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At dipyridamole myocardial scintigraphy, perfusion defects are seldom backed up by significant ECG changes. This would suggest myocardial blood flow heterogeneity, rather than true ischaemia, as the cause of the scintigraphic abnormalities. Electrocardiographic surface mapping has been documented to be more accurate than standard 12-lead ECG in the detection of provoked ischaemia. Thus, to investigate the relationship between ECG changes and perfusion abnormalities, body surface maps were recorded during dipyridamole infusion in 55 subjects (11 normals and 44 patients with ischaemic heart disease) undergoing dipyridamole technetium-99m sestamibi single-photon emission tomography (SPET). All had a normal resting ECG. The extent and severity of the sestamibi defect were quantified. New negative areas in the isointegral maps and rest-dipyridamole map differences >2 SD from normal limits were considered abnormal. After dipyridamole in normals, neither perfusion defects nor >/=1 mm ST segment depression on 12-lead ECG nor new negative areas in isointegral maps occurred. In patients, dipyridamole induced new perfusion defects in 35 (80%) but ST segment depression in only 18 (41%, P<0.001). Of the 35 patients with perfusion defects, 17 (49%, group 1) showed ST segment depression, while the other 18 (51%, group 2) did not. Abnormal body surface maps were found in 100% of group 1 and 88% of group 2 patients (NS). In group 1, the provoked hypoperfusion was of greater extent (P=0.007) and severity (P=0.01) and the onset of map abnormalities was significantly earlier (P<0. 001) than in group 2; time to map abnormalities was also significantly shorter than time to ST segment depression (P=0.01). In the 35 patients with complete scintigraphic, body map and angiographic data, the severity of reversible perfusion defect proved to be the strongest correlate of ST segment depression upon logistic regression analysis. Thus, sestamibi SPET abnormalities after dipyridamole are almost always associated with electrical changes on body surface maps, suggesting myocardial ischaemia as their cause. The much less common 12-lead ECG changes are slower to appear and reflect a more severe hypoperfusion.
STUDY OBJECTIVE: Standardized reporting criteria for risk stratification studies of patients with potential acute coronary syndromes have been proposed. We sought to determine whether the categories in the recommended 6-item ECG classification system predict rates of 30-day death, myocardial infarction, and revascularization. METHODS: We conducted a prospective cohort study of emergency department (ED) chest pain patients who presented to a tertiary care center during a 32-month period. The treating physician classified all ECGs into defined categories. Patients were followed up for 30 days to determine death, myocardial infarction, and revascularization. Our main outcome was the rate of triple composite endpoint of death, myocardial infarction, or revascularization at 30 days from ED presentation in relation to the ECG classification category. RESULTS: There were 3,814 patients who presented to the ED a total of 4,487 times during the study period. Patients had a mean (+/-SD) age of 51.8+/-15.9 years, were more likely to be women (59%) than men, and were most commonly black (68%). The relationship between initial ECG classification and 30-day outcome was highly significant (P<.001), with event rates ranging from 3.2% to 72.7%, depending on ECG classification category. CONCLUSION: The ECG classification system that is being recommended in the standardized guidelines predicts 30-day composite rates of death, acute myocardial infarction, and revascularization.
We found significant variation within each computer and cardiologist method for measurement of the ECG waveform intervals. Comparison between methods revealed that the HP system had a smaller variability than the MAC or the cardiologist, and that the MAC had a smaller variability than the cardiologist. No variability was found when a cardiologist used different paper trace speeds. Using HP measurements, we found a significant difference in ECG intervals over time, which was greater than the variability found within the method at baseline. The delineation of variability within and between ECG interval measurement methods may allow more reliable application of ECG interval changes in the therapeutic medical management of patients and prevention of side effects from drugs that affect ECG intervals. Computerized ECG waveform analysis is a widely available technology whose full role in therapeutic medical management may not be appreciated.
