color deficiencies, and that the prevalence of color vision deficiencies is approximately the same in individuals with mental retardation as in the general population.

Adolescent↗

Color vision and the four-color-map problem.

Four different colors are needed to make maps that avoid adjacent countries of the same color. Because the retinal image is two dimensional, like a map, four dimensions of chromatic experience would also be needed to optimally distinguish regions returning spectrally different light to the eye. We therefore suggest that the organization of human color vision according to four-color classes (reds, greens, blues, and yellows) has arisen as a solution to this logical requirement in topology.

Animals↗

[Congenital color vision deficiencies as a social problem].

Color vision standards for various occupations and schools have been greatly eased recently. However, if the trend is unaccompanied with proper advice for color defective persons, there is a risk of accidents such as occurred in the past when color vision standards had not been introduced, because the color vision defect is unchanged. In this context, the history of color vision standards and the color confusion by color defective persons in their daily life were reviewed. The collected data together with pathophysiological characteristics of defective color vision suggest that at least the following measures are necessary from a practical point of view: (1) By education and awareness, color defective persons can avoid errors in color in most cases. Therefore, ophthalmologists should inform them of their defects in childhood and give instructions on how to compensate for their disadvantages. (2) In public and occupational situations, all the information conveyed by color should include lettering or other forms of redundancy for the convenience of color defective persons.

Color Vision Defects↗

Effect of tinted contact lenses on color vision.

This study was designed to investigate the effects of various contact lens tints on color vision. Color vision performance of eight subjects was evaluated with the Farnsworth-Munsell 100 Hue Test while each subject wore each of 13 differently tinted contact lenses. No significant differences in color vision were found with the various lenses. However, performance on the test was affected by repetition. Regardless of the lens tints tested, color discrimination for the blue quadrant of the 100 Hue Test was the poorest. Further research is needed to determine the effect of tinted contact lenses on scotopic and mesopic vision.

Adult↗

Critical issues in the use and analysis of the Lanthony Desaturate Color Vision test.

The Lanthony Desaturate Color Vision test (D-15d) has been used to demonstrate the incidence of acquired color vision defects resulting from toxic exposure. The D-15d is a sensitive test designed to grade color deficiencies, but results can be difficult to interpret beyond the qualitative level, and the high incidence of errors reported for controls in some toxicology studies raises questions about how to effectively use this test. This article reviews standard administration of the test, physical determinants of performance, classification of acquired color vision defects, and methods of analysis that have been used to quantify results. The basis for a new method of analysis is discussed, illustrating the source of some characteristic errors, and recommendations are made for test protocols to attempt to more closely identify the type of color vision loss with the goal of identifying the site of toxicological insult.

Color Perception↗

More than three different cone pigments among people with normal color vision.

A fundamental feature of normal color vision is that red and green lights can be mixed to appear identical with a monochromatic yellow light. Another characteristic of normal color vision is that people often disagree on the amounts of red and green needed in the mixture to exactly match the yellow. Comparison of such color vision differences with photopigment gene differences reveals that a serine/alanine polymorphism at amino acid position 180 of X-encoded pigments can account for this type of color vision variation. This amino acid change shifts the spectrum of the pigment produced by about 6 nm, a value that would predict a larger minimum color vision difference between individuals than is actually observed. This discrepancy can be explained if, counter to the Young-Helmholtz theory as the explanation of trichromacy, many people with normal color vision have more than three spectrally different cone pigments.

Base Sequence↗

Color vision: how the cortex represents color.

Our understanding of how we see color has benefited from the long tradition of visual psychophysics. More recently, models and methods from psychophysics are guiding modern neuroimaging experiments on color vision. Combining the two techniques can lead to discoveries that neither can make alone.

Cerebral Cortex↗

A quantitative scoring technique for panel tests of color vision.

Panel tests of color vision (eg FM100-Hue test) lack a common quantitative method for the scoring of cap arrangements. We describe a scoring method applicable to all panel tests that makes use of a novel technique to analyze test cap data, namely the calculation of a moment of inertia from the Color Difference Vectors (CDVs) of any arrangement pattern. Using the Farnsworth D-15 panel, as an example, we specify how to determine CDVs and demonstrate the benefits of calculating a moment of inertia for the analysis of these vectors. Moment of inertia analysis yields three factors which quantify cap arrangements: the first is the confusion angle which identifies the type of color defect; the second is the Confusion index (C-index) which quantifies the degree of color loss relative to a perfect arrangement of caps; and the third is the Selectivity index (S-index) which quantifies the amount of polarity or lack of randomness in a cap arrangement. A retrospective study on the result of 53 normal and 66 congenitally color defective observers is reported and provides normative data. We show that the technique differentiates between different types of color defect and provides useful clinical information regarding a loss of color vision. Likewise, a similar observation is made on a smaller sample of FM100-Hue results. A BASIC computer program is provided for anyone wishing to use the technique.

Adolescent↗

Color vision in diabetic school children.

The color vision of 64 diabetic school children was studied. Acquired color vision defects due to diabetes could not be found in any of the children. Two of the children had a congenital red-green color vision defect. In the examination, three different pseudoisochromatic plate tests (Isihara, Standard Pseudoisochromatic Plates part 2, and Lanthony Tritan Album) were used as well as the Nagel anomaloscope and three different cap arrangement tests (Panel D 15, Lanthony Desaturated Panel, and Farnsworth-Munsell 100 hue). The plate tests and the anomaloscope examination were fast, reliable, and well accepted by the children. The cap arrangement tests took more time, and many of the children neither liked nor properly performed these tests. Twelve color dependent glucose strip tests for diabetes care at home were also studied. A few of the youngest school children made mistakes in interpreting the colors of these strips, although their color vision was normal.

Adolescent↗