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Results for “DENTAL PULP EXPOSURE”

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At least 55 records · Page 3Linked to original sources
PubMed2001

Periapical lesion progression and cytokine expression in an LPS hyporesponsive model.

AIM: The purpose of this study was to compare periapical lesion progression and the expression of the bone modulating cytokines IL-1alpha, TNF-alpha, IL-4, IL-6 and IL-11 in periapical lesions of normal and C3H/HeJ (LPS hyporesponsive) mice. METHODOLOGY: Pulps of both mandibular first molars from C3H/HeJ and BALB/c (normal) mice were exposed and inoculated with normal mouse oral microorganisms for 2, 4, 6, and 8 weeks. After euthanasia, specimens were prepared for histological examination. A quantitative evaluation of the lesional area and immunohistochemical stain counts was performed. RESULTS: There were no statistically significant differences in progression of periapical lesions for both mouse strains with time (two-factor ANOVA, P > 0.05). The immunohistochemical staining revealed no overall differences between the two strains in levels of expression of the cytokines (P > 0.05). IL-11 expression did not change from control levels in BALB/c mice, but correlated with the expression of IL-6 and IL-4 in C3H/HeJ mice. CONCLUSION: Responsiveness to LPS may not be significant in the pathogenesis of periapical lesions and in cytokine expression within the lesions, when the lesions are induced by non-specific oral flora.

Analysis of Variance↗
PubMed1997

IL-1 alpha and TNF-alpha expression in early periapical lesions of normal and immunodeficient mice.

T-helper and B-lymphocytes may contribute to mechanisms that result in bone-resorptive cytokine production in periapical lesion. Mice with severe combined immunodeficiency (scid) lack functional B- and T-cell immunity. The purpose of this study was to investigate the progression of pulp necrosis and the histomorphometric features of periapical lesions in scid vs. normal mice. The expression of the bone-resorptive cytokines IL-1 alpha and TNF-alpha was also investigated. Sixteen five-week-old homozygous scid mice and 14 normal BALB/cJ mice were used. The pulps of mandibular first molars were exposed for 1, 2, 3, or 4 weeks. Blocks of tissue containing the mandibular teeth and supporting structures were processed for both light microscopic examination and immunohistochemical staining for IL-1 alpha dna TNF-alpha. Central sections were randomized, their images were blindly digitized into a computer, and the areas of the lesions surrounding the distal root apices were measured. The cells that stained positively for the cytokines in the same area of adjacent sections were counted. Pulp necrosis progressed at similar rates in teeth from both strains. A progressive and significant increase in the periapical lesion size in both strains was observed. The scid mice lesions were significantly smaller than the controls at only the three-week period. There was heavy cytokine staining in periapical lesions from both strains, especially in areas that contained a mixed inflammatory infiltrate or fibroblasts. The number of positively staining cells was proportional to the lesion size. Therefore, pulpal and periapical pathosis were independent of the presence of functional T- and B-cells in this model.

Alveolar Bone Loss↗
PubMedDate not supplied

Caries and dentin. Myths & consequences.

The dentin-pulp complex is sensitive to infection. Restorative treatment should function as a Band-Aid protecting the dentin-pulp complex from bacteria and their byproducts. This article describes different ways of treating the exposed dentin-pulp complex in such a way that bacterial infection can be avoided.

Dental Caries↗
PubMed1975

[Determination of vitality of the dental pulp].

The means and methods most frequently used today for testing the sensitivity of the pulp are examined and critically evaluated. It was found that all of them comply with the requirements they should meet, but that they differ with regard to their field of application and the reliability of the information they furnish.

Aerosols↗
PubMed2000

Treatment of teeth with open apices using mineral trioxide aggregate.

Injuries to the dentition may ultimately result in the interruption of root development. If the pulp remains vital following trauma, this state should be maintained and root-end closure should be induced by apexogenesis. When the pulp is necrotic, the placement of an apical barrier can be utilized as an alternative to establish an environment that facilitates the closure of the apical opening. This article demonstrates the use of mineral trioxide aggregate as an apical barrier material for root-end closure in the permanent teeth of three patients.

Aluminum Compounds↗
PubMed2004

Longevity of composite restorations of traumatically injured teeth.

PURPOSE: To evaluate clinically the long-term (7-year) behavior of resin-based composite restorations and original fragment reattachments. METHODS: From an initial number of 130 young subjects (8-18 years old), only 60 fulfilled the inclusion criteria and consented to the evaluation of long-term follow-up of their restorations. Out of a total of 90 injured teeth, 70 were treated with direct composite restorations, and 20 with the original fragment reattachment technique. These 90 teeth were divided according to traditional (Andreasen, Ellis) classifications and according to a new classification (Spinas-Piroddi). Then the restorations were examined according to a modified version of USPHS method during the 7-year follow-up. RESULTS: Three-year old composite restorations needed some kind of treatment (ranging from polishing to the replacement of the restoration); in the period between 3-5 years, all the restorations (belonging to all of the injury types) needed a complete replacement. The results indicated that a restoration can probably be replaced three or four times before the tooth shows severe reduction of its adhesive properties. Composites cannot be used for long-term restorations; if the subject has completed his growth, the mandatory therapeutic alternatives are prosthetic restorations (crowns, porcelain veneers).

Adolescent↗
PubMed1990

[Pulpectomy. Why? When?].

There are many circumstances under which the condition of the pulp calls for root canal work, due to the real or potential risk of pain, infection, inflammation or functional difficulties (acute, irreversible pulpitis, chronic pulpitic conditions, necrosis and its consequences, etc.). Other circumstances exist in which injury to the pulp is not necessarily irreversible: initial pulpitis, iatrogenic fracture of the pulp, traumatisms, dystrophic deteriorations. The high success rate for endodontic therapy could argue for elimination of impaired or necrose-prone pulp. In fact, however, unsuccessful pulpectomies often lead to loss of the dental organ and successful endodontic treatment severely weakens the whole tooth structure and often implies prosthetic restoration, with the consequent increase in tissular loss. In order to preserve pulp and crown tissues, pulpal vitality should be protected in all cases where such conservative efforts do not worsen the prognosis for maintaining the tooth on its arch or jeopardize a planned restoration. Solutions are presented for various types of situations, according to the risks encountered.

Contraindications↗
PubMed1972

[The pulp].

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Dental Cavity Preparation↗