The 12-lead electrocardiogram (ECG) and a 100-beat signal-averaged Frank lead ECG (SAECG) at a sampling rate of 1,000 Hz and with 16-bit resolution were recorded from 52 women and 256 men with significant coronary artery disease presenting for coronary artery revascularization. The QRS portion of each Frank lead was digitally filtered in four bandwidths: 0-10, 10-60, 60-150, and 150-250 Hz. The root-mean-square (RMS) voltage of each filtered signal was calculated as an absolute value and normalized as a percentage of the sum of the four filters, creating 27 variables. Three groups were formed using the presenting 12-lead ECG: N-ECG, ST-ECG, and MI-ECG. Despite variation in 12-lead morphology, concordance was dominant in the RMS values of the SAECG in sex comparisons within and between groups. There was significant sex difference of the RMS values in 6 of the 15 absolute RMS variables within the three groups. Women had no significant between-group difference, and men had a significant between-group differences in five absolute values and one normalized RMS value. P was considered significant at < .05.
The validity of the reported high prevalence of left ventricular hypertrophy (LVH) among African-American men and women has been questioned owing to conflicting echocardiographic evidence. We used echocardiographic left ventricular mass (LVM) from M-mode measurements to evaluate associations between LVM, body size, and electrocardiographic (ECG) variables in 3,627 white and African-American men and women 65 years of age and older who were participants of the Cardiovascular Health Study (CHS), a multicenter cohort study of risk factors for coronary heart disease and stroke. ECG amplitudes used in LVH criteria were substantially higher in African-Americans, with apparent LVH prevalence 2 to 3 times higher in African American men and women than in white men and women, although there was no significant racial difference in echocardiographic LVM. The higher apparent LVH prevalence by Sokolow-Lyon criteria in African-American men is in part owing to smaller lateral chest diameter. In women, reasons for racial differences in ECG LVH prevalence remain largely unexplained although a small part of the excess LVH in African-American women by the Sokolow-Lyon criteria appears to be owing to a larger lateral chest semidiameter in white women. ECG variables alone were too inaccurate for LVM prediction, and it was necessary to incorporate in all ECG models body weight that was properly adjusted for race and sex. This resulted in modest LVM prediction accuracy, with R-square values ranging from .22 to .36. Race- and sex-specific ECG models introduced for LVM estimation with an appropriate adjustment for body size differences are expected to facilitate evaluation of LVH status in contrasting racial population groups.
The effect of a standardized psychological stress test on frequency and severity of ventricular extrasystoles was compared in 42 patients with the results of 24-hour ECG monitoring and of an exercise ECG test. Frequent ventricular extrasystoles (greater than 1/min) occurred in the 24-hour-ECG in 22, in the psychological stress test in 24 and on physical exercise in 22 patients. 24-hour monitoring gave the only positive finding in ten, the psychological stress test in six, the exercise test in four. Complex arrhythmias (coupled or runs of ventricular extrasystoles) occurred in the 24-hour ECG in 30, with the psychological stress test in 16 and the exercise test in 12 patients. The 24-hour ECG was alone positive in 16, the psychological test in two, the exercise test in one. Thus in an individual patient the psychological stress test may provoke additional arrhythmias which are not recorded in either the 24-hour ECG or after exercise. The findings point to an independent significance of the psychological stress test in the diagnosis of simple and complex ventricular arrhythmias.
Severe maternal complications during beta-mimetic therapy have been reported. In a study of maternal complications related to intravenous tocolysis, which covering a period of 2 years, we paid special attention to the maternal ECG before and during treatment. There was a high prevalence of pretreatment ECG changes: tachycardia (23.6%), disorders of impulse conduction (43.6%), ST-depression (14.5%) and disorders of repolarization (43.6%). During intravenous beta-mimetic therapy there was an increase in the prevalence of tachycardia, prolonged QT-time and disorders of repolarization. We also studied the course in time of the different ECG characteristics during treatment. With regard to the ST-depression, a possible physiological adaptation to the beta-mimetic drug is described. We could not find this possible adaptation with regard to the other ECG characteristics. None of the women in the studied group showed clinical signs of myocardial ischemia, notwithstanding the high prevalence of ECG changes. We conclude that the ECG criteria for discontinuation of tocolytic therapy need re-evaluation.
