[Pick-Herxheimer's acrodermatitis with sclerodermatomyositis, calcinosis & pseudo-neoplastic pyodermatitis vegetans].
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Acrodermatitis↗
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Pyodermatitis-pyostomatitis vegetans: a specific marker for inflammatory bowel disease.
In pyodermatitis-pyostomatitis vegetans annular pustular cutaneous lesions may precede, accompany, or follow the usually extensive vegetating oral disease. Sometimes only cutaneous or only oral lesions occur and previously have been described as separate entities. Clinical, histopathologic, and immunopathologic evidence clearly indicates this is one disease and suggests that it is distinct from pemphigus vegetans. The association between pyodermatitis-pyostomatitis vegetans and inflammatory bowel disease, most commonly ulcerative colitis, has been amply confirmed. Pyodermatitis-pyostomatitis vegetans should be considered a marker for inflammatory bowel disease.
Adolescent↗
Childhood pemphigus.
BACKGROUND: Five children with pemphigus are reported: three with pemphigus vulgaris, one with pemphigus vegetans, and one with pemphigus foliaceus. Only one case of juvenile pemphigus vegetans has been published in the literature. MATERIALS AND METHODS: All three patients with pemphigus vulgaris were treated with oral corticosteroid; in two cases, azathioprine was added for steroid-sparing effect. The patient with pemphigus vegetans had a clinical presentation resembling pemphigus vulgaris, but the lesions in the perianal area healed as hypertrophic granulation tissue. He was treated with oral corticosteroid, azathioprine, and intralesional corticosteroid. The patient with pemphigus foliaceus presented with exfoliative dermatitis, and was treated with oral corticosteroid; methotrexate was added later for steroid-sparing purposes RESULTS: The patients were followed up for 1-4 years; the prognosis of childhood pemphigus is good. CONCLUSIONS: Long-term follow-up is needed to detect flaring of the disease and the side-effects of immunosuppressive drugs.
Adolescent↗
Cytokine pattern in blister fluid and sera of patients with pemphigus.
BACKGROUND: Pemphigus is a chronic auto-immune blistering disease with four main variants, i.e. pemphigus vulgaris (PV), foliaceus (PF), erythematosus (PE) and vegetans. The common histological feature of this disease is acantholysis. OBJECTIVE: The aim of this study was to compare levels of some cytokines in blister fluid and sera of patients with pemphigus, using as control blister fluid of patients with bullous pemphigoid (BP) and bullous contact dermatitis (BCD). METHODS: Using an immuno-enzymatic assay (ELISA), we tested 16 sera and 6 blister fluids of patients with various forms of pemphigus (13 with PV, 1 with PF, 2 with PE), the sera of 16 healthy control subjects, 5 blister fluids of patients with BP and 5 blister fluids of patients with BCD, for the presence of some cytokines (IL-10, IL-8 and IFN-gamma). Intercellular antibodies were searched for and titred; desmoglein 1 and 3 antibody levels were independently evaluated to compare them with the severity of both cutaneous and oral involvement. RESULTS: The levels of IL-10 in the sera of patients with pemphigus were below the detection limits. IL-8 was significantly increased only in 4 samples of sera from pemphigus patients compared with controls, while IFN-gamma was detected at low levels in almost all patients compared with sera of controls. The cytokine levels in blister fluid of patients with pemphigus were significantly higher than in the sera. There was a difference between the expression of cytokines in blister fluid of control patients with BP and BCD compared with those of pemphigus patients. CONCLUSION: This report discusses the anti-inflammatory role played by IL-10 in the chronic form of pemphigus and the hypothesis of a possible role of IL-8 in neutrophil and lymphocyte-monocyte recruitment.
Adolescent↗
[Groups at high risk for skin cancer].
A special program aimed at detecting skin cancer at early stages was worked out and launched into use in 1989. It provides for a series of measures for primary examination and subsequent follow-up of population. Dermatologists conducted examinations of persons at high risk 2-4 times a year depending on the disease. They were joined by oncologists, whenever required, and morphological examinations were sometimes carried out. The group at high risk for skin cancer included patients older than 50, with the following pathologies: (I) Obligate precancerous dermatites: Bowen's syndrome, erythroplasia of Queyrat, Paget's disease (extramammary localization), intraepidermal epithelioma of Jadassohn, late-onset radiation dermatitis, early childhood-Kaposi's disease, Manganotti's chilitis and verrucous precancer of the lip; Optional precancerous dermatosis: childhood-onset epidermodysplasia veruciformis, actinic keratosis, cutaneous horn, keratoacanthoma, carcinoid papillomatosis of Gottron, giant condyloma of Buschke-Lowenstein, leukoplakia and limited precancerous hyperkeratosis of the lip's red edge; (2) Dermatoses involving pathological regeneration: eruthematosis, lupus tuberculosis, psoriasis (more than 15 years old), trophic ulcers, extensive scars (particularly, those caused by burns), chronic ulcerative pyoderma and pyoderma vegetans; (3) Hemorrhagic diathesis on the surface or fundus of neoplasm; (4) Consolidation at neoplasm base; (5) Absence of complaints; (6) Resistance to therapy.
Aged↗
[Inflammatory skin diseases and hypereosinophilia].
Among the dermatoses associated with tissue eosinophilia are pemphigus vegetans, bullous pemphigoid, granuloma facial and Wells' syndrome. Eosinophilic spongiosis can occur in the early stage of pemphigus. Pemphigus herpetiformis, a recently introduced term, does not represent a well defined entity but develops into either pemphigus vulgaris or pemphigus foliaceus. Granuloma facial is basically vasculitis. Eosinophilic cellulitis or Wells' syndrome shows numerous eosinophils which degranulate and through confluence of their granules form the so-called flame figures.
Cellulitis↗