DESIGN: Neonatal hypoxia is often responsible for myocardial ischaemia. To evaluate cardiac involvement in neonates, fetal and neonatal ECG recordings have been performed and parameters indicating heart dysfunction have been analysed. OBJECTIVES: Our interest has been focused on analysis of fetal electrocardiogram recordings using STAN S21 analyser during labour, compared to newborns ECG recordings in the first 12 hours of life, in relation to enzymatic ischaemic markers and acid-base parameters in umbilical blood. MATERIALS AND METHODS: The data were collected from 8 term fetuses and neonates, continuously monitored in the first and second stage of labor. All ECG were recorded with a single spiral scalp electrode connected to the STAN S21 analyser. After birth, umbilical venous blood samples have been collected for determination of pH, base excess and concentrations of creatinine kinase (CK), its isoenzyme (CK-MB), myoglobin, lactate dehydrogenase (LDH), alanine transaminase, aspartate aminotransferase. In the first 12 hours of life, external neonatal ECG was performed. RESULTS: P,QRS and T waves have been present in all cases recorded. There was no suggestion of fetal hypoxia in any case. A little variety of QRS complex has been observed. In our study, we didn't noticed any pathological changes in ECG recordings. The QT interval, corrected by the Bazett formula was normal in all cases. Nevertheless correct ECG recordings, increase of enzymatic ischaemic markers (LDH, CK,CK-MB) has been observed in two cases, corresponding to the normal fetal outcome.
The use of computer ECG systems has become widespread in Japan, and many new models are available. In order to provide a method for comparative evaluation, a microprocessor-based ECG signal generator was built. This generator was used to compare 10 of the computer ECG systems which are currently available in Japan. Since the generator can produce a precisely defined wave form, it is particularly suited for testing the reproducibility of diagnostic interpretation. Several deficiencies of some current ECG analysis systems were noted. Specifically in three systems, there was interference of the interpretation of morphology with the interpretation of rhythm when WPW-like patterns were analyzed. The current evaluation concentrates on the reproducibility of interpretation in the tested systems. As the library of test ECG patterns is expanded in the future, the technique will also become applicable to the evaluation of diagnostic accuracy.
AIMS: The conventional 12-lead electrocardiogram (cECG) derived from 10 electrodes using a cardiograph is the gold standard for diagnosing myocardial ischemia. This study tested the hypothesis that a new 5-electrode 12-lead vector-based ECG (EASI; Philips Medical Systems, formerly Hewlett Packard Co, Boeblingen, Germany) patient monitoring system is equivalent to cECG in diagnosing acute coronary syndromes (ACSs). METHODS: Electrocardiograms (EASI and cECG) were obtained in 203 patients with chest pain on admission and 4 to 8 hours later. Both types of ECGs were graded as ST-elevation myocardial infarction if at least 1 of the 2 consecutive recordings showed ST elevation more than 0.2 mV, as ACS if one or both showed ST elevation less than 0.2 mV, T-wave inversion, or ST depression. Otherwise, the ECG was graded negative. RESULTS: Final diagnosis was identical in 177 patients (87%; 95% confidence interval [CI], 82%-91%; kappa = 0.81; SE = 0.035). ST-elevation myocardial infarction was correctly identified or excluded by EASI with a specificity of 94% (95% CI, 89%-97%) and a sensitivity of 93% (95% CI, 86%-97%; using cECG as the gold standard). Of 118 patients with enzyme elevations, an almost identical number (72 [61% by EASI] and 73 [62% by cECG]) had ST elevations. Both techniques were equivalent in predicting subsequent enzyme elevation (identical, 108/143; 75% of ACS and ST-elevation myocardial infarction ECGs by EASI and cECG). Thus, both ECG methods had exactly the same specificity of 59% (95% CI, 48%-69%) and sensitivity of 91% (95% CI, 85%-96%) for detecting myocardial injury. CONCLUSION: EASI is equivalent to cECG for the diagnosis of myocardial ischemia.
The purpose of this experiment is to study the possibility of intra-QRS high-frequency electrocardiographic (HFECG) changes for the evaluation of and recovery from myocardial ischemia in both the time-domain and spectral-turbulence analyses on the signal-averaged ECG using the Holter ECG monitoring (Holter SAECG) system. A balloon catheter was inserted into the left anterior descending coronary artery (LAD of 8 mongrel dogs and was maintained inflated for 2 hours to occlude the LAD and then was deflated to allow for reperfusion. The cardiac signal from the three orthogonal leads of the surface ECG (X, Y, and Z) was recorded and analyzed with a Del Mar Avionics (model 459, Irvine, CA) recorder and analyzer (model 563). The Holter SAECG was assessed before the LAD occlusion phase (control), during the coronary occlusion phase (ischemia), after the reperfusion phase (recovery). To evaluate intra-QRS ECG changes in the time-domain analysis, root-mean-square (RMS) voltage of the entire QRS in 40-250 HZ (40 RMS), 100-250 Hz (100 RMS), and 150-250 Hz (150 RMS) were studied and the vector magnitude of the QRS was depicted. In the spectral-turbulence analysis and spectrocardiogram to study the discordance of the ECG wave front velocity by fast Fourier transformation analysis, the interslice correlation mean (IC mean) and interslice correlation standard deviation (IC SD), which were calculated as the mean and standard deviation of the Pearson correlation coefficient of each time slice with its neighbor, were investigated. In the time-domain analysis, the LAD occlusion by balloon catheter at ischemia produced a reduction in 40 RMS, 100 RMS, and 150 RMS, while a restoration was seen at recovery in 40 RMS and 100 RMS. In the spectral-turbulence analysis, LAD occlusion at ischemia caused a decrease in IC mean and an increase in IC SD. The waveform of the vector magnitude and the spectrocardiogram seen at control showed changes with ischemia and was restored at recovery with the coronary reperfusion. It was thought possible to capture the intra-QRS HFECG changes that occur during myocardial ischemia and recovery from it in the time-domain analysis and spectral-turbulence analysis on the Holter SAECG system in spite of the limitation of this methodology. To evaluate myocardial ischemia and recovery, this method should be useful clinically.
The accuracy of commercially available ambulatory electrocardiographic monitoring (AEM) systems for reproducing ischemic changes has been questioned. Since these systems are widely used for evaluation of ST-segment changes, both for prognostic purposes and for assessment of the efficacy of antiischemic drugs, such doubts must be clarified. For this purpose, we recorded electrocardiograms (ECGs) during exercise testing, using split leads, simultaneously with a 12-lead electrocardiograph and with the Marquette AEM recorder. We studied 29 patients with proven coronary artery disease and positive exercise tests and 19 individuals with low likelihood of coronary artery disease and negative stress tests. All 29 patients who had ST-segment depression during exercise as recorded on the 12-lead ECG had ST-segment depression in at least one of the three AEM leads (resembling the V5, V3, and aVF leads of the 12-lead system). The maximal degree of ST-segment depression with AEM was similar to 12-lead ECG (2.3 mm and 2.1 mm, respectively). The best lead for ischemia detection with AEM was the V5 type, which detected ischemic changes in 26 of the 29 patients, while the 12-lead V5 detected ischemia in 24 patients. The inferior AEM lead detected ischemia in only 4 patients, while the aVF lead of the 12-lead ECG detected ischemia in 23 patients. Of the 19 patients with negative exercise tests only 1 patient had a 1-mm ST-segment depression on AEM. Thus, of the 48 patients studied, similar responses were observed in 47. The results of indicate that the Marquette AEM system is as accurate as the 12-lead ECG in detecting ischemic changes and in assessing their severity.
It is common knowledge that the ECG diagnosis of completed myocardial infarction in the presence of left bundle-branch block (LBBB) is extremely difficult and often impossible. More than 50 rules have been proposed as criteria for interpreting Q-wave equivalents superimposed on the QRS complex in the presence of LBBB. However, because of misinterpretation of the available literature, physicians frequently recommend that patients with chest pain in the presence of LBBB receive thrombolytic therapy or urgent coronary arteriography on the basis of the assumption that acute injury and ischemia cannot be interpreted in the presence of LBBB. Unfortunately, many physicians fail to realize that although completed infarction is difficult to confirm in the presence of LBBB, ongoing ischemia and injury can be detected in the presence of LBBB and may be seen as often as they are in the presence of normal cardiac conduction. A deflection of the J point (and ST segment) in the direction of the major QRS complex or an elevation of the ST segment of more than 7 to 8 mm opposite the direction of the major QRS complex has been demonstrated to have a sensitivity of more than 50% in detecting acute injury, with a specificity of more than 90%. During the first half of an ongoing prospective study of the use of continuous 12-lead ECG monitoring in the emergency department, we encountered five patients with final diagnoses of acute myocardial infarction in the presence of LBBB who demonstrated significant ECG changes while undergoing continuous ST-segment monitoring with frequent serial ECGs. The five different locations of the infarcts in these five patients were posterior, posterolateral, inferior, anterior, and anterolateral. We present these patients' cases to demonstrate the ECG characteristics of acute injury in the presence of LBBB.
The 12-lead electrocardiogram (ECG) is a powerful clinical tool used in the evaluation of chest pain patients, assisting in the selection of the proper therapy. Unfortunately, the ECG is diagnostic of acute myocardial infarction (AMI) in only one-half of such patients at initial hospital evaluation. In the remaining group of patients with the nondiagnostic 12-lead electrocardiogram, the ECG may be entirely normal, show nonspecific sinus tachycardia (ST) segment-T wave abnormalities, or obvious ischemic changes. In adult chest pain patients treated in the emergency department (ED), 1% to 4% of such patients with an absolutely normal ECG had a final hospital diagnosis of AMI; furthermore, patients with nonspecific electrocardiographic abnormalities experienced AMI in 4% of cases. These findings reinforce the teaching point that the history is the most important tool used in the evaluation of chest pain patients. Furthermore, overreliance on a normal or nonspecifically abnormal ECG in a patient with a classic description of anginal chest pain is dangerous.
Equine chorionic gonadotrophin (eCG) is still used to promote follicular growth in cattle and, more recently with an increased frequency of administration, in ovum pick-up protocols. The aim of this experiment was to verify the possible effect of high frequency of administration on the immune response to eCG. The profiles of eCG binding rate, in the blood of two groups (A, B) of 4 primiparous cross breed beef cows (3-3.5 years old) submitted weekly for 5 to 10 weeks to repeated high doses (1000-2000 IU) of equine chorionic gonadotrophin, are presented in this paper. A sensitive radiometric method was used to detect antibodies in plasma. The profiles clearly indicated a marked increase of eCG binding rate after 3 to 5 injections of the exogenous hormone to the females. The statistical analysis of the results established that treatments induced a significant increase (P < 0.01) in binding rates after 6 and 3 injections in group A and B respectively. These binding rates remained elevated for at least 1 week following the last injection and decreased afterwards. The values of plasma binding rates following repeated eCG administration differed significantly between groups (0.90+/-1.04 and 1.04+/-0.11 for groups A and B before treatment versus 11.77+/-0.92, 6.70+/-0.85 for groups A and B after treatment, P < 0.01) and from one cow to another (P < 0.01) with some cows presenting no significant immune response while others were more reactive against the hormone (at least 3 injections).